Characterization of biological variation of peripheral blood immune cytome in an Indian cohort.

Abstract:

:Immune parameters show characteristic normal baseline levels and variance in the population. We characterised the degree of inter-individual and within-individual variation over one-year time period in 33 immune cell subsets by flow cytometry in peripheral blood mononuclear cells from 43 healthy young adult volunteers. Our analysis revealed that immune subsets that showed low variability between individuals also showed low short-term fluctuations within-individuals, as well as concordance in siblings. However, when baseline levels and degree of fluctuation were considered together, individuals failed to cluster into discreet groups. Together, the data reveal complex inter-relationships between immune subsets in individuals, and provide insights into the observed heterogeneity between individuals and between multiple immune subsets.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kanodia P,Kaur G,Coshic P,Chatterjee K,Neeman T,George A,Rath S,Bal V,Prabhu SB

doi

10.1038/s41598-019-51294-7

subject

Has Abstract

pub_date

2019-10-14 00:00:00

pages

14735

issue

1

issn

2045-2322

pii

10.1038/s41598-019-51294-7

journal_volume

9

pub_type

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