Abstract：
:Glucocorticoids (GC) display pleiotropic effects on the immune system. Macrophages are a major target for GC action. Here we show that dexamethasone (DEX), a synthetic GC, decreased viability of naïve bone marrow-derived macrophages (BMDM), involving an apoptotic mechanism. Administration of DEX together with lipopolysaccharide (LPS) protected BMDM against DEX-mediated cell death, suggesting that activated BMDM respond to DEX differently than naïve BMDM. An insight to the molecular basis of LPS actions was provided by a 7 fold increase in mRNA levels of glucocorticoid receptor beta (GRβ), a GR dominant-negative splice variant which inhibits GRα's transcriptional activity. LPS did not inhibit all DEX-mediated effects on BMDM; DEX significantly reduced the percentage of BMDM expressing high levels of the cell surface markers F4/80 and CD11b and led to a decrease in macrophage inflammatory protein 1 alpha (MIP1-α) mRNA and protein levels. These two DEX-mediated effects were not prevented by LPS. Our finding that LPS did not reduce the DEX-induced elevation of glucocorticoid-induced leucine zipper (GILZ), a mediator of GCs anti-inflammatory actions, may provide an underlying mechanism. These findings enable a better understanding of clinical states, such as sepsis, in which macrophages are activated by endotoxins and treatment by GCs is considered.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Haim YO,Unger ND,Souroujon MC,Mittelman M,Neumann Ddoi
10.1038/srep04323subject
Has Abstractpub_date
2014-03-10 00:00:00pages
4323issn
2045-2322pii
srep04323journal_volume
4pub_type
杂志文章abstract：:Immunotherapies demand for predictive biomarkers to avoid unnecessary adverse effects and costs. Analytic morphomics is the technique to use body composition measures as imaging biomarkers for underlying pathophysiology to predict prognosis or outcome to therapy. We investigated different body composition measures to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46189-6
更新日期：2019-07-05 00:00:00
abstract：:In a 250-kyr transient simulation of the Community Earth System Model (CESM), we identified a precessional forced seesaw of the summer middle-upper tropospheric eddy temperature between Asia and the North Pacific as the paleo-APO (Asian-Pacific oscillation). The paleo-APO variability is out of phase with the precessio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28349
更新日期：2016-07-06 00:00:00
abstract：:The morbidity and mortality rates of human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfection are higher than that of either infection alone. Outcomes and the virological response to antiretrovirals (combination antiretroviral therapy, cART) were explored in HIV/HBV subjects in a cohort of Italian patien...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46976-1
更新日期：2019-08-16 00:00:00
abstract：:Distributed position and orientation systems (DPOSs) can provide abundant time-spatial information for interferometric synthetic aperture radar (InSAR) in airborne earth observation systems. However, some key error terms have not been taken into consideration in the traditional low-order error model, which suppresses ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77595-w
更新日期：2020-11-24 00:00:00
abstract：:The Anfinsen hypothesis, the demonstration of which led to the Nobel prize in Chemistry, posits that all information required to determine a proteins' three dimensional structure is contained within its amino acid sequence. This suggests that it should be possible, in theory, to fold any protein in vitro. In practice,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18906
更新日期：2016-01-19 00:00:00
abstract：:Microtubule affinity regulating kinase 4 (MARK4) becomes a unique anti-cancer drug target as its overexpression is responsible for different types of cancers. In quest of novel, effective MARK4 inhibitors, some acridone derivatives were synthesized, characterized and evaluated for inhibitory activity against human MAR...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38217-8
更新日期：2019-02-08 00:00:00
abstract：:The production of male and female offspring is often determined by the presence of specific sex chromosomes which control sex-specific expression, and sex chromosomes evolve through reduced recombination and specialized gene content. Here we present the genomes of Chrysomya rufifacies, a monogenic blow fly (females pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72880-0
更新日期：2020-09-25 00:00:00
abstract：:Unlike MoS2 ultra-thin films, where solution-based single source precursor synthesis for electronic applications has been widely studied, growing uniform and large area few-layer WS2 films using this approach has been more challenging. Here, we report a method for growth of few-layer WS2 that results in continuous and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58694-0
更新日期：2020-02-03 00:00:00
abstract：:Protein colocalisation is often studied using pixel intensity-based coefficients such as Pearson, Manders, Li or Costes. However, these methods cannot be used to study object-based colocalisations in biological systems. Therefore, a novel method is required to automatically identify regions of fluorescent signal in tw...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08786-1
更新日期：2017-08-21 00:00:00
abstract：:Heterostructures based on two-dimensional (2D) materials have sparked wide interests in both fundamental physics and applied devices. Recently, Dirac/Weyl semimetals are emerging as capable functional materials for optoelectronic devices. However, thus far the interfacial coupling of an all-semimetal 2D heterostructur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29717-8
更新日期：2018-08-27 00:00:00
abstract：:In the chemical mechanical polishing process of semiconductor manufacturing, the concentration of 'large' particles ([Formula: see text]0.5 μm) in the slurry, which is considerably larger in size than the main abrasives ([Formula: see text] 0.1 μm), is a critical parameter that strongly influences manufacturing defect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71768-3
更新日期：2020-09-07 00:00:00
abstract：:In this paper we report for the first time an n-type carbon nanotube field effect transistor which is air- and water-stable, a necessary requirement for electrolyte gated CMOS circuit operation. The device is obtained through a simple process, where the native p-type transistor is converted to an n-type. This conversi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29882-w
更新日期：2018-07-30 00:00:00
