Abstract：
:Skin ageing is an inevitable consequence of life and accelerated by exposure to ultraviolet (UV) rays. Senescence is an irreversible growth arrest and senescent cells accumulate in ageing tissues, at sites of age-related pathologies and in pre-neoplastic lesions. Conventionally, senescent cells have been detected by senescence associated-β-galactosidase (SA-β-gal) staining, a procedure that requires enzymatic activity, which is lost in fixed tissue samples. We previously demonstrated that loss of lamin B1 is a novel marker to identify senescent cells. Here, we demonstrate that loss of lamin B1 facilitates the detection and quantification of senescent cells upon UV-exposure in vitro and upon chronic UV-exposure and skin regeneration in vivo. Taken together, this marker enables the study of environmental conditions on tissue ageing and regeneration in vivo, serves as a diagnostic tool to distinguish senescent from proliferating cells in pre-neoplastic lesions, and facilitates investigating the role of senescent cells in various age-related pathologies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang AS,Ong PF,Chojnowski A,Clavel C,Dreesen Odoi
10.1038/s41598-017-15901-9subject
Has Abstractpub_date
2017-11-15 00:00:00pages
15678issue
1issn
2045-2322pii
10.1038/s41598-017-15901-9journal_volume
7pub_type
杂志文章abstract：:Calcification is important for the diagnosis of papillary thyroid carcinoma (PTC). Runt-related transcription factor 2 (RUNX2), a master transcription factor associated with osteogenic differentiation, is reportedly related to PTC calcification and invasiveness. However, its regulatory role in this process is somewhat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43207-5
更新日期：2019-05-01 00:00:00
abstract：:A body with mechanical sensors may remotely detect particles suspended in the surrounding fluid via controlled agitation. Here we propose a sensory mode that relies on generating unsteady flow and sensing particle-induced distortions in the flow field. We demonstrate the basic physical principle in a simple analytical...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58880-0
更新日期：2020-02-14 00:00:00
abstract：:To investigate the mechanism underlying AT1-AA-induced retinopathy in severe preeclampsia by measuring the positive rate and titer of AT1-AA in plasma from women with severe preeclampsia and normal pregnant women to see whether AT1-AA titer was correlated with the grade of retinopathy. A preeclampsia rat model was als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29036
更新日期：2016-07-06 00:00:00
abstract：UNLABELLED:To fabricate high-performance metal-halide perovskite solar cells, a thermal annealing process is indispensable in preparing high quality perovskite film. And usually such annealing is performed on hot plate. However hot-plate annealing could cause problems such as inhomogeneous heating (induced by non-tight...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21257
更新日期：2016-02-16 00:00:00
abstract：:The study aimed at investigating the extent to which the brain adaptively exploits or compensates interaction torque (IT) during movement control in various velocity and load conditions. Participants performed arm pointing movements toward a horizontal plane without a prescribed reach endpoint at slow, neutral and rap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38845
更新日期：2016-12-12 00:00:00
abstract：:A plasmonic Ag/TiO2 photocatalytic composite was designed by selecting Ag quantum dots (Ag QDs) to act as a surface plasmon resonance (SPR) photosensitizer for driving the visible-light driven photoelectrocatalytic hydrogen evolution. Vertically oriented hierarchical TiO2 nanotube arrays (H-TiO2-NTAs) with macroporous...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10461
更新日期：2015-06-12 00:00:00
abstract：:Enhanced oil recovery using low-salinity solutions to sweep sandstone reservoirs is a widely-practiced strategy. The mechanisms governing this remain unresolved. Here, we elucidate the role of Ca2+ by combining chemical force microscopy (CFM) and molecular dynamics (MD) simulations. We probe the influence of electroly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10327-9
更新日期：2017-09-08 00:00:00
abstract：:The Malay people are an important ethnic composition in Southeast Asia, but their genetic make-up and population structure remain poorly studied. Here we conducted a genome-wide study of four geographical Malay populations: Peninsular Malaysian Malay (PMM), Singaporean Malay (SGM), Indonesian Malay (IDM) and Sri Lanka...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14375
更新日期：2015-09-23 00:00:00
abstract：:Uncertainties over future climatic conditions pose significant challenges when selecting appropriate conservation strategies for heritage sites. Choosing effective strategies is especially important for earthen heritage sites located in dryland regions, as many are experiencing rapid environmentally-driven deteriorati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73456-8
更新日期：2020-10-02 00:00:00
abstract：:The relationship between obstructive sleep apnea (OSA) and chronic rhinosinusitis (CRS) still remains unclear. This retrospective cohort study aimed to investigate the relationship between OSA and subsequent CRS using a population-based dataset. The study used data from the Taiwan Longitudinal Health Insurance Databas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20786
更新日期：2016-02-10 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23132-9
更新日期：2018-03-19 00:00:00
abstract：:Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been identified in humans and mice on the basis of their extensive portfoli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50065-8
更新日期：2019-09-17 00:00:00
abstract：:COVID-19 caused by the SARS-CoV-2 is a current global challenge and urgent discovery of potential drugs to combat this pandemic is a need of the hour. 3-chymotrypsin-like cysteine protease (3CLpro) enzyme is the vital molecular target against the SARS-CoV-2. Therefore, in the present study, 1528 anti-HIV1compounds wer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77524-x
更新日期：2020-11-23 00:00:00
abstract：:Due to their small dimensions, electrophysiology on thin and intricate axonal branches in support of understanding their role in normal and diseased brain function poses experimental challenges. To reduce experimental complexity, we coupled microelectrode arrays (MEAs) to bi-level microchannel devices for the long-ter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09033-3
