FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.

abstract：:Viruses use a strategy of high mutational rates to adapt to environmental and therapeutic pressures, circumventing the deleterious effects of random single-point mutations by coevolved compensatory mutations, which restore protein fold, function or interactions damaged by initial ones. This mechanism has been identifi...

journal_title：Scientific reports

authors： Khwaja A,Galilee M,Marx A,Alian A

更新日期：2016-04-22 00:00:00

abstract：:The increasing antibiotic resistance evolved by Helicobacter pylori has alarmingly reduced the eradication rates of first-line therapies. To overcome the current circulating resistome, we selected a novel potential therapeutic target in order to identify new candidate drugs for treating H. pylori infection. We screene...

journal_title：Scientific reports

authors： González A,Salillas S,Velázquez-Campoy A,Espinosa Angarica V,Fillat MF,Sancho J,Lanas Á

更新日期：2019-08-05 00:00:00

abstract：:We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly, after injection of MSCs which had been pr...

journal_title：Scientific reports

authors： Basu A,Munir S,Mulaw MA,Singh K,Crisan D,Sindrilaru A,Treiber N,Wlaschek M,Huber-Lang M,Gebhard F,Scharffetter-Kochanek K

更新日期：2018-04-18 00:00:00

abstract：:The crystal structure of the Sb6O13 oxide, exhibiting a defect pyrochlore crystal structure with atomic vacancies, has been studied using a complete set of state-of-the-art techniques. The degree of antimony disproportionation in Sb3+ and Sb5+ valence states has been directly determined around 36% and 64%, respectivel...

journal_title：Scientific reports

authors： Mayer SF,Rodrigues JE,Marini C,Fernández-Díaz MT,Falcón H,Asensio MC,Alonso JA

更新日期：2020-10-12 00:00:00

abstract：:Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen ((1)O2) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6-8 weeks for lung cancer), relatively...

journal_title：Scientific reports

authors： Sokolovski SG,Zolotovskaya SA,Goltsov A,Pourreyron C,South AP,Rafailov EU

更新日期：2013-12-12 00:00:00

abstract：:InPBi was predicted to be the most robust infrared optoelectronic material but also the most difficult to synthesize within In-VBi (V = P, As and Sb) 25 years ago. We report the first successful growth of InPBi single crystals with Bi concentration far beyond the doping level by gas source molecular beam epitaxy. The ...

journal_title：Scientific reports

authors： Wang K,Gu Y,Zhou HF,Zhang LY,Kang CZ,Wu MJ,Pan WW,Lu PF,Gong Q,Wang SM

更新日期：2014-06-26 00:00:00

abstract：:Lipid droplet (LD)-associated hydrolase (LDAH) is a newly identified LD protein abundantly expressed in tissues that predominantly store triacylglycerol (TAG). However, how LDAH regulates TAG metabolism remains unknown. We found that upon oleic acid loading LDAH translocalizes from the ER to newly formed LDs, and indu...

journal_title：Scientific reports

authors： Goo YH,Son SH,Paul A

更新日期：2017-06-02 00:00:00

abstract：:A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution. We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variabi...

journal_title：Scientific reports

authors： Liviero F,Scarpa MC,De Stefani D,Folino F,Campisi M,Mason P,Iliceto S,Pavanello S,Maestrelli P

更新日期：2020-09-16 00:00:00

abstract：:Oxidative stress and the formation of plaques which contain amyloid-β (Aβ) peptides are two key hallmarks of Alzheimer's disease (AD). Dityrosine is found in the plaques of AD patients and Aβ dimers have been linked to neurotoxicity. Here we investigate the formation of Aβ dityrosine dimers promoted by Cu2+/+ Fenton r...

journal_title：Scientific reports

authors： Gu M,Bode DC,Viles JH

更新日期：2018-11-01 00:00:00

abstract：:Cold atmospheric plasma (CAP), a technology based on quasi-neutral ionized gas at low temperatures, is currently being evaluated as a new highly selective alternative addition to existing cancer therapies. Here, we present a first attempt to identify the mechanism of CAP action. CAP induced a robust ~2-fold G2/M incre...

journal_title：Scientific reports

authors： Volotskova O,Hawley TS,Stepp MA,Keidar M

更新日期：2012-01-01 00:00:00

abstract：:Excision repair cross-complementing 1 (ERCC1) gene encodes ERCC1 protein, which is mainly responsible for the repair of DNA damage in different diseases including coronary artery atherosclerosis by acting as a rate-limiting element in nucleotide excision repair (NER). Using a three-stage case-control study with 3037 c...