abstract：:Colloidal based films have been widely developed for a wide range of applications including chemical and electrical barrier coatings, photonic materials, biomaterials, and pharmaceutical oral drug delivery. Many previous studies investigate methods to generate uniformity or desired stratification of the final componen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66875-0
更新日期：2020-06-24 00:00:00
abstract：:The aim of this study was to identify genes for which the expression within carotid atherosclerosis was reproducibly associated with the symptoms of cerebral embolization. Two publically available microarray datasets E-MEXP-2257 and GSE21545 were analysed using GeneSpring 11.5. The two datasets utilized a total of 22 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04497-9
更新日期：2017-06-28 00:00:00
abstract：:Peach (Prunus persica, Rosaceae) is an extremely popular tree fruit worldwide, with an annual production near 20 million tons. Peach is widely thought to have origins in China, but its evolutionary history is largely unknown. The oldest evidence for the peach has been Chinese archaeological records dating to 8000-7000...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16794
更新日期：2015-11-26 00:00:00
abstract：:Mechanical forces are critical to modulate cell spreading, contractility, gene expression, and even stem cell differentiation. Yet, existing tools that can apply controllable subcellular forces to a large number of single cells simultaneously are still limited. Here we report a novel ultrasound tweezing cytometry util...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02176
更新日期：2013-01-01 00:00:00
abstract：:In 1842 Charles Darwin claimed that vertical growth on a subsiding foundation caused fringing reefs to transform into barrier reefs then atolls. Yet historically no transition between reef types has been discovered and they are widely considered to develop independently from antecedent foundations during glacio-eustat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04997
更新日期：2014-05-21 00:00:00
abstract：:The human brain contains areas that respond selectively to faces, bodies and scenes. Neuroimaging studies have shown that a subset of these areas preferentially respond more to moving than static stimuli, but the reasons for this functional dissociation remain unclear. In the present study, we simultaneously mapped th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44663-9
更新日期：2019-06-03 00:00:00
abstract：:Systems with a discrete rotational symmetry [Formula: see text] where [Formula: see text] that also have electromagnetic duality symmetry exhibit zero backscattering. The impact of breaking one of the two symmetries on the emerging backscattering has not yet been systematically studied. Here, we investigate the effect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80347-5
更新日期：2021-01-18 00:00:00
abstract：:New high-frequency 5G and satellite communication systems require fully-metallic antennas and electromagnetic components. These components can be implemented with truncated versions of periodic structures. In order to achieve the desired performance of these future devices, it is of crucial importance to have a precis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29565-6
更新日期：2018-07-26 00:00:00
abstract：:The experimental approach for the study of cardiometabolic disorders requires the use of animal models fed with commercial diets whose composition differs notably, even between diets used for control groups. While chow diets are usually made of agricultural by-products, purified low-fat diets (LF) contain a higher per...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59674-0
更新日期：2020-02-19 00:00:00
abstract：:Assembly of nanowires into ordered macroscopic structures with new functionalities has been a recent focus. In this Letter, we report a new route for ordering hydrophilic Ag nanowires with high aspect ratio by flowing through a glass capillary. The present glass capillary with well-defined silver nanowire films inside...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00987
更新日期：2012-01-01 00:00:00
abstract：:Kaposiform hemangioendothelioma (KHE) is a relatively rare vascular tumor with an aggressive and infiltrating nature. Previous studies have revealed an exclusive relationship between KHE and Kasabach-Merritt Phenomenon (KMP), which is associated with high morbidity and mortality. No universally accepted treatment moda...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep36261
更新日期：2016-10-31 00:00:00
abstract：:BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to und...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28491
更新日期：2016-06-24 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-63944-2
更新日期：2020-04-22 00:00:00
abstract：:The accurate diagnosis of malignant cervical lymphadenopathy remains challenging. In this study, we determined the value of quantitative parameters derived from dual-energy computed tomography (DECT) for differentiating malignant cervical lymphadenopathy caused by thyroid carcinoma (TC), salivary gland carcinoma (SC),...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31020
更新日期：2016-08-08 00:00:00
abstract：:Whole-slide imaging of histologic sections captures tissue microenvironments and cytologic details in expansive high-resolution images. These images can be mined to extract quantitative features that describe tissues, yielding measurements for hundreds of millions of histologic objects. A central challenge in utilizin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15092-3
更新日期：2017-11-06 00:00:00
abstract：:We investigated high-efficiency two-terminal tandem photovoltaic (PV) devices consisting of a p/i/n thin film silicon top sub-cell (p/i/n-TFS) and a heterojunction with an intrinsic thin-layer (HIT) bottom sub-cell. We used computer simulations and experimentation. The short-circuit current density (Jsc) of the top su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33734-y
更新日期：2018-10-18 00:00:00
abstract：:Strong hydrogen bonds such as F···H···F offer new strategies to fabricate molecular architectures exhibiting novel structures and properties. Along these lines and, to potentially realize hydrogen-bond mediated superexchange interactions in a frustrated material, we synthesized [H2F]2[Ni3F6(Fpy)12][SbF6]2 (Fpy = 3-flu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23054-6
更新日期：2018-03-16 00:00:00
abstract：:We report on the optical and structural characterization of rubrene polycrystalline films fabricated from vacuum deposition with various substrate temperatures (Tsub). Depending on Tsub, the role of twisted and planar rubrene conformational isomers on the properties of rubrene films is focused. The temperature (T)-dep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40824
更新日期：2017-01-16 00:00:00
