Abstract：
:Ribociclib is a specific cyclin dependent kinase (Cdk) 4/6 inhibitor that induces G1 arrest by blocking the formation of cyclin D1-Cdk4/6 complex and inhibiting retinoblastoma (RB) phosphorylation. Cyclin D1 is overexpressed in over 90% of nasopharyngeal carcinoma (NPC) and CCND1 gene activation plays a critical role in NPC pathogenesis. This study evaluated the preclinical activities of ribociclib in NPC cell lines and patient derived xenograft (PDX) models. Over 95% cell growth inhibition was observed at 96 hours after ribociclib treatment. (IC50 concentrations: HK1 = 1.42 ± 0.23 µM; HK1-LMP1 = 2.18 ± 0.70 µM and C666-1 = 8.26 ± 0.92 µM). HK1 and C666-1 cells were chosen for analysis of ribociclib on kinase signaling, apoptosis and cell cycle. Treatment with ribociclib for 48 hours consistently showed a dose-dependent reduction in phosphorylated and total RB expression and G1 cycle arrest was only observed. Combining ribociclib with the alpha-specific PI3K inhibitor alpelisib showed a synergistic effect in two NPC PDX models in nude mice. The co-treatment induced a significant reduction in tumor volume in both xeno-666 and xeno-2117 compared with ribociclib treatment alone and control (p < 0.01). In summary, ribociclib is active in NPC models and the effect on growth inhibition was augmented when combined with alpelisib. This study supports the clinical evaluation of ribociclib in NPC.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wong CH,Ma BBY,Hui CWC,Lo KW,Hui EP,Chan ATCdoi
10.1038/s41598-018-26201-1subject
Has Abstractpub_date
2018-05-22 00:00:00pages
8010issue
1issn
2045-2322pii
10.1038/s41598-018-26201-1journal_volume
8pub_type
杂志文章abstract：:The intricate molecular processes underlying photosynthesis have long been studied using various analytic approaches. However, the three-dimensional (3D) dynamics of such photosynthetic processes remain unexplored due to technological limitations related to investigating intraorganellar mechanisms in vivo. By developi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29940
更新日期：2016-07-15 00:00:00
abstract：:Volumetric and morphometric studies have demonstrated structural abnormalities related to chronic epilepsies on a cohort- and population-based level. On a single-patient level, specific patterns of atrophy or cortical reorganization may be widespread and heterogeneous but represent potential targets for further person...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10707-1
更新日期：2017-09-07 00:00:00
abstract：:Ammonia physiology is important to numerous disease states including urea cycle disorders and hepatic encephalopathy. However, many unknowns persist regarding the ammonia response to common and potentially significant physiologic influences, such as food. Our aim was to evaluate the dynamic range of ammonia in respons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20503-0
更新日期：2018-02-07 00:00:00
abstract：:Beta oscillations observed in motor cortical local field potentials (LFPs) recorded on separate electrodes of a multi-electrode array have been shown to exhibit non-zero phase shifts that organize into planar waves. Here, we generalize this concept to additional classes of salient patterns that fully describe the spat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22990-7
更新日期：2018-03-26 00:00:00
abstract：:We present a table-top beamline providing a soft X-ray supercontinuum extending up to 370 eV from high-order harmonic generation with sub-13 fs 1300 nm driving pulses and simultaneous production of sub-5 fs pulses centered at 800 nm. Optimization of high harmonic generation in a long and dense gas medium yields a phot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62461-6
更新日期：2020-04-01 00:00:00
abstract：:Harmful algal blooms caused by Phaeocystis globosa have resulted in staggering losses to coastal countries because of their world-wide distribution. Bacteria have been studied for years to control the blooms of harmful alga, however, the action mechanism of them against harmful algal cells is still not well defined. H...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17002
更新日期：2015-11-25 00:00:00
abstract：:For understanding the quantitative effect of nonhydrostatic stress on properties of material, the crystal structure and Raman spectra of 3C-SiC under hydrostatic and nonhydrostatic stress were calculated using a first-principles method. The results show that the lattice constants (a, b, and c) under nonhydrostatic str...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29666-2
更新日期：2018-07-26 00:00:00
