Abstract：
:We report on the ion beam fabrication of all-carbon multi electrode arrays (MEAs) based on 16 graphitic micro-channels embedded in single-crystal diamond (SCD) substrates. The fabricated SCD-MEAs are systematically employed for the in vitro simultaneous amperometric detection of the secretory activity from populations of chromaffin cells, demonstrating a new sensing approach with respect to standard techniques. The biochemical stability and biocompatibility of the SCD-based device combined with the parallel recording of multi-electrodes array allow: i) a significant time saving in data collection during drug screening and/or pharmacological tests over a large number of cells, ii) the possibility of comparing altered cell functionality among cell populations, and iii) the repeatition of acquisition runs over many cycles with a fully non-toxic and chemically robust bio-sensitive substrate.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Picollo F,Battiato A,Bernardi E,Plaitano M,Franchino C,Gosso S,Pasquarelli A,Carbone E,Olivero P,Carabelli Vdoi
10.1038/srep20682subject
Has Abstractpub_date
2016-02-09 00:00:00pages
20682issn
2045-2322pii
srep20682journal_volume
6pub_type
杂志文章abstract：:Hbs1, which is homologous to the GTPase eRF3, is a small G protein implicated in mRNA quality control. It interacts with a translation-release factor 1-like protein Dom34/Pelota to direct decay of mRNAs with ribosomal stalls. Although both proteins are evolutionarily conserved in eukaryotes, the biological function of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39530-6
更新日期：2019-03-01 00:00:00
abstract：:Urothelial carcinoma (UC) is a common disease causing significant morbidity and mortality as well as considerable costs for health systems. Extensive aberrant methylation of DNA is broadly documented in early UC, contributing to genetic instability, altered gene expression and tumor progression. However the triggers i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60796-8
更新日期：2020-03-02 00:00:00
abstract：:To evaluate the association between vision-related quality of life (QoL), physical inactivity, and locomotor dysfunction in subjects with visual impairment.This cross-sectional study included 215 visually impaired subjects recruited from six ophthalmology departments in Japan. The physical inactivity and locomotor dys...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30599-z
更新日期：2018-08-13 00:00:00
abstract：:We here describe the dc magnetic field over the human head produced by healthy hair follicles when the scalp is lightly pressed. This phenomenon was briefly reported decades earlier, where a double-planar SQUID (Superconducting Quantum Interference Devices) gradiometer at a single location was used. We here perform a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52110-y
更新日期：2019-10-30 00:00:00
abstract：:Atmospheric nitrogen (N) dry deposition is an important component in total N deposition. However, uncertainty exists in the assessment of global dry deposition. Here, we develop empirical models for estimating ground N concentrations using NO2 satellite measurements from the Ozone Monitoring Instrument (OMI) and groun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19810
更新日期：2016-01-27 00:00:00
abstract：:Subduction requires the permanent generation of a bend fold in the subducting slab which mechanics is not well understood. Lithospheric bending of subducting slabs was traditionally considered to be accommodated by orthogonal flexure, generating extensional outer rise earthquakes responsible of the external arc elonga...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19682-7
更新日期：2018-01-22 00:00:00
abstract：:Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants linked to PD in SNCA. However, the consequences of this genetic variabi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54865-w
更新日期：2019-12-05 00:00:00
abstract：:Fungal endophytes isolated from mountain-cultivated ginseng (MCG, Panax ginseng Meyer) were explored for their diversity and biocontrol activity against ginseng pathogens (Alternaria panax, Botrytis cinerea, Cylindrocarpon destructans, Pythium sp. and Rhizoctonia solani). A total of 1,300 isolates were isolated from t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16181-z
更新日期：2017-11-24 00:00:00
abstract：:Primary IgA nephropathy (IgAN) diagnosis is based on IgA-dominant glomerular deposits and histological scoring is done on formalin-fixed paraffin embedded tissue (FFPE) sections using the Oxford classification. Our aim was to use this underexploited resource to extract RNA and identify genes that characterize active (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72026-2
更新日期：2020-09-16 00:00:00
abstract：:Energy plants are the main source of bioenergy which will play an increasingly important role in future energy supplies. With limited cultivated land resources in China, the development of energy plants may primarily rely on the marginal land. In this study, based on the land use data from 1990 to 2010(every 5 years i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05816
更新日期：2014-07-24 00:00:00
abstract：UNLABELLED:We investigated hybrid inorganic-organic solar cells combining monocrystalline n-type silicon (n-Si) and a highly conductive polymer poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) ( PEDOT:PSS). The build-in potential, photo- and dark saturation current at this hybrid interface are monitored for va...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13008
更新日期：2015-08-17 00:00:00
abstract：:The phylogenetic characteristics of microbial communities associated with periodontitis have been well studied, however, little is known about the functional endowments of this ecosystem. The present study examined 73 microbial assemblages from 25 individuals with generalized chronic periodontitis and 25 periodontally...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38993
更新日期：2016-12-19 00:00:00
abstract：:Controlled quantum teleportation involves a third party as a controller for the teleportation of state. Here, we present the novel protocols for controlling teleportation of the arbitrary two-qubit and three-qubit states through five-qubit and seven-qubit cluster states respectively. In these schemes, Alice sends the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70446-8
更新日期：2020-08-12 00:00:00
