Abstract:
:We study the driven translocation of a semi-flexible polymer through a nanopore by means of a modified version of the iso-flux tension propagation theory, and extensive molecular dynamics (MD) simulations. We show that in contrast to fully flexible chains, for semi-flexible polymers with a finite persistence length [Formula: see text] the trans side friction must be explicitly taken into account to properly describe the translocation process. In addition, the scaling of the end-to-end distance R N as a function of the chain length N must be known. To this end, we first derive a semi-analytic scaling form for R N, which reproduces the limits of a rod, an ideal chain, and an excluded volume chain in the appropriate limits. We then quantitatively characterize the nature of the trans side friction based on MD simulations. Augmented with these two factors, the theory shows that there are three main regimes for the scaling of the average translocation time τ ∝ N α . In the rod [Formula: see text], Gaussian [Formula: see text] and excluded volume chain [Formula: see text] ≫ 10 6 limits, α = 2, 3/2 and 1 + ν, respectively, where ν is the Flory exponent. Our results are in good agreement with available simulations and experimental data.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sarabadani J,Ikonen T,Mökkönen H,Ala-Nissila T,Carson S,Wanunu Mdoi
10.1038/s41598-017-07227-3subject
Has Abstractpub_date
2017-08-07 00:00:00pages
7423issue
1issn
2045-2322pii
10.1038/s41598-017-07227-3journal_volume
7pub_type
杂志文章abstract::Rho GTPases are master regulators of the eukaryotic cytoskeleton. The activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs). Three RhoGEF isoforms are produced by the gene ARHGEF25; p63RhoGEF580, GEFT and a recently discovered longer isoform of 619 amino acids (p63RhoGEF619). The subc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36825
更新日期:2016-11-11 00:00:00
abstract::Few studies have investigated the relationship between chronic rhinosinusitis (CRS) and erectile dysfunction (ED). This case-control study aimed to investigate the association between CRS and the risk of ED in a large national sample. Tapping Taiwan's National Health Insurance Research Database, we identified people 3...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/srep32195
更新日期:2016-08-31 00:00:00
abstract::Ferroelectric tunneling junctions (FTJs) with tunable tunneling electroresistance (TER) are promising for many emerging applications, including non-volatile memories and neurosynaptic computing. One of the key challenges in FTJs is the balance between the polarization value and the tunneling current. In order to achie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56816-x
更新日期:2019-12-31 00:00:00
abstract::This study aimed to examine hemodynamic responses and the necessity of breaks under long working hours. Thirty-eight healthy males conducted PC-based work from 9:10 to 22:00. Nine 10-minute short breaks and two long breaks (a 1-hour break and a 50-minute break) were provided, and hemodynamic responses were measured re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32908-y
更新日期:2018-09-28 00:00:00
abstract::Neuropathic pain is characterized by an uncertain etiology and by a poor response to common therapies. The ineffectiveness and the frequent side effects of the drugs used to counteract neuropathic pain call for the discovery of new therapeutic strategies. Laser therapy proved to be effective for reducing pain sensitiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45469-5
更新日期:2019-06-26 00:00:00
abstract::The quantities and proportions of protein fractions have notable effects on the nutritional and technological value of milk. Although much is known about the effects of genetic variants on milk proteins, the complex relationships among the set of genes and pathways regulating the different protein fractions synthesis ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18916-4
更新日期:2018-01-12 00:00:00
abstract::The Na+/H+ exchanger-1 (NHE1) supports tumour growth, making NHE1 inhibitors of interest in anticancer therapy, yet their molecular effects are incompletely characterized. Here, we demonstrate that widely used pyrazinoylguanidine-type NHE1 inhibitors potently inhibit growth and survival of cancer cell spheroids, in a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62430-z
更新日期:2020-04-02 00:00:00
abstract::Anoectochilus roxburghii and Anoectochilus formasanus are the major species of genus Anoectochilus used in traditional Chinese medicine for their abundant content of flavonoids and some other medicinal constituents. In recent years, their wild resources are gradually exhausted due to over-collection and ecological det...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56821-0
更新日期:2019-12-27 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-55966-2
更新日期:2020-01-14 00:00:00
abstract::Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron's membrane potential, providing an important component of inhibition in the brain. In addition to the canonical G protein-activation pathway, GIRK channels are activated by small molecules but less is...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04681-x
更新日期:2017-07-04 00:00:00
abstract::Plant cell cultures are an attractive platform for the production of recombinant proteins. A major drawback, hindering the establishment of plant cell suspensions as an industrial platform, is the low product yield obtained thus far. Histone acetylation is associated with increased transcription levels, therefore it i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17006-9
更新日期:2017-12-01 00:00:00
abstract::Understanding the neural basis of poor impulse control in Internet addiction (IA) is important for understanding the neurobiological mechanisms of this syndrome. The current study investigated how neuronal pathways implicated in response inhibition were affected in IA using a Go-Stop paradigm and functional magnetic r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05027
更新日期:2014-05-22 00:00:00
abstract::Orthographic regularity is important for processing Chinese characters. However, the issues how orthographic regularity influences the visual recognition of real Chinese characters and whether common processes related to the potential effect exist between successive (SUCC) and concurrent (CONC) conditions with asynchr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23275
更新日期:2016-03-23 00:00:00
abstract::Prostate cancer is a common malignancy in men worldwide and it is known that oxidative stress is a risk factor for cancer development. A common functional haptoglobin (Hp) polymorphism, originating from a duplication of a gene segment spanning over two exons, results in three distinct phenotypes with different anti-ox...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69333-z
