Abstract:
:Several prenatal and perinatal factors have been found to be associated with developmental dyslexia (reading disorder) in alphabetic language. Given the absence of relevant studies of Chinese children, the present study tries to investigate these risk factors. A total of 45,850 students were recruited from grades three to six, from seven cities of Hubei province. Dyslexia in Chinese was diagnosed based on children's clinical symptoms. The clinical symptoms of children's reading performance were assessed by Dyslexia Checklist for Chinese Children (DCCC) and Pupil Rating Scale Revised Screening for Learning Disabilities (PRS) which were completed by parent/guardian and header teacher respectively. Chinese language exam was used to screen children with poor reading capacity. Questionnaires about prenatal and perinatal factors were completed by parent or guardian. Among the 34,748 eligible participants, 1,200 (3.45%) were diagnosed with dyslexia in Chinese. More boys suffered from dyslexia than the girls and the gender ratio was 3:1. Family history of neuropsychiatric diseases, maternal infectious diseases, difficult vaginal delivery, preterm birth, and neonatal asphyxia were found to increase the risk of developmental dyslexia in China. Closer longitudinal developmental monitoring and preventive measures should be taken for high risk children.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu L,Wang J,Shao S,Luo X,Kong R,Zhang X,Song Rdoi
10.1038/srep36697subject
Has Abstractpub_date
2016-11-07 00:00:00pages
36697issn
2045-2322pii
srep36697journal_volume
6pub_type
杂志文章abstract::Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon receptor (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable and quantitative assessments of in vivo occupancy on each receptor would improve the understanding of the efficacy ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73815-5
更新日期:2020-10-07 00:00:00
abstract::The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, we experimentally me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47440-w
更新日期:2019-07-29 00:00:00
abstract::Jaw1/LRMP is a type II integral membrane protein that is localized at the endoplasmic reticulum (ER) and outer nuclear membrane. We previously reported that a function of Jaw1 is to maintain the nuclear shape as a KASH protein via its carboxyl terminal region, a component of linker of nucleoskeleton and cytoskeleton c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80258-5
更新日期:2021-01-12 00:00:00
abstract::Carbon uptake by terrestrial ecosystems is increasing along with the rising of atmospheric CO2 concentration. Embedded in this trend, recent studies suggested that the interannual variability (IAV) of global carbon fluxes may be dominated by semi-arid ecosystems, but the underlying mechanisms of this high variability ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39748
更新日期:2016-12-23 00:00:00
abstract::Little information is available on chemical forms of heavy metals on integrate plant roots. KNO3 (1 M), 0.05M EDTA at pH6 and 0.01 M HCl were used sequentially to extract the exchangeable, complexed and precipitated forms of Cu(II) and Cd(II) from soybean roots and then to investigate chemical form distribution of Cu(...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36373
更新日期:2016-11-02 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-34064-9
更新日期:2018-10-18 00:00:00
abstract::Ion mobility mass spectrometry (IM-MS) is a technique capable of investigating structural changes of biomolecules based on their collision cross section (CCS). Recent advances in IM-MS allow us to separate carbohydrate isomers with subtle conformational differences, but the relationship between CCS and atomic structur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20012-0
更新日期:2018-01-26 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis. By repurposing microarray probes, we herein analysed the lncRNA expression...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33535
更新日期:2016-09-15 00:00:00
abstract::We study propagation in a cyclic symmetric multicore fiber where the core radii randomly fluctuate along the propagation direction. We propose a hybrid analytic-numerical method to optimize the amplitude and frequency of the fluctuations that suppress power transfer between outer and inner cores. This framework allows...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51854-x
更新日期:2019-10-31 00:00:00
abstract::The strong adhesion of sub-micron sized particles to surfaces is a nuisance, both for removing contaminating colloids from surfaces and for conscious manipulation of particles to create and test novel micro/nano-scale assemblies. The obvious idea of using detergents to ease these processes suffers from a lack of contr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36443
更新日期:2016-11-03 00:00:00
abstract::Age-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30260
更新日期:2016-07-25 00:00:00
abstract::Plant evolutionary history influences the taxonomic composition of the root-associated bacterial community, but whether it can also modulate its functioning is unknown. Here, we tested the hypothesis that crop diversification is a significant factor determining the ecology of the functional group of nitrogen-fixing ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21690
更新日期:2016-02-23 00:00:00
abstract::PDA is a major cause of US cancer-related deaths. Oncogenic Kras presents in 90% of human PDAs. Kras mutations occur early in pre-neoplastic lesions but are insufficient to cause PDA. Other contributing factors early in disease progression include chronic pancreatitis, alterations in epigenetic regulators, and tumor s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77373-8
更新日期:2020-11-26 00:00:00
abstract:ABSTARCT:Graphene has sparked extensive research interest for its excellent physical properties and its unique potential for application in absorption of electromagnetic waves. However, the processing of stable large-scale graphene and magnetic particles on a micrometer-thick conductive support is a formidable challeng...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02639-7
更新日期:2017-05-24 00:00:00
