Parallel expression profiling of hepatic and serum microRNA-122 associated with clinical features and treatment responses in chronic hepatitis C patients.

abstract：:Bone is the most common site of distant relapse in breast cancer, leading to severe complications which dramatically affect the patients' quality of life. It is believed that the crosstalk between metastatic breast cancer cells and osteoclasts is critical for breast cancer-induced osteolysis. In this study, the effect...

journal_title：Scientific reports

authors： Feng MX,Hong JX,Wang Q,Fan YY,Yuan CT,Lei XH,Zhu M,Qin A,Chen HX,Hong D

更新日期：2016-01-08 00:00:00

abstract：:The formation of amyloid-β plaques is one of the hallmarks of Alzheimer's disease. The presence of an amphiphatic cell membrane can accelerate the formation of amyloid-β aggregates, making it a potential druggable target to delay the progression of Alzheimer's disease. We have prepared unsaturated anionic membranes ma...

journal_title：Scientific reports

authors： Khondker A,Alsop RJ,Himbert S,Tang J,Shi AC,Hitchcock AP,Rheinstädter MC

更新日期：2018-08-17 00:00:00

abstract：:The microbial community during fermented vegetable production has a large impact on the quality of the final products. Lactic acid bacteria have been well-studied in such processes, but knowledge about the roles of non-lactic acid bacteria is limited. This study aimed to provide useful knowledge about the relationship...

journal_title：Scientific reports

authors： Sawada K,Koyano H,Yamamoto N,Yamada T

更新日期：2021-01-19 00:00:00

abstract：:Knockin (KI) mouse carrying a point mutation has been an invaluable tool for disease modeling and analysis. Genome editing technologies using the CRISPR/Cas system has emerged as an alternative way to create KI mice. However, if the mice carry nucleotide insertions and/or deletions (InDels) in other genes, which could...

journal_title：Scientific reports

authors： Nakajima K,Kazuno AA,Kelsoe J,Nakanishi M,Takumi T,Kato T

更新日期：2016-10-04 00:00:00

abstract：:Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, espe...

journal_title：Scientific reports

authors： Lu J,Shao Y,Qin X,Liu D,Chen A,Li D,Liu M,Wang X

更新日期：2017-02-20 00:00:00

abstract：:Isoliquiritigenin (ISL), a natural flavonoid extracted from licorice, has been demonstrated to exert attenuation of osteoclastogenesis and anti-angiogenesis activity in a wide variety of cells. Here, we first evaluated the effects of ISL on pathogenesis of osteoarthritis in a mouse model of OA. The data showed that IS...

journal_title：Scientific reports

authors： Ji B,Zhang Z,Guo W,Ma H,Xu B,Mu W,Amat A,Cao L

更新日期：2018-01-29 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Zaluski R,Bittarello AC,Vieira JCS,Braga CP,Padilha PM,Fernandes MDS,Bovi TS,Orsi RO

更新日期：2020-04-07 00:00:00

abstract：:Alternative splicing of cancer-related genes is a common cellular mechanism accounting for cancer cell transcriptome complexity and affecting cell cycle control, proliferation, apoptosis, angiogenesis, invasion, and metastasis. In this study, we describe the discovery and molecular cloning of thirty novel transcripts ...

journal_title：Scientific reports

authors： Adamopoulos PG,Kontos CK,Scorilas A

更新日期：2017-12-11 00:00:00

abstract：:L-asparaginase is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL). The main prerequisite for clinical efficacy of L-asparaginases is micromolar KM for asparagine to allow for complete depletion of this amino acid in the blood. Since currently approved L-asparaginases are of bacterial origin, immun...

journal_title：Scientific reports

authors： Rigouin C,Nguyen HA,Schalk AM,Lavie A

更新日期：2017-08-31 00:00:00

abstract：:Using two different hydrosilylation methods, low temperature thermal and UV initiation, silicon (111) hydrogenated surfaces were functionalized in presence of an OH-terminated alkyne, a CF3-terminated alkyne and a mixed equimolar ratio of the two alkynes. XPS studies revealed that in the absence of premeditated surfac...

journal_title：Scientific reports

authors： Khung YL,Ngalim SH,Scaccabarozi A,Narducci D

更新日期：2015-06-12 00:00:00

abstract：:Dual terahertz (THz) comb spectroscopy enables high spectral resolution, high spectral accuracy, and broad spectral coverage; however, the requirement for dual stabilized femtosecond lasers hampers its versatility. We here report the first demonstration of dual THz comb spectroscopy using a single free-running fibre l...

