Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system.

abstract：:In comparison to genome-wide association studies (GWAS), there has been poor replication of gene expression studies in chronic obstructive pulmonary disease (COPD). We performed microarray gene expression profiling on a large sample of resected lung tissues from subjects with severe COPD. Comparing 111 COPD cases and ...

journal_title：Scientific reports

authors： Morrow JD,Zhou X,Lao T,Jiang Z,DeMeo DL,Cho MH,Qiu W,Cloonan S,Pinto-Plata V,Celli B,Marchetti N,Criner GJ,Bueno R,Washko GR,Glass K,Quackenbush J,Choi AM,Silverman EK,Hersh CP

更新日期：2017-03-13 00:00:00

abstract：:Several studies provide evidence of a link between vector-borne disease outbreaks and El Niño driven climate anomalies. Less investigated are the effects of the North Atlantic Oscillation (NAO). Here, we test its impact on outbreak occurrences of 13 infectious diseases over Europe during the last fifty years, controll...

journal_title：Scientific reports

authors： Morand S,Owers KA,Waret-Szkuta A,McIntyre KM,Baylis M

更新日期：2013-01-01 00:00:00

abstract：:Two-dimensional imaging of spontaneous ultra-weak photon emission was measured in the yeast cells, Arabidopsis plant and the human hand using highly sensitive charge coupled device (CCD) camera. For the first time, the detail analysis of measuring parameters such as accumulation time and binning is provided with the a...

journal_title：Scientific reports

authors： Prasad A,Pospíšil P

更新日期：2013-01-01 00:00:00

abstract：:Live cells are three-dimensional environments where biological molecules move to find their targets and accomplish their functions. However, up to now, most single molecule investigations have been limited to bi-dimensional studies owing to the complexity of 3d-tracking techniques. Here, we present a novel method for ...

journal_title：Scientific reports

authors： Gardini L,Capitanio M,Pavone FS

更新日期：2015-11-03 00:00:00

abstract：:Current theoretical analyses of defect properties without solving the detailed balance equations often estimate Fermi-level pinning position by omitting free carriers and assume defect concentrations can be always tuned by atomic chemical potentials. This could be misleading in some circumstance. Here we clarify that:...

journal_title：Scientific reports

authors： Yang JH,Yin WJ,Park JS,Wei SH

更新日期：2015-11-20 00:00:00

abstract：:Elevated atmospheric CO2 concentrations are contributing to ocean acidification (reduced seawater pH and carbonate concentrations), with potentially major ramifications for marine ecosystems and their functioning. Using a novel in situ experiment we examined impacts of reduced seawater pH on Antarctic sea ice-associat...

journal_title：Scientific reports

authors： Cummings VJ,Barr NG,Budd RG,Marriott PM,Safi KA,Lohrer AM

更新日期：2019-04-15 00:00:00

abstract：:15-lipoxygenase is involved in the generation of specialized pro-resolving lipid mediators that play essential roles in resolution and inflammatory responses. Here, we investigated anti-inflammatory role of Alox15 in skin homeostasis. We demonstrated that knockout (KO) of Alox15 led to hair loss and disrupted the stru...

journal_title：Scientific reports

authors： Kim SN,Akindehin S,Kwon HJ,Son YH,Saha A,Jung YS,Seong JK,Lim KM,Sung JH,Maddipati KR,Lee YH

更新日期：2018-06-11 00:00:00

abstract：:Recently, extracorporeal shock wave therapy (ESWT) has been shown to be a novel therapy for carpal tunnel syndrome (CTS). However, previous studies did not examine the diverse effects of different-session ESWT for different-grades CTS. Thus, we conducted a randomized, single-blind, placebo-controlled study. Sixty-nine...

journal_title：Scientific reports

authors： Ke MJ,Chen LC,Chou YC,Li TY,Chu HY,Tsai CK,Wu YT

更新日期：2016-12-02 00:00:00

abstract：:Among patients with non-small cell lung cancer (NSCLC), best supportive care (BSC) is well-known to improve patient's quality of life and prolong survival. This study aimed to clarify (1) the decision-making factors of BSC alone and (2) the prognostic factors after selection of no further anticancer therapies. We retr...

journal_title：Scientific reports

authors： Kitazawa H,Takeda Y,Naka G,Sugiyama H

更新日期：2019-12-27 00:00:00

abstract：:A method for defect characterization is presented that allows to measure the activation energy, capture cross-section, and defect density in dielectric materials. This is exemplarily performed on aluminum oxide thin films deposited on hydrogen-terminated diamond. During the measurement, samples were illuminated using ...

journal_title：Scientific reports

authors： Oing D,Geller M,Stahl L,Kerski J,Lorke A,Wöhrl N

更新日期：2020-07-27 00:00:00

abstract：:Countries in the Asia Pacific region aim to eliminate malaria by 2030. A cornerstone of malaria elimination is the effective management of Anopheles mosquito vectors. Current control tools such as insecticide treated nets or indoor residual sprays target mosquitoes in human dwellings. We find in a high transmission re...

