HIV Subtypes B and C gp120 and Methamphetamine Interaction: Dopaminergic System Implicates Differential Neuronal Toxicity.

Abstract:

:HIV subtypes or clades differentially induce HIV-associated neurocognitive disorders (HAND) and substance abuse is known to accelerate HIV disease progression. The HIV-1 envelope protein gp120 plays a major role in binding and budding in the central nervous system (CNS) and impacts dopaminergic functions. However, the mechanisms utilized by HIV-1 clades to exert differential effects and the methamphetamine (METH)-associated dopaminergic dysfunction are poorly understood. We hypothesized that clade B and C gp120 structural sequences, modeling based analysis, dopaminergic effect, and METH potentiate neuronal toxicity in astrocytes. We evaluated the effect of clade B and C gp120 and/or METH on the DRD-2, DAT, CaMKs and CREBP transcription. Both the structural sequence and modeling studies demonstrated that clade B gp120 in V1-V4, α -2 and N-glycosylated sites are distinct from clade C gp120. The distinct structure and sequence variation of clade B gp120 differentially impact DRD-2, DAT, CaMK II and CaMK IV mRNA, protein and intracellular expression compared to clade C gp120. However, CREB transcription is upregulated by both clade B and C gp120, and METH co-treatment potentiated these effects. In conclusion, distinct structural sequences of HIV-1 clade B and C gp120 differentially regulate the dopaminergic pathway and METH potentiates neurotoxicity.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Samikkannu T,Rao KVK,Salam AAA,Atluri VSR,Kaftanovskaya EM,Agudelo M,Perez S,Yoo C,Raymond AD,Ding H,Nair MPN

doi

10.1038/srep11130

subject

Has Abstract

pub_date

2015-06-09 00:00:00

pages

11130

issn

2045-2322

pii

srep11130

journal_volume

5

pub_type

杂志文章
  • Regional transcriptome analysis of AMPA and GABAA receptor subunit expression generates E/I signatures of the human brain.

    abstract::Theoretical and experimental work has demonstrated that excitatory (E) and inhibitory (I) currents within cortical circuits stabilize to a balanced state. This E/I balance, observed from single neuron to network levels, has a fundamental role in proper brain function and its impairment has been linked to numerous brai...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68165-1

    authors: Shen K,Zeppillo T,Limon A

    更新日期:2020-07-09 00:00:00

  • Protein aggregation activates erratic stress response in dietary restricted yeast cells.

    abstract::Chronic stress and prolonged activation of defence pathways have deleterious consequences for the cell. Dietary restriction is believed to be beneficial as it induces the cellular stress response machinery. We report here that although the phenomenon is beneficial in a wild-type cell, dietary restriction leads to an i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33433

    authors: Bhadra AK,Das E,Roy I

    更新日期:2016-09-16 00:00:00

  • Refraction-Assisted Solar Thermoelectric Generator based on Phase-Change Lens.

    abstract::Solar thermoelectric generators (STEGs), which are used for various applications, (particularly small size electronic devices), have optical concentration systems for high energy conversion efficiency. In this study, a refraction-assisted STEG (R-STEG) is designed based on phase-change materials. As the phase-change m...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27913

    authors: Kim MS,Kim MK,Jo SE,Joo C,Kim YJ

    更新日期:2016-06-10 00:00:00

  • A combined method for synthesis of superconducting Cu doped Bi2Se3.

    abstract::We present a two-step technique for the synthesis of superconducting CuxBi2Se3. Cu0.15Bi2Se3 single crystals were synthesized using the melt-growth method. Although these samples are non-superconducting, they can be employed to generate high quality superconducting samples if used as precursors in the following electr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22713

    authors: Wang M,Song Y,You L,Li Z,Gao B,Xie X,Jiang M

    更新日期:2016-03-03 00:00:00

  • Circadian misalignment increases mood vulnerability in simulated shift work.

    abstract::Night shift work can associate with an increased risk for depression. As night workers experience a 'misalignment' between their circadian system and daily sleep-wake behaviors, with negative health consequences, we investigated whether exposure to circadian misalignment underpins mood vulnerability in simulated shift...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75245-9

    authors: Chellappa SL,Morris CJ,Scheer FAJL

    更新日期:2020-10-29 00:00:00

  • Tuneable pressure effects in graphene oxide layers.

