Abstract：
:Thomas Kent was an Irish rebel who was executed by British forces in the aftermath of the Easter Rising armed insurrection of 1916 and buried in a shallow grave on Cork prison's grounds. In 2015, ninety-nine years after his death, a state funeral was offered to his living family to honor his role in the struggle for Irish independence. However, inaccuracies in record keeping did not allow the bodily remains that supposedly belonged to Kent to be identified with absolute certainty. Using a novel approach based on homozygous single nucleotide polymorphisms, we identified these remains to be those of Kent by comparing his genetic data to that of two known living relatives. As the DNA degradation found on Kent's DNA, characteristic of ancient DNA, rendered traditional methods of relatedness estimation unusable, we forced all loci homozygous, in a process we refer to as "forced homozygote approach". The results were confirmed using simulated data for different relatedness classes. We argue that this method provides a necessary alternative for relatedness estimations, not only in forensic analysis, but also in ancient DNA studies, where reduced amounts of genetic information can limit the application of traditional methods.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fernandes D,Sirak K,Novak M,Finarelli JA,Byrne J,Connolly E,Carlsson JE,Ferretti E,Pinhasi R,Carlsson Jdoi
10.1038/srep41529subject
Has Abstractpub_date
2017-01-30 00:00:00pages
41529issn
2045-2322pii
srep41529journal_volume
7pub_type
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