Abstract：
:Cancer cells and non-cancer cells differ in their metabolism and they emit distinct volatile compound profiles, allowing to recognise cancer cells by their scent. Insect odorant receptors are excellent chemosensors with high sensitivity and a broad receptive range unmatched by current gas sensors. We thus investigated the potential of utilising the fruit fly's olfactory system to detect cancer cells. Using in vivo calcium imaging, we recorded an array of olfactory receptor neurons on the fruit fly's antenna. We performed multidimensional analysis of antenna responses, finding that cell volatiles from different cell types lead to characteristic response vectors. The distances between these response vectors are conserved across flies and can be used to discriminate healthy mammary epithelial cells from different types of breast cancer cells. This may expand the repertoire of clinical diagnostics, and it is the first step towards electronic noses equipped with biological sensors, integrating artificial and biological olfaction.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Strauch M,Lüdke A,Münch D,Laudes T,Galizia CG,Martinelli E,Lavra L,Paolesse R,Ulivieri A,Catini A,Capuano R,Di Natale Cdoi
10.1038/srep03576subject
Has Abstractpub_date
2014-01-06 00:00:00pages
3576issn
2045-2322pii
srep03576journal_volume
4pub_type
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