Blastocyst hatching site is regularly distributed and does not influence foetal development in mice.

Abstract:

:Hatching out from the zona pellucida (ZP) is a crucial step for blastocyst implantation and development. However, it is still unknown whether the location of the hatching site relative to the inner cell mass (ICM) affects embryo implantation and foetal development. Here, we classified hatching blastocysts into three categories, 0° ≤ θ ≤ 30°, 30° < θ ≤ 60°, and 60° < θ ≤ 90°, in which θ is determined based on the relative position of the hatching site to the arc midpoint of the ICM. Non-surgical embryo transfer (NSET) devices were employed to evaluate blastocyst implantation and embryo development. Of 1,827 hatching blastocysts, 43.84%, 30.60%, and 21.67% were categorized as 30° < θ ≤ 60°, 0° ≤ θ ≤ 30°, and 60° < θ ≤ 90°, respectively. Embryos with different hatching sites showed no distinct differences in blastocyst implantation; surrogate female pregnancy; embryo development to term; litter size, or offspring survival, gender, or body weight. Our results indicate that mouse blastocyst hatching site is not randomly distributed. Embryo implantation and development are not correlated with the blastocyst hatching site in mice. Thus, assessment of the blastocyst hatching site should not be recommended to evaluate mouse blastocyst implantation and developmental potential.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Liu SJ,Sun JB,Hao X,Han Z,Wen X,Wang XY,Zhou CJ,Liang CG

doi

10.1038/s41598-020-59424-2

subject

Has Abstract

pub_date

2020-02-12 00:00:00

pages

2475

issue

1

issn

2045-2322

pii

10.1038/s41598-020-59424-2

journal_volume

10

pub_type

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