Abstract：
:The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and chromatographic profiling of desalted and enzyme-digested SE ethanol extract (SE-EE). Subsequently, we evaluated the anti-neuroinflammatory and ameliorative potential of SE-EE in LPS-inflicted BV-2 microglial cells and scopolamine-induced amnesic C57/BL6N mice, respectively. SE-EE possess considerable polyphenols and flavonoids that are supposedly responsible to improve its bio-efficacy. SE-EE dose-dependently attenuated LPS-induced inflammation in BV-2 cells, significantly repressed behavioural/cognitive impairment, dose-dependently regulated the cholinergic function, suppressed oxidative stress markers, regulated inflammatory cytokines/associated proteins expression and effectively ameliorated p-CREB/BDNF levels, neurogenesis (DCX stain), neuron proliferation (Ki67 stain) in scopolamine-administered mice. Thus, SE-EE extract shows promising multifactorial disease modifying activities and can be further developed as an effective functional food, drug candidate, or supplemental therapy to treat neuroinflammatory mediated disorders.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Karthivashan G,Park SY,Kweon MH,Kim J,Haque ME,Cho DY,Kim IS,Cho EA,Ganesan P,Choi DKdoi
10.1038/s41598-018-25381-0subject
Has Abstractpub_date
2018-05-08 00:00:00pages
7174issue
1issn
2045-2322pii
10.1038/s41598-018-25381-0journal_volume
8pub_type
杂志文章abstract：:The early diverged Magnoliaceae shows a historical temperate-tropical distribution among lineages indicating divergent evolution, yet which ecophysiological traits are phylogenetically conserved, and whether these traits are involved in correlated evolution remain unclear. Integrating phylogeny and 20 ecophysiological...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12246
更新日期：2015-07-16 00:00:00
abstract：:Rapid and efficient processing of external information by the brain is vital to survival in a highly dynamic environment. The key channel humans use to exchange information is language, but the neural underpinnings of its processing are still not fully understood. We investigated the spatio-temporal dynamics of neural...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26558
更新日期：2016-05-24 00:00:00
abstract：:DNA methylation-based biological age (DNAm age), as well as genome-wide average DNA methylation, have been reported to predict breast cancer risk. We aimed to investigate the associations between these DNA methylation-based risk factors and 18 conventional breast cancer risk factors for disease-free women. A sample of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51475-4
更新日期：2019-10-21 00:00:00
abstract：:Interactions between human cytomegalovirus (HCMV) infection and environmental factors can increase susceptibility to essential hypertension (EH). Although endothelial dysfunction is the initial factor of EH, the epigenetic mechanisms through which HCMV infection induces endothelial cell dysfunction are poorly understo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58680-6
更新日期：2020-02-10 00:00:00
abstract：:The contribution of paternal obesity to pregnancy outcomes has been little described. Our aims were to determine whether the effect of an antenatal maternal dietary and lifestyle intervention among women who are overweight or obese on newborn adiposity, was modified by paternal obesity. We conducted a secondary analys...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/s41598-017-01672-w
更新日期：2017-05-08 00:00:00
abstract：:A 3D cell culture is preferred to 2D cell culture since it allows cells to grow in all directions in vitro, similar to how they would in vivo. 3D cell culture plates currently used in tissue engineering research have limited access to control the geometry. Furthermore, 3D cell culture plate manufacturing methods are r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50186-0
更新日期：2019-09-27 00:00:00
abstract：:The prognostic factors of patients who undergo radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is not fully elucidated. We aimed to investigate the role of liver stiffness (LS) and spleen stiffness (SS) measured by acoustic radiation force impulse (ARFI) elastography in determining the prognoses of pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58988-3
更新日期：2020-02-06 00:00:00
abstract：:Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) is an accurate and fast method to measure gene expression. Reproducibility of the analyses is the main limitation of RT-qPCR experiments. Galaxy is an open, web-based, genomic workbench for a reproducible, transparent, and accessible scie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53155-9
更新日期：2019-11-26 00:00:00
abstract：:In the last years, great advances have been made in therapies based in cold atmospheric plasmas (CAP). CAP generate reactive oxygen and nitrogen species (RONS) which can be transferred to liquids. These CAP activated liquids display the same biological efficacy (i.e. on killing cancer cells) as CAP themselves, opening...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52673-w
更新日期：2019-11-06 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep20029. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46385
更新日期：2017-06-30 00:00:00
abstract：:Excessive activation of inflammation and the accompanying lung vascular endothelial barrier disruption are primary pathogenic features of acute lung injury (ALI). Microtubule-associated protein 4 (MAP4), a tubulin assembly-promoting protein, is important for maintaining the microtubule (MT) cytoskeleton and cell-cell ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08895
更新日期：2015-03-09 00:00:00
abstract：:The pathophysiology of stress cardiomyopathy (SCM), also known as takotsubo syndrome, is poorly understood. SCM usually occurs sporadically, often in association with a stressful event, but clusters of cases are reported after major natural disasters. There is some evidence that this is a familial condition. We have e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25827-5
更新日期：2018-05-15 00:00:00
abstract：:Protein phosphorylation enables a rapid adjustment of cellular activities to diverse intracellular and environmental stimuli. Many phosphoproteins are targeted on more than one site, which allows the integration of multiple signals and the implementation of complex responses. However, the hierarchy and interplay betwe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80357-3
更新日期：2021-01-13 00:00:00
abstract：:Olive (Olea europaea L.) is one of the most economically and historically important fruit crops worldwide. Genetic progress for valuable agronomic traits has been slow in olive despite its importance and benefits. Advances in next generation sequencing technologies provide inexpensive and highly reproducible genotypin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55338-w
