Abstract：
:Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Previous studies on the association between Helicobacter pylori (HP) infection and NAFLD are inconsistent. Our study was aimed to find out the relationship between HP infection and NAFLD. We performed a large cross-sectional study in northern Chinese adults in 2015. 13C-urea breath tests were used to determine HP infection status. Abdominal ultrasonography was performed to diagnose NAFLD. Multivariable logistic regression was conducted to identify the association between HP infection and NAFLD. A total of 4081 individuals were included in this study; 2137 (52.36%) participants were HP-positive, and 1022 (47.82%) were diagnosed with NAFLD in HP-positive individuals. The odds ratios (OR) and 95% confidence intervals (CI) of participants with HP infection for NAFLD were 1.20 (1.06-1.36) in crude model and 1.27 (1.07-1.50) in fully adjusted model. When stratified by sex and dyslipidemia, the fully adjusted OR and 95% CI for NAFLD were 1.22 (1.10-1.80) in females and 1.44 (1.18-1.75) in subjects with dyslipidemia. There were not significant increased OR for NAFLD when stratified by age. The study indicate that HP infection is associated with NAFLD, particularly in females and patients with dyslipidemia, suggesting that HP eradication might be an alternative method for the prevention or treatment of NAFLD treatment.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jiang T,Chen X,Xia C,Liu H,Yan H,Wang G,Wu Zdoi
10.1038/s41598-019-41371-2subject
Has Abstractpub_date
2019-03-19 00:00:00pages
4874issue
1issn
2045-2322pii
10.1038/s41598-019-41371-2journal_volume
9pub_type
杂志文章abstract：:Extracellular vesicles (EVs) are membrane surrounded structures released by cells, which have been increasingly recognized as mediators of intercellular communication. Recent reports indicate that EVs participate in important biological processes and could serve as potential source for cancer biomarkers. As an attract...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24669
更新日期：2016-04-19 00:00:00
abstract：:Network robustness represents the ability of networks to withstand failures and perturbations. In social networks, maintenance of individual activities, also called persistence, is significant towards understanding robustness. Previous works usually consider persistence on pre-generated network structures; while in so...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42956
更新日期：2017-02-21 00:00:00
abstract：:The effect on the reproductive system and fertility of living in a space environment remains unclear. Here, we caged 12 male mice under artificial gravity (≈1 gravity) (AG) or microgravity (MG) in the International Space Station (ISS) for 35 days, and characterized the male reproductive organs (testes, epididymides, a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50128-w
更新日期：2019-09-24 00:00:00
abstract：:Exercise physiology is different in males and females. Females are poorly studied due to the complexity of the estrous cycle and this bias has created an exercise sex gap. Here, we evaluated the impact of sexual dimorphism and of the estrous cycle on muscle strength and running power of C57BL/6 mice. Like men, male mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29050-0
更新日期：2018-07-16 00:00:00
abstract：:Lipases are interfacially activated enzymes that catalyze the hydrolysis of ester bonds and constitute prime candidates for industrial and biotechnological applications ranging from detergent industry, to chiral organic synthesis. As a result, there is an incentive to understand the mechanisms underlying lipase activi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52539-1
更新日期：2019-11-07 00:00:00
abstract：:Nano-flowers reported so far were mostly constituted of inorganic or hybrid materials. We have synthesized and crystallized a new organic compound, 1, 2-bis(tritylthio)ethane forming an organic nano-flower consisting of single crystalline petals. Crystal structure at nano and micro level indicates that π-π stacking in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17538-0
更新日期：2017-12-11 00:00:00
abstract：:The Vacuole Membrane Protein 1 -VMP1- is a pancreatitis-associated transmembrane protein whose expression triggers autophagy in several human diseases. In the current study, we unveil the mechanism through which this protein induces autophagosome formation in mammalian cells. We show that VMP1 autophagy-related functi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01055
更新日期：2013-01-01 00:00:00
abstract：:Cell-free enzymatic reaction cascades combine the advantages of well-established in vitro biocatalysis with the power of multi-step in vivo pathways. The absence of a regulatory cell environment enables direct process control including methods for facile bottleneck identification and process optimization. Within this ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48151-y
更新日期：2019-08-13 00:00:00
abstract：:Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflam...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25298
更新日期：2016-04-29 00:00:00
abstract：:Kefir peptides, generated by kefir grain fermentation of milk proteins, showed positive antioxidant effects, lowered blood pressure and modulated the immune response. In this study, kefir peptide was evaluated regarding their anti-inflammatory effects on particulate matter <4 μm (PM4.0)-induced lung inflammation in NF...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47872-4
更新日期：2019-08-08 00:00:00
abstract：:Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38259-y
更新日期：2019-02-28 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-30762-6
更新日期：2018-08-10 00:00:00
abstract：:This work introduces a new population-based stochastic search technique, named multi-variant differential evolution (MVDE) algorithm for solving fifteen well-known real world problems from UCI repository and compared to four popular optimization methods. The MVDE proposes a new self-adaptive scaling factor based on co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74228-0
更新日期：2020-10-14 00:00:00
abstract：:Using dedicated contrast agents high-quality X-ray imaging of soft tissue structures with isotropic micrometre resolution has become feasible. This technique is frequently titled as virtual histology as it allows production of slices of tissue without destroying the sample. The use of contrast agents is, however, ofte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30385
