Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions.

Abstract:

:Chronic obstructive pulmonary disease (COPD) is one of the most common inflammatory diseases resulting from habitual smoking. Impaired clearance of apoptotic cell by airway macrophages contributes to lung inflammation. Milk fat globule-EGF factor 8 (MFG-E8), as a link between apoptotic cells and phagocytes, facilitates clearance of apoptotic cells and attenuates inflammation. We sought to investigate altered expression and potential role of MFG-E8 in COPD. In this study, apoptosis was increased and the level of MFG-E8 was decreased while HMGB1 expression was increased in lung tissues of CS-exposed mice. Compared with CS-exposed WT mice, more apoptotic cells were accumulated in lung tissues of CS-exposed MFG-E8 deficiency mice. Exposure of a range of macrophages to cigarette smoke extract (CSE) resulted in decreased MFG-E8 expression. Administration of rmMFG-E8 ameliorated phagocytic ability of RAW264.7 cells and suppressed inflammatory response induced by CS-exposure. 10% CSE stimulation suppressed Rac1 membrane localization in RAW264.7 cells which was restored by administration of rmMFG-E8. MFG-E8 deficiency diminished uptake of apoptotic thymocytes by peritoneal macrophages upon CSE exposure. Overall, the findings in current work provide a novel target for diagnosing and treating COPD.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang Y,Luo G,Chen J,Jiang R,Zhu J,Hu N,Huang W,Cheng G,Jia M,Su B,Zhang N,Cui T

doi

10.1038/srep42642

subject

Has Abstract

pub_date

2017-02-14 00:00:00

pages

42642

issn

2045-2322

pii

srep42642

journal_volume

7

pub_type

杂志文章
  • A salivary metabolite signature that reflects gingival host-microbe interactions: instability predicts gingivitis susceptibility.

    abstract::Several proteins and peptides in saliva were shown to stimulate gingival wound repair, but the role of salivary metabolites in this process remains unexplored. In vitro gingival re-epithelialization kinetics were determined using unstimulated saliva samples from healthy individuals collected during an experimental gin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59988-z

    authors: Fernandez-Gutierrez MM,Imangaliyev S,Prodan A,Loos BG,Keijser BJF,Kleerebezem M

    更新日期:2020-02-20 00:00:00

  • AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells.

    abstract::The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) in both DNA and RNA. AlkB homolog 3 (ALKBH3) was als...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42271

    authors: Ueda Y,Ooshio I,Fusamae Y,Kitae K,Kawaguchi M,Jingushi K,Hase H,Harada K,Hirata K,Tsujikawa K

    更新日期:2017-02-13 00:00:00

  • Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet.

    abstract::Animals living at high altitudes have evolved distinct phenotypic and genotypic adaptations against stressful environments. We studied the adaptive patterns of altitudinal stresses on transcriptome turnover in subterranean plateau zokors (Myospalax baileyi) in the high-altitude Qinghai-Tibetan Plateau. Transcriptomes ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22483-7

    authors: Cai Z,Wang L,Song X,Tagore S,Li X,Wang H,Chen J,Li K,Frenkel Z,Gao D,Frenkel-Morgenstern M,Zhang T,Nevo E

    更新日期:2018-03-16 00:00:00

  • MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status.

    abstract::Cell competition is a cell-cell interaction by which a cell compares its fitness to that of neighboring cells. The cell with the relatively lower fitness level is the "loser" and actively eliminated, while the cell with the relatively higher fitness level is the "winner" and survives. Recent studies have shown that ce...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28383

    authors: Chiba T,Ishihara E,Miyamura N,Narumi R,Kajita M,Fujita Y,Suzuki A,Ogawa Y,Nishina H

    更新日期:2016-06-21 00:00:00

  • Author Correction: CREB-binding protein plays key roles in juvenile hormone action in the red flour beetle, Tribolium Castaneum.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-30083-8

    authors: Xu J,Roy A,Palli SR

    更新日期:2018-08-02 00:00:00

  • Directly interrogating single quantum dot labelled UvrA2 molecules on DNA tightropes using an optically trapped nanoprobe.

    abstract::In this study we describe a new methodology to physically probe individual complexes formed between proteins and DNA. By combining nanoscale, high speed physical force measurement with sensitive fluorescence imaging we investigate the complex formed between the prokaryotic DNA repair protein UvrA2 and DNA. This approa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18486

    authors: Simons M,Pollard MR,Hughes CD,Ward AD,Van Houten B,Towrie M,Botchway SW,Parker AW,Kad NM

