Design and manufacture of 3D cell culture plate for mass production of cell-spheroids.

abstract：:cAMP responsive element binding protein 3-like 3 (CREB3L3), a transcription factor expressed in the liver and small intestine, governs fasting-response energy homeostasis. Tissue-specific CREB3L3 knockout mice have not been generated till date. To our knowledge, this is the first study using the one-step CRISPR/Cas9 s...

journal_title：Scientific reports

authors： Nakagawa Y,Oikawa F,Mizuno S,Ohno H,Yagishita Y,Satoh A,Osaki Y,Takei K,Kikuchi T,Han SI,Matsuzaka T,Iwasaki H,Kobayashi K,Yatoh S,Yahagi N,Isaka M,Suzuki H,Sone H,Takahashi S,Yamada N,Shimano H

更新日期：2016-06-13 00:00:00

abstract：:Enzymatic conversion of chitin, a β-1,4 linked polymer of N-acetylglucosamine, is of major interest in areas varying from the biorefining of chitin-rich waste streams to understanding how medically relevant fungi remodel their chitin-containing cell walls. Although numerous chitinolytic enzymes have been studied in de...

journal_title：Scientific reports

authors： Liu Z,Gay LM,Tuveng TR,Agger JW,Westereng B,Mathiesen G,Horn SJ,Vaaje-Kolstad G,van Aalten DMF,Eijsink VGH

更新日期：2017-05-11 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Fujishima K,Wang KM,Palmer JA,Abe N,Nakahigashi K,Endy D,Rothschild LJ

更新日期：2019-04-12 00:00:00

abstract：:An empirical approach was taken to screen a novel synthetic compound library designed to be active against Gram-positive bacteria. We obtained five compounds that were active against spores from the model organism Bacillus subtilis and the food-borne pathogen Bacillus cereus during our population based experiments. Us...

journal_title：Scientific reports

authors： Omardien S,Ter Beek A,Vischer N,Montijn R,Schuren F,Brul S

更新日期：2018-06-14 00:00:00

abstract：:It is notable that the adoption of GM glyphosate-tolerant crops increases glyphosate use but reduces non-glyphosate herbicide use; and adoption of GM insect-resistant crops significantly reduces insecticide use. While the health hazard of pesticide use has been well documented, little literature evaluates the health e...

journal_title：Scientific reports

authors： Zhang C,Hu R,Huang J,Huang X,Shi G,Li Y,Yin Y,Chen Z

更新日期：2016-10-10 00:00:00

abstract：:In situ reduction of selenite to elemental selenium (Se(0)), by microorganisms in sediments and soils is an important process and greatly affects the environmental distribution and the biological effects of selenium. However, the mechanism behind such a biological process remains unrevealed yet. Here we use Shewanella...

journal_title：Scientific reports

authors： Li DB,Cheng YY,Wu C,Li WW,Li N,Yang ZC,Tong ZH,Yu HQ

更新日期：2014-01-17 00:00:00

abstract：:Rather than the conventional concept of viewing conductive carbon black (CB) to be chemically inert in microbial electrochemical cells (MECs), here we confirmed the redox activity of CB for its feasibility as an electron sink in the microbial battery (MB). Acting as the cathode of a MB, the solid-state CB electrode sh...

journal_title：Scientific reports

authors： Zhang X,Guo K,Shen D,Feng H,Wang M,Zhou Y,Jia Y,Liang Y,Zhou M

更新日期：2017-08-01 00:00:00

abstract：:Immune parameters show characteristic normal baseline levels and variance in the population. We characterised the degree of inter-individual and within-individual variation over one-year time period in 33 immune cell subsets by flow cytometry in peripheral blood mononuclear cells from 43 healthy young adult volunteers...

journal_title：Scientific reports

authors： Kanodia P,Kaur G,Coshic P,Chatterjee K,Neeman T,George A,Rath S,Bal V,Prabhu SB

更新日期：2019-10-14 00:00:00

abstract：:A connection between airway and gut microbiota related to allergen exposure in childhood allergies was not well addressed. We aimed to identify the microbiota alterations in the airway and gut related to mite-specific IgE responses in young children with airway allergies. This study enrolled 60 children, including 38 ...

journal_title：Scientific reports

authors： Chiu CY,Chan YL,Tsai MH,Wang CJ,Chiang MH,Chiu CC,Su SC

更新日期：2020-08-10 00:00:00

abstract：:Volumetric and morphometric studies have demonstrated structural abnormalities related to chronic epilepsies on a cohort- and population-based level. On a single-patient level, specific patterns of atrophy or cortical reorganization may be widespread and heterogeneous but represent potential targets for further person...

