Magnetic nanoantioxidants with improved radical-trapping stoichiometry as stabilizers for inhibition of peroxide formation in ethereal solvents.

abstract：:Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolism. The importance of mTORC1 signaling in neuronal development and functions has been highlighted by its strong relationship with many neurological and neuropsychiatric diseases. Previous studies demonstrated that hyperactivation of mTORC1...

journal_title：Scientific reports

authors： Sakai Y,Kassai H,Nakayama H,Fukaya M,Maeda T,Nakao K,Hashimoto K,Sakagami H,Kano M,Aiba A

更新日期：2019-02-26 00:00:00

abstract：:To identify a vegetation configuration pattern with a high-efficiency purification ability for total nitrogen (TN), available nitrogen (AN), total phosphorous (TP), available phosphorous (AP), and chemical oxygen demand (COD) based on comprehensive assessment results, a water discharge experiment was performed in the ...

journal_title：Scientific reports

authors： Hou G,Bi H,Yu X,Jia G,Wang D,Zhang Z,Liu Z

更新日期：2019-02-20 00:00:00

abstract：:The incidence of patients under 55 years old diagnosed with Prostate Cancer (EO-PCa) has increased during recent years. The molecular biology of PCa cancer in this group of patients remains unclear. Here, we applied weighted gene coexpression network analysis of the expression of miRNAs from 24 EO-PCa patients (38-45 ...

journal_title：Scientific reports

authors： Parra-Medina R,López-Kleine L,Ramírez-Clavijo S,Payán-Gómez C

更新日期：2020-07-23 00:00:00

abstract：:In many cancers, the establishment of a patient's future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the 'pathological response' to a given therapy. However, histopathological assessment of pathological response remains subjective. Here we...

journal_title：Scientific reports

authors： Patterson NH,Alabdulkarim B,Lazaris A,Thomas A,Marcinkiewicz MM,Gao ZH,Vermeulen PB,Chaurand P,Metrakos P

更新日期：2016-11-14 00:00:00

abstract：:It was hypothesized that supplementation of omega-3 fatty acids could increase physical activity (PA) levels, where traditional interventions often fail. The aim of this double-blind, randomized, placebo-controlled trail was to evaluate the effects of 15-week administration of omega-3 fatty acids on objectively measur...

journal_title：Scientific reports

authors： Svensson V,Johansson E,Fischer M,Deng SL,Hagströmer M,Danielsson P

更新日期：2018-08-24 00:00:00

abstract：:The characterization of fully-defined in vitro hepatic culture systems requires testing of functional and morphological variables to obtain the optimal trophic support, particularly for cell therapeutics including bioartificial liver systems (BALs). Using serum-free fully-defined culture medium formulations, we measur...

journal_title：Scientific reports

authors： Nelson LJ,Treskes P,Howie AF,Walker SW,Hayes PC,Plevris JN

更新日期：2013-01-01 00:00:00

abstract：:Probing the oligomeric state of abundant molecules, such as membrane proteins in intact cells, is essential, but has not been straightforward. We address this challenge with a simple counting strategy that is capable of reporting the oligomeric state of dense, membrane-bound protein complexes. It is based on single-mo...

journal_title：Scientific reports

authors： Fricke F,Beaudouin J,Eils R,Heilemann M

更新日期：2015-09-11 00:00:00

abstract：:Nisin inhibits bacterial growth by generating pores in cell membrane and interrupting cell-wall biosynthesis through specific lipid II interaction. However, the role of the hinge region and C-terminus residues of the peptide in antibacterial action of nisin is largely unknown. Here, using molecular dynamics simulation...

journal_title：Scientific reports

authors： Prince A,Sandhu P,Ror P,Dash E,Sharma S,Arakha M,Jha S,Akhter Y,Saleem M

更新日期：2016-11-29 00:00:00

abstract：:The capture and activation of individual T cells on functionalised surfaces enables real-time analyses of the magnitude and rhythm of intracellular calcium release. Application of Haarlet transformations generate a calcium flux 'threshold', with the frequency of the 'threshold crossings' correlating with the strength ...

journal_title：Scientific reports

authors： Christo SN,Diener KR,Nordon RE,Brown MP,Griesser HJ,Vasilev K,Christo FC,Hayball JD

更新日期：2015-01-14 00:00:00

abstract：:The rainbow trout, a carnivorous fish, displays a 'glucose-intolerant' phenotype revealed by persistent hyperglycaemia when fed a high carbohydrate diet (HighCHO). Epigenetics refers to heritable changes in gene activity and is closely related to environmental changes and thus to metabolism adjustments governed by nut...