    更新日期:2015-12-22 00:00:00

  • Link between plasminogen activator inhibitor-1 and cardiovascular risk in chronic hepatitis C after viral clearance.

    abstract::The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Mult...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42503

    authors: Chang ML,Lin YS,Pao LH,Huang HC,Chiu CT

    更新日期:2017-02-13 00:00:00

  • Quantitative assessment of maternal biomarkers related to one-carbon metabolism and neural tube defects.

    abstract::Periconceptional supplementation with folic acid reduces the occurrence of neural tube defects (NTDs). The association between maternal abnormalities in homocysteine metabolism (e.g., hyperhomocysteinaemia, folate deficiency and low vitamin B12) and the risk of NTDs-affected pregnancies has been widely evaluated in re...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/srep08510

    authors: Tang KF,Li YL,Wang HY

    更新日期:2015-03-02 00:00:00

  • Yeast two-hybrid screening for proteins that interact with PFT in wheat.

    abstract::Fusarium head blight (FHB) is a devastating disease of wheat worldwide. Fhb1 is the most consistently reported quantitative trait locus (QTL) for FHB resistance breeding. A pore-forming toxin-like (PFT) gene at Fhb1 was first cloned by map-based cloning and found to confer FHB resistance in wheat. Proteins often inter...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52030-x

    authors: He Y,Wu L,Liu X,Zhang X,Jiang P,Ma H

    更新日期:2019-10-29 00:00:00

  • Gut, oral and skin microbiome of Indian patrilineal families reveal perceptible association with age.

    abstract::The human microbiome plays a key role in maintaining host homeostasis and is influenced by age, geography, diet, and other factors. Traditionally, India has an established convention of extended family arrangements wherein three or more generations, bound by genetic relatedness, stay in the same household. In the pres...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62195-5

    authors: Chaudhari DS,Dhotre DP,Agarwal DM,Gaike AH,Bhalerao D,Jadhav P,Mongad D,Lubree H,Sinkar VP,Patil UK,Salvi S,Bavdekar A,Juvekar SK,Shouche YS

    更新日期:2020-03-30 00:00:00

  • Ovarian Hormone-dependent and Spinal ERK Activation-regulated Nociceptive Hypersensitivity in Female Rats with Acid Injection-induced Chronic Widespread Muscle Pain.

    abstract::Symptoms of chronic widespread muscle pain (CWP) meet most of the diagnostic criteria for fibromyalgia syndrome, which is prevalent in females. We used an acid injection-induced muscle pain (AIMP) model to mimic CWP. After female rats received an ovariectomy (OVX), acid saline solution was injected into the left gastr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39472-z

    authors: Chang JH,Tsai SY,Zeng YJ,Liu YC,Li CY,Chen KB,Wen YR

    更新日期:2019-02-28 00:00:00

  • Evolution of Sex Determination Loci in Atlantic Salmon.

    abstract::Teleost fish exhibit a remarkable diversity in the control of sex determination, offering the opportunity to identify novel differentiation mechanisms and their ecological consequences. Here, we perform GWAS using 4715 fish and 46,501 SNP to map sex determination to three separate genomic locations in Atlantic salmon ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23984-1

    authors: Kijas J,McWilliam S,Naval Sanchez M,Kube P,King H,Evans B,Nome T,Lien S,Verbyla K

    更新日期:2018-04-04 00:00:00

  • Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation.

    abstract::Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid protein of Alzheimer's disease. However, little is known about the association between fibrinogen a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39056-x

    authors: Page MJ,Thomson GJA,Nunes JM,Engelbrecht AM,Nell TA,de Villiers WJS,de Beer MC,Engelbrecht L,Kell DB,Pretorius E

    更新日期:2019-02-28 00:00:00

  • Aquaponics using a fish farm effluent shifts bacterial communities profile in halophytes rhizosphere and endosphere.

    abstract::The intensification of marine aquaculture raises multiple sustainability issues, namely the handling of nutrient-rich effluents that can adversely impact ecosystems. As integrated multi-trophic aquaculture (IMTA) gains momentum, the use of halophyte plants to phytoremediate aquaculture effluents has received growing a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66093-8

    authors: Oliveira V,Martins P,Marques B,Cleary DFR,Lillebø AI,Calado R

    更新日期:2020-06-22 00:00:00

  • Recent changes in daily climate extremes in an arid mountain region, a case study in northwestern China's Qilian Mountains.