journal_title：Scientific reports

authors： Rummel C,Slavova N,Seiler A,Abela E,Hauf M,Burren Y,Weisstanner C,Vulliemoz S,Seeck M,Schindler K,Wiest R

更新日期：2017-09-07 00:00:00

abstract：:Haze is a serious issue in China with increasing concerns, and understanding the factors driving decadal-scale variations in haze occurrence is relevant for government policymaking. Using a comprehensive observational haze dataset, we demonstrate notable decadal fluctuations in the number of haze days (HD) during wint...

journal_title：Scientific reports

authors： Zhao S,Li J,Sun C

更新日期：2016-06-10 00:00:00

abstract：:From the viewpoint of networks, a ranking system for players or teams in sports is equivalent to a centrality measure for sports networks, whereby a directed link represents the result of a single game. Previously proposed network-based ranking systems are derived from static networks, i.e., aggregation of the results...

journal_title：Scientific reports

authors： Motegi S,Masuda N

更新日期：2012-01-01 00:00:00

abstract：:Despite the relevance of complex root microbial communities for plant health, growth and productivity, the molecular basis of these plant-microbe interactions is not well understood. Verrucomicrobia are cosmopolitans in the rhizosphere, nevertheless their adaptations and functions are enigmatic since the proportion of...

journal_title：Scientific reports

authors： Bünger W,Jiang X,Müller J,Hurek T,Reinhold-Hurek B

更新日期：2020-05-26 00:00:00

abstract：:Genomic selection (GS) by selecting lines prior to field phenotyping using genotyping data has the potential to enhance the rate of genetic gains. Genotype × environment (G × E) interaction inclusion in GS models can improve prediction accuracy hence aid in selection of lines across target environments. Phenotypic dat...

journal_title：Scientific reports

authors： Roorkiwal M,Jarquin D,Singh MK,Gaur PM,Bharadwaj C,Rathore A,Howard R,Srinivasan S,Jain A,Garg V,Kale S,Chitikineni A,Tripathi S,Jones E,Robbins KR,Crossa J,Varshney RK

更新日期：2018-08-03 00:00:00

abstract：:Organochlorine (OC) pesticides and the more persistent polychlorinated biphenyls (PCBs) have well-established dose-dependent toxicities to birds, fish and mammals in experimental studies, but the actual impact of OC pollutants on European marine top predators remains unknown. Here we show that several cetacean species...

journal_title：Scientific reports

authors： Jepson PD,Deaville R,Barber JL,Aguilar À,Borrell A,Murphy S,Barry J,Brownlow A,Barnett J,Berrow S,Cunningham AA,Davison NJ,Ten Doeschate M,Esteban R,Ferreira M,Foote AD,Genov T,Giménez J,Loveridge J,Llavona Á,Mart

更新日期：2016-01-14 00:00:00

abstract：:The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and ch...

journal_title：Scientific reports

authors： Karthivashan G,Park SY,Kweon MH,Kim J,Haque ME,Cho DY,Kim IS,Cho EA,Ganesan P,Choi DK

更新日期：2018-05-08 00:00:00

abstract：:Research on argillite as a possible host rock for nuclear waste disposal is still an open subject since many issues need to be clarified. In the Underground Research Laboratories constructed for this purpose, a damaged zone around the excavation has been systematically observed and characterized by the appearance of m...

journal_title：Scientific reports

authors： Zaoui A,Sekkal W

更新日期：2015-03-06 00:00:00

abstract：:Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at...

journal_title：Scientific reports

authors： Janmaat CJ,van Diepen M,Gasparini A,Evans M,Qureshi AR,Ärnlöv J,Barany P,Elinder CG,Rotmans JI,Vervloet M,Dekker FW,Carrero JJ

更新日期：2018-03-26 00:00:00

abstract：:The influenza A virus RNA polymerase cleaves the 5' end of host pre-mRNAs and uses the capped RNA fragments as primers for viral mRNA synthesis. We performed deep sequencing of the 5' ends of viral mRNAs from all genome segments transcribed in both human (A549) and mouse (M-1) cells infected with the influenza A/HongK...

journal_title：Scientific reports

authors： Sikora D,Rocheleau L,Brown EG,Pelchat M

更新日期：2014-08-26 00:00:00

abstract：:In the Ultimatum Game, two players are offered a chance to win a pie. The proposer suggests how to split the pie. The responder can either accept or reject the deal. If an agreement is not reached, neither player gets anything. Both game theory and evolutionary game theory predict the rational solution that the propos...

