当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Novel multiarm polyethylene glycol-dihydroartemisinin conjugates enhancing therapeutic efficacy in non-small-cell lung cancer.

Novel multiarm polyethylene glycol-dihydroartemisinin conjugates enhancing therapeutic efficacy in non-small-cell lung cancer.

Abstract：

:The clinical application of dihydroartemisinin (DHA) has been hampered due to its poor water-solubility. To overcome this hurdle, we devised a novel polymer-drug conjugate, multiarm polyethylene glycol-dihydroartemisinin (PEG-DHA), made by linking DHA with multiarm polyethylene glycol. Herein, we investigated PEG-DHA on chemical structure, hydrolysis, solubility, hemolysis, cell cytotoxicity in vitro, and efficacy in vivo. The PEG-DHA conjugates have showed moderate drug loadings (2.82 ~ 8.14 wt%), significantly good water-solubilities (82- ~ 163-fold of DHA), excellent in vitro anticancer activities (at concentrations ≥8 μg/ml, showed only 15-20% cell viability) with potency similar to that of native DHA, and long blood circulation half-time (5.75- ~ 16.75-fold of DHA). Subsequent tumor xenograft assays demonstrated a superior therapeutic effect of PEG-DHA on inhibition of tumor growth compared with native DHA. The novel PEG-DHA conjugates can not only improve the solubility and efficacy of DHA but also show the potential of scale-up production and clinical application.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Dai L,Wang L,Deng L,Liu J,Lei J,Li D,He J

doi

10.1038/srep05871

subject

Has Abstract

pub_date

2014-07-29 00:00:00

pages

5871

issn

2045-2322

pii

srep05871

journal_volume

4

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Persistence of arctic-alpine flora during 24,000 years of environmental change in the Polar Urals.

    abstract：:Plants adapted to extreme conditions can be at high risk from climate change; arctic-alpine plants, in particular, could "run out of space" as they are out-competed by expansion of woody vegetation. Mountain regions could potentially provide safe sites for arctic-alpine plants in a warmer climate, but empirical eviden...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55989-9

    authors： Clarke CL,Edwards ME,Gielly L,Ehrich D,Hughes PDM,Morozova LM,Haflidason H,Mangerud J,Svendsen JI,Alsos IG

    更新日期：2019-12-23 00:00:00

  • Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors.

    abstract：:Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07699

    authors： Li Y,Liu Y,Liu J,Liu J,Tang H,Cao C,Zhao D,Ding Y

    更新日期：2015-01-09 00:00:00

  • Oncogenic G12D mutation alters local conformations and dynamics of K-Ras.

    abstract：:K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regulation of its dynamics. Here, we present local changes in K-Ras structure, conformation and dynamics upon G12D ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48029-z

    authors： Vatansever S,Erman B,Gümüş ZH

    更新日期：2019-08-13 00:00:00

  • Neurotransmitters and neuropeptides in gonadal steroid receptor-expressing cells in medial preoptic area subregions of the male mouse.

    abstract：:Testosterone is involved in male sexual, parental and aggressive behaviors through the androgen receptor (AR) and estrogen receptor (ER) α expressed in the brain. Although several studies have demonstrated that ERα and AR in the medial preoptic area (MPOA) are required for exhibiting sexual and aggressive behaviors of...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10213-4

    authors： Tsuneoka Y,Yoshida S,Takase K,Oda S,Kuroda M,Funato H

    更新日期：2017-08-29 00:00:00

  • Geochemistry and tectonic significance of late Paleoproterozoic A-type granites along the southern margin of the North China Craton.

    abstract：:The Longwangzhuang pluton is a typical example of Paleoproterozoic A-type granite intrusions at the southern margin of the North China Craton. This pluton is composed of arfvedsonite granite and minor aegirine-augite granites. Samples from both granite types display similar zircon U-Pb ages with 207U-206Pb ages of 161...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56820-1

    authors： Wang Y,Yang YZ,Siebel W,Zhang H,Zhang YS,Chen F

    更新日期：2020-01-09 00:00:00

  • Suprabasin-derived bioactive peptides identified by plasma peptidomics.

    abstract：:Identification of low-abundance, low-molecular-weight native peptides using non-tryptic plasma has long remained an unmet challenge, leaving potential bioactive/biomarker peptides undiscovered. We have succeeded in efficiently removing high-abundance plasma proteins to enrich and comprehensively identify low-molecular...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79353-4

    authors： Taguchi T,Kodera Y,Oba K,Saito T,Nakagawa Y,Kawashima Y,Shichiri M

    更新日期：2021-01-13 00:00:00

  • Differentiation of malignant cervical lymphadenopathy by dual-energy CT: a preliminary analysis.

