Abstract:
:Evidence indicates that astronauts experience significant bone loss in space. We previously showed that simulated microgravity (μXg) using the NASA developed rotary cell culture system (RCCS) enhanced bone resorbing osteoclast (OCL) differentiation. However, the mechanism by which μXg increases OCL formation is unclear. RANK/RANKL signaling pathway is critical for OCL differentiation. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has been shown to increase osteoclastogenesis. We hypothesize that TRAIL may play an important role in μXg enhanced OCL differentiation. In this study, we identified by RT profiler PCR array screening that μXg induces high levels of TRAIL expression in murine preosteoclast cells in the absence of RANKL stimulation compared to ground based (Xg) cultures. We further identified that μXg elevated the adaptor protein TRAF-6 and fusion genes OC-STAMP and DC-STAMP expression in preosteoclast cells. Interestingly, neutralizing antibody against TRAIL significantly reduced μXg induced OCL formation. We further identified that over-expression of pTRAIL in RAW 264.7 cells enhanced OCL differentiation. These results indicate that TRAIL signaling plays an important role in the μXg increased OCL differentiation. Therefore, inhibition of TRAIL expression could be an effective countermeasure for μXg induced bone loss.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sambandam Y,Baird KL,Stroebel M,Kowal E,Balasubramanian S,Reddy SVdoi
10.1038/srep25143subject
Has Abstractpub_date
2016-05-04 00:00:00pages
25143issn
2045-2322pii
srep25143journal_volume
6pub_type
杂志文章abstract::Infection with Mycobacterium ulcerans causes Buruli Ulcer, a neglected tropical disease. Mosquito vectors are suspected to participate in the transmission and environmental maintenance of the bacterium. However, mechanisms and consequences of mosquito contamination by M. ulcerans are not well understood. We evaluated ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09242
更新日期:2015-03-18 00:00:00
abstract::Magnetic skyrmions are hailed as a potential technology for data storage and other data processing devices. However, their stability against thermal fluctuations is an open question that must be answered before skyrmion-based devices can be designed. In this work, we study paths in the energy landscape via which the t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03391-8
更新日期:2017-06-22 00:00:00
abstract::Shoulder problems are common in patients with a cervical herniated intervertebral disc (HIVD). This study aimed to explore the incidence and risk of shoulder capsulitis/tendonitis following cervical HIVD surgery. We used data from the Taiwan "Longitudinal Health Insurance Database". We identified all patients who were...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26898
更新日期:2016-05-27 00:00:00
abstract::Control of nonlinear large-scale dynamical networks, e.g., collective behavior of agents interacting via a scale-free connection topology, is a central problem in many scientific and engineering fields. For the linear version of this problem, the so-called controllability Gramian has played an important role to quanti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27300
更新日期:2016-06-06 00:00:00
abstract::We analytically and numerically investigate magneto-plasmons in metal films surrounded by a ferromagnetic dielectric. In such waveguide using a metal film with a thickness exceeding the Skin depth, an external magnetic field in the transverse direction can induce a significant spatial asymmetry of mode distribution. S...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28567-8
更新日期:2018-07-12 00:00:00
abstract::Polyphenol oxidases (PPOs) contain the structurally similar enzymes tyrosinases (TYRs) and catechol oxidases (COs). Two cDNAs encoding pro-PPOs from tomato (Solanum lycopersicum) were cloned and heterologously expressed in Escherichia coli. The two pro-PPOs (SlPPO1-2) differ remarkably in their activity as SlPPO1 reac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39687-0
更新日期:2019-03-11 00:00:00
abstract::Several single-center studies have investigated whether narrow-band imaging (NBI) cystoscopy is more effective in detecting primary and recurrent non-muscle invasive bladder cancer (NMIBC) compared with white-light imaging (WLI) cystoscopy. In this study, we further evaluated the diagnostic value of NBI cystoscopy com...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/srep10905
更新日期:2015-06-05 00:00:00
abstract::We employ nematic liquid crystals as the nonlinear medium to recover noisy images via stochastic resonance, in which nonlinear coupling allows signals to grow at the expense of noise. The process is theoretically analyzed and the cross-correlation is numerically calculated. It is found that the quality of output image...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40676-6
更新日期:2019-03-08 00:00:00
abstract::Observations and modeling studies have shown that during CO2 injection into underground carbonate reservoirs, the dissolution of CO2 into formation water forms acidic brine, leading to fluid-rock interactions that can significantly impact the hydraulic properties of the host formation. However, the impacts of these in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60247-4
更新日期:2020-02-27 00:00:00
abstract::Pathogenic meningococci have acquired a 24 kb capsule synthesis island (cps) by horizontal gene transfer which consists of a synthetic locus and associated capsule transport genes flanked by repetitive Regions D and D'. Regions D and D' contain an intact gene encoding a UDP-galactose epimerase (galE1) and a truncated ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44442
更新日期:2017-03-14 00:00:00
abstract::Haber-Bosch nitrogen (N) has been increasingly used in industrial products, e.g., nylon, besides fertilizer. Massive numbers of species of industrial reactive N (Nr) have emerged and produced definite consequences but receive little notice. Based on a comprehensive inventory, we show that (1) the industrial N flux has...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02579
更新日期:2013-01-01 00:00:00
abstract::Cell-free enzymatic reaction cascades combine the advantages of well-established in vitro biocatalysis with the power of multi-step in vivo pathways. The absence of a regulatory cell environment enables direct process control including methods for facile bottleneck identification and process optimization. Within this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48151-y
