Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes.

abstract：:Roquins are a family of highly conserved RNA-binding proteins that also contain a RING-type E3 ubiquitin ligase domain. They repress constitutive decay elements containing mRNAs and play a critical role in RNA homeostasis and immunological self-tolerance. Here we present the crystal structures of the RNA-binding regio...

journal_title：Scientific reports

authors： Zhang Q,Fan L,Hou F,Dong A,Wang YX,Tong Y

更新日期：2015-10-22 00:00:00

abstract：:This study was to evaluate the prognostic value of pretreatment inflammatory indexes including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) in colorectal cancer (CRC) patients receiving neoadjuvant chemoradiot...

journal_title：Scientific reports

authors： Yang J,Xu H,Guo X,Zhang J,Ye X,Yang Y,Ma X

更新日期：2018-02-14 00:00:00

abstract：:The epidermis of snakes efficiently protects against dehydration and mechanical stress. However, only few proteins of the epidermal barrier to the environment have so far been identified in snakes. Here, we determined the organization of the Epidermal Differentiation Complex (EDC), a cluster of genes encoding protein ...

journal_title：Scientific reports

authors： Holthaus KB,Mlitz V,Strasser B,Tschachler E,Alibardi L,Eckhart L

更新日期：2017-03-27 00:00:00

abstract：:Porous carbon spheres (CSs) have distinct advantages in energy storage and conversion applications. We report the preparation of highly monodisperse N-doped microporous CSs through the carbonization of polystyrene-based polymer spheres and subsequent activation. The N-doped microporous CSs have a remarkably high N-dop...

journal_title：Scientific reports

authors： Kim C,Kim K,Moon JH

更新日期：2017-10-31 00:00:00

abstract：:Asbestos is a potent carcinogen associated with malignant mesothelioma and lung cancer but its carcinogenic mechanisms are still poorly understood. Asbestos toxicity is ascribed to its particular physico-chemical characteristics, and one of them is the presence of and ability to adsorb iron, which may cause an alterat...

journal_title：Scientific reports

authors： Pascolo L,Gianoncelli A,Schneider G,Salomé M,Schneider M,Calligaro C,Kiskinova M,Melato M,Rizzardi C

更新日期：2013-01-01 00:00:00

abstract：:Protein analysis using high-performance thin-layer chromatography (HPTLC) is not commonly used but can complement traditional electrophoretic and mass spectrometric approaches in a unique way. Due to various detection protocols and possibilities for hyphenation, HPTLC protein analysis is a promising alternative for e....

journal_title：Scientific reports

authors： Morschheuser L,Wessels H,Pille C,Fischer J,Hünniger T,Fischer M,Paschke-Kratzin A,Rohn S

更新日期：2016-05-25 00:00:00

abstract：:Aryl nitriles are versatile compounds that can be synthesized via transition-metal-mediated cyanation of aryl halides. Most of the supported-heterogeneous catalysts are noble-metals based and there are very limited numbers of efficient non-noble metal based catalysts demonstrated for the cyanation of aryl halides. Her...

journal_title：Scientific reports

authors： Mayakrishnan G,Elayappan V,Kim IS,Chung IM

更新日期：2020-01-20 00:00:00

abstract：:The present study investigated the effect of aldehyde dehydrogenase2 (ALDH2) rs671 polymorphism and alcohol consumption on the severity of primary open-angle glaucoma (POAG). The questionnaire for alcohol consumption pattern and targeted genotyping for ALDH2 rs671 polymorphism was performed from 445 Korean POAG patien...

journal_title：Scientific reports

authors： Han YS,Kim YW,Kim YJ,Park KH,Jeoung JW

更新日期：2020-10-15 00:00:00

abstract：:Auxin response factors (ARFs) are the transcription factors that regulate auxin responses in various aspects of plant growth and development. Although genome-wide analysis of ARF gene family has been done in some species, no information is available regarding ARF genes in chickpea. In this study, we identified 28 ARF ...

journal_title：Scientific reports

authors： Singh VK,Rajkumar MS,Garg R,Jain M

更新日期：2017-09-07 00:00:00

abstract：:Increasing evidence indicates that miRNAs play a vital role in biological processes and are closely related to various human diseases. Research on miRNA-disease associations is helpful not only for disease prevention, diagnosis and treatment, but also for new drug identification and lead compound discovery. A novel se...