    abstract::Changes in climate extremes pose far-reaching consequences to ecological processes and hydrologic cycles in alpine ecosystems of the arid mountain regions. Therefore, regional assessments in various climates and mountain regions are needed for understanding the uncertainties of the change trends for extreme climate ev...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02345-4

    authors: Lin P,He Z,Du J,Chen L,Zhu X,Li J

    更新日期:2017-05-22 00:00:00

  • Prediction of spontaneous closure of traumatic macular hole with spectral domain optical coherence tomography.

    abstract::It has been known that some traumatic macular holes can close spontaneously. However, knowledge about the types of macular hole that can close spontaneously is limited. In this retrospective study, we investigated patients with traumatic macular hole who were followed-up for at least 6 months without any surgical inte...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12343

    authors: Chen H,Chen W,Zheng K,Peng K,Xia H,Zhu L

    更新日期:2015-07-21 00:00:00

  • Form and function of the human and chimpanzee forefoot: implications for early hominin bipedalism.

    abstract::During bipedal walking, modern humans dorsiflex their forefoot at the metatarsophalangeal joints (MTPJs) prior to push off, which tightens the plantar soft tissues to convert the foot into a stiff propulsive lever. Particular features of metatarsal head morphology such as "dorsal doming" are thought to facilitate this...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30532

    authors: Fernández PJ,Holowka NB,Demes B,Jungers WL

    更新日期:2016-07-28 00:00:00

  • Author Correction: Non-Invasive Imaging Through Scattering Medium by Using a Reverse Response Wavefront Shaping Technique.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-62442-9

    authors: Sanjeev A,Kapellner Y,Shabairou N,Gur E,Sinvani M,Zalevsky Z

    更新日期:2020-04-02 00:00:00

  • Functional characterization of the principal sigma factor RpoD of phytoplasmas via an in vitro transcription assay.

    abstract::Phytoplasmas (class, Mollicutes) are insect-transmissible and plant-pathogenic bacteria that multiply intracellularly in both plants and insects through host switching. Our previous study revealed that phytoplasmal sigma factor rpoD of OY-M strain (rpoDOY) could be a key regulator of host switching, because the expres...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11893

    authors: Miura C,Komatsu K,Maejima K,Nijo T,Kitazawa Y,Tomomitsu T,Yusa A,Himeno M,Oshima K,Namba S

    更新日期:2015-07-07 00:00:00

  • Personalized Risk Assessment in Never, Light, and Heavy Smokers in a prospective cohort in Taiwan.

    abstract::The objective of this study was to develop markedly improved risk prediction models for lung cancer using a prospective cohort of 395,875 participants in Taiwan. Discriminatory accuracy was measured by generation of receiver operator curves and estimation of area under the curve (AUC). In multivariate Cox regression a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36482

    authors: Wu X,Wen CP,Ye Y,Tsai M,Wen C,Roth JA,Pu X,Chow WH,Huff C,Cunningham S,Huang M,Wu S,Tsao CK,Gu J,Lippman SM

    更新日期:2016-11-02 00:00:00

  • Electrospray mode transition of microdroplets with semiconductor nanoparticle suspension.

    abstract::Electrosprays operate in several modes depending on the flow rate and electric potential. This allows the deposition of droplets containing nanoparticles into discrete nanodot arrays to fabricate various electronic devices. In this study, seven different suspensions with varying properties were investigated. In the dr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05175-6

    authors: Castillo-Orozco E,Kar A,Kumar R

    更新日期:2017-07-11 00:00:00

  • Controlling striatal function via anterior frontal cortex stimulation.

    abstract::Motivational, cognitive and action goals are processed by distinct, topographically organized, corticostriatal circuits. We aimed to test whether processing in the striatum is under causal control by cortical regions in the human brain by investigating the effects of offline transcranial magnetic stimulation (TMS) ove...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21346-5

    authors: van Holstein M,Froböse MI,O'Shea J,Aarts E,Cools R

    更新日期:2018-02-19 00:00:00

  • Adjuvant radiotherapy for locally advanced upper tract urothelial carcinoma.

