Abstract:
:Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential association between the 6 common single nucleotide polymorphisms (rs35576928, rs737008, rs35262993, rs2301365, rs1646022, rs2070923) in protamines 1 and 2 and male infertility. The -190C > A (rs2301365) polymorphism was identified as a risk factor for male infertility under all models. Interestingly, rs1646022 and rs737008 polymorphisms exerted protective effects against male sterility in Asian and population-based under some models. No associations between the remaining SNPs and male sterility were observed.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jiang W,Sun H,Zhang J,Zhou Q,Wu Q,Li T,Zhang C,Li W,Zhang M,Xia Xdoi
10.1038/srep15300subject
Has Abstractpub_date
2015-10-16 00:00:00pages
15300issn
2045-2322pii
srep15300journal_volume
5pub_type
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