Abstract:
:Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at cohort entry, we investigated the association between baseline serum calcium and the subsequent change in estimated glomerular filtration rate (eGFR, by CKD-EPI) decline using linear mixed models. Mean (SD) baseline corrected serum calcium was 9.6 (0.5) mg/dL. Mean (95%-confidence interval [CI]) eGFR decline was -0.82 (-0.90; -0.74) mL/min/1.73 m2/year. In advanced CKD stages, higher baseline serum calcium was associated with less rapid kidney function decline. The adjusted change (95%-CI) in eGFR decline associated with each mg/dL increase in baseline serum calcium was -0.10 (-0.28; 0.26), 0.39 (0.07; 0.71), 0.34 (-0.02; 0.70) and 0.68 (0.36; 1.00) mL/min/1.73 m2/year for individuals in CKD stage 3a, 3b, 4, and 5, respectively. In a subgroup of patients using vitamin D supplements, the association between baseline serum calcium and CKD progression was eliminated, especially in CKD stage 3b and 4. To conclude, in individuals with CKD stage 3b to 5, lower baseline corrected serum calcium, rather than higher baseline serum calcium, associated with a more rapid CKD progression. Lower serum corrected calcium seems to be indicative for vitamin D deficiency.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Janmaat CJ,van Diepen M,Gasparini A,Evans M,Qureshi AR,Ärnlöv J,Barany P,Elinder CG,Rotmans JI,Vervloet M,Dekker FW,Carrero JJdoi
10.1038/s41598-018-23500-5subject
Has Abstractpub_date
2018-03-26 00:00:00pages
5148issue
1issn
2045-2322pii
10.1038/s41598-018-23500-5journal_volume
8pub_type
杂志文章abstract::Biofilms are complex microbial communities that present serious contamination risks to our environment and health. In this study, atmospheric air plasma and airborne acoustic ultrasound technology were applied to inactivate Escherichia coli and Listeria innocua biofilms. Both technologies were efficient in controlling...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81977-z
更新日期:2021-01-27 00:00:00
abstract::Misfolding and aggregation of prion protein (PrP) causes neurodegenerative diseases like Creutzfeldt-Jakob disease (CJD) and scrapie. Besides the consensus that spontaneous conversion of normal cellular PrPC into misfolded and aggregating PrPSc is the central event in prion disease, an alternative hypothesis suggests ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39213-2
更新日期:2019-02-21 00:00:00
abstract::Salinity is one of the major abiotic factors that affect productivity in oat. Here, we report a comparison of the transcriptomes of two hexaploid oat cultivars, 'Hanyou-5' and 'Huazao-2', which differ with respect to salt tolerance, in seedlings exposed to salt stress. Analysis of the assembled unigenes from the osmot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34505-5
更新日期:2018-11-02 00:00:00
abstract::The present work aimed to investigate the activities and underlying mechanisms of dioscin against alcoholic liver fibrosis (ALF). In vivo liver fibrosis in mice was induced by an alcoholic liquid diet, and in vitro studies were performed on activated HSC-T6 and LX2 cells treated with lipopolysaccharide. Our results sh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18038
更新日期:2015-12-10 00:00:00
abstract::The taxonomic composition of egg-associated microbial communities can play a crucial role in the development of fish embryos. In response, hosts increasingly influence the composition of their associated microbial communities during embryogenesis, as concluded from recent field studies and laboratory experiments. Howe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17084
更新日期:2015-11-27 00:00:00
abstract::HAUSP (herpes virus-associated ubiquitin specific protease, known as ubiquitin specific protease 7), one of DUBs, regulates the dynamics of the p53 and Mdm2 network in response to DNA damage by deubiquitinating both p53 and its E3 ubiquitin ligase, Mdm2. Its concerted action increases the level of functional p53 by pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12793
更新日期:2015-08-04 00:00:00
abstract::College students, as a large part of young adults, are a vulnerable group to several risky behaviors including smoking and drug abuse. This study aimed to utilize and to compare count regression models to identify correlates of cigarette smoking among college students. This was a cross-sectional study conducted on stu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65813-4
更新日期:2020-06-01 00:00:00
abstract::Although cholecystectomy has been reported to be associated with increased risk of developing hepatocellular carcinoma (HCC), the association between cholecystectomy and prognosis of HCC patients underwent curative resection has never been examined. Through retrospective analysis of the data of 3933 patients underwent...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28229
更新日期:2016-06-20 00:00:00
abstract::We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly, after injection of MSCs which had been pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24425-9
更新日期:2018-04-18 00:00:00
abstract::Nearly half of the world's population obtains its daily calories from rice grains, which lack or have insufficient levels of essential micronutrients. The deficiency of micronutrients vital for normal growth is a global health problem, and iron, zinc and vitamin A deficiencies are the most prevalent ones. We developed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07198-5
更新日期:2017-07-31 00:00:00
abstract::N-linked glycosylation is one of the predominant post-translational modifications involved in a number of biological functions. Since experimental characterization of glycosites is challenging, glycosite prediction is crucial. Several predictors have been made available and report high performance. Most of them evalua...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52341-z
更新日期:2019-11-04 00:00:00
abstract::An industrial waste, 1,2,3-trichloropropane (TCP), is toxic and extremely recalcitrant to biodegradation. To date, no natural TCP degraders able to mineralize TCP aerobically have been isolated. In this work, we engineered a biosafety Pseudomonas putida strain KT2440 for aerobic mineralization of TCP by implantation o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07435-x
更新日期:2017-08-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-55966-2
更新日期:2020-01-14 00:00:00