journal_title：Scientific reports

authors： Marandel L,Lepais O,Arbenoits E,Véron V,Dias K,Zion M,Panserat S

更新日期：2016-08-26 00:00:00

abstract：:Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profo...

journal_title：Scientific reports

authors： Paramo T,Tomasio SM,Irvine KL,Bryant CE,Bond PJ

更新日期：2015-12-09 00:00:00

abstract：:In typical numerical simulations, the space-charge force is calculated by slicing a beam into many longitudinal segments and by solving the two-dimensional Poisson equation in each segment. This method neglects longitudinal leakage of the space-charge force to nearby segments owing to its longitudinal spread over 1/γ....

journal_title：Scientific reports

authors： Shobuda Y,Chin YH

更新日期：2018-08-24 00:00:00

abstract：:A growing proportion of head and neck cancers (HNC) result from HPV infection. Between HNC aetiological groups (HPV positive and HPV negative) clinical evidence demonstrates significantly better treatment response among HPV positive cancers. Cancer stem cells (CSCs) are identified in HNC tumour populations as agents o...

journal_title：Scientific reports

authors： Reid P,Staudacher AH,Marcu LG,Olver I,Moghaddasi L,Brown MP,Bezak E

更新日期：2020-02-17 00:00:00

abstract：:The chicken egg resists most environmental microbes suggesting that it potentially contains efficient antimicrobial molecules. Considering that some heparin-binding proteins in mammals are antibacterial, we investigated the presence and the antimicrobial activity of heparin-binding proteins from chicken egg white. Mas...

journal_title：Scientific reports

authors： Guyot N,Labas V,Harichaux G,Chessé M,Poirier JC,Nys Y,Réhault-Godbert S

更新日期：2016-06-13 00:00:00

abstract：:Psychological distress induces oxidative stress and alters mitochondrial metabolism in the nervous and immune systems. Psychological distress promotes alterations in brain metabolism and neurochemistry in wild-type (WT) rats in a similar manner as in Parkinsonian rats lacking endogenous PTEN-induced kinase 1 (PINK1), ...

journal_title：Scientific reports

authors： Grigoruţă M,Dagda RK,Díaz-Sánchez ÁG,Martínez-Martínez A

更新日期：2020-06-17 00:00:00

abstract：:Macrophages are potent immune cells with well-established roles in the response to stress, injury, infection and inflammation. The classically activated macrophages (M1) are induced by lipopolysaccharide (LPS) and express a wide range of pro-inflammatory genes. M2 macrophages are induced by T helper type 2 cytokines s...

journal_title：Scientific reports

authors： Moraes LA,Kar S,Foo SL,Gu T,Toh YQ,Ampomah PB,Sachaphibulkij K,Yap G,Zharkova O,Lukman HM,Fairhurst AM,Kumar AP,Lim LHK

更新日期：2017-12-20 00:00:00

abstract：:Mutations in the SNX14 gene cause spinocerebellar ataxia, autosomal recessive 20 (SCAR20) in both humans and dogs. Studies implicating the phenotypic consequences of SNX14 mutations to be consequences of subcellular disruption to autophagy and lipid metabolism have been limited to in vitro investigation of patient-der...

journal_title：Scientific reports

authors： Bryant D,Seda M,Peskett E,Maurer C,Pomeranz G,Ghosh M,Hawkins TA,Cleak J,Datta S,Hariri H,Eckert KM,Jafree DJ,Walsh C,Demetriou C,Ishida M,Alemán-Charlet C,Vestito L,Seselgyte R,McDonald JG,Bitner-Glindzicz M,Hemb

更新日期：2020-08-13 00:00:00

abstract：:A novel strategy for amplification full-length cDNA and promoter sequences has been developed using bioinformatics technology and multiplexed PCR methods in this study. The amplification of 3' ends of cDNA is performed according to the modified classic 3' RACE techniques, therein the more efficient and effective oligo...

journal_title：Scientific reports

authors： Chen N,Wang WM,Wang HL

更新日期：2016-01-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Liu H,Lv P,Zhu Y,Wu H,Zhang K,Xu F,Zheng L,Zhao J

更新日期：2020-09-09 00:00:00

abstract：:The aim of this study was to analyse postoperative haemorrhage (POH) after a total thyroidectomy and explore the possible risk factors. Records of patients receiving a total thyroidectomy were reviewed and analysed for risk factors of POH. From the 2,678 patients in this study, a total of 39 patients had POH, represen...

journal_title：Scientific reports

authors： Zhang X,Du W,Fang Q

更新日期：2017-08-01 00:00:00

abstract：:The novel nuclear protein nBMP2 is synthesized from the BMP2 gene by translational initiation at an alternative start codon. We generated a targeted mutant mouse, nBmp2NLStm, in which the nuclear localization signal (NLS) was inactivated to prevent nuclear translocation of nBMP2 while still allowing the normal synthes...

