Association between Int7G24A rs334354 polymorphism and cancer risk: a meta-analysis of case-control studies.

Abstract:

:Accumulating evidences have suggested the potential association between Int7G24A (rs334354) polymorphism and cancer risk. However, results from epidemiological studies are controversial. We thus conducted this meta-analysis to clarify the association. Relevant studies were identified on electronic databases according to the inclusion criteria. A total of 13 case-control studies containing 4092 cases and 5909 controls were included in our meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the association. The results of the overall population had suggested that Int7G24A polymorphism had an increased risk for cancer, reaching significant levels in the 2 genetic models (allele model, OR = 1.25, 95% CI 1.09-1.42, P = 0.001; dominant model, OR = 1.24, 95% CI 1.06-1.46, P < 0.008). Besides, significant association was found among Asian population (allele model, OR = 1.27, 95% CI 1.11-1.45, P < 0.001; dominant model, OR = 1.28, 95% CI 1.11-1.49, P < 0.001), whereas there was non-significant relationship detected among Caucasian population (allele model, OR = 1.08, 95% CI 0.92-1.26, P = 0.352; dominant model, OR = 1.05, 95% CI 0.87-1.26, P = 0.639). The present meta-analysis had suggested that Int7G24A polymorphism of gene TGFBR1 involved in the transforming growth factor beta (TGF-β) signaling pathway had a significantly increased risk for cancer development.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wu W,Tong Y,Wei X,Zhao Q,Pan X,Yu G,Lu Q

doi

10.1038/srep11350

subject

Has Abstract

pub_date

2015-06-15 00:00:00

pages

11350

issn

2045-2322

pii

srep11350

journal_volume

5

pub_type

杂志文章,meta分析
  • Retraction Note: Sorcin Predicts Poor Prognosis and Promotes Metastasis by Facilitating Epithelial-mesenchymal Transition in Hepatocellular Carcinoma.

    abstract::This paper has been retracted at the request of the authors. ...

    journal_title:Scientific reports

    pub_type: 撤回出版物

    doi:10.1038/s41598-018-29892-8

    authors: Lei X,Liang Y,Chen J,Xiao S,Lei J,Li J,Duanmu J,Jiang Q,Liu D,Tang C,Li T

    更新日期:2018-08-02 00:00:00

  • Fabrication of efficient planar perovskite solar cells using a one-step chemical vapor deposition method.

    abstract::Organometallic trihalide perovskites are promising materials for photovoltaic applications, which have demonstrated a rapid rise in photovoltaic performance in a short period of time. We report a facile one-step method to fabricate planar heterojunction perovskite solar cells by chemical vapor deposition (CVD), with a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14083

    authors: Tavakoli MM,Gu L,Gao Y,Reckmeier C,He J,Rogach AL,Yao Y,Fan Z

    更新日期:2015-09-22 00:00:00

  • Synergetic effect of metal nickel and graphene as a cocatalyst for enhanced photocatalytic hydrogen evolution via dye sensitization.

    abstract::Exploiting new, low-cost and efficient electrocatalysts for hydrogen evolution reaction (HER) is important to resolve the energy crisis and environment pollution. In this work, graphene decorated with Ni nanoparticles (NPs) were synthesized via one-pot reduction using graphene oxide (GO, the obtained composite was den...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10589

    authors: Zhang W,Li Y,Zeng X,Peng S

    更新日期:2015-06-12 00:00:00

  • Fano resonance assisting plasmonic circular dichroism from nanorice heterodimers for extrinsic chirality.

    abstract::In this work, the circular dichroisms (CD) of nanorice heterodimers consisting of two parallel arranged nanorices with the same size but different materials are investigated theoretically. Symmetry-breaking is introduced by using different materials and oblique incidence to achieve strong CD at the vicinity of Fano re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16069

    authors: Hu L,Huang Y,Fang L,Chen G,Wei H,Fang Y

    更新日期:2015-11-05 00:00:00

  • Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor.

    abstract::Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects caused by current therapies. Deciphering gene regulation pathways provides a reliable prognostic analysis to elucidate the origin of grave disea...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41368

    authors: Huertas CS,Domínguez-Zotes S,Lechuga LM

    更新日期:2017-01-25 00:00:00

  • Tailoring self-organized nanostructured morphologies in kilometer-long polymer fiber.

