Abstract：
:Parvalbumin-containing projection neurons of the medial-septum-diagonal band of Broca ([Formula: see text]) are essential for hippocampal rhythms and learning operations yet are poorly understood at cellular and synaptic levels. We combined electrophysiological, optogenetic, and modeling approaches to investigate [Formula: see text] neuronal properties. [Formula: see text] neurons had intrinsic membrane properties distinct from acetylcholine- and somatostatin-containing MS-DBB subtypes. Viral expression of the fast-kinetic channelrhodopsin ChETA-YFP elicited action potentials to brief (1-2 ms) 470 nm light pulses. To investigate [Formula: see text] transmission, light pulses at 5-50 Hz frequencies generated trains of inhibitory postsynaptic currents (IPSCs) in CA1 stratum oriens interneurons. Using a similar approach, optogenetic activation of local hippocampal PV ([Formula: see text]) neurons generated trains of [Formula: see text]-mediated IPSCs in CA1 pyramidal neurons. Both synapse types exhibited short-term depression (STD) of IPSCs. However, relative to [Formula: see text] synapses, [Formula: see text] synapses possessed lower initial release probability, transiently resisted STD at gamma (20-50 Hz) frequencies, and recovered more rapidly from synaptic depression. Experimentally-constrained mathematical synapse models explored mechanistic differences. Relative to the [Formula: see text] model, the [Formula: see text] model exhibited higher sensitivity to calcium accumulation, permitting a faster rate of calcium-dependent recovery from STD. In conclusion, resistance of [Formula: see text] synapses to STD during short gamma bursts enables robust long-range GABAergic transmission from MS-DBB to hippocampus.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yi F,Garrett T,Deisseroth K,Haario H,Stone E,Lawrence JJdoi
10.1038/s41598-020-80245-wsubject
Has Abstractpub_date
2021-01-22 00:00:00pages
2117issue
1issn
2045-2322pii
10.1038/s41598-020-80245-wjournal_volume
11pub_type
杂志文章abstract：:The present study evaluated the effects of exposing liquid-stored boar semen to different red light LED regimens on sperm quality and reproductive performance. Of all of the tested photo-stimulation procedures, the best pattern consisted of 10 min light, 10 min rest and 10 min of further light (10-10-10 pattern). This...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22569
更新日期：2016-03-02 00:00:00
abstract：:Gold nanoparticle radiosensitization represents a novel technique in enhancement of ionising radiation dose and its effect on biological systems. Variation between theoretical predictions and experimental measurement is significant enough that the mechanism leading to an increase in cell killing and DNA damage is stil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19442
更新日期：2016-01-20 00:00:00
abstract：:Seeing with two eyes usually helps one respond faster. Here we show that with ambiguous stimuli, binocular viewing can paradoxically slow down reaction time. This is explained by the observers basing their decision on a noisy neuronal representation within the visual system, with the added noise breaking the symmetry ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16799
更新日期：2015-11-18 00:00:00
abstract：:Protein degradation is an essential mechanism for maintaining proteostasis in response to internal and external perturbations. Disruption of this process is implicated in many human diseases. We present a new technique, QUAD (Quantification of Azidohomoalanine Degradation), to analyze the global degradation rates in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72410-y
更新日期：2020-09-29 00:00:00
abstract：:On-surface reactions based on Ullmann coupling are known to proceed on coinage-metal substrates (e.g. Au, Ag, Cu), with the chemistry of the surface strongly influencing the reaction progression. In addition, the topography of the surface may be expected to affect the local adsorption geometry of the reactants as well...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13315-1
更新日期：2017-11-06 00:00:00
abstract：:Ancient statues are usually fragile and have a tendency to deteriorate over time, developing cracks, corrosion, and losing color. Before any intervention on the object of art, a conservator must map degradation and take measurements. Deterioration mapping is an extremely long process, as the conservator or restorer mu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78254-w
更新日期：2020-12-14 00:00:00
abstract：:The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) in both DNA and RNA. AlkB homolog 3 (ALKBH3) was als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42271
更新日期：2017-02-13 00:00:00
abstract：:Carbon monoxide (CO) monitoring in human breath is the focus of many investigations as CO could possibly be used as a marker of various diseases. Detecting CO in human breath remains a challenge because low concentrations ( journal_title：Scientific reports pub_type： 临床试验,杂志文章 doi：10.1038/s41598-019-48789-8 更新日期：2019-08-22 00:00:00
abstract：:This study aimed to evaluate the effects of ischemia-reperfusion injury (IRI) on the risk of hepatocellular carcinoma (HCC) recurrence after liver transplantation. Data of 195 patients were retrospectively analysed. Post-reperfusion aspartate (AST), alanine transaminase, and lactate dehydrogenase (LDH) levels were the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27319-y
更新日期：2018-06-12 00:00:00
abstract：:Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51485-2
更新日期：2019-10-16 00:00:00
abstract：:Automatic release and vertical transferring of silicon/silicon oxide nanowire arrays with a high integrity are demonstrated by an Ag-assisted ammonia etching method. By adding a water steaming step between Ag-assisted HF/H2O2 and ammonia etching to form a SiOx protective layer sheathing Si nanowires, we can tune the c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03940
更新日期：2014-02-03 00:00:00
abstract：:Insertion sequences (ISs) are ubiquitous and abundant mobile genetic elements in prokaryotic genomes. ISs often encode only one protein, the transposase, which catalyzes their transposition. Recent studies have shown that transposases of many different IS families interact with the β sliding clamp, a DNA replication f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13329
更新日期：2015-08-26 00:00:00
abstract：:Control of nonlinear large-scale dynamical networks, e.g., collective behavior of agents interacting via a scale-free connection topology, is a central problem in many scientific and engineering fields. For the linear version of this problem, the so-called controllability Gramian has played an important role to quanti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27300
