Bioengineering of non-pathogenic Escherichia coli to enrich for accumulation of environmental copper.

abstract：:Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been est...

journal_title：Scientific reports

authors： Stock K,Estrada MF,Vidic S,Gjerde K,Rudisch A,Santo VE,Barbier M,Blom S,Arundkar SC,Selvam I,Osswald A,Stein Y,Gruenewald S,Brito C,van Weerden W,Rotter V,Boghaert E,Oren M,Sommergruber W,Chong Y,de Hoogt R,Grae

更新日期：2016-07-01 00:00:00

abstract：:Unwanted clots lead to heart attack and stroke that result in a large number of deaths. Currently available anticoagulants have some drawbacks including their non-specific actions. Therefore novel anticoagulants that target specific steps in the coagulation pathway are being sought. Here we describe the identification...

journal_title：Scientific reports

authors： Girish VM,Kini RM

更新日期：2016-08-25 00:00:00

abstract：:First discovered in rural areas of middle-eastern China in 2009, severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonosis affecting hundreds of cases reported in China each year. Using the national surveillance data from 2010 to 2013, we conducted this retrospective epidemiological study a...

journal_title：Scientific reports

authors： Liu K,Zhou H,Sun RX,Yao HW,Li Y,Wang LP,Di Mu,Li XL,Yang Y,Gray GC,Cui N,Yin WW,Fang LQ,Yu HJ,Cao WC

更新日期：2015-04-23 00:00:00

abstract：:Bacteria are able to de-epoxidize or epimerize deoxynivalenol (DON), a mycotoxin, to deepoxy-deoxynivalenol (deepoxy-DON or DOM-1) or 3-epi-deoxynivalenol (3-epi-DON), respectively. Using different approaches, the intestinal toxicity of 3 molecules was compared and the molecular basis for the reduced toxicity investig...

journal_title：Scientific reports

authors： Pierron A,Mimoun S,Murate LS,Loiseau N,Lippi Y,Bracarense AP,Schatzmayr G,He JW,Zhou T,Moll WD,Oswald IP

更新日期：2016-07-06 00:00:00

abstract：:In specific cases, chromatin clearly forms long-range loops that place distant regulatory elements in close proximity to transcription start sites, but we have limited understanding of many loops identified by Chromosome Conformation Capture (such as Hi-C) analyses. In efforts to elucidate their characteristics and fu...

journal_title：Scientific reports

authors： Sobhy H,Kumar R,Lewerentz J,Lizana L,Stenberg P

更新日期：2019-03-14 00:00:00

abstract：:The studies investigating the effects of green tea on blood pressure (BP) have generated inconsistent results. The aim of this study is to quantitatively evaluate the effects of green tea on BP control. PubMed, Embase, and the Cochrane Library (updated to March 2014) were searched for randomized controlled trials eval...

journal_title：Scientific reports

authors： Peng X,Zhou R,Wang B,Yu X,Yang X,Liu K,Mi M

更新日期：2014-09-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a uniformly fatal condition of striated muscle wasting resulting in premature death from respiratory and/or cardiac failure. Symptomatic therapy has prolonged survival by limiting deaths resulting from respiratory insufficiency, but there is currently no effective therapy for most ...

journal_title：Scientific reports

authors： Fischer KD,Heitzman JA,Townsend D

更新日期：2019-08-23 00:00:00

abstract：:Aminopeptidases have emerged as new promising drug targets for the development of novel anti-parasitic drugs. An aspartyl aminopeptidase-like gene has been identified in the Toxoplasma gondii genome (TgAAP), although its function remains unknown. In this study, we characterized TgAAP and performed functional analysis ...

journal_title：Scientific reports

authors： Zheng J,Cheng Z,Jia H,Zheng Y

更新日期：2016-09-28 00:00:00

abstract：:The prevalence of tobacco use in people with schizophrenia is much higher than in general population, which indicates a close relationship between nicotine addiction and schizophrenia. However, the molecular mechanism underlying the high comorbidity of tobacco smoking and schizophrenia remains largely unclear. In this...

journal_title：Scientific reports

authors： Hu Y,Fang Z,Yang Y,Rohlsen-Neal D,Cheng F,Wang J

更新日期：2018-02-13 00:00:00

abstract：:Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We pos...

journal_title：Scientific reports

authors： Deritei D,Aird WC,Ercsey-Ravasz M,Regan ER

更新日期：2016-03-16 00:00:00

abstract：:The consumption of bovine milk and meat is considered a risk factor for colon- and breast cancer formation, and milk consumption has also been implicated in an increased risk for developing Multiple Sclerosis (MS). A number of highly related virus-like DNAs have been recently isolated from bovine milk and sera and fro...