    abstract::Tuneable pressure effects associated with changing interlayer distances in two-dimensional graphene oxide (GO)/reduced GO (rGO) layers are demonstrated through monitoring the changes in the spin-crossover (SCO) temperature (T 1/2) of [Fe(Htrz)2(trz)](BF4) nanoparticles (NPs) incorporated in the interlayer spaces of th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12444-x

    authors: Sekimoto Y,Ohtani R,Nakamura M,Koinuma M,Lindoy LF,Hayami S

    更新日期:2017-09-22 00:00:00

  • Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors.

    abstract::Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07699

    authors: Li Y,Liu Y,Liu J,Liu J,Tang H,Cao C,Zhao D,Ding Y

    更新日期:2015-01-09 00:00:00

  • Healthy lifestyle behaviors and control of hypertension among adult hypertensive patients.

    abstract::The aim of the present study was to evaluate the healthy lifestyle behaviors in hypertensive patients (aware, n = 1364 and not aware, n = 1213) based on 2011 national survey of risk factors of non-communicable disease (SuRFNCD) of Iran. Lifestyle score was calculated based on lifestyle behaviors, including smoking sta...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26823-5

    authors: Akbarpour S,Khalili D,Zeraati H,Mansournia MA,Ramezankhani A,Fotouhi A

    更新日期:2018-05-31 00:00:00

  • Assessing harbour porpoise carcasses potentially subjected to grey seal predation.

    abstract::As a follow-up on the data presented for seals, we herein report and discuss outcomes resulting from a retrospective evaluation of harbour porpoise stranding and necropsy data from Schleswig-Holstein, Germany (n = 4463) to enable an objective evaluation of potential ecological effects of grey seal predation on porpois...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-73258-y

    authors: van Neer A,Gross S,Kesselring T,Grilo ML,Ludes-Wehrmeister E,Roncon G,Siebert U

    更新日期:2020-10-01 00:00:00

  • Action mechanism of corticosteroids to aggravate Guillain-Barré syndrome.

    abstract::Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical impr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13931

    authors: Wang YZ,Lv H,Shi QG,Fan XT,Li L,Yi Wong AH,Hao YL,Si CP,Li CL,Yuki N

    更新日期:2015-09-10 00:00:00

  • Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation.

    abstract::β-Lactamases are a major threat to the clinical use of carbapenems, which are often antibiotics of last resort. Despite this, the reaction outcomes and mechanisms by which β-lactamases degrade carbapenems are still not fully understood. The carbapenem bicyclic core consists of a β-lactam ring fused to a pyrroline ring...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49264-0

    authors: Lohans CT,Freeman EI,Groesen EV,Tooke CL,Hinchliffe P,Spencer J,Brem J,Schofield CJ

    更新日期:2019-09-20 00:00:00

  • A retrospective qualitative report of symptoms and safety from transcranial focused ultrasound for neuromodulation in humans.

    abstract::Low intensity transcranial focused ultrasound (LIFU) is a promising method of non-invasive neuromodulation that uses mechanical energy to affect neuronal excitability. LIFU confers high spatial resolution and adjustable focal lengths for precise neuromodulation of discrete regions in the human brain. Before the full p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62265-8

    authors: Legon W,Adams S,Bansal P,Patel PD,Hobbs L,Ai L,Mueller JK,Meekins G,Gillick BT

    更新日期:2020-03-27 00:00:00

  • Characterization of donor and recipient CD8+ tissue-resident memory T cells in transplant nephrectomies.

    abstract::Tissue-resident memory T (TRM) cells are characterized by their surface expression of CD69 and can be subdivided in CD103+ and CD103- TRM cells. The origin and functional characteristics of TRM cells in the renal allograft are largely unknown. To determine these features we studied TRM cells in transplant nephrectomie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42401-9

    authors: de Leur K,Dieterich M,Hesselink DA,Corneth OBJ,Dor FJMF,de Graav GN,Peeters AMA,Mulder A,Kimenai HJAN,Claas FHJ,Clahsen-van Groningen MC,van der Laan LJW,Hendriks RW,Baan CC

    更新日期:2019-04-12 00:00:00

  • Reproducibility and differences in area of foveal avascular zone measured by three different optical coherence tomographic angiography instruments.