abstract：:The knowledge of diffusion processes in semiconducting alloys is very important both technologically and from a theoretical point of view. Here we show that, self-diffusion in Si1-x Ge x alloys as a function of temperature and Ge concentration can be described by the cBΩ thermodynamic model. This model connects the ac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01301-6
更新日期：2017-05-02 00:00:00
abstract：:Using a non-targeted metabolomics platform, we recently identified C-mannosyltryptophan and pseudouridine as non-traditional kidney function markers. The aims of this study were to obtain absolute concentrations of both metabolites in blood and urine from individuals with and without CKD to provide reference ranges an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17107-5
更新日期：2017-12-12 00:00:00
abstract：:The ability to distinguish and grade malignant cells during surgical procedures in a fast, non-invasive and staining-free manner is of high importance in tumor management. To this extend, Third Harmonic Generation (THG), Second Harmonic Generation (SHG) and Fourier-Transform Infrared (FTIR) spectroscopy were applied t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67857-y
更新日期：2020-07-06 00:00:00
abstract：:The overpopulation of abandoned and stray companion animals has become a global crisis. The main purpose of this study was to develop a novel nanomedicine-based antifertility compound for non-surgical castration of male animals. Mangosteen (Garcinia mangostana L) pericarp extract has been shown to exhibit anti-fertili...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16563-3
更新日期：2017-11-24 00:00:00
abstract：:Short term treatment with low doses of glucocorticoid analogues has been shown to ameliorate neurological symptoms in Ataxia-Telangiectasia (A-T), a rare autosomal recessive multisystem disease that mainly affects the cerebellum, immune system, and lungs. Molecular mechanisms underlying this clinical observation are u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77352-z
更新日期：2020-11-19 00:00:00
abstract：:Bone homeostasis is maintained by the balance of osteoblasts (OBs) and osteoclasts (OCs). Increased activity of OCs not only contributes to pathological bone resorption, such as osteoporosis and periodontitis, but also is responsible for physiological conditions like orthodontic tooth movement (OTM). However, the deta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08016
更新日期：2015-01-26 00:00:00
abstract：:Electrophysiological field potential dynamics have been widely used to investigate brain functions and related psychiatric disorders. Considering recent demand for its applicability to freely moving subjects, especially for animals in a group and socially interacting with each other, here we propose a new method based...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43897-x
更新日期：2019-05-16 00:00:00
abstract：:Chronic kidney disease (CKD) progresses to end-stage renal failure via renal tubulointerstitial fibrosis. Malnutrition, inflammation, and arteriosclerosis interact to exacerbate the poor prognosis of CKD, and their effective management is thus essential. The traditional Japanese medicine Rikkunshito (RKT) exerts appet...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58214-0
更新日期：2020-02-05 00:00:00
abstract：:Although poaching (illegal killing) is an important cause of death for large carnivores globally, the effect of lethal management policies on poaching is unknown for many populations. Two opposing hypotheses have been proposed: liberalizing killing may decrease poaching incidence ('tolerance hunting') or increase it (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70837-x
更新日期：2020-08-17 00:00:00
abstract：:Loss of anorectal resting pressure due to internal anal sphincter (IAS) dysfunctionality causes uncontrolled fecal soiling and leads to passive fecal incontinence (FI). The study is focused on immediate and long-term safety and potential efficacy of bioengineered IAS BioSphincters to treat passive FI in a clinically r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54440-3
更新日期：2019-12-02 00:00:00
abstract：:Light damages photosynthetic machinery, primarily photosystem II (PSII), and it results in photoinhibition. A new photodamage model, the two-step photodamage model, suggests that photodamage to PSII initially occurs at the oxygen evolving complex (OEC) by light energy absorbed by manganese and that the PSII reaction c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16363
更新日期：2015-11-12 00:00:00
abstract：:Solid-state spin-based qubits offer good prospects for scaling based on their long coherence times and nexus to large-scale electronic scale-up technologies. However, high-threshold quantum error correction requires a two-dimensional qubit array operating in parallel, posing significant challenges in fabrication and c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13308-0
