Topological insulator bismuth selenide as a theranostic platform for simultaneous cancer imaging and therapy.

Abstract:

:Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized medicine. Here we investigate the theranostic properties of topological insulator bismuth selenide (Bi2Se3) in in vivo and in vitro system for the first time. We show that Bi2Se3 nanoplates can absorb near-infrared (NIR) laser light and effectively convert laser energy into heat. Such photothermal conversion property may be due to the unique physical properties of topological insulators. Furthermore, localized and irreversible photothermal ablation of tumors in the mouse model is successfully achieved by using Bi2Se3 nanoplates and NIR laser irradiation. In addition, we also demonstrate that Bi2Se3 nanoplates exhibit strong X-ray attenuation and can be utilized for enhanced X-ray computed tomography imaging of tumor tissue in vivo. This study highlights Bi2Se3 nanoplates could serve as a promising platform for cancer diagnosis and therapy.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Li J,Jiang F,Yang B,Song XR,Liu Y,Yang HH,Cao DR,Shi WR,Chen GN

doi

10.1038/srep01998

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

1998

issn

2045-2322

pii

srep01998

journal_volume

3

pub_type

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