Abstract：
:Neurotransmission and secretion of hormones involve a sequence of protein/lipid interactions with lipid turnover impacting on vesicle trafficking and ultimately fusion of secretory vesicles with the plasma membrane. We previously demonstrated that sphingosine, a sphingolipid metabolite, promotes formation of the SNARE complex required for membrane fusion and also increases the rate of exocytosis in isolated nerve terminals, neuromuscular junctions, neuroendocrine cells and in hippocampal neurons. Recently a fungi-derived sphingosine homologue, FTY720, has been approved for treatment of multiple sclerosis. In its non-phosphorylated form FTY720 accumulates in the central nervous system, reaching high levels which could affect neuronal function. Considering close structural similarity of sphingosine and FTY720 we investigated whether FTY720 has an effect on regulated exocytosis. Our data demonstrate that FTY720 can activate vesicular synaptobrevin for SNARE complex formation and enhance exocytosis in neuroendocrine cells and neurons.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Darios FD,Jorgacevski J,Flašker A,Zorec R,García-Martinez V,Villanueva J,Gutiérrez LM,Leese C,Bal M,Nosyreva E,Kavalali ET,Davletov Bdoi
10.1038/s41598-017-05948-zsubject
Has Abstractpub_date
2017-07-20 00:00:00pages
5958issue
1issn
2045-2322pii
10.1038/s41598-017-05948-zjournal_volume
7pub_type
杂志文章abstract：:We present active manipulation of the structural vibrations of an elastic body to generate an acoustic illusion. The resultant illusion misrepresents the nature, size and number of objects in the exterior acoustic domain. We demonstrate our technique, herein termed active structural acoustic illusion, using an elastic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66398-8
更新日期：2020-06-17 00:00:00
abstract：:It is now well established that at a superconductor/ferromagnet (S/F) interface an unconventional superconducting state arises in which the pairing is odd-frequency. The hallmark signature of this superconducting state is generally understood to be an enhancement of the electronic density of states (DoS) at subgap ene...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15483
更新日期：2015-10-27 00:00:00
abstract：:We combine matter-wave interferometry and cavity optomechanics to propose a coherent matter-light interface based on mechanical motion at the quantum level. We demonstrate a mechanism that is able to transfer non-classical features imprinted on the state of a matter-wave system to an optomechanical device, transducing...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03378
更新日期：2013-11-29 00:00:00
abstract：:Although anxiety disorders (ADs) have been recognized as one of the most prevalent mental disorders in mainland China, the prevalence of ADs has not been reported until now. The lack of a consolidated and comparable review on the prevalence of ADs in mainland China necessitated this meta-analysis to measure the preval...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep28033
更新日期：2016-06-16 00:00:00
abstract：:Terrestrial microbial ecosystems are exposed to many types of disturbances varying in their spatial and temporal characteristics. The ability to cope with these disturbances is crucial for maintaining microbial ecosystem functions, especially if disturbances recur regularly. Thus, understanding microbial ecosystem dyn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27785-4
更新日期：2018-06-22 00:00:00
abstract：:The goal of this work was to develop a mathematical model to predict Kaplan-Meier survival curves for chemotherapy combined with radiation in Non-Small Cell Lung Cancer patients for use in clinical trial design. The Gompertz model was used to describe tumor growth, radiation effect was simulated by the linear-quadrati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13646-z
更新日期：2017-10-19 00:00:00
abstract：:A novel one-pot synthesis of tri-substituted purines and the discovery of purine analogues with trypanocidal activity are reported. The reaction is initiated by a metal-free oxidative coupling of primary alkoxides and diaminopyrimidines with Schiff base formation and subsequent annulation in the presence of large N,N-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09139
更新日期：2015-03-16 00:00:00
abstract：:Bleeding risk with antiplatelet therapy is an increasing clinical challenge. However, the inter-individual variation in this risk is poorly understood. We assessed whether the level of plasma creatine kinase, the enzyme that utilizes ADP and phosphocreatine to rapidly regenerate ATP, may modulate bleeding risk through...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06551
更新日期：2014-10-09 00:00:00
abstract：:Infrared detection devices are becoming miniature with micro or nano-scale size. The advantages of downsizing come on the expense of insufficient collection of infrared radiation. Therefore, utilizing nano-plasmonic optical antennas becomes mandatory. However, it is desirable to develop antennas with broad bandwidth, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48648-6
更新日期：2019-08-21 00:00:00
abstract：:Green fluorescent protein (GFP) is one of the most used reporter genes. We have used next-generation sequencing (NGS) to analyse the genetic diversity of a recombinant influenza A virus that expresses GFP and found a remarkable coverage dip in the GFP coding sequence. This coverage dip was present when virus-derived R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26314
更新日期：2016-05-19 00:00:00
abstract：:Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity two synthetic analogues, PhTX-343 and PhTX-12, were developed. Previous work showed a 22-fold selectivity of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38116
更新日期：2016-11-30 00:00:00
abstract：:Plants adapted to extreme conditions can be at high risk from climate change; arctic-alpine plants, in particular, could "run out of space" as they are out-competed by expansion of woody vegetation. Mountain regions could potentially provide safe sites for arctic-alpine plants in a warmer climate, but empirical eviden...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55989-9
更新日期：2019-12-23 00:00:00
abstract：:The transition from unicellular to multicellular organisms poses the question as to when genes that regulate cell-cell interactions emerged during evolution. The receptor and ligand pairing of plexins and semaphorins regulates cellular interactions in a wide range of developmental and physiological contexts. We survey...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38512-y
