Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Winkowski M,Stacewicz Tdoi
10.1038/s41598-020-57571-0subject
Has Abstractpub_date
2020-01-14 00:00:00pages
617issue
1issn
2045-2322pii
10.1038/s41598-020-57571-0journal_volume
10pub_type
已发布勘误abstract::Osteoporosis is associated with reduced density and quality of bone leading to weakened skeleton thereby increasing the risk of fractures responsible for increased morbidity and mortality. Due to preference for western food style the consumption of salt intake in our diets has increased many folds. High dietary salt i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20896-y
更新日期:2018-02-06 00:00:00
abstract::Nanodiamond (ND) has emerged as a promising carbon nanomaterial for therapeutic applications. In previous studies, ND has been reported to have outstanding biocompatibility and high uptake rate in various cell types. ND containing nitrogen-vacancy centers exhibit fluorescence property is called fluorescent nanodiamond...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06919
更新日期:2014-11-05 00:00:00
abstract::Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 week...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27782
更新日期:2016-06-09 00:00:00
abstract::Fusion transcripts can contribute to diversity of molecular networks in the human cortex. In this study, we explored the occurrence of fusion transcripts in normal human cortex along with single neurons and astrocytes. We identified 1305 non-redundant fusion events from 388 transcriptomes representing 59 human cortice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58165-6
更新日期:2020-01-28 00:00:00
abstract::Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51485-2
更新日期:2019-10-16 00:00:00
abstract::Pituitary adenylate cyclase activating polypeptide (PACAP) is a regulatory and cytoprotective neuropeptide, its deficiency implies accelerated aging in mice. It is present in the auditory system having antiapoptotic effects. Expression of Ca2+-binding proteins and its PAC1 receptor differs in the inner ear of PACAP-de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50775-z
更新日期:2019-10-10 00:00:00
abstract::PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28890
更新日期:2016-07-04 00:00:00
abstract::Defect engineering is a promising route for controlling the electronic properties of monolayer transition-metal dichalcogenide (TMD) materials. Here, we demonstrate that the electronic structure of MoS2 depends sensitively on the defect charge, both its sign and magnitude. In particular, we study shallow bound states ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31941-1
更新日期:2018-09-11 00:00:00
abstract::Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized medicine. Here we investigate the theranostic properties of topological insulator bismuth selenide (Bi2Se3) in in vivo and in vitro system for the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01998
更新日期:2013-01-01 00:00:00
abstract::Amorphous silicon oxycarbide (SiOC) is of great technological interest. However, its atomic-level structure is not well understood. Using density functional theory calculations, we show that the clustering tendency of C atoms in SiOC is extremely sensitive to hydrogen (H): without H, the C-C interaction is attractive,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13051
更新日期:2015-08-13 00:00:00
abstract::Proteins that act as global transcriptional regulators play key roles in bacterial adaptation to new niches. These proteins recognize multiple DNA sites across the bacterial genome by different mechanisms. Enterococcus faecalis is able to survive in various niches of the human host, either as a commensal or as a leadi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42484-4
更新日期:2019-04-16 00:00:00
abstract::Magnesium battery is potentially a safe, cost-effective, and high energy density technology for large scale energy storage. However, the development of magnesium battery has been hindered by the limited performance and the lack of fundamental understandings of electrolytes. Here, we present a study in understanding co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03130
更新日期:2013-11-04 00:00:00
abstract::Although it is known that malaria parasites proliferate in the midgut of mosquito vector, their detailed behaviors, from gamete maturation to formation of next generation sporozoite, have not been fully understood at cellular or molecular level. This is mainly attributed to technical difficulties of dissection and who...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38529-3
更新日期:2019-02-11 00:00:00
abstract::Searching, defined for the purpose of the present study as the displacement of an individual to locate resources, is a fundamental behavior of all mobile organisms. In humans this behavior underlies many aspects of everyday life, involving cognitive processes such as sustained attention, memory and inhibition. We expl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19664
更新日期:2016-01-25 00:00:00
abstract::Previous studies have shown that CD61 (integrin-β3) promotes the differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) into germ-like cells. However, the mechanism remains unclear. In this study, we showed that overexpression of CD61 in canine adipose-derived mesenchymal stem cells (cADMSCs) promot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43851
更新日期:2017-03-03 00:00:00
abstract::The interaction between matter and electromagnetic radiation provides a rich understanding of what the matter is composed of and how it can be quantified using spectrometers. In many cases, however, the calibration of the spectrometer changes as a function of time (such as in electron spectrometers), or the absolute c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38482-1