journal_title：Scientific reports

authors： Zhang S,Wang XB,Han YD,Xiong CL,Zhou Y,Wang C,Liu ZJ,Yang N,Zheng F

更新日期：2017-07-25 00:00:00

abstract：:Congenital reproductive tract anomalies could impair fertility. Female and male reproductive tracts are developed from Müllerian ducts and Wolffian ducts, respectively, involving initiation, elongation and differentiation. Genetic basis solely for distal reproductive tract development is largely unknown. Lhfpl2 (lipom...

journal_title：Scientific reports

authors： Zhao F,Zhou J,Li R,Dudley EA,Ye X

更新日期：2016-03-11 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) and phosphate solubilizing bacteria (PSB) could interact synergistically because PSB solubilize sparingly available phosphorous compounds into orthophosphate that AMF can absorb and transport to the host plant. Little is known about the interactions between these two groups in terms ...

journal_title：Scientific reports

authors： Nacoon S,Jogloy S,Riddech N,Mongkolthanaruk W,Kuyper TW,Boonlue S

更新日期：2020-03-18 00:00:00

abstract：:Our previous study suggested that microtubule network alteration affects the process of glycolysis in cardiomyocytes (CMs) via the regulation of hypoxia-inducible factor (HIF)-1α during the early stages of hypoxia. However, little is known regarding the underlying mechanisms of microtubule network alteration-induced c...

journal_title：Scientific reports

authors： Jiang X,Zhang D,Zhang H,Huang Y,Teng M

更新日期：2015-03-17 00:00:00

abstract：:Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no specific studies of how GNS ...

journal_title：Scientific reports

authors： Wang Y,Gao Z,Han Z,Liu Y,Yang H,Akkin T,Hogan CJ,Bischof JC

更新日期：2021-01-13 00:00:00

abstract：:Axolotls have the amazing ability to regenerate. When compared to humans, axolotls display a very fast wound closure, no scarring and are capable to replace lost appendages perfectly. Understanding the signaling mechanism leading to this perfect healing is a key step to help develop regenerative treatments for humans....

journal_title：Scientific reports

authors： Sader F,Denis JF,Laref H,Roy S

更新日期：2019-02-04 00:00:00

abstract：:A major issue in human olfaction research is to characterize the main dimensions that organize the space of odors. The present study examines this question and shows that, beside pleasantness, trigeminal sensations, and particularly irritation, play an important role. These results were consistent along two different ...

journal_title：Scientific reports

authors： Licon CC,Manesse C,Dantec M,Fournel A,Bensafi M

更新日期：2018-05-31 00:00:00

abstract：:Neural crest cells (NCC) are stem cells that generate different lineages, including neuroendocrine, melanocytic, cartilage, and bone. The differentiation potential of NCC varies according to the level from which cells emerge along the neural tube. For example, only anterior "cranial" NCC form craniofacial bone, wherea...

journal_title：Scientific reports

authors： Huang M,Miller ML,McHenry LK,Zheng T,Zhen Q,Ilkhanizadeh S,Conklin BR,Bronner ME,Weiss WA

更新日期：2016-01-27 00:00:00

abstract：:The kidney is a high-energy demand organ rich in mitochondria especially renal tubular cells. Emerging evidence suggests that mitochondrial dysfunction, redox imbalance and kidney injury are interconnected. Artemether has biological effects by targeting mitochondria and exhibits potential therapeutic value for kidney ...

journal_title：Scientific reports

authors： Han P,Cai Y,Wang Y,Weng W,Chen Y,Wang M,Zhan H,Yu X,Wang T,Shao M,Sun H

更新日期：2021-01-14 00:00:00

abstract：:Invariant Natural killer T (iNKT) cells rapidly produce copious amounts of multiple cytokines after in vivo activation, allowing for the direct detection of a number of cytokines directly ex vivo. However, for some cytokines this approach is suboptimal. Here, we report technical variations that allow the improved dete...

journal_title：Scientific reports

authors： Sag D,Özkan M,Kronenberg M,Wingender G

更新日期：2017-11-30 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic and inflammatory microenvironment that is formed primarily by activated, myofibroblast-like, stellate cells. Although the stellate cells are thought to contribute to tumorigenesis, metastasis and drug resistance of PDAC, the signaling events involv...

