当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Production of reactive species in alginate hydrogels for cold atmospheric plasma-based therapies.

Production of reactive species in alginate hydrogels for cold atmospheric plasma-based therapies.

Abstract：

:In the last years, great advances have been made in therapies based in cold atmospheric plasmas (CAP). CAP generate reactive oxygen and nitrogen species (RONS) which can be transferred to liquids. These CAP activated liquids display the same biological efficacy (i.e. on killing cancer cells) as CAP themselves, opening the door for minimally invasive therapies. However, injection of a liquid in the body results in fast diffusion due to extracellular fluids and blood flow. Therefore, the development of efficient vehicles which allow local confinement and delivery of RONS to the diseased site is a fundamental requirement. In this work, we investigate the generation of RONS (H2O2, NO2-, short-lived RONS) in alginate hydrogels by comparing two atmospheric pressure plasma jets: kINPen and a helium needle, at a range of plasma treatment conditions (time, gas flow, distance to the sample). The physic-chemical properties of the hydrogels remain unchanged by the plasma treatment, while the hydrogel shows several-fold larger capacity for generation of RONS than a typical isotonic saline solution. Part of the RONS are quickly released to a receptor media, so special attention has to be put on the design of hydrogels with in-situ crosslinking. Remarkably, the hydrogels show capacity for sustained release of the RONS. The plasma-treated hydrogels remain fully biocompatible (due the fact that the species generated by plasma are previously washed away), indicating that no cytotoxic modifications have occurred on the polymer. Moreover, the RONS generated in alginate solutions showed cytotoxic potential towards bone cancer cells. These results open the door for the use of hydrogel-based biomaterials in CAP-associated therapies.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Labay C,Hamouda I,Tampieri F,Ginebra MP,Canal C

doi

10.1038/s41598-019-52673-w

subject

Has Abstract

pub_date

2019-11-06 00:00:00

pages

16160

issue

1

issn

2045-2322

pii

10.1038/s41598-019-52673-w

journal_volume

9

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions.

    abstract：:Data-independent acquisition mass spectrometry promises higher performance in terms of quantification and reproducibility compared to data-dependent acquisition mass spectrometry methods. To enable high-accuracy quantification of Staphylococcus aureus proteins, we have developed a global ion library for data-independe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10059-w

    authors： Michalik S,Depke M,Murr A,Gesell Salazar M,Kusebauch U,Sun Z,Meyer TC,Surmann K,Pförtner H,Hildebrandt P,Weiss S,Palma Medina LM,Gutjahr M,Hammer E,Becher D,Pribyl T,Hammerschmidt S,Deutsch EW,Bader SL,Hecker M,Mo

    更新日期：2017-09-08 00:00:00

  • Management of Respiratory Distress Syndrome in Preterm Infants In Wales: A Full Audit Cycle of a Quality Improvement Project.

    abstract：:Respiratory Distress Syndrome (RDS) is the commonest diagnosis after premature birth. We aimed to audit clinical practices before and after introduction of a national guideline in Wales on RDS management. Anonymised, prospective data on all infants born at <34 weeks of gestation and cared for at one of the participati...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60091-6

    authors： Course C,Chakraborty M

    更新日期：2020-02-26 00:00:00

  • Uniform two-dimensional crystals of polystyrene nanospheres fabricated by a surfactant-assisted spin-coating method with polyoxyethylene tridecyl ether.

    abstract：:Spin-coated self-assemblies of colloidal particles have been developed recently as an attractive close-packed monolayer of the particles for a variety of applications, but they are limited by the small area of their monolayers, especially given their low uniformity and monolayer coverage on large-area substrates. We r...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47990-z

    authors： Park B,Na SY,Bae IG

    更新日期：2019-08-07 00:00:00

  • Formation of Biphasic Hydroxylapatite-Beta Magnesium Tricalcium Phosphate in Heat Treated Salmonid Vertebrae.

    abstract：:Ichthyoarchaeological evidence is uncommon at ancient hunter-gatherer sites from various regions and timeframes. This research contributes to the development of microarchaeological techniques useful for identifying fishing economies in situations where classifiable bones are unavailable. Specifically, traces of heat a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03737-2

    authors： Butler DH,Shahack-Gross R

    更新日期：2017-06-15 00:00:00

  • Green tide development associated with submarine groundwater discharge in a coastal harbor, Jeju, Korea.