journal_title：Scientific reports

authors： Cordner RD,Friend LN,Mayo JL,Badgley C,Wallmann A,Stallings CN,Young PL,Miles DR,Edwards JG,Bridgewater LC

更新日期：2017-04-18 00:00:00

abstract：:Accumulating evidence implies that cell fusion is one of the driving forces of cancer invasion and metastasis. However, considerably less is still known about the triggering factors and underlying mechanisms associated with cancer-host cell fusion, particularly in inflammatory tumor microenvironment. In this study, we...

journal_title：Scientific reports

authors： Yan TL,Wang M,Xu Z,Huang CM,Zhou XC,Jiang EH,Zhao XP,Song Y,Song K,Shao Z,Liu K,Shang ZJ

更新日期：2017-01-23 00:00:00

abstract：:Raman microspectroscopy provides the means to obtain local orientations on polycrystalline materials at the submicrometer level. The present work demonstrates how orientation-distribution maps composed of Raman intensity distributions can be acquired on large areas of several hundreds of square micrometers. A polycrys...

journal_title：Scientific reports

authors： Schmid T,Schäfer N,Levcenko S,Rissom T,Abou-Ras D

更新日期：2015-12-17 00:00:00

abstract：:Two decades ago, a phenomenon resembling Landau damping was described in the synchronization of globally coupled oscillators: the evidence of a regime where the order parameter decays when linear theory predicts neutral stability for the incoherent state. We here show that such an effect is far more generic, as soon a...

journal_title：Scientific reports

authors： Qiu T,Zhang Y,Liu J,Bi H,Boccaletti S,Liu Z,Guan S

更新日期：2015-12-14 00:00:00

abstract：:Phagocytosis is a required mechanism for the defense against pathogens. Staphylococcus aureus, an important bacterial pathogen, can promptly escape from phagosomes and proliferate within the cytoplasm of host. However, the mechanism of phagocytosis against S. aureus has not been intensively investigated. In this study...

journal_title：Scientific reports

authors： Zhu F,Zhou Y,Jiang C,Zhang X

更新日期：2015-10-07 00:00:00

abstract：:Regulation of the chromatin state is crucial for biological processes such as the regulation of transcription, DNA replication, and DNA damage repair. Here we show that knockdown of the BRD8 bromodomain protein - a subunit of the p400/Tip60 complex - leads to p21 induction, and concomitant cell cycle arrest in G1/S. W...

journal_title：Scientific reports

authors： Lashgari A,Fauteux M,Maréchal A,Gaudreau L

更新日期：2018-09-20 00:00:00

abstract：:The Andaman day gecko (Phelsuma andamanensis) is endemic to the Andaman Archipelago, located ~ 6000 km away from Madagascar where the genus Phelsuma likely evolved. We complemented existing phylogenetic data with additional markers to show that this species consistently branches off early in the evolution of the genus...

journal_title：Scientific reports

authors： Mohan AV,Orozco-terWengel P,Shanker K,Vences M

更新日期：2020-07-16 00:00:00

abstract：:Recent studies demonstrate that the invasion and metastasis of gastric cancer (GC) is closely associated with a multi-subunit vacuolar H+-ATPase (V-ATPase). Here we investigated the expression and role of the human ATP6V1A gene that encodes the catalytic subunit A of V-ATPase in GC. We found that ATP6V1A expression le...

journal_title：Scientific reports

authors： Wang P,Wang L,Sha J,Lou G,Lu N,Hang B,Mao JH,Zou X

更新日期：2017-06-07 00:00:00

abstract：:Reporter gene imaging allows for non-invasive monitoring of molecular processes in living cells, providing insights on the mechanisms underlying pathology and therapy. A lysine-rich protein (LRP) chemical exchange saturation transfer (CEST) MRI reporter gene has previously been developed and used to image tumor cells,...

journal_title：Scientific reports

authors： Perlman O,Ito H,Gilad AA,McMahon MT,Chiocca EA,Nakashima H,Farrar CT

更新日期：2020-11-26 00:00:00

abstract：:It is well established that topographical features modulate cell behaviour, including cell morphology, proliferation and differentiation. To define the effects of topography on human induced pluripotent stem cells (iPSC), we plated cells on a topographical library containing over 1000 different features in medium lack...

journal_title：Scientific reports

authors： Reimer A,Vasilevich A,Hulshof F,Viswanathan P,van Blitterswijk CA,de Boer J,Watt FM

更新日期：2016-01-13 00:00:00