journal_title：Scientific reports

authors： Waite JL,Swain S,Lynch PA,Sharma SK,Haque MA,Montgomery J,Thomas MB

更新日期：2017-01-16 00:00:00

abstract：:The activation and growth of tumour-initiating cells with stem-like properties in distant organs characterize colorectal cancer (CRC) growth and metastasis. Thus, inhibition of colon cancer stem cell (CCSC) growth holds promise for CRC growth and metastasis prevention. We and others have shown that farnesyl dimethyl c...

journal_title：Scientific reports

authors： Husain K,Coppola D,Yang CS,Malafa MP

更新日期：2021-01-26 00:00:00

abstract：:In clinical populations, olfactory abilities parallel executive function, implicating shared neuroanatomical substrates within the ventral prefrontal cortex. In healthy individuals, the relationship between olfaction and personality traits or certain cognitive and behavioural characteristics remains unexplored. We the...

journal_title：Scientific reports

authors： Herman AM,Critchley H,Duka T

更新日期：2018-10-22 00:00:00

abstract：:Although the search for quantitative trait loci for behaviour remains a considerable challenge, the complicated genetic architecture of quantitative traits is beginning to be understood. The current project utilised heterogeneous stock (HS) male mice (n = 580) to investigate the genetic basis for brain weights, activi...

journal_title：Scientific reports

authors： Janecka M,Marzi SJ,Parsons MJ,Liu L,Paya-Cano JL,Smith RG,Fernandes C,Schalkwyk LC

更新日期：2017-02-01 00:00:00

abstract：:The purpose of this study is to investigate whether implementing a myofascial release (MFR) protocol designed to restore the myofascial properties of the diaphragm has any effect on the symptoms, quality of life, and consumption of proton pump inhibitors (PPI) drugs by patients with non-erosive gastroesophageal reflux...

journal_title：Scientific reports

authors： Martínez-Hurtado I,Arguisuelas MD,Almela-Notari P,Cortés X,Barrasa-Shaw A,Campos-González JC,Lisón JF

更新日期：2019-05-13 00:00:00

abstract：:Dirac-like surface states on surfaces of topological insulators have a chiral spin structure with spin locked to momentum, which is interesting in physics and may also have important applications in spintronics. In this work, by measuring the tunable helicity-dependent photocurrent (HDP), we present an identification ...

journal_title：Scientific reports

authors： Duan J,Tang N,He X,Yan Y,Zhang S,Qin X,Wang X,Yang X,Xu F,Chen Y,Ge W,Shen B

更新日期：2014-05-08 00:00:00

abstract：:Since 2001, hundreds of thousands of hours of underwater acoustic recordings have been made throughout the Southern Ocean south of 60° S. Detailed analysis of the occurrence of marine mammal sounds in these circumpolar recordings could provide novel insights into their ecology, but manual inspection of the entirety of...

journal_title：Scientific reports

authors： Miller BS,IWC-SORP\/SOOS Acoustic Trends Working Group.,Balcazar N,Nieukirk S,Leroy EC,Aulich M,Shabangu FW,Dziak RP,Lee WS,Hong JK

更新日期：2021-01-12 00:00:00

abstract：:Fibrin glue has been used clinically for decades in a wide variety of surgical specialties and is now being investigated as a medium for local, prolonged drug delivery. Effective local delivery of antibacterial substances is important perioperatively in patients with implanted medical devices or postoperatively for de...

journal_title：Scientific reports

authors： Rubalskii E,Ruemke S,Salmoukas C,Aleshkin A,Bochkareva S,Modin E,Mashaqi B,Boyle EC,Boethig D,Rubalsky M,Zulkarneev E,Kuehn C,Haverich A

更新日期：2019-02-14 00:00:00

abstract：:Voltage gated sodium channels are key players in aberrant pain signaling and sensitization of nociceptors after peripheral nerve injury. The extent to which sodium channel activity after injury contributes to synaptic transmission at the first pain synapse however remains unclear. To investigate the effect of axotomy ...

journal_title：Scientific reports

authors： Vysokov N,McMahon SB,Raouf R

更新日期：2019-09-09 00:00:00

abstract：:Streptococcus agalactiae (GBS) is the leading cause worldwide of neonatal sepsis. We sought to assess to which extent HIV exposure of neonates is associated with GBS neonatal disease. Furthermore, we assessed to which extent HIV infection in women is associated with maternal rectovaginal GBS carriage, the single most ...

journal_title：Scientific reports

authors： Cools P,van de Wijgert JHHM,Jespers V,Crucitti T,Sanders EJ,Verstraelen H,Vaneechoutte M