    abstract::This study was performed to compare the area of the foveal avascular zone (FAZ-area) obtained by three optical coherence tomography angiography (OCTA) instruments. This was a cross-sectional, non-interventional study of twenty-seven healthy right eyes. The superficial and deep FAZ-area was measured manually with three...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09255-5

    authors: Shiihara H,Sakamoto T,Yamashita T,Kakiuchi N,Otsuka H,Terasaki H,Sonoda S

    更新日期:2017-08-29 00:00:00

  • Asymptotic entropy of the Gibbs state of complex networks.

    abstract::In this work we study the entropy of the Gibbs state corresponding to a graph. The Gibbs state is obtained from the Laplacian, normalized Laplacian or adjacency matrices associated with a graph. We calculated the entropy of the Gibbs state for a few classes of graphs and studied their behavior with changing graph orde...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78626-2

    authors: Glos A,Krawiec A,Pawela Ł

    更新日期:2021-01-11 00:00:00

  • A Practical Model Evaluating Antiviral Cytokines by Natural Killer Cells in Treatment Naïve Patients with Chronic Hepatitis B Virus Infection.

    abstract::Natural killer (NK) cells play a major role in anti-viral immunity as first line defense during hepatitis B infection, particularly in untreated patients whose T cells functions are profoundly impaired. Cytokine interferon (IFN)-γ and tumor necrosis factor (TNF)-α produced by NK cells are important anti-viral factors....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06192-1

    authors: Li X,Gu Y,Guo X,Gu L,Zhou L,Wu X,Wang X,Stamataki Z,Huang Y

    更新日期:2017-07-19 00:00:00

  • A common protocol for the simultaneous processing of multiple clinically relevant bacterial species for whole genome sequencing.

    abstract::Whole-genome sequencing is likely to become increasingly used by local clinical microbiology laboratories, where sequencing volume is low compared with national reference laboratories. Here, we describe a universal protocol for simultaneous DNA extraction and sequencing of numerous different bacterial species, allowin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80031-8

    authors: Raven KE,Girgis ST,Akram A,Blane B,Leek D,Brown N,Peacock SJ

    更新日期:2021-01-08 00:00:00

  • Prevalence, patterns, and predictors of meditation use among US adults: A nationally representative survey.

    abstract::Emerging evidence suggests substantial health benefits from using meditation. While there are some indications that the popularity of meditation is increasing, little is known about the prevalence, patterns, and predictors of meditation use in the general population. In this secondary analysis of data from the 2012 US...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36760

    authors: Cramer H,Hall H,Leach M,Frawley J,Zhang Y,Leung B,Adams J,Lauche R

    更新日期:2016-11-10 00:00:00

  • Interrelationship of rotavirus infection and Creatine Kinase-MB isoenzyme levels in children hospitalized with acute gastroenteritis in Guangzhou, China, 2012-2015.

    abstract::Elevated levels of Creatine Kinase-MB (CK-MB) Isoenzyme are a common phenomenon among rotavirus (RV) diarrhea. However, few studies have addressed this issue using large sample size. In current study, 1,118 children (age <5 years) hospitalized with diarrhea in Guangzhou Women and Children's Medical Center from 2012 to...

    journal_title:Scientific reports

    pub_type: 历史文章,杂志文章

    doi:10.1038/s41598-017-07636-4

    authors: Zheng J,Zheng H,Gupta RK,Li H,Shi H,Pan L,Gong S,Liang H

    更新日期:2017-08-09 00:00:00

  • An understanding of third-party friendships in a tolerant macaque.

    abstract::Complex societies are shaped by social relationships between multiple individuals. The pressure to track these relationships has driven the evolution of social cognition in primates. Importantly, it can be adaptive to track not only personal relationships, but also those established between third-parties. Primates hav...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66407-w

    authors: Whitehouse J,Meunier H

    更新日期:2020-06-17 00:00:00

  • Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.

    abstract::Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set enrichment analysis using summary statistics from a large-scale ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50507-3

    authors: Horgusluoglu-Moloch E,Risacher SL,Crane PK,Hibar D,Thompson PM,Saykin AJ,Nho K,Alzheimer’s Disease Neuroimaging Initiative (ADNI).

