Abstract:
:We demonstrate a designed interaction between two isolated cell populations of Euglena gracilis and Chlamydomonas reinhardtii, separately confined in two 25-square micro-aquariums of lab-on-chip size. The interaction was realized by interlinking two identical optical feedback systems, which measured the cell distribution. To analyze the cell populations, we measured the cell distribution in the 25 squares and irradiated the cells with a blue light pattern as an external stimulus. The cell distribution dataset was exchanged between the two systems. Governed by a designed interaction algorithm, the feedback systems produced a dynamic blue light illumination pattern that evoked the photophobic responses of both species. We also induced autonomous cell density oscillation and cell distribution separation and clustering, and analyzed how the types and diversities of the photophobic responses affected the oscillation period and separation and clustering. We conclude that artificial interlink feedback is a promising method for investigating diverse cell-cell interactions in ecological communities, and for developing soft-computing applications with living cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ozasa K,Won J,Song S,Maeda Mdoi
10.1038/srep24602subject
Has Abstractpub_date
2016-04-21 00:00:00pages
24602issn
2045-2322pii
srep24602journal_volume
6pub_type
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