Abstract：
:We have developed an optimized protocol for plasma targeted mRNA sequencing in our previous study. Here, we performed plasma targeted mRNA sequencing for 40 colorectal adenoma patients and 39 colonoscopy-proven normal controls in order to find potential circulating mRNA markers for colorectal adenoma. Results showed that GSK3A and RHOA were differential expressed genes identified by a cut-off of fold change >2 and adjusted P value < 0.05. More detailed analysis showed that the expression of both GSK3A (0.01-fold with adjusted P < 1 × 10-6) and RHOA (0.35-fold with adjusted P < 0.01) in adenoma patients was significantly lower than those in normal healthy subjects. Based on the enrichment analysis of biological process for potential markers, we found that the regulation of programmed cell death (GO: 0043067; GO: 0043069), regulation of cell death (GO: 0010941; GO: 0060548) and cell differentiation (GO: 0021861) were the main processes involved in adenoma formation. In summary, this study is a cutting-edge research on the detection of plasma mRNA in colorectal adenoma patients and normal healthy subjects.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xue VW,Cheung MT,Chan PT,Luk LLY,Lee VH,Au TC,Yu AC,Cho WCS,Tsang HFA,Chan AK,Wong SCCdoi
10.1038/s41598-019-49445-xsubject
Has Abstractpub_date
2019-09-10 00:00:00pages
12943issue
1issn
2045-2322pii
10.1038/s41598-019-49445-xjournal_volume
9pub_type
杂志文章abstract：:Conduction Electron Paramagnetic Resonance Imaging (CEPRI) is presented as a sensitive technique for mapping metallic lithium species. The method is demonstrated using different samples that are either thick or thin compared to the microwave skin depth. As a thin sample, microstructured metallic lithium deposits in a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32112-y
更新日期：2018-09-25 00:00:00
abstract：:Cesium (Cs) removal from nuclear liquid wastewater has become an emerging issue for safeguarding public health after the accident at the Fukushima Daiichi Nuclear Power Plant. A novel macrocyclic ligand of o-benzo-p-xylyl-22-crown-6-ether (OBPX22C6) was developed and successfully immobilized onto mesoporous silica for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19937
更新日期：2016-01-28 00:00:00
abstract：:Dopamine is an important neurotransmitter that plays a key role in a wide range of both locomotive and cognitive functions in humans. Disturbances on the dopaminergic system cause, among others, psychosis, Parkinson's disease and Huntington's disease. Antipsychotics are drugs that interact primarily with the dopamine ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78446-4
更新日期：2020-12-09 00:00:00
abstract：:Mueller microscopes enable imaging of the optical anisotropic properties of biological or non-biological samples, in phase and amplitude, at sub-micrometre scale. However, the development of Mueller microscopes poses an instrumental challenge: the production of polarimetric parameters must be sufficiently quick to ens...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40467-z
更新日期：2019-03-08 00:00:00
abstract：:Polygenic risk scores (PRS) from genome-wide association studies (GWAS) are increasingly used to predict disease risks. However some included variants could be false positives and the raw estimates of effect sizes from them may be subject to selection bias. In addition, the standard PRS approach requires testing over ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41262
更新日期：2017-02-01 00:00:00
abstract：:Variations in isotopic composition of water vapor in the atmosphere is an important indicator of the processes within the hydrological cycle. Isotopic signature of water vapor and precipitation can be helpful in partitioning evaporation and transpiration fluxes. It is well known that transpiration from forested region...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55186-8
更新日期：2019-12-09 00:00:00
abstract：:Interference of two combined white light beams produces Newton colors if one of the beams is retarded relative to the other by from 400 nm to 2000 nm. In this case the corresponding interfering spectral components are added as two scalars at the beam combination. If the retardance is below 400 nm the two-beam interfer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17340
更新日期：2015-11-27 00:00:00
abstract：:Stryphnodendron adstringens is a medicinal plant belonging to the Leguminosae family, and it is commonly found in the southeastern savannas, endemic to the Cerrado biome. The goal of this study was to assemble and annotate the chloroplast genome of S. adstringens and to compare it with previously known genomes of the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50620-3
更新日期：2019-10-02 00:00:00
abstract：:Cell-based assays are growing in importance for screening drugs and investigating their mechanisms of action. Most of the assays use so-called "normal" cell strain because it is difficult to produce cell lines in which the disease conditions are reproduced. In this study, we used a cell-resealing technique, which reve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15443-0
更新日期：2017-11-09 00:00:00
abstract：:Bronchospasm compresses the bronchial epithelium, and this compressive stress has been implicated in asthma pathogenesis. However, the molecular mechanisms by which this compressive stress alters pathways relevant to disease are not well understood. Using air-liquid interface cultures of primary human bronchial epithe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57755-8
更新日期：2020-01-22 00:00:00
abstract：:We present a combined geomorphological and biochronological study aimed at providing age constraints to the deposits forming a wide paleo-surface in the coastal area of the Tyrrhenian Sea, south of Anzio promontory (central Italy). We review the faunal assemblage recovered in Campoverde, evidencing the occurrence of t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36111-x
更新日期：2018-12-13 00:00:00
abstract：:Due to chromatic aberration, blue images are defocused when the eye is focused to the middle of the visible spectrum, yet we normally are not aware of chromatic blur. The eye suffers from monochromatic aberrations which degrade the optical quality of all images projected on the retina. The combination of monochromatic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79911-w
更新日期：2021-01-11 00:00:00
abstract：:Prosthesis embodiment, the perception of a prosthesis as part of one's body, may be an important component of functional recovery for individuals with upper limb absence. This work determined whether embodiment differs between body-powered and myoelectric prosthesis users. In a sample of nine individuals with transrad...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72470-0