    abstract::There is relatively little literature on adjuvant radiotherapy after radical nephroureterectomy with bladder cuff excision (RNU) for patients with upper tract urothelial carcinoma (UTUC). This study was designed to determine the efficacy of adjuvant radiotherapy for patients with pT3N0M0 UTUC. We retrospectively revie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38175

    authors: Huang YC,Chang YH,Chiu KH,Shindel AW,Lai CH

    更新日期:2016-12-02 00:00:00

  • Analysis of Bioactive Amino Acids from Fish Hydrolysates with a New Bioinformatic Intelligent System Approach.

    abstract::The current economics of the fish protein industry demand rapid, accurate and expressive prediction algorithms at every step of protein production especially with the challenge of global climate change. This help to predict and analyze functional and nutritional quality then consequently control food allergies in hype...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10890-1

    authors: Elaziz MA,Hemdan AM,Hassanien A,Oliva D,Xiong S

    更新日期:2017-09-07 00:00:00

  • Increase in predation risk and trophic level induced by nocturnal visits of piscivorous fishes in a temperate seagrass bed.

    abstract::The majority of surveys on food webs of aquatic ecosystems have been conducted during the day owning to difficulties in sampling animals at night. In this study, to examine diurnal changes in predator-prey interactions in a temperate seagrass Zostera marina bed, a quantitative day/night survey of fish, the dominant an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04217-3

    authors: Shoji J,Mitamura H,Ichikawa K,Kinoshita H,Arai N

    更新日期:2017-06-20 00:00:00

  • Effects of dietary n-3-PUFA supplementation, post-insemination plane of nutrition and pregnancy status on the endometrial transcriptome of beef heifers.

    abstract::Supplementation of cattle diets with n-3-polyunsaturated fatty acids (PUFA) can improve reproductive efficiency. Conversely, short-term fluctuations in feed supply can impact pregnancy establishment. The objectives of this study were to examine the effects of (1) dietary supplementation with n-3-PUFA and (2) post-inse...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77604-y

    authors: Surlis C,Cormican P,Waters SM,Lonergan P,Keogh K,Doyle DN,Kenny DA

    更新日期:2020-11-27 00:00:00

  • Responses of solid tumor cells in DMEM to reactive oxygen species generated by non-thermal plasma and chemically induced ROS systems.

    abstract::In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma, we generated superoxide anion (O2(-)), hydroxyl radical (HO·), and hydrogen per...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08587

    authors: Kaushik N,Uddin N,Sim GB,Hong YJ,Baik KY,Kim CH,Lee SJ,Kaushik NK,Choi EH

    更新日期:2015-02-26 00:00:00

  • Anodal tDCS over the primary motor cortex improves motor imagery benefits on postural control: A pilot study.

    abstract::Performing everyday actions requires fine postural control, which is a major focus of functional rehabilitation programs. Among the various range of training methods likely to improve balance and postural stability, motor imagery practice (MIP) yielded promising results. Transcranial direct current stimulation (tDCS) ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00509-w

    authors: Saruco E,Di Rienzo F,Nunez-Nagy S,Rubio-Gonzalez MA,Jackson PL,Collet C,Saimpont A,Guillot A

    更新日期:2017-03-28 00:00:00

  • Lake sediment fecal and biomass burning biomarkers provide direct evidence for prehistoric human-lit fires in New Zealand.

    abstract::Deforestation associated with the initial settlement of New Zealand is a dramatic example of how humans can alter landscapes through fire. However, evidence linking early human presence and land-cover change is inferential in most continental sites. We employed a multi-proxy approach to reconstruct anthropogenic land ...

    journal_title:Scientific reports

    pub_type: 历史文章,杂志文章

    doi:10.1038/s41598-018-30606-3

    authors: Argiriadis E,Battistel D,McWethy DB,Vecchiato M,Kirchgeorg T,Kehrwald NM,Whitlock C,Wilmshurst JM,Barbante C

    更新日期:2018-08-14 00:00:00

  • Relationship Between Homodimeric Glucocorticoid Receptor and Transcriptional Regulation Assessed via an In Vitro Fluorescence Correlation Spectroscopy-Microwell System.

    abstract::Glucocorticoid receptor (GR) is a hormone-activated transcription regulatory protein involved in metabolism as well as adrenocortical responses to psychosocial stress. Ligand-activated GR localizes to the nucleus, where GR homodimers regulate gene transcription via direct binding to glucocorticoid response elements (G...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25393-w

    authors: Oasa S,Mikuni S,Yamamoto J,Kurosaki T,Yamashita D,Kinjo M

    更新日期:2018-05-10 00:00:00