更新日期：2016-06-06 00:00:00
abstract：:Agglomeration-triggered deactivation of supported platinum electrocatalysts markedly hinders their application in methanol oxidation reaction (MOR). In this study, graphene-supported nickel-iron layered double hydroxide (NiFe-LDH/rGO), in which Fe3+ was introduced to replace Ni2+ partially in the Ni(OH)2 lattice to pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19876-z
更新日期：2018-01-22 00:00:00
abstract：:Recent advances in next-generation sequencing technologies have paved the path for a considerable amount of sequencing data at a relatively low cost. This has revolutionized the genomics and transcriptomics studies. However, different challenges are now created in handling such data with available bioinformatics platf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75270-8
更新日期：2020-10-26 00:00:00
abstract：:Aberrant restoration of AR activity is linked with prostate tumor growth, therapeutic failures and development of castrate-resistant prostate cancer. Understanding the processes leading to AR-reactivation should provide the foundation for novel avenues of drug discovery. A differential gene expression study was conduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10068-9
更新日期：2017-08-29 00:00:00
abstract：:Polymer electrolyte membranes (PEM) and Pt-based catalysts are two crucial components which determine the properties and price of fuel cells. Even though, PEM faces problem of fuel crossover in liquid fuel cells such as direct methanol fuel cell (DMFC) and direct borohydride fuel cell (DBFC), which lowers power output...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00567
更新日期：2012-01-01 00:00:00
abstract：:Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated nuclear receptor which controls lipid and glucose metabolism. It is also the master regulator of adipogenesis. In adipocytes, ligand-dependent PPARγ activation is associated with proteasomal degradation; therefore, regulation of PPARγ degradati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38550
更新日期：2016-12-05 00:00:00
abstract：:Carbonic anhydrase plays a key role in CO2 transport, acid-base and ion regulation and metabolic processes in vertebrates. While several carbonic anhydrase isoforms have been identified in numerous vertebrate species, basal lineages such as the cyclostomes have remained largely unexamined. Here we investigate the repe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33954
更新日期：2016-10-05 00:00:00
abstract：:The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis results in sustained elevated levels of glucocorticoids which impair neu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39867-y
更新日期：2019-03-01 00:00:00
abstract：:The aim of this study was to assess the association between the shoulder tenderness and the inflammatory changes on magnetic resonance imaging (MRI) in the rheumatoid shoulder. Forty-one shoulders of 41 patients with rheumatoid arthritis (RA) were examined. We evaluated synovitis, erosion and bone marrow edema, by cou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55938-6
更新日期：2019-12-20 00:00:00
abstract：:Measurement of intracranial aneurysm wall motion may refine the current rupture risk estimation. A golden standard for measuring aneurysm pulsation is lacking. The aim is to evaluate magnitudes of aneurysm pulsation as published in current literature. Embase and PubMed were searched for publications containing quantit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81753-z
更新日期：2021-01-26 00:00:00
abstract：:Bacterial communities from freshwater lakes are shaped by various factors such as nutrients, pH value, temperature, etc. Their compositions and relative abundances would undergo changes to adapt the changing environments, and in turn could affect the environments of freshwater lakes. Analyses of the freshwater lake's ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30616
更新日期：2016-07-27 00:00:00
abstract：:Individuals with lower limb amputation need a secure suspension system for their prosthetic devices. A new coupling system was developed that is capable of suspending the prosthesis. The system's safety is ensured through an acoustic alarm system. This article explains how the system works and provides an in vivo eval...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02270
更新日期：2013-01-01 00:00:00
abstract：:The clinical application of dihydroartemisinin (DHA) has been hampered due to its poor water-solubility. To overcome this hurdle, we devised a novel polymer-drug conjugate, multiarm polyethylene glycol-dihydroartemisinin (PEG-DHA), made by linking DHA with multiarm polyethylene glycol. Herein, we investigated PEG-DHA ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05871
更新日期：2014-07-29 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep30212. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46831
更新日期：2017-05-26 00:00:00
abstract：:Dynamic Nuclear Polarization (DNP) has been introduced to overcome the sensitivity limitations of nuclear magnetic resonance (NMR) spectroscopy also of supported lipid bilayers. When investigated by solid-state NMR techniques the approach typically involves doping the samples with biradicals and their investigation at...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20895
更新日期：2016-02-15 00:00:00
abstract：:Papain-like cysteine proteases (PLCPs) are a class of proteolytic enzymes involved in many plant processes. Compared with the extensive research in Arabidopsis thaliana, little is known in castor bean (Ricinus communis) and physic nut (Jatropha curcas), two Euphorbiaceous plants without any recent whole-genome duplica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18760-6
更新日期：2018-01-10 00:00:00
abstract：:Medial arterial calcification (MAC) is a common outcome in diabetes and chronic kidney disease (CKD). It occurs as linear mineral deposits along the degraded elastin lamellae and is responsible for increased aortic stiffness and subsequent cardiovascular events. Current treatments for calcification, particularly in CK...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39639-8
更新日期：2019-02-22 00:00:00
abstract：:Dopamine is a key neurotransmitter in the retina and plays a central role in the light adaptive processes of the visual system. The sole source of retinal dopamine is dopaminergic amacrine cells (DACs). We and others have previously demonstrated that DACs are activated by rods, cones, and intrinsically photosensitive ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28916
更新日期：2016-06-30 00:00:00