abstract：:Manganese has long been employed as a T1-shortening agent in magnetic resonance imaging (MRI) applications, but these techniques are limited by the biotoxicity of bulk-manganese. Positron emission tomography (PET) offers superior contrast sensitivity compared with MRI, and recent preclinical PET studies employing 52gM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03202-0
更新日期：2017-06-08 00:00:00
abstract：:Although redox reactions are recognized to fractionate iron (Fe) isotopes, the dominant mechanisms controlling the Fe isotope fractionation and notably the role of organic matter (OM) are still debated. Here, we demonstrate how binding to organic ligands governs Fe isotope fractionation beyond that arising from redox ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81494-z
更新日期：2021-01-21 00:00:00
abstract：:The real time detection of quantitative oxygen release from the cathode is performed by in-situ Gas Chromatography as a tool to not only determine the amount of oxygen release from a lithium-ion cell but also to address the safety concerns. This in-situ gas chromatography technique monitoring the gas evolution during ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23394
更新日期：2016-03-22 00:00:00
abstract：:In the study, 15 K. pneumoniae strains were isolated from the mink experiencing respiratory distress in mideastern Shandong province, China, and the prevalence of K. pneumoniae in the sampled mink was 11.9% (15/126). Fourteen (93.33%) of the 15 K. pneumoniae isolates were identified as serotype K2 and hypermucoviscosi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17681-8
更新日期：2017-12-11 00:00:00
abstract：:Bragg coherent X-ray diffraction imaging (BCDI) has emerged as a powerful technique to image the local displacement field and strain in nanocrystals, in three dimensions with nanometric spatial resolution. However, BCDI relies on both dataset collection and phase retrieval algorithms that can induce artefacts in the r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53774-2
更新日期：2019-11-22 00:00:00
abstract：:This study investigated the glucono-δ-lactone (GDL)-induced aggregation of isoflavones and soy proteins in soymilk. High-performance liquid chromatography (HPLC) analysis indicated that isoflavones mixed with β-conglycinin (7S) and glycinin (11S) proteins formed 7S-isoflavone and 11S-isoflavone complexes in soymilk su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35718
更新日期：2016-10-20 00:00:00
abstract：:Measurement of intracranial aneurysm wall motion may refine the current rupture risk estimation. A golden standard for measuring aneurysm pulsation is lacking. The aim is to evaluate magnitudes of aneurysm pulsation as published in current literature. Embase and PubMed were searched for publications containing quantit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81753-z
更新日期：2021-01-26 00:00:00
abstract：:Pure iron has been confirmed as a promising biodegradable metal. However, the degradation rate of pure iron should be accelerated to meet the clinical requirements. In this work, two different designs of platinum disc arrays, including sizes of Φ20 μm × S5 μm and Φ4 μm × S4 μm, have been coated on the surface of pure ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23627
更新日期：2016-04-01 00:00:00
abstract：:This study investigates the effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on persistent post-concussion syndrome (PCS). The study design was a randomized (coin toss), placebo controlled, and double-blind study. Thirty-seven participants with PCS were assessed for eligibility; 22 were randomised and 18 ...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-41923-6
更新日期：2019-04-02 00:00:00
abstract：:Gaussia luciferase (GLuc) is a small luciferase (18.2 kDa; 168 residues) and is thus attracting much attention as a reporter protein, but the lack of structural information is hampering further application. Here, we report the first solution structure of a fully active, recombinant GLuc determined by heteronuclear mul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76486-4
更新日期：2020-11-18 00:00:00
abstract：:Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42360-1
更新日期：2019-04-17 00:00:00
abstract：:The activation of the majority of AGC kinases is regulated by two phosphorylation events on two conserved serine/threonine residues located on the activation loop and on the hydrophobic motif, respectively. In AGC kinase family, phosphomimetic substitutions with aspartate or glutamate, leading to constitutive activati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56937-3
更新日期：2020-01-17 00:00:00
abstract：:We investigate collective modes in three dimensional (3D) gapless multi-Weyl semimetals with anisotropic energy band dispersions (i.e., with a positive integer J). For comparison, we also consider the gapless semimetals with the isotropic band dispersions (i.e. E ~ kJ). We calculate analytically long-wavelength plasma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34023
更新日期：2016-09-30 00:00:00
abstract：:Breast cancer is the leading cause of cancer death among women worldwide. Like other cancers, mammary carcinoma progression involves acidification of the tumor microenvironment, which is an important factor for cancer detection and treatment strategies. However, the effects of acidity on mammary carcinoma cell morphol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78989-6
更新日期：2020-12-15 00:00:00
abstract：:Phytoene desaturases catalyse from two to six desaturation reactions on phytoene, generating a large diversity of molecules that can then be cyclised and produce, depending on the organism, many different carotenoids. We constructed a phylogenetic tree of a subset of phytoene desaturases from the CrtI family for which...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77876-4
更新日期：2020-12-03 00:00:00
abstract：:Functions of septin cytoskeletal polymers in tumorigenesis are still poorly defined. Their role in the regulation of cytokinesis and cell migration were proposed to contribute to cancer associated aneuploidy and metastasis. Overexpression of Septin 9 (Sept9) promotes migration of cancer cell lines. SEPT9 mRNA and prot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44976
更新日期：2017-03-24 00:00:00
abstract：:Recent discoveries have highlighted the novel metabolic functions of adipose tissue in enhancing hypermetabolism after trauma. As the exact function and expression profiles of serum lipids and free fatty acids (FFA) are essentially unknown, we determined the lipidomic expression profile after burn in correlation to cl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38707
更新日期：2016-12-16 00:00:00