更新日期：2017-10-23 00:00:00

abstract：:In contrast to annual plants, in perennial plants, the shoot apical meristem (SAM) can undergo seasonal transitions between dormancy and activity; understanding this transition is crucial for understanding growth in perennial plants. However, little is known about the molecular mechanisms of SAM development in trees. ...

journal_title：Scientific reports

authors： Xu H,Cao D,Chen Y,Wei D,Wang Y,Stevenson RA,Zhu Y,Lin J

更新日期：2016-02-02 00:00:00

abstract：:High-quality broadband ultrasound transducers yield superior imaging performance in biomedical ultrasonography. However, proper design to perfectly bridge the energy between the active piezoelectric material and the target medium over the operating spectrum is still lacking. Here, we demonstrate a new anisotropic cone...

journal_title：Scientific reports

authors： Li Z,Yang DQ,Liu SL,Yu SY,Lu MH,Zhu J,Zhang ST,Zhu MW,Guo XS,Wu HD,Wang XL,Chen YF

更新日期：2017-02-17 00:00:00

abstract：:Electroporation (EP), the increase of cell membrane permeability due to the application of electric pulses, is a universal phenomenon with a broad range of applications. In medicine, some of the foremost EP-based tumor treatments are electrochemotherapy (ECT), irreversible electroporation, and gene electrotransfer (GE...

journal_title：Scientific reports

authors： Marino M,Luján E,Mocskos E,Marshall G

更新日期：2021-01-14 00:00:00

abstract：:The negatively-charged nitrogen vacancy (NV(-)) center in diamond is of great interest for quantum information processing and quantum key distribution applications due to its highly desirable long coherence times at room temperature. One of the challenges for their use in these applications involves the requirement to...

journal_title：Scientific reports

authors： Khalid A,Chung K,Rajasekharan R,Lau DW,Karle TJ,Gibson BC,Tomljenovic-Hanic S

更新日期：2015-06-25 00:00:00

abstract：:We previously identified novel bioactive polysaccharides from Bactrocera cucurbitae and Antheraea yamamai that activate innate immunity in RAW264 murine macrophages. However, in terms of potential applications in the cultivation of prawns, there were problems with the availability of these insects. However, we have no...

journal_title：Scientific reports

authors： Ali MFZ,Yasin IA,Ohta T,Hashizume A,Ido A,Takahashi T,Miura C,Miura T

更新日期：2018-06-11 00:00:00

abstract：:Nacre, the gold standard for biomimicry, provides an excellent example and guideline for assembling high-performance composites. Inspired by the layered structure and extraordinary strength and toughness of natural nacre, nacre-like nanolignocellulose/poly (vinyl alcohol)/TiO2 composites possessed the similar layered ...

journal_title：Scientific reports

authors： Chen Y,Wang H,Dang B,Xiong Y,Yao Q,Wang C,Sun Q,Jin C

更新日期：2017-05-12 00:00:00

abstract：:Systemic lupus erythematosus (SLE) features a decreased pool of CD4+CD25+Foxp3+ T regulatory (Treg) cells. We had previously observed NKG2D+CD4+ T cell expansion in contrast to a decreased pool of Treg cells in SLE patients, but whether NKG2D+CD4+ T cells contribute to the decreased Treg cells remains unclear. In the ...

journal_title：Scientific reports

authors： Yang D,Tian Z,Zhang M,Yang W,Tang J,Wu Y,Ni B

更新日期：2017-04-28 00:00:00

abstract：:Brain natriuretic peptide (BNP) is the most effective predictor of outcomes in chronic heart failure (CHF). This study sought to determine the qualitative relationship between the BNP levels at discharge and on the day of cardiovascular events in CHF patients. We devised a mathematical probabilistic model between the ...

journal_title：Scientific reports

authors： Fukuda H,Suwa H,Nakano A,Sakamoto M,Imazu M,Hasegawa T,Takahama H,Amaki M,Kanzaki H,Anzai T,Mochizuki N,Ishii A,Asanuma H,Asakura M,Washio T,Kitakaze M

更新日期：2016-11-15 00:00:00

abstract：:Salvia miltiorrhiza is one of the most widely-used medicinal plants. Here, we systematically analyzed the RNA editing events in its mitochondria. We developed a pipeline using REDItools to predict RNA editing events from stand-specific RNA-Seq data. The predictions were validated using reverse transcription, RT-PCR am...

journal_title：Scientific reports

authors： Wu B,Chen H,Shao J,Zhang H,Wu K,Liu C

更新日期：2017-02-10 00:00:00

abstract：:Metallic nanostructures are of immense scientific interest owing to unexpectedly strong interaction with light in deep subwavelength scales. Resonant excitations of surface and cavity plasmonic modes mediate strong light localization in nanoscale objects. Nevertheless, the role of surface plasmon-polaritons (SPP) in l...

journal_title：Scientific reports

authors： Yoon JW,Lee JH,Song SH,Magnusson R

更新日期：2014-07-14 00:00:00