    abstract：:We measured the magnitude of submarine fresh groundwater discharge (SFGD) and associated nutrient inputs to Jocheon harbor, on Jeju Island, Korea, during four sampling periods, in order to determine the link between SFGD and Ulva sp. green tide development. Good correlations among salinity, 222Rn, and dissolved inorga...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06711-0

    authors： Kwon HK,Kang H,Oh YH,Park SR,Kim G

    更新日期：2017-07-24 00:00:00

  • YebC, a putative transcriptional factor involved in the regulation of the proteolytic system of Lactobacillus.

    abstract：:The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09124-1

    authors： Brown L,Villegas JM,Elean M,Fadda S,Mozzi F,Saavedra L,Hebert EM

    更新日期：2017-08-17 00:00:00

  • Contact effects in thin 3D-topological insulators: how does the current flow?

    abstract：:The effect of different contact configurations (semi-infinite extended-channel, normal metal and ferromagnetic metal) on quantum transport through thin Bi2Se3 three-dimensional (3D) topological insulator (TI) slab (channel) has been investigated through Non-Equilibrium Green Function. The issue of contact dependent cu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09479

    authors： Gupta G,Jalil MB,Liang G

    更新日期：2015-03-30 00:00:00

  • Attentional Guidance from Multiple Working Memory Representations: Evidence from Eye Movements.

    abstract：:Recent studies have shown that the representation of an item in visual working memory (VWM) can bias the deployment of attention to stimuli in the visual scene possessing the same features. When multiple item representations are simultaneously held in VWM, whether these representations, especially those held in a non-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32144-4

    authors： Zhang B,Liu S,Doro M,Galfano G

    更新日期：2018-09-17 00:00:00

  • The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.

    abstract：:Traumatic brain injury (TBI) increases the risk of Alzheimer's disease (AD). Calpain activation and tau hyperphosphorylation have been implicated in both TBI and AD. However, the link between calpain and tau phosphorylation has not been fully identified. We recently discovered that the two major calpain isoforms in th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12236-3

    authors： Wang Y,Hall RA,Lee M,Kamgar-Parsi A,Bi X,Baudry M

    更新日期：2017-09-18 00:00:00

  • LncRNA HOTAIR regulates glucose transporter Glut1 expression and glucose uptake in macrophages during inflammation.

    abstract：:Inflammation plays central roles in the immune response. Inflammatory response normally requires higher energy and therefore is associated with glucose metabolism. Our recent study demonstrates that lncRNA HOTAIR plays key roles in NF-kB activation, cytokine expression, and inflammation. Here, we investigated if HOTAI...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80291-4

    authors： Obaid M,Udden SMN,Alluri P,Mandal SS

    更新日期：2021-01-08 00:00:00

  • Enzyme-guided DNA Sewing Architecture.

    abstract：:With the advent of nanotechnology, a variety of nanoarchitectures with varied physicochemical properties have been designed. Owing to the unique characteristics, DNAs have been used as a functional building block for novel nanoarchitecture. In particular, a self-assembly of long DNA molecules via a piece DNA staple ha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17722

    authors： Song IH,Shin SW,Park KS,Lansac Y,Jang YH,Um SH

    更新日期：2015-12-04 00:00:00

  • Responses of LAI to rainfall explain contrasting sensitivities to carbon uptake between forest and non-forest ecosystems in Australia.

    abstract：:Non-forest ecosystems (predominant in semi-arid and arid regions) contribute significantly to the increasing trend and interannual variation of land carbon uptake over the last three decades, yet the mechanisms are poorly understood. By analysing the flux measurements from 23 ecosystems in Australia, we found the the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11063-w

    authors： Li L,Wang YP,Beringer J,Shi H,Cleverly J,Cheng L,Eamus D,Huete A,Hutley L,Lu X,Piao S,Zhang L,Zhang Y,Yu Q

    更新日期：2017-09-15 00:00:00

  • Distribution Analysis via Mass Spectrometry Imaging of Ephedrine in the Lungs of Rats Orally Administered the Japanese Kampo Medicine Maoto.

    abstract：:Maoto, a traditional Japanese Kampo medicine, has been used to treat various respiratory diseases, including respiratory infections and influenza. Ephedrine (EPD), the main ingredient in maoto, is also clinically used to treat respiratory diseases. However, the pharmacokinetics and distribution of EPD in the lungs aft...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44098

    authors： Matsumoto T,Kushida H,Matsushita S,Oyama Y,Suda T,Watanabe J,Kase Y,Setou M

