Abstract:
:Chicken anemia virus (CAV) is an important pathogen that causes severe immunosuppression in young chickens. We have characterized 13 CAVs isolated from different commercial farms in southern China between 2011 and 2012. We discovered 92 variable residues compared to 37 other CAV complete genome sequences from other parts of the world listed in GenBank; these residues have not been previously observed. All of the Chinese CAV genomes that were characterized in this study had a glutamine at position 394, a hallmark of highly pathogenic CAVs. We also discovered that intra-group genetic recombination plays a role in generating genetic diversity in natural populations of CAV. The GD-J-12 isolate was a possible recombinant between GD-C-12 and GD-M-12 in the genomic region that encompassed both the coding and non-coding regions.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang X,Liu Y,Wu B,Sun B,Chen F,Ji J,Ma J,Xie Qdoi
10.1038/srep03519subject
Has Abstractpub_date
2013-12-17 00:00:00pages
3519issn
2045-2322pii
srep03519journal_volume
3pub_type
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