journal_title：Scientific reports

authors： Eilebrecht S,Hotz-Wagenblatt A,Sarachaga V,Burk A,Falida K,Chakraborty D,Nikitina E,Tessmer C,Whitley C,Sauerland C,Gunst K,Grewe I,Bund T

更新日期：2018-02-12 00:00:00

abstract：:Atmospheric new particle formation (NPF) and growth significantly influences climate by supplying new seeds for cloud condensation and brightness. Currently, there is a lack of understanding of whether and how marine biota emissions affect aerosol-cloud-climate interactions in the Arctic. Here, the aerosol population ...

journal_title：Scientific reports

authors： Dall Osto M,Beddows DCS,Tunved P,Krejci R,Ström J,Hansson HC,Yoon YJ,Park KT,Becagli S,Udisti R,Onasch T,O Dowd CD,Simó R,Harrison RM

更新日期：2017-06-12 00:00:00

abstract：:Subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion develops with progressive white matter and cognitive impairments, yet no effective therapy is available. We investigated the temporal effects of minocycline on an experimental SIVD exerted by right unilateral common carotid arteries...

journal_title：Scientific reports

authors： Ma J,Zhang J,Hou WW,Wu XH,Liao RJ,Chen Y,Wang Z,Zhang XN,Zhang LS,Zhou YD,Chen Z,Hu WW

更新日期：2015-07-15 00:00:00

abstract：:This study aims to develop a prognostic risk prediction model for the development of silicosis among workers exposed to silica dust in China. The prediction model was performed by using retrospective cohort of 3,492 workers exposed to silica in an iron ore, with 33 years of follow-up. We developed a risk score system ...

journal_title：Scientific reports

authors： Tse LA,Dai J,Chen M,Liu Y,Zhang H,Wong TW,Leung CC,Kromhout H,Meijer E,Liu S,Wang F,Yu IT,Shen H,Chen W

更新日期：2015-06-19 00:00:00

abstract：:Epidemiologic studies have identified a positive association between obesity and colorectal neoplasia. Adiposity induces systemic low-grade inflammation, which is commonly assessed with a sensitive biomarker, C-reactive protein (CRP). To understand the molecular mechanisms of obesity in the etiology of colorectal neop...

journal_title：Scientific reports

authors： Kigawa N,Budhathoki S,Yamaji T,Iwasaki M,Inoue M,Tsugane S

更新日期：2017-06-30 00:00:00

abstract：:We report on measurements of the switching current distributions on two-dimensional superconducting NbTiN strips that are 5 nm thick and 80 nm wide. We observe that the width of the switching current distributions has a non-monotonous temperature dependence, where it is constant at the lowest temperatures up to about ...

journal_title：Scientific reports

authors： Ejrnaes M,Salvoni D,Parlato L,Massarotti D,Caruso R,Tafuri F,Yang XY,You LX,Wang Z,Pepe GP,Cristiano R

更新日期：2019-05-29 00:00:00

abstract：:In this work, TiN film deposited by plasma enhanced atomic layer deposition (PEALD) is adopted to modify the commercial anatase TiO2 powders. A series of analyses indicate that the surface modification of 20, 50 and 100 cycles of TiN by PEALD does not change the morphology, crystal size, lattice parameters, and surfac...

journal_title：Scientific reports

authors： Cao YQ,Zhao XR,Chen J,Zhang W,Li M,Zhu L,Zhang XJ,Wu D,Li AD

更新日期：2018-08-14 00:00:00

abstract：:The existing acoustic emission (AE) source location methods assume that acoustic waves propagate along straight lines, and the source location is determined by average wave velocity. Because of the heterogeneity of materials, location results often fail to meet the accuracy requirement. For this reason, an AE source l...

journal_title：Scientific reports

authors： Zhou ZL,Zhou J,Dong LJ,Cai X,Rui YC,Ke CT

更新日期：2017-08-07 00:00:00

abstract：:Colorectal cancer is one of the main causes of cancer death worldwide, and novel biomarkers are urgently needed for its early diagnosis and treatment. The utilization of metabolomics to identify and quantify metabolites in body fluids may allow the detection of changes in their concentrations that could serve as diagn...

journal_title：Scientific reports

authors： Martín-Blázquez A,Díaz C,González-Flores E,Franco-Rivas D,Jiménez-Luna C,Melguizo C,Prados J,Genilloud O,Vicente F,Caba O,Pérez Del Palacio J

更新日期：2019-12-27 00:00:00

abstract：:Evaluation of precipitation and nitrogen (N) deposition in desert ecosystems helps to elucidate the reaction of desert ecosystems to future environmental changes. An in-situ field experiment was established to examine the influence of a long-term enhanced precipitation and N deposition on the photosynthetic traits and...