    更新日期：2017-03-08 00:00:00

  • Mapping the Surface Microbiome and Metabolome of Brown Seaweed Fucus vesiculosus by Amplicon Sequencing, Integrated Metabolomics and Imaging Techniques.

    abstract：:The brown alga Fucus vesiculosus is a keystone marine species, which is subject to heavy surface colonisation. This study was designed to analyse the surface epibiome of F. vesiculosus in conjunction with the composition and spatial distribution of its surface metabolome. The amplicon sequencing, SEM and CARD-FISH ima...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37914-8

    authors： Parrot D,Blümel M,Utermann C,Chianese G,Krause S,Kovalev A,Gorb SN,Tasdemir D

    更新日期：2019-01-31 00:00:00

  • Dysfunctional EAT thickness may promote maladaptive heart remodeling in CVD patients through the ST2-IL33 system, directly related to EPAC protein expression.

    abstract：:Dysfunctional epicardial adipose tissue (EAT) secretome can influence the heart's stretch response. However, the molecular mechanisms are still poorly understood. The aim of this study was to clarify how dysfunctional EAT promotes maladaptive heart remodeling in cardiovascular disease (CVD) through ST2 production asso...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46676-w

    authors： Vianello E,Dozio E,Bandera F,Schmitz G,Nebuloni M,Longhi E,Tacchini L,Guazzi M,Corsi Romanelli MM

    更新日期：2019-07-17 00:00:00

  • Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression.

    abstract：:Mechanical factors play a key role in regulating the development of cartilage degradation in osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and chondrocytes. To explore the effects of mechanical stress on cartilage morphology, we observed cartilages in different regions by...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37268

    authors： Liu Q,Hu X,Zhang X,Duan X,Yang P,Zhao F,Ao Y

    更新日期：2016-11-17 00:00:00

  • An assessment of the amount of untapped fold level novelty in under-sampled areas of the tree of life.

    abstract：:Previous studies of protein fold space suggest that fold coverage is plateauing. However, sequence sampling has been -and remains to a large extent- heavily biased, focusing on culturable phyla. Sustained technological developments have fuelled the advent of metagenomics and single-cell sequencing, which might correct...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14717

    authors： Barry Roche D,Brüls T

    更新日期：2015-10-05 00:00:00

  • Hepatocellular carcinoma-targeting oncolytic adenovirus overcomes hypoxic tumor microenvironment and effectively disperses through both central and peripheral tumor regions.

    abstract：:Cancer-specific promoter driven replication of oncolytic adenovirus (Ad) is cancer-specific, but shows low transcriptional activity. Thus, we generated several chimeric α-fetoprotein (AFP) promoter variants, containing reconstituted enhancer and silencer regions, to preferentially drive Ad replication in hepatocellula...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20268-6

    authors： Yoon AR,Hong J,Kim M,Yun CO

    更新日期：2018-02-02 00:00:00

  • Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model.

    abstract：:Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy due to its very low bioavailability. In...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66493-w

    authors： Park HW,Park CG,Park M,Lee SH,Park HR,Lim J,Paek SH,Choy YB

    更新日期：2020-06-12 00:00:00

  • Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells.

    abstract：:Targeted protein degradation (TPD) through a proteasome-dependent pathway induced by heterofunctional small molecules is initiated by the formation of a ternary complex with recruited E3 ligases. This complex formation affects the degradation ability of TPD molecules, and thus we tested for visualization of the intrac...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59966-5

    authors： Kaji T,Koga H,Kuroha M,Akimoto T,Hayata K

    更新日期：2020-02-20 00:00:00

  • Comparative indoor and outdoor stability measurements of polymer based solar cells.

    abstract：:We report comparative indoor and outdoor stability testing of organic solar cells based on a blend between a donor-acceptor polyfluorene copolymer and a fullerene derivative. The outdoor testing was conducted for a period over 12,000 hours in Sheffield, England, with a Ts80 lifetime determined in excess of 10,000 hour...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01505-w

    authors： Zhang Y,Yi H,Iraqi A,Kingsley J,Buckley A,Wang T,Lidzey DG

    更新日期：2017-05-02 00:00:00

  • Insecticidal activity and biochemical composition of Citrullus colocynthis, Cannabis indica and Artemisia argyi extracts against cabbage aphid (Brevicoryne brassicae L.).