更新日期：2017-08-17 00:00:00
abstract：:Quantitative measurement and analysis of tumor metabolic activities could provide a more optimal solution to personalized accurate dose painting. We collected PET images of 58 lung cancer patients, in which the tumor exhibits heterogeneous FDG uptake. We design an automated delineation and quantitative heterogeneity m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28818-8
更新日期：2018-07-13 00:00:00
abstract：:Type 2 Diabetes (T2D) is increasing but the effectiveness of large-scale diabetes screening programmes is debated. We assessed associations between coverage of a national cardiovascular and diabetes risk assessment programme in England (NHS Health Check) and detection and management of incident cases of non-diabetic h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58033-3
更新日期：2020-01-27 00:00:00
abstract：:In the presence of a lateral periodic potential modulation, two-dimensional electrons may exhibit interesting phenomena, such as a graphene-like energy-momentum dispersion, Bloch oscillations, or the Hofstadter butterfly band structure. To create a sufficiently strong potential modulation using conventional semiconduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20967
更新日期：2016-02-11 00:00:00
abstract：:Proton irradiation is often used as a proxy for neutron irradiation but the irradiated layer is typically <50 μm deep; this presents a problem when trying to obtain mechanical test data as a function of irradiation level. Two novel methodologies have been developed to record stress-strain curves for thin proton-irradi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62241-2
更新日期：2020-03-24 00:00:00
abstract：:Surgical treatment of tendon lesions still yields unsatisfactory clinical outcomes. The use of bioresorbable scaffolds represents a way forward to improve tissue repair. Scaffolds for tendon reconstruction should have a structure mimicking that of the natural tendon, while providing adequate mechanical strength and st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35536-8
更新日期：2018-11-21 00:00:00
abstract：:For many applications heterogeneity is a direct indicator of material quality. Reliable determination of chemical heterogeneity is however not a trivial task. Spectral imaging can be used for determining the spatial distribution of an analyte in a sample, thus transforming each pixel of an image into a sampling cell. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28889-7
更新日期：2018-07-11 00:00:00
abstract：:Several MRI contrast agent clinical formulations are now known to leave deposits of the heavy metal gadolinium in the brain, bones, and other organs of patients. This persistent biological accumulation of gadolinium has been recently recognized as a deleterious outcome in patients administered Gd-based contrast agents...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22511-6
更新日期：2018-03-13 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory condition with variable clinical presentation and disease progression. Importantly, animal models of RA are widely used to examine disease pathophysiology/treatments. Here, we exploited known vendor colony-based differences in endocrine/immune responses to gain insig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00652-4
更新日期：2017-04-06 00:00:00
abstract：:A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-22153-8
更新日期：2018-03-06 00:00:00
abstract：:The compound Sr0.5Ce0.5FBiS2 belongs to the intensively studied family of layered BiS2 superconductors. It attracts special attention because superconductivity at T sc = 2.8 K was found to coexist with local-moment ferromagnetic order with a Curie temperature T C = 7.5 K. Recently it was reported that upon replacing...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17637-y
更新日期：2017-12-12 00:00:00
abstract：:The purposes of this study are to investigate the neural representation of a speech stimulus in the auditory system of individuals with normal hearing (NH) and those with hearing aids (HAs) and to explore the impact of noise reduction algorithms (NR) on auditory brainstem response to complex sounds (cABR). Twenty NH i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66970-2
更新日期：2020-07-01 00:00:00
abstract：:The association between alcohol consumption and kidney function is intriguing, but study results are mixed and controversial. We examined the association of alcohol consumption with the overall change in kidney function over 12 years. We analyzed data from a population-based cohort that was part of the Korean Genome a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81777-5
更新日期：2021-01-27 00:00:00
abstract：:Metasurfaces are ideal candidates for conformal wave manipulation on curved objects due to their low profiles and rich functionalities. Here we design and analyze conformal metasurfaces for practical optical applications at 532 nm visible band for the first time. The inclusions are silicon disk nanoantennas embedded i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38440
更新日期：2016-12-08 00:00:00
abstract：:The occurrence of toxic metals in the aquatic environment is as caused by a variety of contaminations which makes difficulty in the concentration prediction. In this study, conventional methods of back-propagation neural network (BPNN) and nonlinear autoregressive network with exogenous inputs (NARX) were applied as b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70438-8
更新日期：2020-08-10 00:00:00
abstract：:Genetic polymorphisms in drug metabolizing enzymes and drug transporters may affect irinotecan toxicity. Although genetic polymorphisms have been shown to influence the irinotecan toxicity, data are limited in Thai population. Thus, the aim of this study was to assess the allele and genotype frequencies and the relati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70351-0
更新日期：2020-08-10 00:00:00
abstract：:Numerous studies have reported cold atmospheric plasma cytotoxic activities in various cancer cell lines, either by direct exposure to non-thermal plasma or indirectly by activating a medium (plasma-activated medium, PAM) prior to cell treatment. We suggested the use of in vitro 3D tumor model spheroids to determine t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41408-6
更新日期：2019-03-19 00:00:00
