Abstract：
:Kaposiform hemangioendothelioma (KHE) is a relatively rare vascular tumor with an aggressive and infiltrating nature. Previous studies have revealed an exclusive relationship between KHE and Kasabach-Merritt Phenomenon (KMP), which is associated with high morbidity and mortality. No universally accepted treatment modality exists for refractory KHE with or without KMP. The aim of this study was to evaluate the safety and efficacy of interferon-alpha (IFN-α) therapy for treatment of refractory KHE. Twelve consecutive patients with KHE were treated with subcutaneous injections of IFN-α after other treatments had failed. Eleven patients exhibited a reduction in tumor size of more than 50%, and the platelet count for all five patients with KMP returned to normal level after IFN-α therapy. The duration of IFN-α treatment ranged from 3 months to 9 months (mean: 6.3 months). The response time for IFN-α treatment ranged from 10 days to 5 weeks (mean: 3.6 weeks). Additionally, no severe complications, such as neurological damage or spastic diplegia, were observed in these patients. In conclusion, our study suggested that IFN-α therapy is effective and safe for refractory KHE, and IFN-α may be used as an alternative after other treatments have failed.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wu HW,Wang X,Zhang L,Zhao HG,Wang YA,Su LX,Fan XD,Zheng JWdoi
10.1038/srep36261subject
Has Abstractpub_date
2016-10-31 00:00:00pages
36261issn
2045-2322pii
srep36261journal_volume
6pub_type
临床试验,杂志文章abstract：:Circadian clocks are endogenous oscillators driving daily rhythms in physiology. The cell-autonomous clock is governed by an interlocked network of transcriptional feedback loops. Hundreds of clock-controlled genes (CCGs) regulate tissue specific functions. Transcriptome studies reveal that different organs (e.g. live...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05782
更新日期：2014-07-22 00:00:00
abstract：:Much of atmospheric water originates from transpiration, the process by which plants release H2O from pores, known as stomata, that simultaneously intake CO2 for photosynthesis. Controlling stomatal aperture can regulate the extent of water transport in response to dynamic environmental factors including osmotic stres...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32394
更新日期：2016-08-31 00:00:00
abstract：:This study examines the analytical and numerical solution of electromagnetic surface waves supported by a resistive metasurface-covered grounded metamaterial structure. To simulate the metamaterial, the Kramers-Kronig relation based on the causality principle is used, while the modeling of the resistive metasurface ha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72396-7
更新日期：2020-09-23 00:00:00
abstract：:Many experimental techniques rely on specific recognition and stringent binding of proteins by antibodies. This can readily be achieved by introducing an epitope tag. We employed an approach that uses a relative lack of evolutionary conservation to inform epitope tag site selection, followed by integration of the tag-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36986
更新日期：2016-11-28 00:00:00
abstract：:The global problem of unowned domestic cats, driven by their phenomenal reproductive success, carries significant economic, animal welfare and biodiversity costs. Desexing owned cats prior to puberty prevents unwanted litters that contribute to unowned cat populations. The prevalence and predictors of desexing, and th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79513-6
更新日期：2021-01-18 00:00:00
abstract：:When lightning strikes soil, it may generate a cylindrical tube of glass known as a fulgurite. The morphology of a fulgurite is ultimately a consequence of the energy of the lightning strike that formed it, and hence fulgurites may be useful in elucidating the energy distribution frequency of cloud-to-ground lightning...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30586
更新日期：2016-07-28 00:00:00
abstract：:In our experiment, it was observed that the emission of direct-gap band in germanium with Ge-GeSn layers on one-dimensional (1D) structure. The results of experiment and calculation demonstrate that the uniaxial tensile strain in the (111) and (110) direction can efficiently transform Ge to a direct bandgap material w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24802
更新日期：2016-04-21 00:00:00
abstract：:The brain is organized into large scale spatial networks that can be detected during periods of rest using fMRI. The brain is also a dynamic organ with activity that changes over time. We developed a method and investigated properties where the connections as a function of time are derived and quantified. The point ba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39156
更新日期：2016-12-19 00:00:00
abstract：:For people suffering from severe paralysis, communication can be difficult or nearly impossible. Technology systems called brain-computer interfaces (BCIs) are being developed to assist these people with communication by using their brain activity to control a computer without any muscle activity. To benefit the devel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50834-5
更新日期：2019-10-02 00:00:00
abstract：:Here, we report a newly designed knee plug to be used in the 3rd generation of Autologous Chondrocyte Implantation (ACI) in order to heal the damaged knee cartilage. It is composed of three components: The first component (Bone Portion) is a 3D printed hard scaffold with large pores (~ 850 µm), made by hydroxyapatite ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73863-x
更新日期：2020-10-12 00:00:00
abstract：:Embryonic Stem Cells (ESCs) are expected to show a stable euploid karyotype, but in the last decade (sub)chromosomal aberrations have been systematically described in these cell lines when maintained in vitro. Culture conditions and long-term culture have been traditionally proposed as possible factors involved in the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05324
更新日期：2014-06-17 00:00:00
abstract：:This paper describes an origami-inspired self-folding method to form three-dimensional (3D) microstructures of co-cultured cells. After a confluent monolayer of fibroblasts (NIH/3T3 cells) with loaded hepatocytes (HepG2 cells) was cultured onto two-dimensional (2D) microplates, degradation of the alginate sacrificial ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22598-x
更新日期：2018-03-14 00:00:00
abstract：:It has been demonstrated that development of three-dimensional printing technology has supported the researchers and surgeons to apply the bone tissue engineering to the oromandibular reconstruction. In this study, poly caprolactone/beta tricalcium phosphate (PCL/β-TCP) scaffolds were fabricated by multi-head depositi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61944-w