    abstract：:Plant extracts contain many active compounds, which are tremendously fruitful for plant defence against several insect pests. The prime objectives of the present study were to calculate the extraction yield and to evaluate the leaf extracts of Citrullus colocynthis (L.), Cannabis indica (L.) and Artemisia argyi (L.) a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-57092-5

    authors： Ahmed M,Peiwen Q,Gu Z,Liu Y,Sikandar A,Hussain D,Javeed A,Shafi J,Iqbal MF,An R,Guo H,Du Y,Wang W,Zhang Y,Ji M

    更新日期：2020-01-16 00:00:00

  • Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis.

    abstract：:Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential as...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/srep15300

    authors： Jiang W,Sun H,Zhang J,Zhou Q,Wu Q,Li T,Zhang C,Li W,Zhang M,Xia X

    更新日期：2015-10-16 00:00:00

  • Geometric principles of second messenger dynamics in dendritic spines.

    abstract：:Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state. Additionally, roughly 14-19% of mature spines have a specialized endoplasmic reticulum called the spine ap...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48028-0

    authors： Cugno A,Bartol TM,Sejnowski TJ,Iyengar R,Rangamani P

    更新日期：2019-08-12 00:00:00

  • Histologic tissue components provide major cues for machine learning-based prostate cancer detection and grading on prostatectomy specimens.

    abstract：:Automatically detecting and grading cancerous regions on radical prostatectomy (RP) sections facilitates graphical and quantitative pathology reporting, potentially benefitting post-surgery prognosis, recurrence prediction, and treatment planning after RP. Promising results for detecting and grading prostate cancer on...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66849-2

    authors： Han W,Johnson C,Gaed M,Gómez JA,Moussa M,Chin JL,Pautler S,Bauman GS,Ward AD

    更新日期：2020-06-18 00:00:00

  • Genetic polymorphism analyses of 30 InDels in Chinese Xibe ethnic group and its population genetic differentiations with other groups.

    abstract：:In the present study, we obtained population genetic data and forensic parameters of 30 InDel loci in Chinese Xibe ethnic group from northwestern China and studied the genetic relationships between the studied Xibe group and other reference groups. The observed heterozygosities ranged from 0.1704 at HLD118 locus to 0....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08260

    authors： Meng HT,Zhang YD,Shen CM,Yuan GL,Yang CH,Jin R,Yan JW,Wang HD,Liu WJ,Jing H,Zhu BF

    更新日期：2015-02-05 00:00:00

  • Autonomous oscillation/separation of cell density artificially induced by optical interlink feedback as designed interaction between two isolated microalgae chips.

    abstract：:We demonstrate a designed interaction between two isolated cell populations of Euglena gracilis and Chlamydomonas reinhardtii, separately confined in two 25-square micro-aquariums of lab-on-chip size. The interaction was realized by interlinking two identical optical feedback systems, which measured the cell distribut...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24602

    authors： Ozasa K,Won J,Song S,Maeda M

    更新日期：2016-04-21 00:00:00

  • Long-term exercise training improves memory in middle-aged men and modulates peripheral levels of BDNF and Cathepsin B.

    abstract：:Aging is accompanied by a decline in memory and other brain functions. Physical exercise may mitigate this decline through the modulation of factors participating in the crosstalk between skeletal muscle and the brain, such as neurotrophins and oxidative stress parameters. We aimed to determine whether long term exerc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40040-8

    authors： De la Rosa A,Solana E,Corpas R,Bartrés-Faz D,Pallàs M,Vina J,Sanfeliu C,Gomez-Cabrera MC

    更新日期：2019-03-04 00:00:00

  • First record of Podocarpoid fossil wood in South China.

    abstract：:A new species of fossil conifer wood, Podocarpoxylon donghuaiense sp. nov., is described from the late Eocene of Nadu Formation in Baise Basin of the Guangxi Province, South China. This fossil wood is characterized by distinct growth rings, circular to oval tracheids in cross section, 1-2-seriate opposite pits on radi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32294

    authors： Li L,Jin JH,Quan C,Oskolski AA

    更新日期：2016-08-30 00:00:00

  • Effect of cow-calf contact on cow motivation to reunite with their calf.

    abstract：:Early cow-calf separation prevents much of cows' natural maternal behaviour. Early separation is thought to prevent the development of a cow-calf bond. To assess this bond, we measured motivation of dairy cows to reunite with their calf. To vary the degree of bonding, some cows were allowed continued contact with thei...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70927-w

    authors： Wenker ML,Bokkers EAM,Lecorps B,von Keyserlingk MAG,van Reenen CG,Verwer CM,Weary DM

    更新日期：2020-08-28 00:00:00