Abstract：
:The ability to form mineral structures under biological control is widespread among animals. In several species, specific proteins have been shown to be involved in biomineralization, but it is uncertain how they influence the shape of the growing biomineral and the resulting skeleton. Calcareous sponges are the only sponges that form calcitic spicules, which, based on the number of rays (actines) are distinguished in diactines, triactines and tetractines. Each actine is formed by only two cells, called sclerocytes. Little is known about biomineralization proteins in calcareous sponges, other than that specific carbonic anhydrases (CAs) have been identified, and that uncharacterized Asx-rich proteins have been isolated from calcitic spicules. By RNA-Seq and RNA in situ hybridization (ISH), we identified five additional biomineralization genes in Sycon ciliatum: two bicarbonate transporters (BCTs) and three Asx-rich extracellular matrix proteins (ARPs). We show that these biomineralization genes are expressed in a coordinated pattern during spicule formation. Furthermore, two of the ARPs are spicule-type specific for triactines and tetractines (ARP1 or SciTriactinin) or diactines (ARP2 or SciDiactinin). Our results suggest that spicule formation is controlled by defined temporal and spatial expression of spicule-type specific sets of biomineralization genes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Voigt O,Adamska M,Adamski M,Kittelmann A,Wencker L,Wörheide Gdoi
10.1038/srep45658subject
Has Abstractpub_date
2017-04-13 00:00:00pages
45658issn
2045-2322pii
srep45658journal_volume
7pub_type
杂志文章abstract：:Multiple predatory insect lineages have developed a raptorial lifestyle by which they strike and hold prey using modified forelegs armed with spine-like structures and other integumentary specialisations. However, how structures enabling the raptorial function evolved in insects remains largely hypothetical or inferre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49398-1
更新日期：2019-09-13 00:00:00
abstract：:In April 2012 we carried out a 1-year hematological study on a population of wild Japanese monkeys inhabiting the forest area of Fukushima City. This area is located 70 km from the Fukushima Daiichi Nuclear Power Plant (NPP), which released a large amount of radioactive material into the environment following the Grea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05793
更新日期：2014-07-24 00:00:00
abstract：:We report the molecular basis of the largest Tunisian cohort with inherited retinal dystrophies (IRD) reported to date, identify disease-causing pathogenic variants and describe genotype-phenotype correlations. A subset of 26 families from a cohort of 73 families with clinical diagnosis of autosomal recessive IRD (AR-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67792-y
更新日期：2020-07-08 00:00:00
abstract：:Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and comp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45557
更新日期：2017-04-03 00:00:00
abstract：:It is generally believed that anthropogenic aerosols cool the atmosphere; therefore, they offset the global warming resulting from greenhouse gases to some extent. Reduction in sulphate, a primary anthropogenic aerosol, is necessary for mitigating air pollution, which causes atmospheric warming. Here, the changes in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78805-1
更新日期：2020-12-10 00:00:00
abstract：:Previous studies have documented that decompression led to endothelial dysfunction with controversial results. This study aimed to clarify the relationship between endothelial dysfunction, bubble formation and decompression rate. Rats were subjected to simulated air dives with one of four decompression rates: one slow...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33390
更新日期：2016-09-12 00:00:00
abstract：:Central visual field (CVF) loss has been linked to poorer vision-related quality of life in eyes with open-angle glaucoma (OAG) and can occur even in early-stage OAG eyes. The present study investigated whether the detection of choroidal microvasculature dropout (CMvD) during follow-up, which may be a sign of perfusio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44942-5
更新日期：2019-06-12 00:00:00
abstract：:Childhood and adolescent overweight and obesity are increasing in China, but limited information is available on its secular trends in Guangzhou. In this cross-sectional study, ten-wave successive data were obtained from the physical fitness surveillance for students in Guangzhou from 2003 to 2012. A total of 2,619,15...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-12094-z
更新日期：2017-09-21 00:00:00
abstract：:Bradysia odoriphaga and Bradysia difformis are devastating pests of vegetable, ornamental crops and edible mushrooms causing significant losses. Temperature may be an important factor restricting their population abundance in the summer. To determine the effects of short-term heat shock on adults, their survival, long...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13560-4
更新日期：2017-10-17 00:00:00
abstract：:R.PabI is a type II restriction enzyme that recognizes the 5'-GTAC-3' sequence and belongs to the HALFPIPE superfamily. Although most restriction enzymes cleave phosphodiester bonds at specific sites by hydrolysis, R.PabI flips the guanine and adenine bases of the recognition sequence out of the DNA helix and hydrolyz...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35197
更新日期：2016-10-12 00:00:00
abstract：:The intensity and frequency of precipitation events are predicted to change over the coming decades. For many areas, longer periods without rainfall are expected. We investigated the importance of irrigation frequency under water deficit conditions for growth, physiology and chemistry of wheat (Triticum aestivum). Dro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66812-1
更新日期：2020-06-22 00:00:00
abstract：:We examined the physical and mechanical properties of wood in Siberian larch (Larix sibirica) trees that grow naturally in five Mongolian provenances (Khentii, Arkhangai, Zavkhan, Khuvsgul, and Selenge) and the geographic variations between them. Five trees with stem diameters of 20 to 30 cm at 1.3 m above ground were...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69781-7
更新日期：2020-07-31 00:00:00