更新日期:2019-08-13 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-66682-7
更新日期:2020-06-16 00:00:00
abstract::Based on the polarization-sensitive absorption of graphene under conditions of total internal reflection, a novel optical sensor combining graphene and a microfluidic structure was constructed to achieve the sensitive real-time monitoring of refractive indexes. The atomic thickness and strong broadband absorption of g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00908
更新日期:2012-01-01 00:00:00
abstract::Thymoquinone has been reported to exhibit antioxidant and anti-inflammatory effects. Inflammation plays an important role in pathogenesis of diabetic peripheral neuropathy. This study investigated the effects of TQ on proliferation and apoptosis of Schwann cells exposed to high glucose conditions and electrophysiologi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31656
更新日期:2016-08-22 00:00:00
abstract::We developed a simple, scalable and high-throughput method for fabrication of large-area three-dimensional rose-like microflowers with controlled size, shape and density on graphene films by femtosecond laser micromachining. The novel biomimetic microflower that composed of numerous turnup graphene nanoflakes can be f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17557
更新日期:2015-11-30 00:00:00
abstract::The classical view of nerve growth factor (NGF) action in the nervous system is linked to its retrograde axonal transport. However, almost nothing is known on the trafficking properties of its unprocessed precursor proNGF, characterized by different and generally opposite biological functions with respect to its matur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20272
更新日期:2016-02-01 00:00:00
abstract::HIV-infected subjects under virological control still exhibit a persistent proinflammatory state. Thus, chronic HIV infection changes the host homeostasis towards an adapted immune response that may affect the outcome of coinfections. However, little is known about the impact of HIV infection on inflammatory amplifica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43275-7
更新日期:2019-05-08 00:00:00
abstract::Nonalcoholic steatohepatitis (NASH) is a hepatic phenotype of the metabolic syndrome, and increases the risk of cirrhosis and hepatocellular carcinoma (HCC). Although increasing evidence points to the therapeutic implications of certain types of anti-diabetic agents in NASH, it remains to be elucidated whether their e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57935-6
更新日期:2020-01-22 00:00:00
abstract::It is well known that tumour-associated macrophages (TAMs) play an important role in tumour development by modulating the tumour microenvironment, and targeting of protumour activation or the M2 polarization of TAMs is expected to be an effective therapy for cancer patients. We previously demonstrated that onionin A (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29588
更新日期:2016-07-12 00:00:00
abstract::Visual reasoning is critical in many complex visual tasks in medicine such as radiology or pathology. It is challenging to explicitly explain reasoning processes due to the dynamic nature of real-time human cognition. A deeper understanding of such reasoning processes is necessary for improving diagnostic accuracy and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77550-9
更新日期:2020-12-10 00:00:00
abstract::Users of social media often share their feelings or emotional states through their posts. In this study, we developed a deep learning model to identify a user's mental state based on his/her posting information. To this end, we collected posts from mental health communities in Reddit. By analyzing and learning posting...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68764-y
更新日期:2020-07-16 00:00:00
abstract::Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vivo. In this study, a small-d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03851-1
更新日期:2017-06-15 00:00:00
abstract::The distribution of corals in Japan covers a wide range of latitudes, encompassing tropical to temperate zones. However, coral communities in temperate zones contain only a small subset of species. Among the parameters that determine the distribution of corals, temperature plays an important role. We tested the resili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18467
更新日期:2015-12-18 00:00:00
abstract::Drug interaction analysis, which reports the extent to which the presence of one drug affects the efficacy of another, is a powerful tool to select potent combinatorial therapies and predict connectivity between cellular components. Combinatorial effects of drug pairs often vary even for drugs with similar mechanism o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42644
更新日期:2017-02-16 00:00:00
abstract::Run-and-tumble motility is widely used by swimming microorganisms including numerous prokaryotic and eukaryotic organisms. Here, we experimentally investigate the run-and-tumble dynamics of the bacterium E. coli in polymeric solutions. We find that even small amounts of polymer in solution can drastically change E. co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15761
更新日期:2015-10-28 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-74319-y
更新日期:2020-10-28 00:00:00
abstract::The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required. In order to identify new candidates as potential drug targets, we combined large-scale transposon mutagenesis data analysis and bioinforma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17593
更新日期:2015-12-01 00:00:00
abstract::Neurokinin B (NKB) is a hypothalamic neuropeptide binding preferentially to the neurokinin 3 receptor. Expression of the gene encoding NKB is elevated in postmenopausal women. Furthermore, rodent studies suggest that NKB signalling may mediate menopausal hot flushes. However, the effects of NKB administration on hot f...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/srep08466
更新日期:2015-02-16 00:00:00
abstract::The triatomine Rhodnius prolixus, a vector of the etiological agent of Chagas disease, has long been used as model to understand important aspects of insect physiology. Despite this history, the impact of the nutritional state on regulatory pathways associated with reproductive performance in triatomines has never bee...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67932-4
更新日期:2020-07-10 00:00:00