Abstract:
:In all organisms, salts produce either appetitive or aversive responses depending on the concentration. While low-salt concentration in food elicits positive responses to ingest, high-salt triggers aversion. Still the mechanisms involved in this dual behavior have just started to be uncovered in some organisms. In Rhodnius prolixus, using pharmacological and behavioral assays, we demonstrated that upon high-salt detection in food a nitric oxide (NO) dependent cascade is activated. This activation involves a soluble guanylate cyclase (sGC) and the production of cyclic guanosine monophosphate (cGMP). Thus, appetitive responses to low-salt diets turn to aversion whenever this cascade is activated. Conversely, insects feed over aversive high-salt solutions when it is blocked by reducing NO levels or by affecting the sGC activity. The activation of NO/sGC/cGMP cascade commands the avoidance feeding behavior in R. prolixus. Investigations in other insect species should examine the possibility that high-salt aversion is mediated by NO/sSG/cGMP signaling.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cano A,Pontes G,Sfara V,Anfossi D,Barrozo RBdoi
10.1038/s41598-017-15861-0subject
Has Abstractpub_date
2017-11-14 00:00:00pages
15551issue
1issn
2045-2322pii
10.1038/s41598-017-15861-0journal_volume
7pub_type
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