Abstract:
:Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized medicine. Here we investigate the theranostic properties of topological insulator bismuth selenide (Bi2Se3) in in vivo and in vitro system for the first time. We show that Bi2Se3 nanoplates can absorb near-infrared (NIR) laser light and effectively convert laser energy into heat. Such photothermal conversion property may be due to the unique physical properties of topological insulators. Furthermore, localized and irreversible photothermal ablation of tumors in the mouse model is successfully achieved by using Bi2Se3 nanoplates and NIR laser irradiation. In addition, we also demonstrate that Bi2Se3 nanoplates exhibit strong X-ray attenuation and can be utilized for enhanced X-ray computed tomography imaging of tumor tissue in vivo. This study highlights Bi2Se3 nanoplates could serve as a promising platform for cancer diagnosis and therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li J,Jiang F,Yang B,Song XR,Liu Y,Yang HH,Cao DR,Shi WR,Chen GNdoi
10.1038/srep01998subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1998issn
2045-2322pii
srep01998journal_volume
3pub_type
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