更新日期：2016-07-27 00:00:00
abstract：:The absorption spectra in array of Ge, Al and Ge/Al-shell nanoparticles immersed in alumina (Al2O3) matrix is calculated in framework of ab initio macroscopic dielectric model. It is demonstrated that absorption is strongly enhanced when germanium nanospheres are encapsulated by Al-shell. Two absorption peaks, appeari...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56673-8
更新日期：2020-01-09 00:00:00
abstract：:Computer-aided image analysis (CAI) can help objectively quantify morphologic features of hematoxylin-eosin (HE) histopathology images and provide potentially useful prognostic information on breast cancer. We performed a CAI workflow on 1,150 HE images from 230 patients with invasive ductal carcinoma (IDC) of the bre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10690
更新日期：2015-05-29 00:00:00
abstract：:To determine the effects of the estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on dietary advice-mediated changes in fasting glucose and arterial stiffness, 374 subjects with normal fasting glucose (NFG; control group, no treatment) and 142 subjects with impaired fasting glucose (IFG group, dietary a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10192-6
更新日期：2017-08-29 00:00:00
abstract：:Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retai...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64678-x
更新日期：2020-05-08 00:00:00
abstract：:Focal adhesion kinase (FAK) is a 125 kDa protein recruited as a participant in focal adhesion dynamics and serves as a signaling scaffold for the assembly and subsequent maturation of focal contact. Identification of new FAK binding proteins could reveal potential signaling targets and contribute to further developmen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49145-6
更新日期：2019-09-09 00:00:00
abstract：:The initiation of polymorphic ventricular tachycardia in long QT syndrome type 2 (LQT2) has been associated with a characteristic ECG pattern of short-long RR intervals. We hypothesize that this characteristic pattern increases APD dispersion in LQT2, thereby promoting arrhythmia. We investigated APD dispersion and it...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51230-9
更新日期：2019-10-16 00:00:00
abstract：:Large-area, pinhole-free CH3NH3PbI3 perovskite thin films were successfully fabricated on 5 cm × 5 cm flexible indium tin oxide coated polyethylene naphthalate (ITO-PEN) substrates through a sequential evaporation/spin-coating deposition method in this research. The influence of the rate-controlled evaporation of PbI2...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18970-y
更新日期：2018-01-11 00:00:00
abstract：:A clinical study was designed to record a wide range of physiological values from patients undergoing haemodialysis treatment in the Renal Unit of the Churchill Hospital in Oxford. Video was recorded for a total of 84 dialysis sessions from 40 patients during the course of 1 year, comprising an overall video recording...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75152-z
更新日期：2020-10-28 00:00:00
abstract：:Membrane protein oligomerization mediates a wide range of biological events including signal transduction, viral infection and membrane curvature induction. However, the relative contributions of protein-protein and protein-membrane interactions to protein oligomerization remain poorly understood. Here, we used the Ca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62343-x
更新日期：2020-03-24 00:00:00
abstract：:It is of paramount importance to improve the control over large area growth of high quality molybdenum disulfide (MoS2) and other types of 2D dichalcogenides. Such atomically thin materials have great potential for use in electronics, and are thought to make possible the first real applications of spintronics. Here in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06699-7
更新日期：2017-07-25 00:00:00
abstract：:As an important online information retaining and processing function, working memory plays critical roles in many other cognitive functions. Several long-term factors, such as age, addiction and diseases, have been affirmed to impair working memory, but whether or how the short-term factors, like painful stimuli or em...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04702-9
更新日期：2017-07-03 00:00:00
abstract：:Nearly half of the world's population obtains its daily calories from rice grains, which lack or have insufficient levels of essential micronutrients. The deficiency of micronutrients vital for normal growth is a global health problem, and iron, zinc and vitamin A deficiencies are the most prevalent ones. We developed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07198-5
更新日期：2017-07-31 00:00:00
abstract：:Aluminium nitride (AlN) is a promising semiconductor material for use as a substrate in high-power, high-frequency electronic and deep-ultraviolet optoelectronic devices. We study the feasibility of a novel AlN fabrication technique by using the Al/GaN substitution reaction method. The substitution method we propose h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69992-y
更新日期：2020-08-03 00:00:00
abstract：:Tumor genetic heterogeneity may underlie poor clinical outcomes because diverse subclones could be comprised of metastatic and drug resistant cells. Targeted deep sequencing has been used widely as a diagnostic tool to identify actionable mutations in cancer patients. In this study, we evaluated the clinical utility o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41098-0
更新日期：2019-03-14 00:00:00
abstract：:Classical swine fever virus (CSFV) non-structural protein 3 (NS3) is a multifunctional non-structural protein that plays a major role in viral replication. However, how exactly NS3 exerts these functions remains unknown. Here, we identified tumour necrosis factor receptor-associated factor 6 (TRAF6) as a novel NS3-int...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06934-1
更新日期：2017-07-27 00:00:00
abstract：:The natural ligand 17β-estradiol (E2) is so far believed to induce a unique agonist-bound active conformation in the ligand binding domain (LBD) of the estrogen receptors (ERs). Both subtypes, ERα and ERβ, are transcriptionally activated in the presence of E2 with ERβ being somewhat less active than ERα under similar ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03774-x
更新日期：2017-06-14 00:00:00