更新日期：2020-03-18 00:00:00
abstract：:The use of lithium (Li) metal anodes has been reconsidered because of the necessity for a higher energy density in secondary batteries. However, Li metal anodes suffer from 'dead' Li formation and surface deactivation which consequently form a porous layer of redundant Li aggregates. In this work, a fibrous metal felt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30830
更新日期：2016-08-03 00:00:00
abstract：:Although silicon (Si) has been widely reported to alleviate plant nutrient deficiency, the underlying mechanism in potassium (K) deficiency is poorly understood. In this study, sorghum seedlings were treated with Si under a K deficiency condition for 15 days. Under control conditions, plant growth was not affected by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22882
更新日期：2016-03-10 00:00:00
abstract：:The myxozoan parasite, Tetracapsuloides bryosalmonae has a two-host life cycle alternating between freshwater bryozoans and salmonid fish. Infected fish can develop Proliferative Kidney Disease, characterised by a gross lymphoid-driven kidney pathology in wild and farmed salmonids. To facilitate an in-depth understand...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77881-7
更新日期：2021-01-25 00:00:00
abstract：:Recently, structural colour formation and light control by accumulated guanine crystals were reported. However, the relationship between light interference by guanine platelets and light intensity in an individual platelet must be examined further. This study presents experimental evidence that the guanine crystal pla...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34866-x
更新日期：2018-11-19 00:00:00
abstract：:Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet count (PC) were shown to be prognostic in several solid malignancies. We analysed 603 R0 resected patients to assess whether NLR, PLR and PC correlate with other well-known prognostic factors and survival of patients with colorectal ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01652-0
更新日期：2017-05-04 00:00:00
abstract：:Gold is a noble metal typically stable as a solid in a face-centered cubic (FCC) structure under ambient conditions; however, under particular circumstances aberrant allotropes have been synthesized. In this work, we document the phase transformation of 25 nm thick nanocrystalline (NC) free-standing gold thin-film via...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74779-2
更新日期：2020-10-20 00:00:00
abstract：:Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no specific studies of how GNS ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79393-w
更新日期：2021-01-13 00:00:00
abstract：:Hundreds of cellular host factors are required to support dengue virus infection, but their identity and roles are incompletely characterized. Here, we identify human host dependency factors required for efficient dengue virus-2 (DENV2) infection of human cells. We focused on two, TTC35 and TMEM111, which we previousl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45910-9
更新日期：2019-07-04 00:00:00
abstract：:When multiple information are spread on social networks, there may be Cooperation and Competition among these information. Based on a new spreading model of multiple information, we studied Cooperation and Competition in information spreading, and analyzed the influence of different factors on Cooperation and Competit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69098-5
更新日期：2020-07-22 00:00:00
abstract：:Here we report two types of defect-induced photoluminescence (PL) blinking behaviors observed in single epitaxial InGaAs quantum dots (QDs). In the first type of PL blinking, the "off" period is caused by the trapping of hot electrons from the higher-lying excited state (absorption state) to the defect site so that it...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08898
更新日期：2015-03-10 00:00:00
abstract：:A binary metallic superoscillatory lens assisted with annular subwavelength slits is proposed, which generates a longitudinally-polarized super-resolution focal point. The annular slits are designed to selectively transmit radially-polarized light. Simulations using the finite element method show a 0.24 λ focal spot w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56810-3
更新日期：2020-01-28 00:00:00
abstract：:A fracture is the most dangerous complication of osteoporosis in patients because the associated disability and mortality rates are high. Osteoporosis impairs fracture healing and prognosis, but how intramembranous ossification (IO) or endochondral ossification (EO) during fracture healing are affected and whether the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22095-1
更新日期：2018-03-01 00:00:00
abstract：:Programmed death-1 (PD-1) is an immunosuppressive receptor functionally bound with programmed death-ligand 1 (PD-L1), which has been reported in various malignancies. However, only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). In this study, we aim to invest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43627
更新日期：2017-03-03 00:00:00
abstract：:Radiation weighting factor wR for photons and electrons has been defined as unity independently of the energy of the particles. However, the biological effects depend on the incident energies according to in vitro experimental data. In this study, we have quantified the energy concentration along electron tracks in te...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54081-6
更新日期：2019-11-27 00:00:00
abstract：:The sex-determining gene SRY induces SOX9 expression in the testes of eutherian mammals via two pathways. SRY binds to testis-specific enhancer of Sox9 (TESCO) with SF1 to activate SOX9 transcription. SRY also up-regulates ER71 expression, and ER71 activates Sox9 transcription. After the initiation of testis different...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32874
更新日期：2016-09-09 00:00:00
abstract：:Although there is evidence that non-steroidal anti-inflammatory drugs (NSAIDs) might be able to prevent pancreatic cancer, the findings from epidemiological studies have been inconsistent. In this paper, we conducted a meta-analysis of observational studies to examine this possibility. We searched PubMed and Embase fo...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep15460
更新日期：2015-10-21 00:00:00
abstract：:Innate immunity has been extended to respond environmental pathogen other than microbial components. Here we explore a novel pollen/TLR4 innate immunity in allergic inflammation. In experimental allergic conjunctivitis induced by short ragweed (SRW) pollen, typical allergic signs, stimulated IL-33/ST2 signaling and ov...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36150
更新日期：2016-10-31 00:00:00