更新日期：2017-10-17 00:00:00
abstract：:Dendritic cell (DC)-derived exosomes (Dexo) contain the machinery necessary to activate potent antigen-specific immune responses. As promising cell-free immunogens, Dexo have been tested in previous clinical trials for cancer vaccine immunotherapy, yet resulted in limited therapeutic benefit. Here, we explore a novel ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17622
更新日期：2015-12-03 00:00:00
abstract：:Spatially uniform reconstitution of dried reagents is critical to the function of paper microfluidic devices. Advancing fluid fronts in paper microfluidic devices drive (convect) and concentrate rehydrated reagents to the edges, causing steep chemical gradients and imperfect mixing. This largely unsolved problem in pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52202-9
更新日期：2019-10-31 00:00:00
abstract：:Src family of kinases (SFKs) has been found to play an important role in the regulation of nociception. However, how each member of this family acts in the central nervous system (CNS) structures involved in the relay and/or modulation of nociceptive signals, and thereby contributes to the formation and maintenance of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40572-z
更新日期：2019-03-07 00:00:00
abstract：:The known angiotensin II (AngII) physiological effect of aldosterone synthesis and secretion is mediated by either Gq/11 proteins or βarrestin1 (βarr1), both of which can couple to its type 1 receptors (AT₁Rs), present in adrenocortical zona glomerulosa (AZG) cell membranes. In the present study, we examined the relat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08116
更新日期：2015-01-29 00:00:00
abstract：:A three-dimensional semiclassical model is used to study double ionization of Ar when driven by a near-infrared and near-single-cycle laser pulse for intensities ranging from 0.85 × 1014 W/cm2 to 5 × 1014 W/cm2. Asymmetry parameters, distributions of the sum of the two electron momentum components along the direction ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07635-5
更新日期：2017-08-08 00:00:00
abstract：:Multi-stranded helices are widespread in nature. The interplay of polymeric properties with biological function is seldom discussed. This study probes analogies between structural and mechanical properties of collagen and DNA. We modeled collagen with Eulerian rotational and translational parameters of adjacent rungs ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12878-3
更新日期：2017-10-16 00:00:00
abstract：:The metal-air battery is a form of renewable energy generation technology that produces energy electrochemically and can address energy concerns in the near future. However, state-of-the-art Pt electrocatalysts often suffer from agglomeration or detachment from carbon supports under prolonged operation, eventually lim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49194-x
更新日期：2019-09-03 00:00:00
abstract：:The hepatitis C virus (HCV) is one of the leading causes of chronic hepatitis, liver cirrhosis and hepatocellular carcinomas and infects approximately 170 million people worldwide. Although several reporter systems have been developed, many shortcomings limit their use in the assessment of HCV infections. Here, we rep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08865
更新日期：2015-03-09 00:00:00
abstract：:In this prospective pilot study, we aimed to evaluate the ability of cardiac magnetic resonance imaging (CMR) parameters of right ventricular function and pulmonary artery stiffness to identify pulmonary hypertension (PH), predict major adverse cardiovascular events (MACEs) in patients with secondary PH due to chronic...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-32784-6
更新日期：2018-09-27 00:00:00
abstract：:Individuals with lower limb amputation need a secure suspension system for their prosthetic devices. A new coupling system was developed that is capable of suspending the prosthesis. The system's safety is ensured through an acoustic alarm system. This article explains how the system works and provides an in vivo eval...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02270
更新日期：2013-01-01 00:00:00
abstract：:Hbs1, which is homologous to the GTPase eRF3, is a small G protein implicated in mRNA quality control. It interacts with a translation-release factor 1-like protein Dom34/Pelota to direct decay of mRNAs with ribosomal stalls. Although both proteins are evolutionarily conserved in eukaryotes, the biological function of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39530-6
更新日期：2019-03-01 00:00:00