更新日期:2020-08-04 00:00:00
abstract::Gas flow behavior in porous media with micro- and nanoscale pores has always been attracted great attention. Gas transport mechanism in such pores is a complex problem, which includes continuous flow, slip flow and transition flow. In this study, the microtubes of quartz microcapillary and nanopores alumina membrane w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46430-2
更新日期:2019-07-15 00:00:00
abstract::Epidemiological studies have shown that atherosclerotic risk factors accelerate the pathological process underlying Alzheimer's disease (AD) via chronic cerebral hypoperfusion. In this study, we aimed to clarify the mechanisms by which cerebral hypoperfusion may exacerbate AD pathology. We applied bilateral common car...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39494-7
更新日期:2019-02-26 00:00:00
abstract::We report the molecular basis of the largest Tunisian cohort with inherited retinal dystrophies (IRD) reported to date, identify disease-causing pathogenic variants and describe genotype-phenotype correlations. A subset of 26 families from a cohort of 73 families with clinical diagnosis of autosomal recessive IRD (AR-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67792-y
更新日期:2020-07-08 00:00:00
abstract::Facio-Scapulo Humeral dystrophy (FSHD) is the third most common myopathy, affecting 1 amongst 10,000 individuals (FSHD1, OMIM #158900). This autosomal dominant pathology is associated in 95% of cases with genetic and epigenetic alterations in the subtelomeric region at the extremity of the long arm of chromosome 4 (q ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46861-x
更新日期:2019-07-17 00:00:00
abstract::Salinity is one of the major abiotic factors that affect productivity in oat. Here, we report a comparison of the transcriptomes of two hexaploid oat cultivars, 'Hanyou-5' and 'Huazao-2', which differ with respect to salt tolerance, in seedlings exposed to salt stress. Analysis of the assembled unigenes from the osmot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34505-5
更新日期:2018-11-02 00:00:00
abstract::It has been known that some traumatic macular holes can close spontaneously. However, knowledge about the types of macular hole that can close spontaneously is limited. In this retrospective study, we investigated patients with traumatic macular hole who were followed-up for at least 6 months without any surgical inte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12343
更新日期:2015-07-21 00:00:00
abstract::Attention can be allocated to mental representations to select information from working memory. To date, it remains ambiguous whether such retroactive shifts of attention involve the inhibition of irrelevant information or the prioritization of relevant information. Investigating asymmetries in posterior alpha-band os...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70004-2
更新日期:2020-08-17 00:00:00
abstract::Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from mutations in the dystrophin gene. The mdx/utrn -/- mouse, lacking in both dystrophin and its autosomal homologue utrophin, is commonly used to model the clinical symptoms of DMD. Interestingly, these mice are infertile but the mechanisms ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05993-8
更新日期:2017-08-07 00:00:00
abstract::In this study, the improved Aesop's fable paradigm-a series of experiments originally used to test whether some animals understand the causality associated with water replacement-was used to explore the cognitive ability of Azure-winged magpies (Cyanopica cyanus). Experimental results on causal cue tasks showed that t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80452-5
更新日期:2021-01-12 00:00:00
abstract::In spin-based nanosystems for quantum information processing, electron spin qubits are subject to decoherence due to their interactions with nuclear spin environments. In this paper, we present an exact master equation for a central spin-1/2 system in time-dependent external fields and coupled to a spin-half bath in t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19977-9
更新日期:2018-01-24 00:00:00
abstract::The analysis of DNA methylation at CpG dinucleotides has become a major research focus due to its regulatory role in numerous biological processes, but the requisite need for assays which amplify bisulfite-converted DNA represents a major bottleneck due to the unique design constraints imposed on bisulfite-PCR primers...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41328
更新日期:2017-01-24 00:00:00
abstract::An important number of healthy and diseased tissues shows spatial variations in their metabolic capacities across the tissue. The liver is a prime example of such heterogeneity where the gradual changes in various metabolic activities across the liver sinusoid is termed as "zonation" of the liver. Here, we introduce t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27179-6
更新日期:2018-06-12 00:00:00
abstract::Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1∆/∆ mice are deaf, Tmc2∆/∆ mice have normal hearing, and double homozygous Tmc1∆/∆; Tmc2∆/∆ mice have deafness and profound vestibular dysfunction. These phenotypes are consistent with their different spatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29709-8
更新日期:2018-08-14 00:00:00
abstract::Given new distribution patterns of the endangered North Atlantic right whale (NARW; Eubalaena glacialis) population in recent years, an improved understanding of spatio-temporal movements are imperative for the conservation of this species. While so far visual data have provided most information on NARW movements, pas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13359-3
更新日期:2017-10-18 00:00:00
abstract::Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors with low survival rates and the leading cause of death in neurofibromatosis type 1 (NF1) patients under 40 years old. Surgical resection is the standard of care for MPNSTs, but is often incomplete and can generate loss of function, necessitating t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37035
更新日期:2016-11-11 00:00:00
abstract::Photoacoustic (optoacoustic) imaging can visualize vasculature deep in tissue using the high contrast of hemoglobin to light, with the high-resolution possible with ultrasound detection. Since angiogenesis, one of the hallmarks of cancer, leads to increased vascularity, photoacoustics holds promise in imaging breast c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11778
更新日期:2015-07-10 00:00:00