abstract::During the last decades, atmospheric nitrogen loading in mountain ranges of the Northern Hemisphere has increased substantially, resulting in high nitrate concentrations in many lakes. Yet, how increased nitrogen has affected denitrification, a key process for nitrogen removal, is poorly understood. We measured actual...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59759-w
更新日期:2020-02-20 00:00:00
abstract::Quantum coherence is one of the primary non-classical features of quantum systems. While protocols such as the Leggett-Garg inequality (LGI) and quantum tomography can be used to test for the existence of quantum coherence and dynamics in a given system, unambiguously detecting inherent "quantumness" still faces serio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00885
更新日期:2012-01-01 00:00:00
abstract::Imaging and histopathological studies have demonstrated that structural changes of the retina affect subjects with Alzheimer's disease (AD) or mild cognitive impairment (MCI). The aim of this study was to quantitatively investigate the retinal vessels in these disorders, using dynamic vessel analyzer (DVA) and optical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37271-6
更新日期:2019-01-11 00:00:00
abstract::Breast tissue heterogeneity is related to risk factors that lead to more aggressive tumour growth and worse prognosis, yet such heterogeneity has not been well characterized. The aim of this study is to reveal the heterogeneous signal patterns of the apparent diffusion coefficient (ADC) of a tumour and its surrounding...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03122-z
更新日期:2017-06-06 00:00:00
abstract::Depressive disorder (DD) is a mental illness affecting more than 300 million people worldwide, whereas social stigma and subtle, variant symptoms impede diagnosis. Psychomotor retardation is a common component of DD with a negative impact on motor function, usually reflected on patients' routine activities, including,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50002-9
更新日期:2019-09-16 00:00:00
abstract::Streptomyces coelicolor is a Gram-positive microorganism often used as a model of physiological and morphological differentiation in streptomycetes, prolific producers of secondary metabolites with important biological activities. In the present study, we analysed Streptomyces coelicolor growth and differentiation in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32027-8
更新日期:2018-09-12 00:00:00
abstract::Hydrogen in the Earth's deep interior has been thought to exist as a hydroxyl group in high-pressure minerals. We present Muon Spin Rotation experiments on SiO2 stishovite, which is an archetypal high-pressure mineral. Positive muon (which can be considered as a light isotope of proton) implanted in stishovite was fou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08437
更新日期:2015-02-13 00:00:00
abstract::Dirt and microorganisms are the major problems in textiles which can generate unpleasant odor during their growth. Here, zinc oxide (ZnO) nanoparticles prepared by sol-gel method were loaded on the cotton fabrics using spin coating technique to enhance their antimicrobial properties and water repellency. The effects o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22324-7
更新日期:2018-03-02 00:00:00
abstract::Increasing structural complexity at nanoscale can permit superior control over photophysical properties in the precursor-derived semiconductors. We demonstrate here the synthesis of silicon carbonitride (SiCN)/boron nitride (BN) nanocomposites via a polymer precursor route wherein the cobalt polyamine complexes used a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39866
更新日期:2017-01-13 00:00:00
abstract::Horizontal gene transfer (HGT) drives the evolution of recipient organism particularly if it provides a novel function which enhances the fitness or its adaption to the environment. Virus-host co-evolution is attractive for studying co-evolutionary processes, since viruses strictly replicate inside of the host cells a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26934
更新日期:2016-06-07 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-46788-3
更新日期:2019-07-18 00:00:00
abstract::Urbanization is associated with dramatic increases in noise and light pollution, which affect animal behaviour, physiology and fitness. However, few studies have examined these stressors simultaneously. Moreover, effects of urbanization during early-life may be detrimental but are largely unknown. In developing great ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02940-5
更新日期:2017-06-05 00:00:00
abstract::An effective metal oxide coating with solution processes by the metal organic decomposition method as deposited at room temperature (RT) poses great challenge. In this study, we report the characterization and evaluation of the semiconductor properties of a zinc hydroxide thin film with RT just as deposition by soluti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27953-6
更新日期:2018-07-20 00:00:00
abstract::To relieve the environmental issues of sewage sludge (SS) disposal and greenhouse gas (GHG) emission in China, we proposed an integrated method for the first time to simultaneously deal with these two problems. The hot slags below 920 °C could act as a good heat carrier for sludge gasification and the increasing CO2 c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11436
更新日期:2015-06-15 00:00:00
abstract::Temperature index (TI) models are convenient for modelling glacier ablation since they require only a few input variables and rely on simple empirical relations. The approach is generally assumed to be reliable at lower elevations (below 3500 m above sea level, a.s.l) where air temperature (Ta) relates well to the ene...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41657-5
更新日期:2019-03-27 00:00:00
abstract::Worldwide, prostate cancer (PCa) is the second most common malignancy in males. We undertook a meta-analysis to compare the efficacy and safety of conventional laparoscopic radical prostatectomy with a transperitoneal (TLRP) approach, versus that of an extraperitoneal (ELRP) approach, for treatment of localized PCa. A...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep14442
更新日期:2015-10-13 00:00:00
abstract::Coherent Anti-Stokes Raman Spectroscopy (CARS) is performed on single spores (conidia) of the fungus Aspergillus nidulans in order to establish a baseline measurement for fungal spores. Chemical maps of single spores are generated and spectral differentiation between the cell wall and the cytoplasm is achieved. Princi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37978-6
更新日期:2019-02-11 00:00:00