Abstract:
:Some previous studies have indicated that valproate (VPA) might change the pharmacokinetics and enhance the effects of propofol. We evaluated whether clinical VPA therapy affected the propofol blood level, the protein-unbound free propofol level, and/or the anesthetic effects of propofol in the clinical setting. The subjects were divided into the control group (not medicated with antiepileptics), the mono-VPA group (medicated with VPA alone), and the poly-VPA group (medicated with VPA, other antiepileptics, and/or psychoactive drugs). General anesthesia was induced via the administration of a single bolus of propofol and a remifentanil infusion, and when the bispectral index (BIS) exceeded 60 sevoflurane was started. There were no significant differences in the total blood propofol level at 5, 10, 15, and 20 min or the protein-unbound free propofol level at 5 min after the intravenous administration of propofol between the 3 groups. However, the minimum BIS was significantly lower and the time until the BIS exceeded 60 was significantly longer in the poly-VPA group. In the multivariate regression analysis, belonging to the poly-VPA group was found to be independently associated with the minimum BIS value and the time until the BIS exceeded 60. Clinical VPA therapy did not influence the pharmacokinetics of propofol. However, multi-drug therapy involving VPA might enhance the anesthetic effects of propofol.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kodama M,Higuchi H,Ishii-Maruhama M,Nakano M,Honda-Wakasugi Y,Maeda S,Miyawaki Tdoi
10.1038/s41598-020-58460-2subject
Has Abstractpub_date
2020-01-31 00:00:00pages
1578issue
1issn
2045-2322pii
10.1038/s41598-020-58460-2journal_volume
10pub_type
临床试验,杂志文章abstract::Abscisic acid (ABA) is a phytohormone that is necessary for stress adaptation. Recent studies have reported that attenuated levels of ABA improved grain yield and seedling growth under low temperature in cereals. To improve plant growth under low temperature, we attempted to generate ABA-insensitive transgenic rice by...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30866-z
更新日期:2018-08-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-56287-0
更新日期:2019-12-19 00:00:00
abstract::It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00431-1
更新日期:2017-04-03 00:00:00
abstract::Most of the human genome is non-coding. However, some of the non-coding part is transcriptionally active. In humans, the tandemly repeated (TR) pericentromeric non-coding DNA-human satellites 2 and 3 (HS2, HS3)-are transcribed in somatic cells. These transcripts are also found in pre- and post-implantation embryos. Th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76628-8
更新日期:2020-11-12 00:00:00
abstract::Although giant proximity effect (GPE) can shed important information on understanding superconducting pairing mechanisms and superconducting electronics, reports on the GPE are few because the fabrication of the junctions with GPE is technologically difficult. Here, we report a GPE in the single-crystalline MgB2 bilay...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40263-9
更新日期:2019-03-01 00:00:00
abstract::Soil erosion due to underground leakage is a major factor causing land degradation in karst regions. Rhizosphere effects (REs) on soil anti-erodibility (SAE) can alleviate this type of soil erosion by improving soil physical processes such as aggregate stability. However, the magnitudes and causes of interspecific var...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58784-z
更新日期:2020-02-12 00:00:00
abstract::MBL2 gene encodes mannose-binding lectin, is a member of innate immune system. Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent. A meta-analysis wa...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep35728
更新日期:2016-11-23 00:00:00
abstract::Living organisms in drying environments build anisotropic structures and exhibit directionality through self-organization of biopolymers. However, the process of macro-scale assembly is still unknown. Here, we introduce a dissipative structure through a non-equilibrium process between hydration and deposition in the d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05883-z
更新日期:2017-07-21 00:00:00
abstract::The anterior chamber of the eye (ACE) has emerged as a promising clinical islet transplantation site because of its multiple advantages over the conventional intra-hepatic portal site. This includes reduced surgical invasiveness and increased islet graft survival rate. It also allows for enhanced accessibility and mon...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40404-0
更新日期:2019-03-08 00:00:00
abstract::Invasive species populations periodically collapse from high to low abundance, sometimes even to extinction. Pathogens and the burden they place on invader immune systems have been hypothesised as a mechanism for these collapses. We examined the association of the bacterial pathogen (Pseudomonas spp.) and the viral co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41843-5
更新日期:2019-04-08 00:00:00
abstract::The aim of this study was to investigate left ventricular (LV) global myocardial strain and LV involvement characteristics in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and to evaluate their predictive value of adverse cardiac events. Sixty consecutive ARVD/C patients with a defin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50535-z
更新日期:2019-10-02 00:00:00
abstract::We study the time-development processes of spin and charge transport phenomena in a topological Dirac semimetal attached to a ferromagnetic insulator with a precessing magnetization. Compared to conventional normal metals, topological Dirac semimetals manifest a large inverse spin Hall effect when a spin current is pu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55802-7
更新日期:2019-12-23 00:00:00
abstract::Recently, there has been a debate whether implicit Theory of Mind can be reliably measured using anticipatory looking tasks. Previous anticipatory looking paradigms used video stimuli to measure implicit Theory of Mind; however, numerous replications of these paradigms were unsuccessful. This lack of replications may ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80614-5
更新日期:2021-01-13 00:00:00
abstract::A plasmonic Ag/TiO2 photocatalytic composite was designed by selecting Ag quantum dots (Ag QDs) to act as a surface plasmon resonance (SPR) photosensitizer for driving the visible-light driven photoelectrocatalytic hydrogen evolution. Vertically oriented hierarchical TiO2 nanotube arrays (H-TiO2-NTAs) with macroporous...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10461
