Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion.

Abstract:

:Olfactory receptors (ORs) mediate olfactory chemo-sensation in OR neurons. Herein, we have demonstrated that the OR chemo-sensing machinery functions in pancreatic β-cells and modulates insulin secretion. First, we found several OR isoforms, including OLFR15 and OLFR821, to be expressed in pancreatic islets and a β-cell line, MIN6. Immunostaining revealed OLFR15 and OLFR821 to be uniformly expressed in pancreatic β-cells. In addition, mRNAs of Olfr15 and Olfr821 were detected in single MIN6 cells. These results indicate that multiple ORs are simultaneously expressed in individual β-cells. Octanoic acid, which is a medium-chain fatty acid contained in food and reportedly interacts with OLFR15, potentiated glucose-stimulated insulin secretion (GSIS), thereby improving glucose tolerance in vivo. GSIS potentiation by octanoic acid was confirmed in isolated pancreatic islets and MIN6 cells and was blocked by OLFR15 knockdown. While Gα olf expression was not detectable in β-cells, experiments using inhibitors and siRNA revealed that the pathway dependent on phospholipase C-inositol triphosphate, rather than cAMP-protein kinase A, mediates GSIS potentiation via OLFR15. These findings suggest that the OR system in pancreatic β-cells has a chemo-sensor function allowing recognition of environmental substances obtained from food, and potentiates insulin secretion in a cell-autonomous manner, thereby modulating systemic glucose metabolism.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Munakata Y,Yamada T,Imai J,Takahashi K,Tsukita S,Shirai Y,Kodama S,Asai Y,Sugisawa T,Chiba Y,Kaneko K,Uno K,Sawada S,Hatakeyama H,Kanzaki M,Miyazaki JI,Oka Y,Katagiri H

doi

10.1038/s41598-018-19765-5

subject

Has Abstract

pub_date

2018-01-24 00:00:00

pages

1499

issue

1

issn

2045-2322

pii

10.1038/s41598-018-19765-5

journal_volume

8

pub_type

杂志文章
  • Predictions of children's emotionality from evolutionary and epigenetic hypotheses.

    abstract::Sex-dependent effects of mismatched prenatal-postnatal maternal conditions are predicted by combining two evolutionary hypotheses: that foetal conditions provide a forecast of likely postnatal environments (Predictive Adaptive Response), and that the female foetus is better adapted than the male to maternal adversity ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39513-7

    authors: Hill J,Pickles A,Wright N,Braithwaite E,Sharp H

    更新日期:2019-02-21 00:00:00

  • Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons.

    abstract::IgLONs are members of the immunoglobulin superfamily of cell adhesion proteins implicated in the process of neuronal outgrowth, cell adhesion and subdomain target recognition. IgLONs form homophilic and heterophilic complexes on the cell surface that repress or promote growth depending on the neuronal population, the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08315-0

    authors: Sanz RL,Ferraro GB,Girouard MP,Fournier AE

    更新日期:2017-08-11 00:00:00

  • Allocation of photosynthesized carbon in an intensively farmed winter wheat-soil system as revealed by 14CO2 pulse labelling.

    abstract::Understanding the rhizodeposited carbon (C) dynamics of winter wheat (Triticum aestivum L.), is crucial for soil fertility and C sequestration. Pot-grown winter wheat was pulse labelled with 14CO2 at the key growth stages. 14C in the shoots, roots and soil was measured at 5 or 2 days after 14C-labelling (DAL 5/2) at e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21547-y

    authors: Sun Z,Chen Q,Han X,Bol R,Qu B,Meng F

    更新日期:2018-02-16 00:00:00

  • The effect of high glucose on lipid metabolism in the human placenta.

    abstract::Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose concentrations affect placental lipid metabolism. Placentas from women ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50626-x

    authors: Hulme CH,Nicolaou A,Murphy SA,Heazell AEP,Myers JE,Westwood M

    更新日期:2019-10-01 00:00:00

  • Magnetic properties of the complex concentrated alloy system CoFeNi0.5Cr0.5Alx.

    abstract::We study the change in magnetisation with paramagnetic Al addition in the CoFeNi0.5Cr0.5-Alx (x: 0, 0.5, 1, and 1.5) complex concentrated alloy. The compositions were developed utilising the Mulliken electronegativity and d-electron/atom ratio. Spherical FeCr rich nanoprecipitates are observed for X: 1.0 and 1.5 in an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71463-3

    authors: Morley NA,Lim B,Xi J,Quintana-Nedelcos A,Leong Z

    更新日期:2020-09-02 00:00:00

  • Competitive non-SELEX for the selective and rapid enrichment of DNA aptamers and its use in electrochemical aptasensor.