journal_title：Scientific reports

authors： Wang X,Chen X,Wang L

更新日期：2014-04-01 00:00:00

abstract：:In this study, we made a comparative efficacy and safety assessment of two different fixed combinations of drugs, viz., tafluprost/timolol (TAF/TIM) and latanoprost/carteolol (LAT/CAR), by determining their effects on intraocular pressure (IOP) in ocular normotensive monkeys and examining their toxic effects on ocular...

journal_title：Scientific reports

authors： Fuwa M,Shimazaki A,Mieda M,Yamashita N,Akaishi T,Taniguchi T,Kato M

更新日期：2019-05-16 00:00:00

abstract：:The expression level of folate receptor alpha (FRα) is located highly rate in ovarian cancer though it is remained absent in normal tissues. This highly tumor restricted expression profile makes FRα a promising target for tumor therapy and diagnosis. In this research we report a FRα binding peptide C7(Met-His-Thr-Ala-...

journal_title：Scientific reports

authors： Xing L,Xu Y,Sun K,Wang H,Zhang F,Zhou Z,Zhang J,Zhang F,Caliskan B,Qiu Z,Wang M

更新日期：2018-05-30 00:00:00

abstract：:Optical clearing methods can facilitate deep optical imaging in biological tissue by reducing light scattering and this has enabled accurate three-dimensional signal visualization and quantification of complex biological structures. Unfortunately, existing optical clearing approaches present a compromise between maxim...

journal_title：Scientific reports

authors： Chen L,Li G,Li Y,Li Y,Zhu H,Tang L,French P,McGinty J,Ruan S

更新日期：2017-09-22 00:00:00

abstract：:The negatively-charged nitrogen vacancy (NV(-)) center in diamond is of great interest for quantum information processing and quantum key distribution applications due to its highly desirable long coherence times at room temperature. One of the challenges for their use in these applications involves the requirement to...

journal_title：Scientific reports

authors： Khalid A,Chung K,Rajasekharan R,Lau DW,Karle TJ,Gibson BC,Tomljenovic-Hanic S

更新日期：2015-06-25 00:00:00

abstract：:The incidence of resistant Candida isolates, especially Candida albicans, has increased continuously. To overcome the resistance, research on antifungal agent sensitizers has attracted considerable attention. Omeprazole and lansoprazole were found to inhibit the growth of sensitive C. albicans and hyphae formation in ...

journal_title：Scientific reports

authors： Lu M,Yan H,Yu C,Yuan L,Sun S

更新日期：2020-01-16 00:00:00

abstract：:Quick inhibition of approach tendencies in response to signals of potential threats is thought to promote survival. However, little is known about the effect of viewing fearful expressions on the early dynamics of the human motor system. We used the high temporal resolution of single-pulse and paired-pulse transcrania...

journal_title：Scientific reports

authors： Borgomaneri S,Vitale F,Avenanti A

更新日期：2015-09-21 00:00:00

abstract：:A toolbox for the quantum simulation of polarons in ultracold atoms is presented. Motivated by the impressive experimental advances in the area of ultracold atomic mixtures, we theoretically study the problem of ultracold atomic impurities immersed in a Bose-Einstein condensate mixture (BEC). The coupling between impu...

journal_title：Scientific reports

authors： Compagno E,De Chiara G,Angelakis DG,Palma GM

更新日期：2017-05-24 00:00:00

abstract：:In this work, photoacoustic eigen-spectrum analysis was proposed for noninvasively characterizing the mechanical properties of materials. We theoretically predicted the relationship between the photoacoustic eigen-spectra of cylindrical optical absorbers and their mechanical properties. Experimental measurements of ei...

journal_title：Scientific reports

authors： Gao X,Tao C,Zhu R,Liu X

更新日期：2018-05-17 00:00:00

abstract：:Chronic hepatitis viral infection, alcoholic intoxication, and obesity cause liver fibrosis, which progresses to decompensated liver cirrhosis, a disease for which medical demands cannot be met. Since there are currently no approved anti-fibrotic therapies for established liver fibrosis, the development of novel modal...

journal_title：Scientific reports

authors： Itaba N,Kono Y,Watanabe K,Yokobata T,Oka H,Osaki M,Kakuta H,Morimoto M,Shiota G

更新日期：2019-05-02 00:00:00

abstract：:In all organisms, salts produce either appetitive or aversive responses depending on the concentration. While low-salt concentration in food elicits positive responses to ingest, high-salt triggers aversion. Still the mechanisms involved in this dual behavior have just started to be uncovered in some organisms. In Rho...

journal_title：Scientific reports

authors： Cano A,Pontes G,Sfara V,Anfossi D,Barrozo RB

更新日期：2017-11-14 00:00:00