High inhaled oxygen concentration quadruples exhaled CO in healthy volunteers monitored by a highly sensitive laser spectrometer.

abstract：:Tissue fibrosis underlies the majority of human mortality to date with close to half of all reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and reputed irreversible once established. Although some preventive options are being reported, therapeutic options are still scarce and in...

journal_title：Scientific reports

authors： Nono JK,Fu K,Mpotje T,Varrone G,Aziz NA,Mosala P,Hlaka L,Kamdem SD,Xu D,Spangenberg T,Brombacher F

更新日期：2020-06-30 00:00:00

abstract：:An increase in adipose tissue is caused by the increased size and number of adipocytes. Lipids accumulate in intracellular stores, known as lipid droplets (LDs). Recent studies suggest that parameters such as LD size, shape and dynamics are closely related to the development of obesity. Berberine (BBR), a natural plan...

journal_title：Scientific reports

authors： Haselgrübler R,Lanzerstorfer P,Röhrl C,Stübl F,Schurr J,Schwarzinger B,Schwarzinger C,Brameshuber M,Wieser S,Winkler SM,Weghuber J

更新日期：2019-07-19 00:00:00

abstract：:c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7). It has been reported that MKK7-JNK signaling plays an important regul...

journal_title：Scientific reports

authors： Yamasaki T,Deki-Arima N,Kaneko A,Miyamura N,Iwatsuki M,Matsuoka M,Fujimori-Tonou N,Okamoto-Uchida Y,Hirayama J,Marth JD,Yamanashi Y,Kawasaki H,Yamanaka K,Penninger JM,Shibata S,Nishina H

更新日期：2017-08-04 00:00:00

abstract：:Angulin proteins are a group of evolutionally conserved type I transmembrane proteins that contain an extracellular Ig-like domain. In mammals, three angulin proteins have been identified, namely immunoglobulin-like domain containing receptor 1 (ILDR1), immunoglobulin-like domain containing receptor 2 (ILDR2), and lip...

journal_title：Scientific reports

authors： Liu Y,Nie H,Liu C,Zhai X,Sang Q,Wang Y,Shi D,Wang L,Xu Z

更新日期：2017-08-07 00:00:00

abstract：:CD4(+)CD25(+) T cells are critical for maintenance of immunologic self-tolerance. We measured the number of CD4(+)CD25(+) cells in the patients with primary malignant hypertension related kidney injury, to explore the molecular pathogenesis of this disease. We selected 30 patients with primary malignant hypertension r...

journal_title：Scientific reports

authors： Huang H,Luo Y,Liang Y,Long X,Peng Y,Liu Z,Wen X,Jia M,Tian R,Bai C,Li C,He F,Lin Q,Wang X,Dong X

更新日期：2016-06-09 00:00:00

abstract：:Dyslipidemia in pregnancy are associated with risk of adverse outcomes. As an adverse pregnancy outcome, small-for-gestational-age has been extensively studied in Western countries. However, similar studies have rarely been conducted in Asian countries. Data were derived from 5695 pairs of non-diabetic mothers and neo...

journal_title：Scientific reports

authors： Chen Q,Chen H,Xi F,Sagnelli M,Zhao B,Chen Y,Yang M,Xu D,Jiang Y,Chen G,Luo Q

更新日期：2020-11-16 00:00:00

abstract：:Generally confinement size is considered to determine the dimensionality of nanostructures. While the exciton Bohr radius is used as a criterion to define either weak or strong confinement in optical experiments, the binding energy of confined excitons is difficult to measure experimentally. One alternative is to use ...

journal_title：Scientific reports

authors： Kim H,Lee W,Park S,Kyhm K,Je K,Taylor RA,Nogues G,Dang LS,Song JD

更新日期：2017-01-05 00:00:00

abstract：:Mechanical forces are critical to modulate cell spreading, contractility, gene expression, and even stem cell differentiation. Yet, existing tools that can apply controllable subcellular forces to a large number of single cells simultaneously are still limited. Here we report a novel ultrasound tweezing cytometry util...

journal_title：Scientific reports

authors： Fan Z,Sun Y,Di Chen,Tay D,Chen W,Deng CX,Fu J

更新日期：2013-01-01 00:00:00

abstract：:DNA-stabilized silver clusters (Ag-DNA) show excellent promise as a multi-functional nanoagent for molecular investigations in living cells. The unique properties of these fluorescent nanomaterials allow for intracellular optical sensors with tunable cytotoxicity based on simple modifications of the DNA sequences. Thr...

journal_title：Scientific reports

authors： Bossert N,de Bruin D,Götz M,Bouwmeester D,Heinrich D

更新日期：2016-11-30 00:00:00

abstract：:The mosquito, Aedes baisasi, which inhabits brackish mangrove swamps, is known to feed on fish. However, its host assemblage has not been investigated at the species level. We amplified and sequenced the cytochrome oxidase subunit I barcoding regions as well as some other regions from blood-fed females to identify hos...