更新日期:2019-02-14 00:00:00
abstract::Triple-doped (Yb(3+)/Er(3+)/Tm(3+)) KMnF3 nanocubes with uniform sizes of 250 nm were synthesized by a facile hydrothermal route using the oleic acid as the capping agent. It was found that these nanocubes can simultaneously exhibited four-color (blue, green, red and NIR) upconversion emissions under a single 980 nm n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17088
更新日期:2015-11-26 00:00:00
abstract::Higher and lower levels of alertness typically lead to a leftward and rightward bias in attention, respectively. This relationship between alertness and spatial attention potentially has major implications for health and safety. The current study examined alertness and spatial attention under simulated shiftworking co...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-020-71800-6
更新日期:2020-09-11 00:00:00
abstract::Despite the fact that magnetic thrombolytic composites is an emerging area, all known so far systems are based on the similar mechanism of action: thrombolytic enzyme releases from the magnetic carrier leaving non-active matrix, thus making the whole system active only for a limited period of time. Such systems often ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28119
更新日期:2016-06-20 00:00:00
abstract::Silicon has emerged as the most promising high-capacity material for lithium-ion batteries. Waste glass can be a potential low cost and environmentally benign silica resource enabling production of nanosized silicon at the industry level. Windshields are generally made of laminated glass comprising two separate glass ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19529-1
更新日期:2018-01-17 00:00:00
abstract::Solar powered hydrogen evolution reaction (HER) is one of the key reactions in solar-to-chemical energy conversion. It is desirable to develop photocathodic materials that exhibit high activity toward photoelectrochemical (PEC) HER at more positive potentials because a higher potential means a lower overpotential for ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35158
更新日期:2016-10-17 00:00:00
abstract::Angiogenesis plays a key role in several diseases including cancer, ischemic vascular disease, and Alzheimer's disease. Chemical genetic screening of endothelial tube formation provides a robust approach for identifying signalling components that impact microvascular network morphology as well as endothelial cell biol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70440-0
更新日期:2020-08-14 00:00:00
abstract::The development of microstructure during melting, reactive wetting and solidification of solder pastes on Cu-plated printed circuit boards has been studied by synchrotron radiography. Using Sn-3.0Ag-0.5Cu/Cu and Sn-0.7Cu/Cu as examples, we show that the interfacial Cu6Sn5 layer is present within 0.05 s of wetting, and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40010
更新日期:2017-01-12 00:00:00
abstract::Constrained by the diffraction limit, a lens can only resolve features larger than half of the incident wavelength owing to the decaying nature of evanescent waves. Several novel devices have been proposed, for example, superlenses and hyperlenses to break this limit. In this work, we present a flat hyperlens composed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62243-0
更新日期:2020-03-24 00:00:00
abstract::Hyaluronic acid (HA) is a glycosaminoglycan that plays many roles in health and disease and is a key biomarker of certain cancers. Therefore, its detection at an early stage, by histochemical methods, is of importance. However, intracellular HA can be masked by other HA-binding macromolecules, rendering its visualizat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40348-5
更新日期:2019-03-08 00:00:00
abstract::State of the art X-ray Free Electron Laser facilities currently provide the brightest X-ray pulses available, typically with mJ energy and several hundred femtosecond duration. Here we present one- and two-dimensional Particle-in-Cell simulations, utilising the process of stimulated Raman amplification, showing that t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16755
更新日期:2015-11-16 00:00:00
abstract::During inflammatory response, blood leukocytes adhere to the endothelium. This process involves numerous adhesion molecules, including a transmembrane chemokine, CX3CL1, which behaves as a molecular cluster. How this cluster assembles and whether this association has a functional role remain unknown. The analysis of C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65988-w
更新日期:2020-06-03 00:00:00
abstract::Platelets of α-zirconium phosphate (α-ZrP) obtained from the reflux method in H3PO4 are successfully exfoliated into water via the intercalation of alkanol amines. With volume fractions greater than 0.02 they are stacked into tactoids of few layers with a repeat distance in the order of 10 nm. The tactoids align into ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51934-y
更新日期:2019-11-08 00:00:00
abstract::Estrogens protect against diet-induced obesity in women and female rodents. For example, a lack of estrogens in postmenopausal women is associated with an increased risk of weight gain, cardiovascular diseases, low-grade inflammation, and cancer. Estrogens act with leptin to regulate energy homeostasis in females. Lep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56723-1
更新日期:2019-12-27 00:00:00
abstract::The ability to control the spatial distribution and temporal release of a therapeutic remains a central challenge for biomedical research. Here, we report the development and optimization of a novel substrate mediated therapeutic delivery system comprising of hyaluronic acid covalently functionalized liposomes (HALNPs...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14683
更新日期:2015-10-01 00:00:00