abstract：:Hearing impairment is one of the most common sensory deficits in humans. Hearing aids are helpful to patients but can have poor sound quality or transmission due to insufficient output or acoustic feedback, such as for high frequencies. Implantable devices partially overcome these issues but require surgery with limit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40860-8
更新日期：2019-03-12 00:00:00
abstract：:Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, a time when most single-copy sex-linked genes are transcriptionally repressed. This observation led to the hypoth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27360-x
更新日期：2018-06-12 00:00:00
abstract：:This study investigates the efficacy of systemic growth hormone (GH) therapy in ameliorating the deleterious effects of chronic denervation (CD) injury on nerve regeneration and resulting motor function. Using a forelimb CD model, 4 groups of Lewis rats were examined (n = 8 per group): Group-1 (negative control) 8 wee...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39738-6
更新日期：2019-02-28 00:00:00
abstract：:Rift Valley fever virus (RVFV) is a mosquito-borne hemorrhagic fever virus affecting both humans and animals with severe morbidity and mortality and is classified as a potential bioterror agent due to the possible aerosol transmission. At present there is no human vaccine or antiviral therapy available. Thus, there is...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20362-9
更新日期：2018-01-31 00:00:00
abstract：:The gut of Drosophila melanogaster includes a proximal acidic region (~pH 2), however the genome lacks the H(+)/K(+) ATPase characteristic of the mammalian gastric parietal cell, and the molecular mechanisms of acid generation are poorly understood. Here, we show that maintenance of the low pH of the acidic region is ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27242
更新日期：2016-06-02 00:00:00
abstract：:Hatching out from the zona pellucida (ZP) is a crucial step for blastocyst implantation and development. However, it is still unknown whether the location of the hatching site relative to the inner cell mass (ICM) affects embryo implantation and foetal development. Here, we classified hatching blastocysts into three c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59424-2
更新日期：2020-02-12 00:00:00
abstract：:The reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) can be achieved by ectopic expression of defined transcription factors (Oct3/4, Sox2, Klf4 and c-Myc). However, to date, some iPSCs have been generated using viral vectors; thus, unexpected insertional mutagenesis in the target cells...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07323
更新日期：2014-12-04 00:00:00
abstract：:Alkaline sulfide-rich hot springs provide a unique environment for microbial community and arsenic (As) biogeochemistry. In this study, a representative alkaline sulfide-rich hot spring, Zimeiquan in the Tengchong geothermal area, was chosen to study arsenic geochemistry and microbial community using Illumina MiSeq se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25262
更新日期：2016-04-29 00:00:00
abstract：:The detection and assessment of intravascular filling defects is important, because they may represent a process central to cerebral malaria pathogenesis: neurovascular sequestration. We have developed and validated a framework that can automatically detect intravascular filling defects in fluorescein angiogram images...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11154
更新日期：2015-06-08 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-24098-4
更新日期：2018-04-12 00:00:00
abstract：:A coherent anti-Stokes Raman scattering (CARS) rigid endoscope was developed to visualize peripheral nerves without labeling for nerve-sparing endoscopic surgery. The developed CARS endoscope had a problem with low imaging speed, i.e. low imaging rate. In this study, we demonstrate that noise reduction with deep learn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72241-x
更新日期：2020-09-16 00:00:00
abstract：:Functional neuroimaging, using genetically-encoded Ca2+ sensors in larval zebrafish, offers a powerful combination of high spatiotemporal resolution and higher vertebrate relevance for quantitative neuropharmacological profiling. Here we use zebrafish larvae with pan-neuronal expression of GCaMP6s, combined with light...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06646-6
更新日期：2017-07-26 00:00:00
abstract：:Application of metabolic magnetic resonance imaging measures such as cerebral blood flow in translational medicine is limited by the unknown link of observed alterations to specific neurophysiological processes. In particular, the sensitivity of cerebral blood flow to activity changes in specific neurotransmitter syst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22444-0
更新日期：2018-03-06 00:00:00
abstract：:Maintaining vigilance over long periods of time is especially critical in performing fundamental everyday activities and highly responsible professional tasks (e.g., driving, performing surgery or piloting). Here, we investigated the role of aerobic fitness as a crucial factor related to the vigilance capacity. To thi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27556
更新日期：2016-06-08 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-57826-w
更新日期：2020-01-15 00:00:00
abstract：:We evaluated regression of iris neovascularization (INV) using en-face anterior-segment optical coherence tomography angiography (AS-OCTA) after anti-vascular endothelial growth factor (VEGF) therapy. Seven consecutive eyes with INV were examined before and after anti-VEGF therapy, and all AS-OCTA scans were obtained ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46514-z
更新日期：2019-07-16 00:00:00
abstract：:We perform this meta-analysis to compare the efficacy and safety of cryoablation versus radiofrequency ablation for patients with cavotricuspid valve isthmus dependent atrial flutter. By searching EMBASE, MEDLINE, PubMed and Cochrane electronic databases from March 1986 to September 2014, 7 randomized clinical trials ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep10910
更新日期：2015-06-03 00:00:00
abstract：:Monitoring one's actions is essential for goal-directed performance. In the event-related potential (ERP), errors are followed by fronto-centrally distributed negativities. These error(-related) negativity (Ne/ERN) amplitudes are often found to be attenuated in patients with Parkinson's disease (PD) compared to health...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41222
更新日期：2017-01-24 00:00:00