更新日期：2019-02-13 00:00:00
abstract：:Lightweight multifunctional electromagnetic (EM) absorbing materials with outstanding thermal properties, chemical resistance and mechanical stability are crucial for space, aerospace and electronic devices and packaging. Therefore, 3D porous graphene aerogels are attracting ever growing interest. In this paper we pre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52230-5
更新日期：2019-10-31 00:00:00
abstract：:Biochar can influence native soil organic carbon (SOC) mineralisation through "priming effects". However, the long-term direction, persistence and extent of SOC priming by biochar remain uncertain. Using natural (13)C abundance and under controlled laboratory conditions, we show that biochar-stimulated SOC mineralisat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03687
更新日期：2014-01-21 00:00:00
abstract：:Bipedalism is a defining feature of the human lineage. Despite evidence that walking on two feet dates back 6-7 Ma, reconstructing hominin gait evolution is complicated by a sparse fossil record and challenges in inferring biomechanical patterns from isolated and fragmentary bones. Similarly, patterns of social behavi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28766
更新日期：2016-07-12 00:00:00
abstract：:We propose an approach for characterizing structural heterogeneity of lung cancer nodules using Computed Tomography Texture Analysis (CTTA). Measures of heterogeneity were used to test the hypothesis that heterogeneity can be used as predictor of nodule malignancy and patient survival. To do this, we use the National ...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-38831-0
更新日期：2019-03-14 00:00:00
abstract：:Understanding of lipid oxidation mechanisms (e.g., auto-oxidation and photo-oxidation) in foods and cosmetics is deemed essential to maintain the quality of such products. In this study, the oxidation mechanisms in foods and cosmetics were evaluated through analysis of linoleic acid hydroperoxide (LAOOH) and linoleic ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43645-1
更新日期：2019-05-14 00:00:00
abstract：:'Big data' in healthcare encompass measurements collated from multiple sources with various degrees of data quality. These data require quality control assessment to optimise quality for clinical management and for robust large-scale data analysis in healthcare research. Height and weight data represent one of the mos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66925-7
更新日期：2020-06-23 00:00:00
abstract：:Due to distinct biological behavior of mucinous adenocarcinoma (MAC) and signet ring cell cancer (SRC), the efficacy of radiotherapy on long-term outcome for rectal cancer (RC) patients with mucinous tumors is still unclear. Here, we identified 1808 RC patients with MAC/SRC from Surveillance, Epidemiology, and End-Res...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43821
更新日期：2017-03-08 00:00:00
abstract：:Duchenne muscular dystrophy (DMD) is a disease marked by the development of skeletal muscle weakness and wasting. DMD results from mutations in the gene for the cytoskeletal protein dystrophin. The loss of dystrophin expression is not limited to muscle weakness but has multiple systemic consequences. Managing the nutr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31753-3
更新日期：2018-09-11 00:00:00
abstract：:Pigeons learned to discriminate two different patterns displayed with miniature light-emitting diode arrays. They were then tested with 84 interspersed, non-reinforced degraded pattern pairs. Choices ranged between 100% and 50% for one or other of the patterns. Stimuli consisting of few pixels yielded low choice score...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50212-1
更新日期：2019-09-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17820
更新日期：2015-12-04 00:00:00
abstract：:Antiphospholipid syndrome is associated with an increased risk of thrombosis and pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however, whether endogenous Anxa5 prevents foetal loss during normal pregnancy. We found significant reductions in litter size and foetal weight in Anxa5-null...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00827
更新日期：2012-01-01 00:00:00
abstract：:Bariatric surgery is the most effective treatment for weight loss. Vertical sleeve gastrectomy (VSG) involves the resection of ~ 80% of the stomach and was conceived to purely restrict oral intake. However, evidence suggests more complex mechanisms, particularly postoperative changes in gut microbiota, in facilitating...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77285-7
更新日期：2020-11-23 00:00:00
abstract：:A 3D cell culture is preferred to 2D cell culture since it allows cells to grow in all directions in vitro, similar to how they would in vivo. 3D cell culture plates currently used in tissue engineering research have limited access to control the geometry. Furthermore, 3D cell culture plate manufacturing methods are r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50186-0
更新日期：2019-09-27 00:00:00
abstract：:Recreational boating is an increasing activity in coastal areas and its spatiotemporal overlap with key habitats of marine species pose a risk for negative noise impacts. Yet, recreational vessels are currently unaccounted for in vessel noise models using Automatic Identification System (AIS) data. Here we conduct a c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51222-9
更新日期：2019-10-29 00:00:00
abstract：:We aimed to explore the effects of type-2 diabetes mellitus (T2DM) and hypoglycemic therapy on the salivary microbiome in periodontitis patients and identify the potential salivary micro-biomarker for the early warning of T2DM. Saliva samples were collected from healthy individuals (Health), periodontitis patients (P)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72035-1
更新日期：2020-09-21 00:00:00
abstract：:Bioactive gibberellins (GAs) are essential phytohormones involved in the regulation of many aspects of plant development. GA receptors are crucial in GA signal transduction in plants. The GA receptor GoGID1 promotes plant elongation and improves biomass production when ectopically expressed in tobacco. Here, we discov...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41296
更新日期：2017-01-27 00:00:00
abstract：:The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18944-0
更新日期：2018-01-11 00:00:00