journal_title：Scientific reports

authors： Li J,Chen X,Huang Q,Wang Y,Xie Y,Dai Z,Zou X,Li Z

更新日期：2020-10-21 00:00:00

abstract：:In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma, we generated superoxide anion (O2(-)), hydroxyl radical (HO·), and hydrogen per...

journal_title：Scientific reports

authors： Kaushik N,Uddin N,Sim GB,Hong YJ,Baik KY,Kim CH,Lee SJ,Kaushik NK,Choi EH

更新日期：2015-02-26 00:00:00

abstract：:Cyanobacteria are a diverse group of photosynthetic bacteria that exhibit phototaxis, or motion in response to light. Cyanobacteria such as Synechocystis sp. secrete a mixture of complex polysaccharides that facilitate cell motion, while their type 4 pili allow them to physically attach to each other. Even though cell...

journal_title：Scientific reports

authors： Varuni P,Menon SN,Menon GI

更新日期：2017-12-19 00:00:00

abstract：:Vitamin D may reduce mortality from prostate cancer (PC). We examined the associations of post-treatment plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations with PC mortality. Participants were PC cases from the New South Wales Prostate Cancer Care. All contactable and consenting participants, at 4.9...

journal_title：Scientific reports

authors： Nair-Shalliker V,Bang A,Egger S,Clements M,Gardiner RA,Kricker A,Seibel MJ,Chambers SK,Kimlin MG,Armstrong BK,Smith DP

更新日期：2020-05-08 00:00:00

abstract：:Transition metal cobalt (Co) nanoparticle was designed as catalyst to promote the conversion reaction of Sn to SnO2 during the delithiation process which is deemed as an irreversible reaction. The designed nanocomposite, named as SnO2/Co3O4/reduced-graphene-oxide (rGO), was synthesized by a simple two-step method comp...

journal_title：Scientific reports

authors： Wang Y,Huang ZX,Shi Y,Wong JI,Ding M,Yang HY

更新日期：2015-03-17 00:00:00

abstract：:Editor's Note: this Article has been retracted; the Retraction Note is available at https://www.nature.com/articles/s41598-020-76500-9. ...

journal_title：Scientific reports

authors： Sudhakar YA,Verma RK,Pawar SC

更新日期：2020-11-26 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Lara NLM,van den Driesche S,Macpherson S,França LR,Sharpe RM

更新日期：2019-10-28 00:00:00

abstract：:In recent and future synchrotron radiation facilities, relativistic electron bunches with increasingly high charge density are needed for producing brilliant light at various wavelengths, from X-rays to terahertz. In such conditions, interaction of electron bunches with their own emitted electromagnetic fields leads t...

journal_title：Scientific reports

authors： Bielawski S,Blomley E,Brosi M,Bründermann E,Burkard E,Evain C,Funkner S,Hiller N,Nasse MJ,Niehues G,Roussel E,Schedler M,Schönfeldt P,Steinmann JL,Szwaj C,Walther S,Müller AS

更新日期：2019-07-17 00:00:00

abstract：:We report an observation of rapid (exceeding 2,000 K/s) heating of polydimethylsiloxane (PDMS), one of the most popular microchannel materials, under cyclic loadings at high (~MHz) frequencies. A microheater was developed based on the finding. The heating mechanism utilized vibration damping in PDMS induced by sound w...

journal_title：Scientific reports

authors： Ha BH,Lee KS,Destgeer G,Park J,Choung JS,Jung JH,Shin JH,Sung HJ

更新日期：2015-07-03 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is one of the most common inflammatory diseases resulting from habitual smoking. Impaired clearance of apoptotic cell by airway macrophages contributes to lung inflammation. Milk fat globule-EGF factor 8 (MFG-E8), as a link between apoptotic cells and phagocytes, facilitate...

journal_title：Scientific reports

authors： Wang Y,Luo G,Chen J,Jiang R,Zhu J,Hu N,Huang W,Cheng G,Jia M,Su B,Zhang N,Cui T

更新日期：2017-02-14 00:00:00

abstract：:Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs). Ac...

journal_title：Scientific reports

authors： Garscha U,Romp E,Pace S,Rossi A,Temml V,Schuster D,König S,Gerstmeier J,Liening S,Werner M,Atze H,Wittmann S,Weinigel C,Rummler S,Scriba GK,Sautebin L,Werz O

更新日期：2017-08-24 00:00:00

abstract：:Hominin dietary specialization is crucial to understanding the evolutionary changes of craniofacial biomechanics and the interaction of food processing methods' effects on teeth. However, the diet-related dental wear processes of the earliest European hominins remain unknown because most of the academic attention has ...