    abstract::The SELEX (Systematic Evolution of Ligands by EXponential enrichment) method has been used successfully since 1990, but work is still required to obtain highly specific aptamers. Here, we present a novel approach called 'Competitive non-SELEX' (and termed as 'SELCOS' (Systematic Evolution of Ligands by COmpetitive Sel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43187-6

    authors: Kushwaha A,Takamura Y,Nishigaki K,Biyani M

    更新日期:2019-04-30 00:00:00

  • Reproductive resource partitioning in two sympatric Goniothalamus species (Annonaceae) from Borneo: floral biology, pollinator trapping and plant breeding system.

    abstract::The floral phenology, pollination ecology and breeding systems of two sympatric early-divergent angiosperms, Goniothalamus tapisoides and G. suaveolens (Annonaceae) are compared. The flowers are protogynous and morphologically similar, with anthesis over 23-25 h. Both species are predominantly xenogamous and pollinate...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35674

    authors: Lau JY,Pang CC,Ramsden L,Saunders RM

    更新日期:2016-10-21 00:00:00

  • An Epidemiological Human Disease Network Derived from Disease Co-occurrence in Taiwan.

    abstract::In "classic" biomedical research, diseases have usually been studied individually. The pioneering human disease network (HDN) studies jointly consider a large number of diseases, analyse their interconnections, and provide a more comprehensive description of diseases. However, most of the existing HDN studies are base...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21779-y

    authors: Jiang Y,Ma S,Shia BC,Lee TS

    更新日期:2018-03-14 00:00:00

  • An RNAi supplemented diet as a reverse genetics tool to control bluegreen aphid, a major pest of legumes.

    abstract::Aphids are important agricultural pests causing major yield losses worldwide. Since aphids can rapidly develop resistance to chemical insecticides there is an urgent need to find alternative aphid pest management strategies. Despite the economic importance of bluegreen aphid (Acyrthosiphon kondoi), very few genetic re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58442-4

    authors: Jacques S,Reidy-Crofts J,Sperschneider J,Kamphuis LG,Gao LL,Edwards OR,Singh KB

    更新日期:2020-01-31 00:00:00

  • Better brain connectivity is associated with higher total fat mass and lower visceral adipose tissue in military pilots.

    abstract::A lack of exercise leads to being overweight or obese affecting regional brain structure and functional connectivity associated with impaired cognitive function and dementia. In recent decades, several studies of healthy individuals suggest that adiposity may also produce negative independent effects on the brain. We ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-57345-3

    authors: Cárdenas D,Madinabeitia I,Vera J,de Teresa C,Alarcón F,Jiménez R,Catena A

    更新日期:2020-01-17 00:00:00

  • Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A.

    abstract::Plasmodium falciparum merozoite invasion into erythrocytes is an essential step of the blood-stage cycle, survival of parasites, and malaria pathogenesis. P. falciparum merozoite Rh5 interacting protein (PfRipr) forms a complex with Rh5 and CyRPA in sequential molecular events leading to erythrocyte invasion. Recently...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63611-6

    authors: Nagaoka H,Kanoi BN,Ntege EH,Aoki M,Fukushima A,Tsuboi T,Takashima E

    更新日期:2020-04-20 00:00:00

  • Spatio-temporal dynamics of soil bacterial communities as a function of Amazon forest phenology.

    abstract::Most tropical evergreen rain forests are characterised by varying degrees of precipitation seasonality that influence plant phenology and litterfall dynamics. Soil microbes are sensitive to soil water:air ratio and to nutrient availability. We studied if within-year seasonality in precipitation and litterfall-derived ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22380-z

    authors: Buscardo E,Geml J,Schmidt SK,Freitas H,da Cunha HB,Nagy L

    更新日期:2018-03-12 00:00:00

  • Genetic analysis and molecular mapping of QTLs for resistance to rice black-streaked dwarf disease in rice.

    abstract::Rice black-streaked dwarf disease, caused by rice black-streaked dwarf virus (RBSDV), is transmitted by small brown planthoppers (Laodelphax striatellus Fallén, SBPH) and causes severe yield loss in epidemic years in China and other East Asian countries. Breeding for resistance to RBSDV is a promising strategy to cont...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10509

    authors: Zhou T,Du L,Wang L,Wang Y,Gao C,Lan Y,Sun F,Fan Y,Wang G,Zhou Y

    更新日期:2015-07-22 00:00:00

  • Chronic stress and antidepressant treatment alter purine metabolism and beta oxidation within mouse brain and serum.