abstract::We propose a graph-theoretical formalism to study generic circuit quantum electrodynamics systems consisting of a two level qubit coupled with a single-mode resonator in arbitrary coupling strength regimes beyond rotating-wave approximation. We define colored-weighted graphs, and introduce different products between t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37544
更新日期:2016-11-21 00:00:00
abstract::Alterations of carbohydrate structures in cancer cells are the most promising targets for developing clinical diagnostic reagents. Pancreatic cancer is one of the most difficult cancers to diagnose because it lacks definitive symptoms. Two antibodies were raised against human pancreatic ribonuclease 1 that bind to the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06715
更新日期:2014-10-22 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the highest incidences in cancers; however, traditional chemotherapy often suffers from low efficiency caused by drug resistance. Herein, we report an arsenite-loaded dual-drug (doxorubicin and arsenic trioxide, i.e., DOX and ATO) nanomedicine system (FeAsOx@SiO2-DOX, Combo NP)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31009
更新日期:2016-08-03 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-36257-8
更新日期:2018-11-27 00:00:00
abstract::The development of the optical bio-chemical sensing technology is an extremely important scientific and technological issue for diagnosis and monitoring of diseases, control of industrial processes, environmental detection of air and water pollutants. Owing to their distinctive features, chalcogenide amorphous thin fi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03678-w
更新日期:2017-06-14 00:00:00
abstract::Promoter activation drives gene transcriptional output. Here we report generating site-specifically integrated single-copy promoter transgenes and measuring their expression to indicate promoter activities at single-mRNA level. mRNA counts, Pol II density and Pol II firing rates of the Ccnb1 promoter transgene resembl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02240-y
更新日期:2017-05-18 00:00:00
abstract::Evaluating and tuning the properties of two-dimensional (2D) materials is a major focus of advancing 2D science and technology. While many claim that the photonic properties of a 2D layer provide evidence that the material is "high quality", this may not be true for electronic performance. In this work, we deconvolute...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16970-6
更新日期:2017-12-05 00:00:00
abstract::This work presents a new method for assisting in the identification process of missing persons in several contexts, such as enforced disappearances. We apply a Bayesian technique to incorporate non-genetic variables in the construction of prior information. In that way, we can learn from the already-solved cases of a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59841-3
更新日期:2020-03-19 00:00:00
abstract::Widely regarded as an imminent threat to our oceans, ocean acidification has been documented in all oceanic basins. Projected changes in seawater chemistry will have catastrophic biotic effects due to ocean acidification hindering biogenic carbonate production, which will in turn lead to substantial changes in marine ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58501-w
更新日期:2020-01-31 00:00:00
abstract::Designer nucleases, like zinc-finger nucleases (ZFNs), represent valuable tools for targeted genome editing. Here, we took advantage of the gamma-retroviral life cycle and produced vectors to transfer ZFNs in the form of protein, mRNA and episomal DNA. Transfer efficacy and ZFN activity were assessed in quantitative p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04656
更新日期:2014-04-11 00:00:00
abstract::Nanospheres of lead (Pb) have recently been identified in zircon (ZrSiO4) with the potential to compromise the veracity of U-Pb age determinations. The key assumption that the determined age is robust against the effects of Pb mobility, as long as Pb is not lost from the zircon during subsequent geological events, is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49882-8
更新日期:2019-09-23 00:00:00
abstract::In the present study, a surface-active enzyme, lipase was immobilized in polyethyleneimine (PEI) microcapsules and then modified with oxidized multiwall carbon nanotubes (MWCNTs). The resulting lipase microcapsules exhibited higher activity and stability, since the activity of microcapsules was 21.9 folds than that of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29670
更新日期:2016-07-18 00:00:00
abstract::Anatase TiO2 nanoparticles with exposed {001} facets were synthesized from Ti powder via a sequential hydrothermal reaction process. At the first-step hydrothermal reaction, H-titanate nanowires were obtained in NaOH solution with Ti powder, and at second-step hydrothermal reaction, anatase TiO2 nanoparticles with exp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12143
更新日期:2015-07-20 00:00:00
abstract::Transcription activator-like effector (TALE) nuclease (TALEN) is a site-specific nuclease, which can be freely designed and easily constructed. Numerous methods of constructing TALENs harboring different TALE scaffolds and repeat variants have recently been reported. However, the functionalities of structurally differ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03379
更新日期:2013-11-29 00:00:00
abstract::MicroRNAs are potent regulators of gene expression that have been widely implicated in reproduction and embryo development. Recent studies have demonstrated that miR-21, a microRNA extensively studied in the context of disease, is important in multiple facets of reproductive biology including folliculogenesis, ovulati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29874-w
更新日期:2018-08-01 00:00:00
abstract::Through a geomorphological study relying on statistically assessed classes of hilltop elevations, we reconstruct a suite of paleo-surfaces along the Tiber River Valley north of Rome that we identify as fluvial terraces formed by interplay between global sea-level fluctuations and regional upift. Using biostratigraphic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02437-1
更新日期:2017-05-31 00:00:00