journal_title：Scientific reports

authors： Miyake T,Aihara N,Maeda K,Shinzato C,Koyanagi R,Kobayashi H,Yamahira K

更新日期：2019-03-08 00:00:00

abstract：:The stickiness of cooked rice is important for eating quality and consumer acceptance. The first molecular understanding of stickiness is obtained from leaching and molecular structural characteristics during cooking. Starch is a highly branched glucose polymer. We find (i) the molecular size of leached amylopectin is...

journal_title：Scientific reports

authors： Li H,Fitzgerald MA,Prakash S,Nicholson TM,Gilbert RG

更新日期：2017-03-06 00:00:00

abstract：:Current chemical markers based quality assessment methods largely fail to reflect intrinsic chemical complexity and multiple mechanisms of action of botanical drugs (BD). The development of novel quality markers is greatly needed. Here we propose bioactive chemical markers (BCM), defined as a group of chemo-markers th...

journal_title：Scientific reports

authors： Yang Z,Shao Q,Ge Z,Ai N,Zhao X,Fan X

更新日期：2017-05-25 00:00:00

abstract：:High-throughput technologies have identified significant changes in patterns of mRNA expression over cancer development but the functional significance of these changes often rests upon the assumption that observed changes in levels of mRNA accurately reflect changes in levels of their encoded proteins. We systematica...

journal_title：Scientific reports

authors： Zhang M,Matyunina LV,Walker LD,Chen W,Xiao H,Benigno BB,Wu R,McDonald JF

更新日期：2017-08-15 00:00:00

abstract：:An ultrasensitive DNA biosensor has been developed through in-situ labeling of electroactive melamine-Cu(2+) complex (Mel-Cu(2+)) on the end of hairpin-like probe using gold nanoparticles (AuNPs) as the signal amplification platform. The 3'-thiolated hairpin-like probe was first immobilized to the gold electrode surfa...

journal_title：Scientific reports

authors： Wang Q,Gao F,Ni J,Liao X,Zhang X,Lin Z

更新日期：2016-03-02 00:00:00

abstract：:Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make attractive targets for new drugs. Here, by genome-wide phenotypic profiling, we identify and cat...

journal_title：Scientific reports

authors： Dragset MS,Ioerger TR,Zhang YJ,Mærk M,Ginbot Z,Sacchettini JC,Flo TH,Rubin EJ,Steigedal M

更新日期：2019-08-06 00:00:00

abstract：:This study sought to evaluate the association of 28 single nucleotide polymorphisms (SNPs) within NFKB and inflammasome pathway genes with the risk of rheumatoid arthritis (RA) and response to TNF inhibitors (TNFi). We conducted a case-control study in a European population of 1194 RA patients and 1328 healthy control...

journal_title：Scientific reports

authors： Manuel Sánchez-Maldonado J,Martínez-Bueno M,Canhão H,Ter Horst R,Muñoz-Peña S,Moñiz-Díez A,Rodríguez-Ramos A,Escudero A,Sorensen SB,Hetland ML,Ferrer MA,Glintborg B,Filipescu I,Pérez-Pampin E,Conesa-Zamora P,García A,den

更新日期：2020-03-09 00:00:00

abstract：:Application of PCR to multiplexing assays is not trivial; it requires multiple fluorescent labels for amplicon detection and sophisticated software for data interpretation. Alternative PCR-free methods exploiting new concepts in nanotechnology exhibit high sensitivities but require multiple labeling and/or amplificati...

journal_title：Scientific reports

authors： Papadakis G,Tsortos A,Kordas A,Tiniakou I,Morou E,Vontas J,Kardassis D,Gizeli E

更新日期：2013-01-01 00:00:00

abstract：:The number and subtype composition of N-methyl-d-aspartate receptor (NMDAR) at synapses determines their functional properties and role in learning and memory. Genetically increased or decreased amount of GluN2B affects hippocampus-dependent memory in the adult brain. But in some experimental conditions (e.g., memory ...

journal_title：Scientific reports

authors： Sun YY,Cai W,Yu J,Liu SS,Zhuo M,Li BM,Zhang XH

更新日期：2016-08-04 00:00:00

abstract：:Jellyfish locomotion and orientation have been studied in the past both in the laboratory, testing mostly small jellyfish, and in the field, where it was impossible to control the seawater currents. Utilizing an outdoor water flume, we tested the locomotion of jellyfish when swimming against and with currents of up to...