    abstract::Major depressive disorder (MDD) is a complex condition with unclear pathophysiology. Molecular disruptions within limbic brain regions and the periphery contribute to depression symptomatology and a more complete understanding the diversity of molecular changes that occur in these tissues may guide the development of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75114-5

    authors: Hamilton PJ,Chen EY,Tolstikov V,Peña CJ,Picone JA,Shah P,Panagopoulos K,Strat AN,Walker DM,Lorsch ZS,Robinson HL,Mervosh NL,Kiraly DD,Sarangarajan R,Narain NR,Kiebish MA,Nestler EJ

    更新日期:2020-10-22 00:00:00

  • Fear of Killer Whales Drives Extreme Synchrony in Deep Diving Beaked Whales.

    abstract::Fear of predation can induce profound changes in the behaviour and physiology of prey species even if predator encounters are infrequent. For echolocating toothed whales, the use of sound to forage exposes them to detection by eavesdropping predators, but while some species exploit social defences or produce cryptic a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55911-3

    authors: Aguilar de Soto N,Visser F,Tyack PL,Alcazar J,Ruxton G,Arranz P,Madsen PT,Johnson M

    更新日期:2020-02-06 00:00:00

  • Whole-genome sequencing of the endangered bovine species Gayal (Bos frontalis) provides new insights into its genetic features.

    abstract::Gayal (Bos frontalis) is a semi-wild and endangered bovine species that differs from domestic cattle (Bos taurus and Bos indicus), and its genetic background remains unclear. Here, we performed whole-genome sequencing of one Gayal for the first time, with one Red Angus cattle and one Japanese Black cattle as controls....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19787

    authors: Mei C,Wang H,Zhu W,Wang H,Cheng G,Qu K,Guang X,Li A,Zhao C,Yang W,Wang C,Xin Y,Zan L

    更新日期:2016-01-25 00:00:00

  • A Novel Lubricant Based on Covalent Functionalized Graphene Oxide Quantum Dots.

    abstract::Dodecyl amine edge functionalized few-layer graphene oxide quantum dots were synthesized in good yields. The covalent functionalization was demonstrated with NMR and AFM-IR. The resulting structure and particle size was measured with AFM and HRTEM. The thermal stability of the compound was investigated and showed a st...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-24062-2

    authors: Wolk A,Rosenthal M,Neuhaus S,Huber K,Brassat K,Lindner JKN,Grothe R,Grundmeier G,Bremser W,Wilhelm R

    更新日期:2018-04-11 00:00:00

  • A salivary metabolite signature that reflects gingival host-microbe interactions: instability predicts gingivitis susceptibility.

    abstract::Several proteins and peptides in saliva were shown to stimulate gingival wound repair, but the role of salivary metabolites in this process remains unexplored. In vitro gingival re-epithelialization kinetics were determined using unstimulated saliva samples from healthy individuals collected during an experimental gin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59988-z

    authors: Fernandez-Gutierrez MM,Imangaliyev S,Prodan A,Loos BG,Keijser BJF,Kleerebezem M

    更新日期:2020-02-20 00:00:00

  • Quantum speed limit based on the bound of Bures angle.

    abstract::In this paper, we investigate the unified bound of quantum speed limit time in open systems based on the modified Bures angle. This bound is applied to the damped Jaynes-Cummings model and the dephasing model, and the analytical quantum speed limit time is obtained for both models. As an example, the maximum coherent ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62409-w

    authors: Wu SX,Yu CS

    更新日期:2020-03-26 00:00:00

  • Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage.

    abstract::In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of the tooth. New odontoblast-like cells are only produced in response to a damage or trauma. Little is known about the molecular events that initiate mesenchymal stem c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03145-6

    authors: Babb R,Chandrasekaran D,Carvalho Moreno Neves V,Sharpe PT

    更新日期:2017-06-08 00:00:00

  • The synergy between the insect-inspired claws and adhesive pads increases the attachment ability on various rough surfaces.

    abstract::To attach reliably on various inclined rough surfaces, many insects have evolved both claws and adhesive pads on their feet. However, the interaction between these organs still remains unclear. Here we designed an artificial attachment device, which mimics the structure and function of claws and adhesive pads, and tes...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26219

    authors: Song Y,Dai Z,Wang Z,Ji A,Gorb SN

    更新日期:2016-05-20 00:00:00

  • Genetic diversity of Nile tilapia (Oreochromis niloticus) throughout West Africa.