    abstract::While nanowires and nanospheres have been utilized in the design of a diverse array of nanoscale devices, recent schemes frequently require nanoscale architectures of higher complexity. However, conventional techniques are largely unsatisfactory for the production of more intricate nanoscale shapes and patterns, and e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04864

    authors: Khudiyev T,Tobail O,Bayindir M

    更新日期:2014-05-06 00:00:00

  • Transient autonomic responses during sustained attention in high and low fit young adults.

    abstract::Maintaining vigilance over long periods of time is especially critical in performing fundamental everyday activities and highly responsible professional tasks (e.g., driving, performing surgery or piloting). Here, we investigated the role of aerobic fitness as a crucial factor related to the vigilance capacity. To thi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27556

    authors: Luque-Casado A,Perakakis P,Ciria LF,Sanabria D

    更新日期:2016-06-08 00:00:00

  • Urotensin II-induced store-operated Ca2+ entry contributes to glomerular mesangial cell proliferation and extracellular matrix protein production under high glucose conditions.

    abstract::Glomerular mesangial cell (GMC) proliferation and matrix expansion are pathological hallmarks of a wide range of kidney diseases, including diabetic nephropathy. Although the circulating level of peptide hormone urotensin II (UII) and kidney tissue expression of UII and UII receptors (UTR) are increased in diabetic ne...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18143-x

    authors: Soni H,Adebiyi A

    更新日期:2017-12-22 00:00:00

  • Label-free in vivo Raman microspectroscopic imaging of the macromolecular architecture of oocytes.

    abstract::Confocal Raman spectroscopy (CRS) can provide information about oocyte competency through measurement of changes in the macromolecular architecture during oocyte development and maturation. Hitherto most spectroscopic studies have been limited to fixed oocytes due to the inherent difficulties working with live cells. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08973-0

    authors: Heraud P,Marzec KM,Zhang QH,Yuen WS,Carroll J,Wood BR

    更新日期:2017-08-21 00:00:00

  • Controlling the spins angular momentum in ferromagnets with sequences of picosecond acoustic pulses.

    abstract::Controlling the angular momentum of spins with very short external perturbations is a key issue in modern magnetism. For example it allows manipulating the magnetization for recording purposes or for inducing high frequency spin torque oscillations. Towards that purpose it is essential to modify and control the angula...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08511

    authors: Kim JW,Vomir M,Bigot JY

    更新日期:2015-02-17 00:00:00

  • Analysis of tractable allosteric sites in G protein-coupled receptors.

    abstract::Allosteric modulation of G protein-coupled receptors represent a promising mechanism of pharmacological intervention. Dramatic developments witnessed in the structural biology of membrane proteins continue to reveal that the binding sites of allosteric modulators are widely distributed, including along protein surface...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42618-8

    authors: Wakefield AE,Mason JS,Vajda S,Keserű GM

    更新日期:2019-04-16 00:00:00

  • Digit ratio (2D:4D) and transgender identity: new original data and a meta-analysis.

    abstract::Previously reported associations between second-to-fourth digit length ratio (2D:4D), a proxy for prenatal androgen load, and transgender identity have been inconsistent. The objectives of the present study were to provide additional original data and an updated meta-analysis concerning this association. In a study of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72486-6

    authors: Siegmann EM,Müller T,Dziadeck I,Mühle C,Lenz B,Kornhuber J

    更新日期:2020-11-09 00:00:00

  • Three-dimensional observation and analysis of remineralization in dentinal caries lesions.

    abstract::The remineralization mechanism in dental caries lesions is not completely understood. This study reports on ultrastructural and chemical changes observed within arrested caries lesions. Carious human teeth were observed using scanning electron microscopy (SEM) and focused-ion-beam (FIB)-SEM. The crystals detected in t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61111-1

    authors: Yoshihara K,Nagaoka N,Nakamura A,Hara T,Hayakawa S,Yoshida Y,Van Meerbeek B

    更新日期:2020-03-09 00:00:00

  • Genetic engineering of parthenocarpic tomato plants using transient SlIAA9 knockdown by novel tissue-specific promoters.