更新日期：2020-09-22 00:00:00
abstract：:Nitrogen metabolism in gut systems remains poorly studied in spite of its importance for microbial growth and its implications for the metabolism of the host. Prevotella spp. are the most predominant bacteria detected in the rumen, but their presence has also been related to health and disease states in the human gut ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08463-3
更新日期：2017-08-10 00:00:00
abstract：:Soils are an important source of nitrogen in many of the world's cropping systems. Especially in low-input production systems, nitrogen release from soil organic matter turn-over is the major part of the crop's nitrogen supply and research suggests that this process is significantly affected by changes in climate. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42274-y
更新日期：2019-04-10 00:00:00
abstract：:The dispersion properties of metamaterials and photonic crystals (PhCs) lead to an intensive research in the development of cavity resonators for the confinement of electromagnetic (e-m) radiation. In this work, we investigate the formation of Fabry-Pérot (FP) modes associated with hyperbolic-like dispersion (HLD) reg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67965-9
更新日期：2020-07-06 00:00:00
abstract：:Maize is rapidly replacing traditionally cultivated dual purpose crops of South Asia, primarily due to the better economic remuneration. This has created an impetus for improving maize for both grain productivity and stover traits. Molecular techniques can largely assist breeders in determining approaches for effectiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80118-2
更新日期：2021-01-12 00:00:00
abstract：:Extracellular matrix (ECM) mechanical properties upregulate cancer invasion, cell contractility, and focal adhesion formation. Alteration in energy metabolism is a known characteristic of cancer cells (i.e., Warburg effect) and modulates cell invasion. There is little evidence to show if collagen density can alter can...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35381-9
更新日期：2018-11-20 00:00:00
abstract：:Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Sp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77639-1
更新日期：2020-11-25 00:00:00
abstract：:Aneurysmal subarachnoid hemorrhage (aSAH)-induced cerebral vasospasm and delayed ischemic neurological deficit (DIND) are the major causes of morbidity and mortality in patients with aSAH. The effects of statins-use for patients with aSAH remain controversial. Here,a total of 249 patients from six randomized controlle...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep04573
更新日期：2014-04-25 00:00:00
abstract：:PCR inhibitors in clinical specimens negatively affect the sensitivity of diagnostic PCR and RT-PCR or may even cause false-negative results. To overcome PCR inhibition, increase the sensitivity of the assays and simplify the detection protocols, simple methods based on quantitative nested real-time PCR and RT-PCR wer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21224-0
更新日期：2018-02-21 00:00:00
abstract：:The typical photodetectors can only detect one specific optical spectral band, such as InGaAs and graphene-PbS quantum dots for near-infrared (NIR) light detection, CdS and Si for visible light detection, and ZnO and III-nitrides for UV light detection. So far, none of the developed photodetector can achieve the multi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02368
更新日期：2013-01-01 00:00:00
abstract：:Evening chronotype associates with health complications possibly via lifestyle factors, while the contribution of genetics is unknown. The aim was to study the relative contributions of genetics, lifestyle, and circadian-related physiological characteristics in metabolic risk of evening chronotype. In order to capture...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18268-z
更新日期：2018-01-17 00:00:00
abstract：:Chicken anemia virus (CAV) is an important pathogen that causes severe immunosuppression in young chickens. We have characterized 13 CAVs isolated from different commercial farms in southern China between 2011 and 2012. We discovered 92 variable residues compared to 37 other CAV complete genome sequences from other pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03519
更新日期：2013-12-17 00:00:00
abstract：:We aimed to assess the role of computerized tomography attenuation values (Hounsfield unit-HU) for differentiating pyonephrosis from hydronephrosis and for predicting postoperative infectious complications in patients with obstructive uropathy. We analysed data from 122 patients who underwent nephrostomy tube or urete...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75672-8
更新日期：2020-10-29 00:00:00
abstract：:(1) Objective: Greenhouse workers are considered a special occupational group who are exposed to more toxic and harmful substances than ordinary farmers. The health problem of this group is a public health problem that warrants attention. Taking greenhouse workers in Ningxia, China, as the research sample, this study ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65662-1
更新日期：2020-05-26 00:00:00
abstract：:In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of the tooth. New odontoblast-like cells are only produced in response to a damage or trauma. Little is known about the molecular events that initiate mesenchymal stem c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03145-6
更新日期：2017-06-08 00:00:00
abstract：:Mesoporous silica is an emerging technology to solve problems of existing and to support projected revolutionary applications ranging from targeted drug delivery to artificial kidney. However, one of the major driving mechanisms, electric charging of internal mesoporous surfaces, has not been characterized yet. In the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36487-w
更新日期：2019-01-15 00:00:00
abstract：:Filth flies cause billions of dollars of losses annually to the animal production industry. Fluralaner is a relatively new pesticide currently sold for control of fleas, ticks, and mites on companion animals and poultry. We examined the efficacy of fluralaner against three species of filth flies. Insecticide-susceptib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68121-z
更新日期：2020-07-07 00:00:00
abstract：:Geographical origin determination of white rice has become the major issue of food industry. However, there is still lack of a high-throughput method for rapidly and reproducibly differentiating the geographical origins of commercial white rice. In this study, we developed a method that employed lipidomics and deep le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08892-0
更新日期：2017-08-17 00:00:00