journal_title：Scientific reports

authors： Morvaridi S,Dhall D,Greene MI,Pandol SJ,Wang Q

更新日期：2015-11-16 00:00:00

abstract：:Inflammatory and cardiovascular biomarkers have been associated with obesity, but little is known about how they change upon dietary intervention and concomitant weight loss. Further, protein biomarkers might be useful for predicting weight loss in overweight and obese individuals. We performed secondary analyses in t...

journal_title：Scientific reports

authors： Figarska SM,Rigdon J,Ganna A,Elmståhl S,Lind L,Gardner CD,Ingelsson E

更新日期：2020-05-13 00:00:00

abstract：:Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and other mechanisms. Different genetic instability processes result in characteristic non-random patterns of DNA mutations, also known as mutational signatures. We developed mutSignatures, an integrated R-based computational framewor...

journal_title：Scientific reports

authors： Fantini D,Vidimar V,Yu Y,Condello S,Meeks JJ

更新日期：2020-10-26 00:00:00

abstract：:The recent past has seen impressive progress in the treatment of various malignancies using immunotherapy. One of the most promising approaches involves immune checkpoint inhibitors. However, the clinical results with these agents have demonstrated variability in the response. Pancreatic cancer, in particular, has pro...

journal_title：Scientific reports

authors： Yoo B,Jordan VC,Sheedy P,Billig AM,Ross A,Pantazopoulos P,Medarova Z

更新日期：2019-03-18 00:00:00

abstract：:Recent studies indicate that urinary mitochondrial DNA (mtDNA) is predictive of ischemic AKI and is related to delayed graft function (DGF) in renal transplantation. Nevertheless, the clinical implications and prognostic value of urinary mtDNA in kidney transplantation remain undetermined. Here, we aimed to evaluate t...

journal_title：Scientific reports

authors： Kim K,Moon H,Lee YH,Seo JW,Kim YG,Moon JY,Kim JS,Jeong KH,Lee TW,Ihm CG,Lee SH

更新日期：2019-12-09 00:00:00

abstract：:Cystatin C (CysC) is implicated in neuroprotection and repair in the nervous system in response to diverse neurotoxic conditions. In addition to being secreted from cells in a soluble form, CysC is released by cells in association with extracellular vesicles (EVs), including exosomes. We demonstrate that EVs containin...

journal_title：Scientific reports

authors： Pérez-González R,Sahoo S,Gauthier SA,Kim Y,Li M,Kumar A,Pawlik M,Benussi L,Ghidoni R,Levy E

更新日期：2019-07-31 00:00:00

abstract：:Despite the unique nature of endemic species, their origin and population history remain poorly studied. We investigated the population history of 28 coral reef fish species, close related, from the Gambier and Marquesas Islands, from five families, with range size varying from widespread to small-range endemic. We an...

journal_title：Scientific reports

authors： Delrieu-Trottin E,Mona S,Maynard J,Neglia V,Veuille M,Planes S

更新日期：2017-01-16 00:00:00

abstract：:Maculinea (=Phengaris) are endangered butterflies that are characterized by a very complex biological cycle. Maculinea larvae behave as obligate parasites whose survival is strictly dependent on both particular food plants and species-specific Myrmica ants. In this interaction, Maculinea caterpillars induce Myrmica wo...

journal_title：Scientific reports

authors： Di Salvo M,Calcagnile M,Talà A,Tredici SM,Maffei ME,Schönrogge K,Barbero F,Alifano P

更新日期：2019-05-29 00:00:00

abstract：:TRAF-interacting protein with a forkhead-associated (FHA) domain (TIFA), originally identified as an adaptor protein of TRAF6, has recently been shown to be involved in innate immunity, induced by a pathogen-associated molecular pattern (PAMP). ADP-β-D-manno-heptose, a newly identified PAMP, binds to alpha-kinase 1 (A...

journal_title：Scientific reports

authors： Nakamura T,Hashikawa C,Okabe K,Yokote Y,Chirifu M,Toma-Fukai S,Nakamura N,Matsuo M,Kamikariya M,Okamoto Y,Gohda J,Akiyama T,Semba K,Ikemizu S,Otsuka M,Inoue JI,Yamagata Y

更新日期：2020-03-20 00:00:00

abstract：:Continuous gas-phase synthesis of nanoparticles is associated with rapid agglomeration, which can be a limiting factor for numerous applications. In this report, we challenge this paradigm by providing experimental evidence to support that gas-phase methods can be used to produce ultrapure non-agglomerated "singlet" n...

journal_title：Scientific reports

authors： Feng J,Biskos G,Schmidt-Ott A

更新日期：2015-10-29 00:00:00