    abstract：:The accurate diagnosis of malignant cervical lymphadenopathy remains challenging. In this study, we determined the value of quantitative parameters derived from dual-energy computed tomography (DECT) for differentiating malignant cervical lymphadenopathy caused by thyroid carcinoma (TC), salivary gland carcinoma (SC),...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31020

    authors： Yang L,Luo D,Li L,Zhao Y,Lin M,Guo W,Zhou C

    更新日期：2016-08-08 00:00:00

  • Using Bayesian modelling to investigate factors governing antibiotic-induced Candida albicans colonization of the GI tract.

    abstract：:Receipt of broad-spectrum antibiotics enhances Candida albicans colonization of the GI tract, a risk factor for haematogenously-disseminated candidiasis. To understand how antibiotics influence C. albicans colonization, we treated mice orally with vancomycin or a combination of penicillin, streptomycin, and gentamicin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08131

    authors： Shankar J,Solis NV,Mounaud S,Szpakowski S,Liu H,Losada L,Nierman WC,Filler SG

    更新日期：2015-02-03 00:00:00

  • Cilioretinal Arteries and Cilioretinal Veins in Eyes with Pathologic Myopia.

    abstract：:We investigated the clinical characteristics of cilioretinal arteries (CAs) and cilioretinal veins (CVs) in eyes with pathologic myopia. Ninety-five eyes with pathologic myopia and CAs were studied. The retrobulbar vessels from which the CAs originated were identified by indocyanine green angiography (ICGA). The resul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-38616-5

    authors： Watanabe T,Kasahara K,Futagami S,Fang Y,Du R,Moriyama M,Uramoto K,Yokoi T,Onishi Y,Yoshida T,Kamoi K,Jonas JB,Ohno-Matsui K

    更新日期：2019-02-21 00:00:00

  • Diplosporous development in Boehmeria tricuspis: Insights from de novo transcriptome assembly and comprehensive expression profiling.

    abstract：:Boehmeria tricuspis includes sexually reproducing diploid and apomictic triploid individuals. Previously, we established that triploid B. tricuspis reproduces through obligate diplospory. To understand the molecular basis of apomictic development in B. tricuspis, we sequenced and compared transcriptomic profiles of th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46043

    authors： Tang Q,Zang G,Cheng C,Luan M,Dai Z,Xu Y,Yang Z,Zhao L,Su J

    更新日期：2017-04-06 00:00:00

  • Using already-solved cases of a mass disaster event for prioritizing the search among remaining victims: a Bayesian approach.

    abstract：:This work presents a new method for assisting in the identification process of missing persons in several contexts, such as enforced disappearances. We apply a Bayesian technique to incorporate non-genetic variables in the construction of prior information. In that way, we can learn from the already-solved cases of a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59841-3

    authors： Caridi I,Alvarez EE,Somigliana C,Puerto MS

    更新日期：2020-03-19 00:00:00

  • FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.

    abstract：:The Rho-family small GTPase Cdc42 localizes at plasma membrane and Golgi complex and aside from protrusion and migration operates in vesicle trafficking, endo- and exocytosis as well as establishment and/or maintenance of cell polarity. The formin family members FMNL2 and -3 are actin assembly factors established to r...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09952-1

    authors： Kage F,Steffen A,Ellinger A,Ranftler C,Gehre C,Brakebusch C,Pavelka M,Stradal T,Rottner K

    更新日期：2017-08-29 00:00:00

  • Tactile learning transfer from the hand to the face but not to the forearm implies a special hand-face relationship.

    abstract：:In the primary somatosensory cortex, large-scale cortical and perceptual changes have been demonstrated following input deprivation. Recently, we found that the cortical and perceptual changes induced by repetitive somatosensory stimulation (RSS) at a finger transfer to the face. However, whether such cross-border cha...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-018-30183-5

    authors： Muret D,Dinse HR

    更新日期：2018-08-06 00:00:00

  • P-fimbriae in the presence of anti-PapA antibodies: new insight of antibodies action against pathogens.