    更新日期:2019-10-10 00:00:00

  • Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats.

    abstract::Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental phenotype in relati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53199-x

    authors: Napso T,Hung YP,Davidge ST,Care AS,Sferruzzi-Perri AN

    更新日期:2019-11-28 00:00:00

  • Tailoring tobacco hairy root metabolism for the production of stilbenes.

    abstract::Tobacco hairy root (HR) cultures, which have been widely used for the heterologous production of target compounds, have an innate capacity to bioconvert exogenous t-resveratrol (t-R) into t-piceatannol (t-Pn) and t-pterostilbene (t-Pt). We established genetically engineered HR carrying the gene encoding stilbene synth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18330-w

    authors: Hidalgo D,Georgiev M,Marchev A,Bru-Martínez R,Cusido RM,Corchete P,Palazon J

    更新日期:2017-12-21 00:00:00

  • Optically induced metal-to-dielectric transition in Epsilon-Near-Zero metamaterials.

    abstract::Epsilon-Near-Zero materials exhibit a transition in the real part of the dielectric permittivity from positive to negative value as a function of wavelength. Here we study metal-dielectric layered metamaterials in the homogenised regime (each layer has strongly subwavelength thickness) with zero real part of the permi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27700

    authors: Kaipurath RM,Pietrzyk M,Caspani L,Roger T,Clerici M,Rizza C,Ciattoni A,Di Falco A,Faccio D

    更新日期:2016-06-13 00:00:00

  • Consequences of Nosema apis infection for male honey bees and their fertility.

    abstract::The queens of eusocial bees, ants and wasps mate only during a very short period early in life and males therefore produce ejaculates consisting of large numbers of high quality sperm. Such extreme selection for high fecundity resulted in males investing minimally into their somatic survival, including their immune sy...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10565

    authors: Peng Y,Baer-Imhoof B,Millar AH,Baer B

    更新日期:2015-06-30 00:00:00

  • Micro Fabry-Pérot Interferometer at Rayleigh Range.

    abstract::The Fabry-Pérot interferometer is used in a variety of high-precision optical interferometry applications, such as gravitational wave detection. It is also used in various types of laser resonators to act as a narrow band filter. In addition, ultra-compact Fabry-Pérot interferometers are used in the optical resonators...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33665-8

    authors: Tsujiie Y,Kawamura Y

    更新日期:2018-10-12 00:00:00

  • High temporal resolution of leaf area data improves empirical estimation of grain yield.

    abstract::Empirical yield estimation from satellite data has long lacked suitable combinations of spatial and temporal resolutions. Consequently, the selection of metrics, i.e., temporal descriptors that predict grain yield, has likely been driven by practicality and data availability rather than by systematic targetting of cri...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51715-7

    authors: Waldner F,Horan H,Chen Y,Hochman Z

    更新日期:2019-10-31 00:00:00

  • Dynamic Changes in the Splenic Transcriptome of Chickens during the Early Infection and Progress of Marek's Disease.

    abstract::Gallid alphaherpesvirus 2 (GaHV2) is an oncogenic avian herpesvirus inducing Marek's disease (MD) and rapid-onset T-cell lymphomas. To reveal molecular events in MD pathogenesis and tumorigenesis, the dynamic splenic transcriptome of GaHV2-infected chickens during early infection and pathogenic phases has been determi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11304-y

    authors: Dang L,Teng M,Li HW,Li HZ,Ma SM,Zhao P,Li XJ,Deng RG,Zhang GP,Luo J

    更新日期:2017-09-14 00:00:00

  • Self-organization of network dynamics into local quantized states.

    abstract::Self-organization and pattern formation in network-organized systems emerges from the collective activation and interaction of many interconnected units. A striking feature of these non-equilibrium structures is that they are often localized and robust: only a small subset of the nodes, or cell assembly, is activated....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21360

    authors: Nicolaides C,Juanes R,Cueto-Felgueroso L

    更新日期:2016-02-17 00:00:00

  • Suspending effect on low-frequency charge noise in graphene quantum dot.

    abstract::Charge noise is critical in the performance of gate-controlled quantum dots (QDs). Such information is not yet available for QDs made out of the new material graphene, where both substrate and edge states are known to have important effects. Here we show the 1/f noise for a microscopic graphene QD is substantially lar...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08142

    authors: Song XX,Li HO,You J,Han TY,Cao G,Tu T,Xiao M,Guo GC,Jiang HW,Guo GP

    更新日期:2015-01-30 00:00:00