journal_title：Scientific reports

authors： Hu G,Mizuguchi T,Oe R,Nitta K,Zhao X,Minamikawa T,Li T,Zheng Z,Yasui T

更新日期：2018-07-24 00:00:00

abstract：:Unimpaired readers process words incredibly fast and hence it was assumed that top-down processing, such as predicting upcoming words, would be too slow to play an appreciable role in reading. This runs counter the major postulate of the predictive coding framework that our brain continually predicts probable upcoming...

journal_title：Scientific reports

authors： Hawelka S,Schuster S,Gagl B,Hutzler F

更新日期：2015-02-13 00:00:00

abstract：:We study the driven translocation of a semi-flexible polymer through a nanopore by means of a modified version of the iso-flux tension propagation theory, and extensive molecular dynamics (MD) simulations. We show that in contrast to fully flexible chains, for semi-flexible polymers with a finite persistence length [F...

journal_title：Scientific reports

authors： Sarabadani J,Ikonen T,Mökkönen H,Ala-Nissila T,Carson S,Wanunu M

更新日期：2017-08-07 00:00:00

abstract：:Genome engineering is a rapidly evolving field that benefits from the availability of different tools that can be used to perform genome manipulation tasks. We describe here the development of the Flp-TAL recombinases that can target genomic FRT-like sequences in their native chromosomal locations. Flp-TAL recombinase...

journal_title：Scientific reports

authors： Voziyanova E,Li F,Shah R,Voziyanov Y

更新日期：2020-10-15 00:00:00

abstract：:Transforming growth factor-β/Smad3 signaling plays a critical role in the process of chronic kidney disease (CKD), but targeting Smad3 systematically may cause autoimmune disease by impairing immunity. In this study, we used whole-transcriptome RNA-sequencing to identify the differential gene expression profile, gene ...

journal_title：Scientific reports

authors： Zhou Q,Xiong Y,Huang XR,Tang P,Yu X,Lan HY

更新日期：2015-12-09 00:00:00

abstract：:Elevated emissions of sulfur dioxide, nitrogen oxides and ammonia in China have resulted in high levels of sulfur and nitrogen deposition, being contributors to soil acidification, especially in and near large cities. However, knowledge gaps still exist in the way that large cities shape spatial patterns of acid depos...

journal_title：Scientific reports

authors： Du E,de Vries W,Liu X,Fang J,Galloway JN,Jiang Y

更新日期：2015-07-27 00:00:00

abstract：:Recent studies have discovered an intriguing nonstationary relationship between El Ninõ-Southern Oscillation (ENSO) and the Western Pacific (WP) teleconnection pattern, one of the most prominent winter atmospheric circulation patterns in the North Pacific, with a regime-dependent interdecadal modulation of significant...

journal_title：Scientific reports

authors： Park YH,Kim BM,Pak G,Yamamoto M,Vivier F,Durand I

更新日期：2018-06-22 00:00:00

abstract：:The relationship among the single nucleotide polymorphisms (SNPs) of the C-X-C motif chemokine ligand 12 gene (CXCL12) and the serum lipid profiles in the Chinese population has rarely been described, especially in somewhat old-fashioned and isolated Maonan minority. The goal of the current study was to elucidate the ...

journal_title：Scientific reports

authors： Qiu L,Yin RX,Nie RJ,Hu XJ,Khounphinith E,Zhang FH

更新日期：2019-12-20 00:00:00

abstract：:Nanodiamonds containing high density ensembles of negatively charged nitrogen-vacancy (NV(-)) centers are promising fluorescent biomarkers due to their excellent photostability and biocompatibility. The NV(-) centers in the particles have a fluorescence lifetime of up to 20 ns, which distinctly differs from those (<10...

journal_title：Scientific reports

authors： Hui YY,Su LJ,Chen OY,Chen YT,Liu TM,Chang HC

更新日期：2014-07-04 00:00:00

abstract：:We report abnormal magnetic field effects on electrogenerated chemiluminescence (MFEECL) based on triplet emission from the Ru(bpy)3Cl2-TPrA electrochemical system: the appearance of MFEECL after magnetic field ceases. In early studies the normal MFEECL have been observed from electrochemical systems during the applic...

journal_title：Scientific reports

authors： Pan H,Shen Y,Wang H,He L,Hu B

更新日期：2015-03-16 00:00:00

abstract：:Salt crystallization is a major cause of weathering of rocks, artworks and monuments. Damage can only occur if crystals continue to grow in confinement, i.e. within the pore space of these materials, thus generating mechanical stress. We report the direct measurement, at the microscale, of the force exerted by growing...