journal_title：Scientific reports

authors： Pérez-Pérez A,Lozano M,Romero A,Martínez LM,Galbany J,Pinilla B,Estebaranz-Sánchez F,Bermúdez de Castro JM,Carbonell E,Arsuaga JL

更新日期：2017-02-27 00:00:00

abstract：:Clinical benefit from trastuzumab and other anti-human epidermal growth factor receptor-2 (HER2) therapies in patients with HER2-positive gastric cancer (GC) remains limited by primary or acquired resistance. We aimed to investigate the impact of concomitant molecular alterations to HER2 amplification on the clinical ...

journal_title：Scientific reports

authors： Lee JY,Hong M,Kim ST,Park SH,Kang WK,Kim KM,Lee J

更新日期：2015-03-19 00:00:00

abstract：:Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose ...

journal_title：Scientific reports

authors： Takahashi M,Okimura Y,Iguchi G,Nishizawa H,Yamamoto M,Suda K,Kitazawa R,Fujimoto W,Takahashi K,Zolotaryov FN,Hong KS,Kiyonari H,Abe T,Kaji H,Kitazawa S,Kasuga M,Chihara K,Takahashi Y

更新日期：2011-01-01 00:00:00

abstract：:The investigation of chemical and structural dynamics in battery materials is essential to elucidation of structure-property relationships for rational design of advanced battery materials. Spatially resolved techniques, such as scanning/transmission electron microscopy (S/TEM), are widely applied to address this chal...

journal_title：Scientific reports

authors： Lin F,Markus IM,Doeff MM,Xin HL

更新日期：2014-07-16 00:00:00

abstract：:Cancer cells and non-cancer cells differ in their metabolism and they emit distinct volatile compound profiles, allowing to recognise cancer cells by their scent. Insect odorant receptors are excellent chemosensors with high sensitivity and a broad receptive range unmatched by current gas sensors. We thus investigated...

journal_title：Scientific reports

authors： Strauch M,Lüdke A,Münch D,Laudes T,Galizia CG,Martinelli E,Lavra L,Paolesse R,Ulivieri A,Catini A,Capuano R,Di Natale C

更新日期：2014-01-06 00:00:00

abstract：:The anti-diabetic biguanide drugs metformin (METF) and phenformin (PHEN) may have anti-cancer effects. Biguanides suppress plasma growth factors, but nonetheless, the view that these mitochondrial inhibitors accumulate in tumor tissue to an extent that leads to severe energetic stress or alleviation of hypoxia-induced...

journal_title：Scientific reports

authors： Iversen AB,Horsman MR,Jakobsen S,Jensen JB,Garm C,Jessen N,Breining P,Frøkiær J,Busk M

更新日期：2017-08-25 00:00:00

abstract：:Phytoplankton subsumes the great variety of unicellular photoautotrophs that perform roughly half of Earth's primary production. They achieve this despite their challenging oceanic habitat, with opposing vertical gradients of nutrients (which often limit their growth near the surface) and light (which becomes limiting...

journal_title：Scientific reports

authors： Wirtz K,Smith SL

更新日期：2020-01-24 00:00:00

abstract：:Colorectal cancer (CRC) is a cancer of growing incidence that associates with a high mortality rate worldwide. There is a poor understanding of the heterogeneity of CRC with regard to causative genetic mutations and gene regulatory mechanisms. Previous studies have identified several susceptibility genes in small-scal...

journal_title：Scientific reports

authors： Zhao M,Liu Y,Huang F,Qu H

更新日期：2016-08-01 00:00:00

abstract：:Memory function deficits induced by Alzheimer's disease (AD) are believed to be one of the causes of an increased risk of tripping in patients. Working memory contributes to accurate stepping over obstacles during locomotion, and AD-induced deficits of this memory function may lead to an increased risk of contact with...

journal_title：Scientific reports

authors： Setogawa S,Yamaura H,Arasaki T,Endo S,Yanagihara D

更新日期：2014-11-27 00:00:00

abstract：:The human β-defensin-1 (HBD1) is an antimicrobial peptide constitutively expressed by epithelial cells at mucosal surfaces. In addition to its microbicidal properties, the loss of HBD1 expression in several cancers suggests that it may also have an anti-tumor activity. Here, we investigated the link between HBD1 expre...

journal_title：Scientific reports

authors： Bonamy C,Sechet E,Amiot A,Alam A,Mourez M,Fraisse L,Sansonetti PJ,Sperandio B

更新日期：2018-12-21 00:00:00