Abstract：
:Gold nanoparticle radiosensitization represents a novel technique in enhancement of ionising radiation dose and its effect on biological systems. Variation between theoretical predictions and experimental measurement is significant enough that the mechanism leading to an increase in cell killing and DNA damage is still not clear. We present the first experimental results that take into account both the measured biodistribution of gold nanoparticles at the cellular level and the range of the product electrons responsible for energy deposition. Combining synchrotron-generated monoenergetic X-rays, intracellular gold particle imaging and DNA damage assays, has enabled a DNA damage model to be generated that includes the production of intermediate electrons. We can therefore show for the first time good agreement between the prediction of biological outcomes from both the Local Effect Model and a DNA damage model with experimentally observed cell killing and DNA damage induction via the combination of X-rays and GNPs. However, the requirement of two distinct models as indicated by this mechanistic study, one for short-term DNA damage and another for cell survival, indicates that, at least for nanoparticle enhancement, it is not safe to equate the lethal lesions invoked in the local effect model with DNA damage events.
journal_name
Sci Repjournal_title
Scientific reportsauthors
McQuaid HN,Muir MF,Taggart LE,McMahon SJ,Coulter JA,Hyland WB,Jain S,Butterworth KT,Schettino G,Prise KM,Hirst DG,Botchway SW,Currell FJdoi
10.1038/srep19442subject
Has Abstractpub_date
2016-01-20 00:00:00pages
19442issn
2045-2322pii
srep19442journal_volume
6pub_type
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