    abstract::Nile tilapia (Oreochromis niloticus) is a globally significant aquaculture species rapidly gaining status as a farmed commodity. In West Africa, wild Nile tilapia genetic resources are abundant yet knowledge of fine-scale population structure and patterns of natural genetic variation are limited. Coinciding with this ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53295-y

    authors: Lind CE,Agyakwah SK,Attipoe FY,Nugent C,Crooijmans RPMA,Toguyeni A

    更新日期:2019-11-14 00:00:00

  • Radon emission from soil gases in the active fault zones in the Capital of China and its environmental effects.

    abstract::The release of radon in active fault zones is a sustained radioactive pollution source of the atmospheric environment. The species, concentration and flux of radon emitted in soil gas in active fault zones in the Capital of China were investigated by in-situ field measurements. Two main species of radon discharging fr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35262-1

    authors: Chen Z,Li Y,Liu Z,Wang J,Zhou X,Du J

    更新日期:2018-11-13 00:00:00

  • Random mutagenesis of the hyperthermophilic archaeon Pyrococcus furiosus using in vitro mariner transposition and natural transformation.

    abstract::Transposition mutagenesis is a powerful tool to identify the function of genes, reveal essential genes and generally to unravel the genetic basis of living organisms. However, transposon-mediated mutagenesis has only been successfully applied to a limited number of archaeal species and has never been reported in Therm...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36711

    authors: Guschinskaya N,Brunel R,Tourte M,Lipscomb GL,Adams MWW,Oger P,Charpentier X

    更新日期:2016-11-08 00:00:00

  • The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons.

    abstract::SLC7A10 (Asc-1) is a sodium-independent amino acid transporter known to facilitate transport of a number of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-enantiomers. It has been described as a neuronal transporter with a primary role related to modulation of excitatory glutama...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35592

    authors: Ehmsen JT,Liu Y,Wang Y,Paladugu N,Johnson AE,Rothstein JD,du Lac S,Mattson MP,Höke A

    更新日期:2016-10-19 00:00:00

  • A continuous evolution system for contracting the host range of bacteriophage T7.

    abstract::Bacteriophage T7 is an intracellular parasite that recognizes its host via its tail and tail fiber proteins, known as receptor-binding proteins (RBPs). The RBPs attach to specific lipopolysaccharide (LPS) features on the host. Various studies have shown expansion of the phage's host range via mutations in the genes en...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-57221-0

    authors: Holtzman T,Globus R,Molshanski-Mor S,Ben-Shem A,Yosef I,Qimron U

    更新日期:2020-01-15 00:00:00

  • Hierarchically-structured silver nanoflowers for highly conductive metallic inks with dramatically reduced filler concentration.

    abstract::Silver has long been employed as an electrically conductive component, and morphology-dependent properties have been actively investigated. Here we present a novel scalable synthesis method of flower-shaped silver nanoparticles (silver nanoflowers, Ag NFs). The preferential affinity of citrate molecules on (111) surfa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34894

    authors: C MA,K P F,Singh S,Baik S

    更新日期:2016-10-07 00:00:00

  • Characterization and its implication of a novel taste receptor detecting nutrients in the honey bee, Apis mellifera.

    abstract::Umami taste perception indicates the presence of amino acids, which are essential nutrients. Although the physiology of umami perception has been described in mammals, how insects detect amino acids remains unknown except in Drosophila melanogaster. We functionally characterized a gustatory receptor responding to L-am...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46738-z

    authors: Lim S,Jung J,Yunusbaev U,Ilyasov R,Kwon HW

    更新日期:2019-08-12 00:00:00

  • Association between Helicobacter pylori infection and non-alcoholic fatty liver disease in North Chinese: a cross-sectional study.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Previous studies on the association between Helicobacter pylori (HP) infection and NAFLD are inconsistent. Our study was aimed to find out the relationship between HP infection and NAFLD. We performed a large cross-sectional study in northern Chinese...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41371-2

    authors: Jiang T,Chen X,Xia C,Liu H,Yan H,Wang G,Wu Z

    更新日期:2019-03-19 00:00:00

  • Microgravity Induction of TRAIL Expression in Preosteoclast Cells Enhances Osteoclast Differentiation.

    abstract::Evidence indicates that astronauts experience significant bone loss in space. We previously showed that simulated microgravity (μXg) using the NASA developed rotary cell culture system (RCCS) enhanced bone resorbing osteoclast (OCL) differentiation. However, the mechanism by which μXg increases OCL formation is unclea...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25143

    authors: Sambandam Y,Baird KL,Stroebel M,Kowal E,Balasubramanian S,Reddy SV

    更新日期:2016-05-04 00:00:00