journal_title：Scientific reports

authors： Malul D,Lotan T,Makovsky Y,Holzman R,Shavit U

更新日期：2019-12-30 00:00:00

abstract：:When compared to surface ecosystems, groundwater sampling has unique constraints, including limited access to ecosystems through wells. In order to monitor groundwater, a detailed understanding of groundwater biota and what biological sampling of wells truly reflects, is paramount. This study aims to address this unce...

journal_title：Scientific reports

authors： Korbel K,Chariton A,Stephenson S,Greenfield P,Hose GC

更新日期：2017-01-19 00:00:00

abstract：:Macrophages are an important component of the innate immune response. Priming and activation of macrophages is stimulated by cytokines (i.e IFNγ). However, growth hormone (GH) can also stimulate macrophage activation. Based on these observations, the goal of this work was to 1) to compare the transcriptome profile of ...

journal_title：Scientific reports

authors： Schneider A,Wood HN,Geden S,Greene CJ,Yates RM,Masternak MM,Rohde KH

更新日期：2019-12-18 00:00:00

abstract：:Muscle attachment sites (entheses) on dry bones are regularly used by paleontologists to infer soft tissue anatomy and to reconstruct behaviors of extinct organisms. This method is commonly applied to fossil hominin hand bones to assess their abilities to participate in Paleolithic stone tool behaviors. Little is know...

journal_title：Scientific reports

authors： Williams-Hatala EM,Hatala KG,Hiles S,Rabey KN

更新日期：2016-06-23 00:00:00

abstract：:To enhance the carbon dioxide (CO2) uptake of metal-organic frameworks (MOFs), amine functionalization of their pore surfaces has been studied extensively. In general, amine-functionalized MOFs have been synthesized via post-synthetic modifications. Herein, we introduce a one-step construction of a MOF ([(NiLethylamin...

journal_title：Scientific reports

authors： Kim YK,Hyun SM,Lee JH,Kim TK,Moon D,Moon HR

更新日期：2016-01-13 00:00:00

abstract：:Plant diversity has been shown to determine the composition and functioning of soil biota. Although root-derived organic inputs are discussed as the main drivers of soil communities, experimental evidence is scarce. While there is some evidence that higher root biomass at high plant diversity increases substrate avail...

journal_title：Scientific reports

authors： Eisenhauer N,Lanoue A,Strecker T,Scheu S,Steinauer K,Thakur MP,Mommer L

更新日期：2017-04-04 00:00:00

abstract：:Microbiome analysis using metagenomic sequencing has revealed a vast microbial diversity associated with plants. Identifying the molecular functions associated with microbiome-plant interaction is a significant challenge concerning the development of microbiome-derived technologies applied to agriculture. An alternati...

journal_title：Scientific reports

authors： Armanhi JS,de Souza RS,de Araújo LM,Okura VK,Mieczkowski P,Imperial J,Arruda P

更新日期：2016-07-12 00:00:00

abstract：:Tropical deforestation is responsible for around one tenth of total anthropogenic carbon emissions, and tropical protected areas (PAs) that reduce deforestation can therefore play an important role in mitigating climate change and protecting biodiversity and ecosystem services. While the effectiveness of PAs in reduci...

journal_title：Scientific reports

authors： Bebber DP,Butt N

更新日期：2017-10-25 00:00:00

abstract：:Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles ...

journal_title：Scientific reports

authors： Ho J,He W,Chan MTV,Tse G,Liu T,Wong SH,Leung CCH,Wong WT,Tsang S,Zhang L,Chan RYP,Gin T,Leung J,Lau BWM,Wu WKK,Ngai SPC

更新日期：2017-10-18 00:00:00

abstract：:Studies of locomotor activity in Svalbard reindeer reported the temporary absence of diel rhythms under Arctic photic conditions. However, using Lomb-Scargle periodogram analyses with high statistical power we found diel or circadian rhythmicity throughout the entire year in measures of behaviour, temperature in the r...

journal_title：Scientific reports

authors： Arnold W,Ruf T,Loe LE,Irvine RJ,Ropstad E,Veiberg V,Albon SD

更新日期：2018-09-27 00:00:00

abstract：:Glaucoma optic neuropathy (GON) is a condition where pathogenic intraocular pressure (IOP) results in axonal damage following retinal ganglion cell (RGC) death, and further results in secondary damage of the lateral geniculate nucleus (LGN). Therapeutic targets for glaucoma thus focus on both the LGN and RGC. However,...

journal_title：Scientific reports

authors： Fujishiro T,Kawasaki H,Aihara M,Saeki T,Ymagishi R,Atarashi T,Mayama C,Araie M

更新日期：2014-10-13 00:00:00

abstract：:p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their removal from chromatin and other molecular complexes. Changes in p97 ex...

journal_title：Scientific reports

authors： Rycenga HB,Wolfe KB,Yeh ES,Long DT

更新日期：2019-07-17 00:00:00