更新日期：2019-12-10 00:00:00
abstract：:PDCD4, the protein encoded by the tumor suppressor gene PDCD4 (programmed cell death 4) has been implicated in the control of cellular transcription and translation by modulating the activity of specific transcription factors and suppressing the translation of mRNAs with structured 5'-UTRs. Most studies of human PDCD4...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59678-w
更新日期：2020-02-17 00:00:00
abstract：:Komagataeibacter nataicola is an acetic acid bacterium (AAB) that can produce abundant bacterial cellulose and tolerate high concentrations of acetic acid. To globally understand its fermentation characteristics, we present a high-quality complete genome sequence of K. nataicola RZS01. The genome consists of a 3,485,1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04589-6
更新日期：2017-06-30 00:00:00
abstract：:We characterised changes in reproductive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the menopause (reproductive age) in mid-life women and explored their associations with lifestyle and reproductive factors. We used data from 1608 women from a UK cohort who had repeat hormone measures and expe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77871-9
更新日期：2020-12-04 00:00:00
abstract：:A Quality Improvement bundle was implemented with the goal of standardizing the multidisciplinary approach to delivery room management. We used a Pre-Post Quality Improvement initiative with the following aims: (1) Placement of a functioning pulse oximeter by two minutes after birth, (2) Delayed intubation, (3) Normot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37397
更新日期：2016-11-21 00:00:00
abstract：:Sea-surface temperature (SST) warming events, which are projected to increase in frequency and intensity with climate change, represent major threats to coral reefs. How these events impact reef carbonate budgets, and thus the capacity of reefs to sustain vertical growth under rising sea levels, remains poorly quantif...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40581
更新日期：2017-01-13 00:00:00
abstract：:Melting is considered to be one of the most fundamental problems in physical science. Generally, dimensionality plays an important role in melting. In three-dimension, it's well known that a crystal melts directly into a liquid via a first-order transition. In two-dimension (2D), however, the melting process has been ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24056
更新日期：2016-04-07 00:00:00
abstract：:We present two transmission-mode dielectric Fresnel-Zone Plate Lens (FZPL) antennas for use within the V-band spectrum. The proposed FZPs are realized via pure plastic material using two different additive manufacturing processes. The proposed FZP lenses are designed with half (λ/2) and quarter (λ/4) phase correction ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23179-8
更新日期：2018-03-28 00:00:00
abstract：:Solid state memory and switching devices aimed at replacing the flash memory technology operate by switching from the high to low resistance when conductive filaments are created in response to the electric pulse. The filaments are identified with either structurally different protrusions or purely electronic conducti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30700-6
更新日期：2018-08-15 00:00:00
abstract：:Inhomogeneity in the ground state is an intriguing, emergent phenomenon in magnetism. Recently, it has been observed in the magnetostructural channel of the geometrically frustrated α-NaMnO2, for the first time in the absence of active charge degrees of freedom. Here we report an in-depth numerical and local-probe exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09272
更新日期：2015-03-19 00:00:00
abstract：:Cardiac magnetic resonance (CMR) has emerged as a powerful tool for in vivo assessments of cardiac parameters in experimental animal models of cardiovascular diseases, but its reproducibility in this setting remains poorly explored. To address this issue, we investigated the test-retest reproducibility of preclinical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07083-1
更新日期：2017-07-27 00:00:00
abstract：:Statins present many beneficial effects in chronic liver disease, but concerns about safety exist. We evaluated the hepatic effects of a nitric oxide-releasing atorvastatin (NCX 6560) compared to conventional statins. Simvastatin, atorvastatin and NCX 6560 were evaluated in four-week bile duct-ligated rats (BDL) simul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40461
更新日期：2017-01-13 00:00:00
abstract：:Attachment of nanoparticles (NPs) to the surface of carrier red blood cells (RBCs) profoundly alters their interactions with the host organism, decelerating NP clearance from the bloodstream while enabling NP transfer from the RBC surface to the vascular cells. These changes in pharmacokinetics of NPs imposed by carri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19897-8
更新日期：2018-01-25 00:00:00
abstract：:Leiomyomas, adenomyosis, and endometriosis are reported to be risk factors for endometrial carcinoma (EC), and adenomyosis and endometriosis also for ovarian carcinoma (OC). We aimed to describe the prevalence of these conditions in EC patients with or without an OC diagnosis, and to investigate their relationship wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59916-1
更新日期：2020-02-27 00:00:00
abstract：:It is well known the thermal properties of three-dimensional (3-D) hybrid graphene (GR)-carbon nanotube (CNT) structures are not superior to that of the individual GR and CNT, however, the 3-D hybrid GR-CNT structures can effectively improve the thermal properties of polymer matrix. Therefore, understanding the therma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14710-4
更新日期：2017-10-31 00:00:00
abstract：:Structural disorder is widespread in eukaryotic proteins and is vital for their function in diverse biological processes. It is therefore highly desirable to be able to predict the degree of order and disorder from amino acid sequence. It is, however, notoriously difficult to predict the degree of local flexibility wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71716-1
更新日期：2020-09-08 00:00:00
abstract：:To date, the significant anti-cancer capacity of cold atmospheric plasma (CAP) on dozens of cancer cell lines has been demonstrated in vitro and in mice models. Conventionally, CAP was directly applied to irradiate cancer cells or tumor tissue. Over past three years, the CAP irradiated media was also found to kill can...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18339
更新日期：2015-12-17 00:00:00
