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Longrange PCR-based next-generation sequencing in pharmacokinetics and pharmacodynamics study of propofol among patients under general anaesthesia.

Abstract：

:The individual response of patients to propofol results from the influence of genetic factors. However, the state of knowledge in this matter still remains insufficient. The aim of our study was to determine genetic predictors of variable pharmacokinetics and pharmacodynamics of propofol within selected 9 genes coding for propofol biotransformation enzymes, receptors and transporters. Our studies are the first extensive pharmaocgenetics research of propofol using high throughput sequencing technology. After the design and optimization of long range PCR-based next-generation sequencing experiment, we screened promoter and coding sequences of all genes analyzed among 87 Polish patients undergoing general anaesthesia with propofol. Initially we found that two variants, c.516 G > T in the CYP2B6 gene and c.2677 T > G in the ABCB1 gene, significantly correlate with propofol's metabolic profile, however after Bonferroni correction the P-values were not statistically significant. Our results suggest, that variants within the CYP2B6 and ABCB1 genes correlate stronger with propofol's metabolic profile compared to other 7 genes. CYP2B6 and ABCB1 variants can play a potentially important role in response to this anaesthetic and they are promising object for further studies.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zakerska-Banaszak O,Skrzypczak-Zielinska M,Tamowicz B,Mikstacki A,Walczak M,Prendecki M,Dorszewska J,Pollak A,Lechowicz U,Oldak M,Huminska-Lisowska K,Molinska-Glura M,Szalata M,Slomski R

doi

10.1038/s41598-017-15657-2

subject

Has Abstract

pub_date

2017-11-13 00:00:00

pages

15399

issue

1

issn

2045-2322

pii

10.1038/s41598-017-15657-2

journal_volume

7

pub_type

临床试验,杂志文章

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