journal_title：Scientific reports

authors： Zhao WQ,Lv XH,Li YG,Wang ZK,Zhang W,Zhuang L

更新日期：2019-03-08 00:00:00

abstract：:During interpersonal interactions, people perform actions with different forms of vitality, communicating their positive or negative attitude toward others. For example, a handshake can be "soft" or "vigorous", a caress can be 'kind' or 'rushed'. While previous studies have shown that the dorso-central insula is a key...

journal_title：Scientific reports

authors： Di Cesare G,Vannucci F,Rea F,Sciutti A,Sandini G

更新日期：2020-10-09 00:00:00

abstract：:Damage of enteric neurons and partial or total loss of selective neuronal populations are reported in intestinal disorders including inflammatory bowel diseases and necrotizing enterocolitis. To develop three-dimensional scaffolds for enteric neurons we propose the decoration of ionic-complementary self-assembling pep...

journal_title：Scientific reports

authors： Brun P,Zamuner A,Peretti A,Conti J,Messina GML,Marletta G,Dettin M

更新日期：2019-04-03 00:00:00

abstract：:Resin composites containing reinforcing inert glass fillers combined with bioactive glass (BG) can aid in the prevention of secondary caries, which is a major cause of failure of contemporary composite restorations. A series of previous studies on experimental resin composites filled with BG 45S5 has demonstrated that...

journal_title：Scientific reports

authors： Par M,Spanovic N,Tauböck TT,Attin T,Tarle Z

更新日期：2019-11-21 00:00:00

abstract：:A method for defect characterization is presented that allows to measure the activation energy, capture cross-section, and defect density in dielectric materials. This is exemplarily performed on aluminum oxide thin films deposited on hydrogen-terminated diamond. During the measurement, samples were illuminated using ...

journal_title：Scientific reports

authors： Oing D,Geller M,Stahl L,Kerski J,Lorke A,Wöhrl N

更新日期：2020-07-27 00:00:00

abstract：:Nearly half of the world's population obtains its daily calories from rice grains, which lack or have insufficient levels of essential micronutrients. The deficiency of micronutrients vital for normal growth is a global health problem, and iron, zinc and vitamin A deficiencies are the most prevalent ones. We developed...

journal_title：Scientific reports

authors： Singh SP,Gruissem W,Bhullar NK

更新日期：2017-07-31 00:00:00

abstract：:Recent advances in next-generation sequencing technologies have paved the path for a considerable amount of sequencing data at a relatively low cost. This has revolutionized the genomics and transcriptomics studies. However, different challenges are now created in handling such data with available bioinformatics platf...

journal_title：Scientific reports

authors： Naranpanawa DNU,Chandrasekara CHWMRB,Bandaranayake PCG,Bandaranayake AU

更新日期：2020-10-26 00:00:00

abstract：:An important step in oxide photochemistry, the loading of electrons into shallow trap states, was studied using infrared (IR) spectroscopy on both, rutile TiO2 powders and single-crystal, r-TiO2(110) oriented samples. After UV-irradiation or n-doping by exposure to H-atoms broad IR absorption lines are observed for th...

journal_title：Scientific reports

authors： Sezen H,Buchholz M,Nefedov A,Natzeck C,Heissler S,Di Valentin C,Wöll C

更新日期：2014-01-22 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Huang S,Sun C,Hou Y,Tang Y,Zhu Z,Zhang Z,Zhang Y,Wang L,Zhao Q,Chen MG,Guo Z,Wang D,Ju W,Zhou Q,Wu L,He X

更新日期：2019-05-03 00:00:00

abstract：:Childhood obesity is a risk factor for asthma, but the molecular mechanisms linking both remain elusive. Since obesity leads to chronic low-grade inflammation and affects metabolic signaling we hypothesized that postnatal hyperalimentation (pHA) induced by maternal high-fat-diet during lactation leads to early-onset o...

journal_title：Scientific reports

authors： Dinger K,Kasper P,Hucklenbruch-Rother E,Vohlen C,Jobst E,Janoschek R,Bae-Gartz I,van Koningsbruggen-Rietschel S,Plank C,Dötsch J,Alejandre Alcázar MA

更新日期：2016-04-18 00:00:00

abstract：:Dynamic Nuclear Polarization (DNP) has been introduced to overcome the sensitivity limitations of nuclear magnetic resonance (NMR) spectroscopy also of supported lipid bilayers. When investigated by solid-state NMR techniques the approach typically involves doping the samples with biradicals and their investigation at...

journal_title：Scientific reports

authors： Salnikov ES,Aisenbrey C,Aussenac F,Ouari O,Sarrouj H,Reiter C,Tordo P,Engelke F,Bechinger B

更新日期：2016-02-15 00:00:00