更新日期:2015-06-12 00:00:00
abstract::Nonstoichiometric silicon nitride SiNx is a promising material for developing a new generation of high-speed, reliable flash memory device based on the resistive effect. The advantage of silicon nitride over other dielectrics is its compatibility with the silicon technology. In the present work, a silicon nitride-base...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82159-7
更新日期:2021-01-28 00:00:00
abstract::The interplay between the quasi 1-dimensional CuO-chains and the 2-dimensional CuO2 planes of YBa(2)Cu(3)O(6+x) (YBCO) has been in focus for a long time. Although the CuO-chains are known to be important as charge reservoirs that enable superconductivity for a range of oxygen doping levels in YBCO, the understanding o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07017
更新日期:2014-11-12 00:00:00
abstract::The prion protein (PrPC), a mainly neuronal protein, is known to modulate glucose homeostasis in mouse models. We explored the underlying mechanism in mouse models and the human pancreatic β-cell line 1.1B4. We report expression of PrPC on mouse pancreatic β-cells, where it promoted uptake of iron through divalent-met...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24786-1
更新日期:2018-04-26 00:00:00
abstract::Organic solar cells (OSCs) have attracted great attention in the past 30 years, and the power conversion efficiency (PCE) now reaches around 10%, largely owning to the rapid material developments. Meanwhile with the progress in the device performance, more and more interests are turning to understanding the fundamenta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40134
更新日期:2017-01-10 00:00:00
abstract::Fibroblast growth factor 21 (FGF21) is a metabolic hormone having anti-oxidative and anti-hypertrophic effects. However, the regulation of FGF21 expression during acute myocardial infarction (AMI) remains unclear. We tested blood samples from 50 patients with AMI and 43 patients with stable angina pectoris (sAP) for F...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48356-1
更新日期:2019-08-14 00:00:00
abstract::NanoRNAs are RNA fragments 2 to 5 nucleotides in length that are generated as byproducts of RNA degradation and abortive transcription initiation. Cells have specialized enzymes to degrade nanoRNAs, such as the DHH phosphoesterase family member NanoRNase A (NrnA). This enzyme was originally identified as a 3' → 5' exo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09403-x
更新日期:2017-09-11 00:00:00
abstract::The aim of the study was to determine damage severity of wood-destroying insects on logs stored in forest depots. The Bevan damage classification (BDC) system, developed in 1987, was utilized to determine damage severity in log depots in 21 locations throughout seven provinces in Turkey. Pheromone traps were placed in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70696-6
更新日期:2020-08-13 00:00:00
abstract::Gold nanoparticle radiosensitization represents a novel technique in enhancement of ionising radiation dose and its effect on biological systems. Variation between theoretical predictions and experimental measurement is significant enough that the mechanism leading to an increase in cell killing and DNA damage is stil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19442
更新日期:2016-01-20 00:00:00
abstract::Two-dimensional (2D) acoustic vortex allows new physics and applications different from three-dimensional counterparts, yet existing mechanisms usually have to rely on active array composed of transducers which may result in complexity, high cost and, in particular, undesired spatial aliasing effect. We propose to gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60836-3
更新日期:2020-03-02 00:00:00
abstract::Olfactory dysfunction is a robust and early sign for Parkinson's disease (PD). Previous studies have revealed its association with dementia and related neural changes in PD. Yet, how olfactory dysfunction affects white matter (WM) microstructure in newly diagnosed and untreated PD remains unclear. Here we comprehensiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12947-7
更新日期:2017-10-02 00:00:00
abstract::Graphene has shown enormous potential for innovation in various research fields. The current chemical approaches based on exfoliation of graphite via graphite oxide (GO) are potential for large-scale synthesis of graphene but suffer from high cost, great operation difficulties, and serious waste discharge. We report a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03439
更新日期:2013-12-06 00:00:00
abstract::The rare-earth monopnictide family is attracting an intense current interest driven by its unusual extreme magnetoresistance (XMR) property and the potential presence of topologically non-trivial surface states. The experimental observation of non-trivial surface states in this family of materials are not ubiquitous. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69414-z
更新日期:2020-07-31 00:00:00
abstract::In order to screen out an effective bone loss protectant from natural plant polyphenol and to elucidate the mechanism of the plant polyphenols that alleviate bone loss under simulated microgravity, the proliferation activities of 9 total polyphenol extracts from natural product (TPENP) on osteoblasts were measured. Po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30992-8
更新日期:2018-08-24 00:00:00
abstract::Archaeological evidence suggests that dogs were introduced to the islands of Oceania via Island Southeast Asia around 3,300 years ago, and reached the eastern islands of Polynesia by the fourteenth century AD. This dispersal is intimately tied to human expansion, but the involvement of dogs in Pacific migrations is no...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27363-8
更新日期:2018-06-14 00:00:00
abstract::The circadian clock coordinates an organism's growth, development and physiology with environmental factors. One illuminating example is the rhythmic growth of hypocotyls and cotyledons in Arabidopsis thaliana. Such daily oscillations in leaf position are often referred to as sleep movements or nyctinasty. Here, we re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65372-8
更新日期:2020-05-26 00:00:00
abstract::Osteoporosis is associated with reduced density and quality of bone leading to weakened skeleton thereby increasing the risk of fractures responsible for increased morbidity and mortality. Due to preference for western food style the consumption of salt intake in our diets has increased many folds. High dietary salt i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20896-y
更新日期:2018-02-06 00:00:00