    abstract::Parthenocarpy is the development of an ovary into a seedless fruit without pollination. The ubiquitous downregulation of SlIAA9 induces not only parthenocarpic fruit formation but also an abnormal vegetative phenotype. To make parthenocarpic transgenic tomato plants without unwanted phenotypes, we found two genes, nam...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55400-7

    authors: Kim JS,Ezura K,Lee J,Ariizumi T,Ezura H

    更新日期:2019-12-11 00:00:00

  • Two-dimensional echocardiography after return of spontaneous circulation and its association with in-hospital survival after in-hospital cardiopulmonary resuscitation.

    abstract::This retrospective cohort study investigated the association between in-hospital survival and two-dimensional (2D) echocardiography within 24 hours after the return of spontaneous circulation (ROSC) in patients who underwent in-hospital cardiopulmonary resuscitation (ICPR) after in-hospital cardiopulmonary arrest (IHC...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56153-z

    authors: Song IA,Cha JK,Oh TK,Jo YH,Yoon YE

    更新日期:2020-01-08 00:00:00

  • UPLC-Tandem Mass Spectrometry for Quantification of Busulfan in Human Plasma: Application to Therapeutic Drug Monitoring.

    abstract::Busulfan (Bu) is an alkylating agent commonly used in preparative regimens for hematologic malignant and non-malignant patients undergoing hematopoietic stem cell transplantation (HSCT). The objective of the present study was to develop an UPLC-MS/MS method for quantification of Bu in human plasma. A total of 55 patie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65919-9

    authors: Matar KM,Alshemmari SH,Refaat S,Anwar A

    更新日期:2020-06-02 00:00:00

  • Addition of a histone deacetylase inhibitor increases recombinant protein expression in Medicago truncatula cell cultures.

    abstract::Plant cell cultures are an attractive platform for the production of recombinant proteins. A major drawback, hindering the establishment of plant cell suspensions as an industrial platform, is the low product yield obtained thus far. Histone acetylation is associated with increased transcription levels, therefore it i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17006-9

    authors: Santos RB,Pires AS,Abranches R

    更新日期:2017-12-01 00:00:00

  • Resonances of nanoparticles with poor plasmonic metal tips.

    abstract::The catalytic and optical properties of metal nanoparticles can be combined to create platforms for light-driven chemical energy storage and enhanced in-situ reaction monitoring. However, the heavily damped plasmon resonances of many catalytically active metals (e.g. Pt, Pd) prevent this dual functionality in pure nan...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17431

    authors: Ringe E,DeSantis CJ,Collins SM,Duchamp M,Dunin-Borkowski RE,Skrabalak SE,Midgley PA

    更新日期:2015-11-30 00:00:00

  • S100A8 promotes migration and infiltration of inflammatory cells in acute anterior uveitis.

    abstract::Uveitis, the pathologic condition of inflammation of the uvea, frequently leads to severe vision loss and blindness. S100A8 is a calcium-binding protein which mainly expresses in granulocytes and monocytes and plays a prominent role in the regulation of inflammatory processes and immune response. Here, we determined t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36140

    authors: Wang Y,Zhang Z,Zhang L,Li X,Lu R,Xu P,Zhang X,Dai M,Dai X,Qu J,Lu F,Chi Z

    更新日期:2016-10-27 00:00:00

  • The browning and re-browning of lakes: Divergent lake-water organic carbon trends linked to acid deposition and climate change.

    abstract::Dissolved organic carbon (DOC) concentrations and water colour are increasing in many inland waters across northern Europe and northeastern North America. This inland-water "browning" has profound physical, chemical and biological repercussions for aquatic ecosystems affecting water quality, biological community struc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52912-0

    authors: Meyer-Jacob C,Michelutti N,Paterson AM,Cumming BF,Keller WB,Smol JP

    更新日期:2019-11-13 00:00:00

  • Matrix description of the complete topology of three-dimensional cells.

    abstract::A new, efficient method based on a series of matrices is introduced to completely describe the detailed topology of individual domains and their topology evolution in three-dimensional cellular structures. With this approach, we found a lot of new topological grain forms which are never reported before, i.e., there ar...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25877

    authors: Xue W,Wang H,Liu G,Meng L,Xiang S,Ma G,Li W

    更新日期:2016-05-10 00:00:00

  • IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation.