    abstract：:Uropathogenic strains of Escherichia coli establish urinary tract infections by attaching to host epithelial cells using adhesive organelles called fimbriae. Fimbriae are helix-like structures with a remarkable adaptability, offering safeguarding for bacteria exposed to changing fluid forces in the urinary tract. We c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03393

    authors： Mortezaei N,Singh B,Bullitt E,Uhlin BE,Andersson M

    更新日期：2013-12-02 00:00:00

  • Evaluation of Reanalysis Surface Incident Solar Radiation Data in China.

    abstract：:Surface incident solar radiation (Rs) of reanalysis products is widely used in ecological conservation, agricultural production, civil engineering and various solar energy applications. It is of great importance to have a good knowledge of the uncertainty of reanalysis Rs products. In this study, we evaluated the Rs e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60460-1

    authors： Zhang X,Lu N,Jiang H,Yao L

    更新日期：2020-02-26 00:00:00

  • CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process.

    abstract：:CD31hiEmcnhi vessels were a subtype of vessels in the murine skeletal system, with high levels of platelet and endothelial cell adhesion molecule-1 (PECAM-1/CD31) and endomucin (Emcn). They were reported coupling angiogenesis and osteogenesis during bone development. We investigated the distribution of these vessels i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04150-5

    authors： Wang J,Gao Y,Cheng P,Li D,Jiang H,Ji C,Zhang S,Shen C,Li J,Song Y,Cao T,Wang C,Yang L,Pei G

    更新日期：2017-07-10 00:00:00

  • Broadband and wide field-of-view plasmonic metasurface-enabled waveplates.

    abstract：:Quasi two-dimensional metasurfaces composed of subwavelength nanoresonator arrays can dramatically alter the properties of light in an ultra-thin planar geometry, enabling new optical functions such as anomalous reflection and refraction, polarization filtering, and wavefront modulation. However, previous metasurface-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07511

    authors： Jiang ZH,Lin L,Ma D,Yun S,Werner DH,Liu Z,Mayer TS

    更新日期：2014-12-19 00:00:00

  • Ionization Study of Isomeric Molecules in Strong-field Laser Pulses.

    abstract：:Through the use of the technique of time-of-flight mass spectroscopy, we obtain strong-field ionization yields for randomly oriented 1,2-dichloroethylene (1,2-DCE) (C2H2Cl2) and 2-butene (C4H8). We are interested in studying the effect of conformal structure in strong-field ionization and, in particular, the role of m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42149

    authors： Zigo S,Le AT,Timilsina P,Trallero-Herrero CA

    更新日期：2017-02-10 00:00:00

  • Author Correction: The endocannabinoid hydrolase FAAH is an allosteric enzyme.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-62514-w

    authors： Dainese E,Oddi S,Simonetti M,Sabatucci A,Angelucci CB,Ballone A,Dufrusine B,Fezza F,De Fabritiis G,Maccarrone M

    更新日期：2020-03-31 00:00:00

  • Proton pump inhibitors act synergistically with fluconazole against resistant Candida albicans.

    abstract：:The incidence of resistant Candida isolates, especially Candida albicans, has increased continuously. To overcome the resistance, research on antifungal agent sensitizers has attracted considerable attention. Omeprazole and lansoprazole were found to inhibit the growth of sensitive C. albicans and hyphae formation in ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-57174-4

    authors： Lu M,Yan H,Yu C,Yuan L,Sun S

    更新日期：2020-01-16 00:00:00

  • Improving ultrasound images with elevational angular compounding based on acoustic refraction.

    abstract：:Ultrasound imaging is affected by coherent noise or speckle, which reduces contrast and overall image quality and degrades the diagnostic precision of the collected images. Elevational angular compounding (EAC) is an attractive means of addressing this limitation, since it reduces speckle noise while operating in real...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75092-8

    authors： Afshari P,Zakian C,Ntziachristos V

    更新日期：2020-10-23 00:00:00

  • The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity.

    abstract：:Resistance to 157 different herbicides and 88% of known sites of action has been observed, with many weeds resistant to two or more modes. Coupled with tighter environmental regulation, this demonstrates the need to identify new modes of action and novel herbicides. The plant sphingolipid biosynthetic enzyme, inositol...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44544-1

    authors： Pinneh EC,Mina JG,Stark MJR,Lindell SD,Luemmen P,Knight MR,Steel PG,Denny PW

    更新日期：2019-05-30 00:00:00

  • Cooperative growth of Geobacter sulfurreducens and Clostridium pasteurianum with subsequent metabolic shift in glycerol fermentation.

