Abstract：
:Epidemiological studies have shown that atherosclerotic risk factors accelerate the pathological process underlying Alzheimer's disease (AD) via chronic cerebral hypoperfusion. In this study, we aimed to clarify the mechanisms by which cerebral hypoperfusion may exacerbate AD pathology. We applied bilateral common carotid artery stenosis (BCAS) to a mice model of AD and evaluated how the equilibrium of amyloid β oligomers respond to hypoperfusion. BCAS accelerated amyloid β (Aβ) convergence to the aggregation seed, facilitating the growth of Aβ plaques, but without changing the total Aβ amount in the brain. Furthermore, Aβ oligomers with high molecular weight increased in the brain of BCAS-operated mice. Considering Aβ is in an equilibrium among monomeric, oligomeric, and aggregation forms, our data suggest that cerebral hypoperfusion after BCAS shifted this equilibrium to a state where a greater number of Aβ molecules participate in Aβ assemblies to form aggregation-prone Aβ oligomers with high molecular weight. The reduced blood flow in the cerebral arteries due to BCAS attenuated the dynamics of the interstitial fluid leading to congestion, which may have facilitated Aβ aggregation. We suggest that cerebral hypoperfusion may accelerate AD by enhancing the tendency of Aβ to become aggregation-prone.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bannai T,Mano T,Chen X,Ohtomo G,Ohtomo R,Tsuchida T,Koshi-Mano K,Hashimoto T,Okazawa H,Iwatsubo T,Tsuji S,Toda T,Iwata Adoi
10.1038/s41598-019-39494-7subject
Has Abstractpub_date
2019-02-26 00:00:00pages
2827issue
1issn
2045-2322pii
10.1038/s41598-019-39494-7journal_volume
9pub_type
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