    abstract::Elaborate regulatory networks of the Bone Morphogenetic Protein (BMP) pathways ensure precise signalling outcome during cell differentiation and tissue homeostasis. Here, we identified IRS4 as a novel regulator of BMP signal transduction and provide molecular insights how it integrates into the signalling pathway. We ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08676-6

    authors: Dörpholz G,Murgai A,Jatzlau J,Horbelt D,Belverdi MP,Heroven C,Schreiber I,Wendel G,Ruschke K,Stricker S,Knaus P

    更新日期:2017-08-18 00:00:00

  • Evolution of conduction channel and its effect on resistance switching for Au-WO₃-x-Au devices.

    abstract::We performed a systematic investigation on the dynamic behavior of conduction filaments (CFs) in WO₃-x-based devices. It was found that the electric forming produced an electric structure consisted of a conductive channel (virtual cathode) started from cathode and an insulating band surrounding anode. Both the virtual...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04058

    authors: Hong DS,Chen YS,Li Y,Yang HW,Wei LL,Shen BG,Sun JR

    更新日期:2014-02-11 00:00:00

  • Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment.

    abstract::Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patients. Therefore, companion diagnostics are needed in order to identify patients for whom these therapies are eff...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39345-5

    authors: Iwahori K,Shintani Y,Funaki S,Yamamoto Y,Matsumoto M,Yoshida T,Morimoto-Okazawa A,Kawashima A,Sato E,Gottschalk S,Okumura M,Kumanogoh A,Wada H

    更新日期:2019-02-22 00:00:00

  • Comparative analysis of rhizosphere soil physiochemical characteristics and microbial communities between rusty and healthy ginseng root.

    abstract::Ginseng rusty root (GRR) symptom is one of the primary diseases of ginseng. There has been a problem of ginseng rusty root, leading to a severe decline in the quality of ginseng. To clarify the relationship between root symptoms of ginseng rust and soil, the physical and chemical properties, enzyme activity, community...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71024-8

    authors: Bian X,Xiao S,Zhao Y,Xu Y,Yang H,Zhang L

    更新日期:2020-09-25 00:00:00

  • Pre-yield non-affine fluctuations and a hidden critical point in strained crystals.

    abstract::A crystalline solid exhibits thermally induced localised non-affine droplets in the absence of external stress. Here we show that upon an imposed shear, the size of these droplets grow until they percolate at a critical strain, well below the value at which the solid begins to yield. This critical point does not manif...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10644

    authors: Das T,Ganguly S,Sengupta S,Rao M

    更新日期:2015-06-03 00:00:00

  • Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients.

    abstract::Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA. SCA patients and healthy controls (AA) performed an acute submaximal exercise test until subject...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48364-1

    authors: Grau M,Jerke M,Nader E,Schenk A,Renoux C,Collins B,Dietz T,Bizjak DA,Joly P,Bloch W,Connes P,Prokop A

    更新日期:2019-08-14 00:00:00

  • Microenvironment-triggered dual-activation of a photosensitizer- fluorophore conjugate for tumor specific imaging and photodynamic therapy.

    abstract::Photodynamic therapy is attracting increasing attention, but how to increase its tumor-specificity remains a daunting challenge. Herein we report a theranostic probe (azo-PDT) that integrates pyropheophorbide α as a photosensitizer and a NIR fluorophore for tumor imaging. The two functionalities are linked with a hypo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68847-w

    authors: Wang C,Wang S,Wang Y,Wu H,Bao K,Sheng R,Li X

    更新日期:2020-07-22 00:00:00

  • Association between preterm brain injury and exposure to chorioamnionitis during fetal life.

    abstract::Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects intrauterine inflammation, can trigger a fetal inflammatory response, and is closely associated with premature birth. In a cohort of 90 preterm infan...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37932

    authors: Anblagan D,Pataky R,Evans MJ,Telford EJ,Serag A,Sparrow S,Piyasena C,Semple SI,Wilkinson AG,Bastin ME,Boardman JP

    更新日期:2016-12-01 00:00:00

  • Author Correction: Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-46785-6

    authors: Rombaut D,Chiu HS,Decaesteker B,Everaert C,Yigit N,Peltier A,Janoueix-Lerosey I,Bartenhagen C,Fischer M,Roberts S,D'Haene N,De Preter K,Speleman F,Denecker G,Sumazin P,Vandesompele J,Lefever S,Mestdagh P

    更新日期:2019-07-17 00:00:00