journal_title：Scientific reports

authors： Desarnaud J,Bonn D,Shahidzadeh N

更新日期：2016-08-05 00:00:00

abstract：:Guppy (Poecilia reticulata) is an ideal model for studying environmental estrogens, and its large caudal fin has a high capacity to regenerate. This study analyzed the feasibility of caudal fin for detecting vitellogenin (Vtg), the most commonly used biomarker of environmental estrogens. Firstly, a sandwich ELISA for ...

journal_title：Scientific reports

authors： Wang J,Ma S,Zhang Z,Zheng M,Dong Y,Ru S

更新日期：2017-08-09 00:00:00

abstract：:The study of the synchronization patterns of small neuron networks that control several biological processes has become an interesting growing discipline. Some of these synchronization patterns of individual neurons are related to some undesirable neurological diseases, and they are believed to play a crucial role in ...

journal_title：Scientific reports

authors： Lozano Á,Rodríguez M,Barrio R

更新日期：2016-03-29 00:00:00

abstract：:Two supramolecular complexes of trans-1⊂CB[8] and trans-2⊂CB[8] were successfully achieved by the controlled selective complexation process of cucurbit[8]uril (CB[8]) with hetero-guest pair containing azobenzene and bispyridinium moieties in aqueous solution, exhibiting the reversibly light-driven movements of CB[8] u...

journal_title：Scientific reports

authors： Cheng HB,Zhang YM,Xu C,Liu Y

更新日期：2014-02-27 00:00:00

abstract：:The loss of retinal pericytes (RPCs) is a hallmark of early stage diabetic retinopathy (DR), but the mechanism underlying RPC death is unclear. Although it was postulated in previous studies using bovine RPCs that autoantibodies against RPCs might develop and induce RPC death, it is unknown whether autoantibodies agai...

journal_title：Scientific reports

authors： Zhang L,Li Y,Payne J,Srivastava S,Fan X,Fung J,Li X,Kern TS,Lin F

更新日期：2016-02-03 00:00:00

abstract：:Drug repositioning strategies have improved substantially in recent years. At present, two advances are poised to facilitate new strategies. First, the LINCS project can provide rich transcriptome data that reflect the responses of cells upon exposure to various drugs. Second, machine learning algorithms have been app...

journal_title：Scientific reports

authors： Xie L,He S,Wen Y,Bo X,Zhang Z

更新日期：2017-08-02 00:00:00

abstract：:The ability to form mineral structures under biological control is widespread among animals. In several species, specific proteins have been shown to be involved in biomineralization, but it is uncertain how they influence the shape of the growing biomineral and the resulting skeleton. Calcareous sponges are the only ...

journal_title：Scientific reports

authors： Voigt O,Adamska M,Adamski M,Kittelmann A,Wencker L,Wörheide G

更新日期：2017-04-13 00:00:00

abstract：:Cellular reprogramming involves profound alterations in genome-wide gene expression that is precisely controlled by a hypothetical epigenetic code. Small molecules have been shown to artificially induce epigenetic modifications in a sequence independent manner. Recently, we showed that specific DNA binding hairpin pyr...

journal_title：Scientific reports

authors： Pandian GN,Nakano Y,Sato S,Morinaga H,Bando T,Nagase H,Sugiyama H

更新日期：2012-01-01 00:00:00

abstract：:We investigated if fermentation with probiotic cultures could improve the production of health-promoting biological compounds in Astragalus membranaceus. We tested the probiotics Enterococcus faecium, Lactobacillus plantarum and Enterococcus faecium + Lactobacillus plantarum and applied PacBio single molecule, real-ti...

journal_title：Scientific reports

authors： Qiao H,Zhang X,Shi H,Song Y,Bian C,Guo A

更新日期：2018-08-08 00:00:00

abstract：:The potency of cellular immune responses strongly depends on T cell avidity to antigen. Yet, functional avidity measurements are rarely performed in patients, mainly due to the technical challenges of characterizing heterogeneous T cells. The mean functional T cell avidity can be determined by the IFN-γ Elispot assay,...

journal_title：Scientific reports

authors： Ioannidou K,Baumgaertner P,Gannon PO,Speiser MF,Allard M,Hebeisen M,Rufer N,Speiser DE

更新日期：2017-03-13 00:00:00