    abstract：:Interspecies electron transfer is a common way to couple metabolic energy balances between different species in mixed culture consortia. Direct interspecies electron transfer (DIET) mechanism has been recently characterised with Geobacter species which couple the electron balance with other species through physical co...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44334

    authors： Moscoviz R,de Fouchécour F,Santa-Catalina G,Bernet N,Trably E

    更新日期：2017-03-13 00:00:00

  • Aspiration-assisted bioprinting of the osteochondral interface.

    abstract：:Osteochondral defects contain damage to both the articular cartilage and underlying subchon- dral bone, which remains a significant challenge in orthopedic surgery. Layered structure of bone, cartilage and the bone-cartilage interface must be taken into account in the case of biofabrication of the osteochondral (OC) i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69960-6

    authors： Ayan B,Wu Y,Karuppagounder V,Kamal F,Ozbolat IT

    更新日期：2020-08-04 00:00:00

  • Robust superhydrophobic surface on Al substrate with durability, corrosion resistance and ice-phobicity.

    abstract：:Practical application of superhydrophobic surfaces is limited by the fragility of nanoscale asperities. Combining chemical etching and anodization, microscale pits and nanoscale pores, instead of the micro and nano protrusions on traditional superhydrophobic surfaces mimicking Lutos leaves, were fabricated on commerci...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20933

    authors： Wang G,Liu S,Wei S,Liu Y,Lian J,Jiang Q

    更新日期：2016-02-08 00:00:00

  • A Microstructured Fiber with Defined Borosilicate Regions to Produce a Radial Micronozzle Array for Nanoelectrospray Ionization.

    abstract：:This work highlights the possibility of using microstructured fibres with predefined doped regions to produce functional microstructures at a fibre facet with differential chemical etching. A specially designed silica microstructured fibre (MSF) that possesses specific boron-doped silica regions was fabricated for the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21279

    authors： Fu Y,Morency S,Bachus K,Simon D,Hutama T,Gibson GTT,Messaddeq Y,Oleschuk RD

    更新日期：2016-02-19 00:00:00

  • Long-term follow-up of therapeutic ERCP in 78 patients aged 90 years or older.

    abstract：:This study aimed to determine the performance and long-term outcomes of therapeutic ERCP in very old patients. Patients aged or over 90 (Group A, n = 78) and consecutive sex-matched controls (Group B, n = 312) under 65 selected were compared. More patients in Group A had chronic concomitant diseases, but the success a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04918

    authors： Hu L,Sun X,Hao J,Xie T,Liu M,Xin L,Sun T,Liu M,Zou W,Ye B,Liu F,Wang D,Cao N,Liao Z,Li Z

    更新日期：2014-05-13 00:00:00

  • Liver stiffness measured by acoustic radiation force impulse elastography predicted prognoses of hepatocellular carcinoma after radiofrequency ablation.

    abstract：:The prognostic factors of patients who undergo radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is not fully elucidated. We aimed to investigate the role of liver stiffness (LS) and spleen stiffness (SS) measured by acoustic radiation force impulse (ARFI) elastography in determining the prognoses of pa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58988-3

    authors： Lee PC,Chiou YY,Chiu NC,Chen PH,Liu CA,Kao WY,Huo TI,Huang YH,Hou MC,Lin HC,Wu JC,Su CW

    更新日期：2020-02-06 00:00:00

  • Experimental study of the nonreciprocal effective interactions between microparticles in an anisotropic plasma.

    abstract：:There is a variety of cases in nature when the action-reaction symmetry is broken. In particular, suitable conditions for this are realized in colloidal suspensions and complex plasmas. Since the first theories and simulations of the nonreciprocal effective interactions between microparticles in complex plasmas were p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70441-z

    authors： Lisin EA,Petrov OF,Sametov EA,Vaulina OS,Statsenko KB,Vasiliev MM,Carmona-Reyes J,Hyde TW

    更新日期：2020-08-12 00:00:00

  • Reconstruction of lactate utilization system in Pseudomonas putida KT2440: a novel biocatalyst for l-2-hydroxy-carboxylate production.

    abstract：:As an important method for building blocks synthesis, whole cell biocatalysis is hindered by some shortcomings such as unpredictability of reactions, utilization of opportunistic pathogen, and side reactions. Due to its biological and extensively studied genetic background, Pseudomonas putida KT2440 is viewed as a pro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06939

    authors： Wang Y,Lv M,Zhang Y,Xiao X,Jiang T,Zhang W,Hu C,Gao C,Ma C,Xu P

    更新日期：2014-11-06 00:00:00