A cytosolic carbonic anhydrase molecular switch occurs in the gills of metamorphic sea lamprey.

abstract：:Age-related accumulation of ploidy changes is associated with decreased expression of genes controlling chromosome segregation and cohesin functions. To determine the consequences of whole chromosome instability (W-CIN) we down-regulated the spindle assembly checkpoint component BUB1 and the mitotic cohesin SMC1A, and...

journal_title：Scientific reports

authors： Andriani GA,Almeida VP,Faggioli F,Mauro M,Tsai WL,Santambrogio L,Maslov A,Gadina M,Campisi J,Vijg J,Montagna C

更新日期：2016-10-12 00:00:00

abstract：:Hypothalamic growth hormone-releasing hormone (GHRH) neurons orchestrate body growth/maturation and have been implicated in feeding responses and ageing. However, the electrical patterns that dictate GHRH neuron functions have remained elusive. Since the inhibitory neuropeptide somatostatin (SST) is considered to be a...

journal_title：Scientific reports

authors： Osterstock G,Mitutsova V,Barre A,Granier M,Fontanaud P,Chazalon M,Carmignac D,Robinson IC,Low MJ,Plesnila N,Hodson DJ,Mollard P,Méry PF

更新日期：2016-04-13 00:00:00

abstract：:Phlebotonics' effects were evaluated to reduce time-to-stop bleeding and anal irritation in 130 patients who complained of hemorrhoidal disease (HD); bleeding and pain after hemorrhoidectomy (31 patients) and hemorrhoidal thrombosis (34 patients) in the short time. Sixty patients were randomized to receive the routine...

journal_title：Scientific reports

authors： Chiaretti M,Fegatelli DA,Pappalardo G,Venti MDS,Chiaretti AI

更新日期：2020-05-14 00:00:00

abstract：:The South Asian subcontinent is characterized by a complex history of human migrations and population interactions. In this study, we used genome-wide data to provide novel insights on the demographic history and population relationships of six Indo-European populations from the Indian State of West Maharashtra. The s...

journal_title：Scientific reports

authors： Debortoli G,Abbatangelo C,Ceballos F,Fortes-Lima C,Norton HL,Ozarkar S,Parra EJ,Jonnalagadda M

更新日期：2020-06-22 00:00:00

abstract：:The growing attention to the luminescent nanocarriers is strongly stimulated by their potential application as drug delivery systems and by the necessity to monitor their distribution in cells and tissues. In this communication we report on the synthesis of amphiphilic polypeptides bearing C-terminal phosphorescent la...

journal_title：Scientific reports

authors： Vlakh EG,Grachova EV,Zhukovsky DD,Hubina AV,Mikhailova AS,Shakirova JR,Sharoyko VV,Tunik SP,Tennikova TB

更新日期：2017-02-03 00:00:00

abstract：:We performed an integrated analysis of the transcriptome and metabolome from purple (Pr) and normal cultivated varieties (CK) of Dendrobium officinale to gain insights into the regulatory networks associated with phenylpropanoid metabolism and to identify the key regulatory genes of pigmentation. Metabolite and transc...

journal_title：Scientific reports

authors： Zhan X,Qi J,Zhou B,Mao B

更新日期：2020-10-19 00:00:00

abstract：:We have engineered the electronic structure at the interface between Cu2O and ZnO nanorods (NRs) array, through adjusting the carrier concentration of Cu2O. The electrodeposition of Cu2O at pH 11 acquired the highest carrier concentration, resulting in the largest interfacial electric field between Cu2O and ZnO, which...

journal_title：Scientific reports

authors： Kang Z,Yan X,Wang Y,Bai Z,Liu Y,Zhang Z,Lin P,Zhang X,Yuan H,Zhang X,Zhang Y

更新日期：2015-01-20 00:00:00

abstract：:Novel activated boron nitride (BN) as an effective adsorbent for pollutants in water and air has been reported in the present work. The activated BN was synthesized by a simple structure-directed method that enabled us to control the surface area, pore volume, crystal defects and surface groups. The obtained BN exhibi...

journal_title：Scientific reports

authors： Li J,Xiao X,Xu X,Lin J,Huang Y,Xue Y,Jin P,Zou J,Tang C

更新日期：2013-11-13 00:00:00

abstract：:Lipomas are benign fatty tumors with a high prevalence rate, mostly found in adults but have a good prognosis. Until now, reason for lipoma occurrence not been identified. We performed whole exome sequencing to define the mutational spectrum in ten lipoma patients along with their matching control samples. We presente...

journal_title：Scientific reports

authors： Kanojia D,Dakle P,Mayakonda A,Parameswaran R,Puhaindran ME,Min VLK,Madan V,Koeffler P

更新日期：2019-10-07 00:00:00

abstract：:A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Giancardo L,Sánchez-Ferro A,Arroyo-Gallego T,Butterworth I,Mendoza CS,Montero P,Matarazzo M,Obeso JA,Gray ML,Estépar RSJ

更新日期：2018-10-16 00:00:00

abstract：:Regional abnormalities in brain structure and function, as well as disrupted connectivity, have been found repeatedly in adolescents with conduct disorder (CD). Yet, the large-scale brain topology associated with CD is not well characterized, and little is known about the systematic neural mechanisms of CD. We employe...

journal_title：Scientific reports

authors： Jiang Y,Liu W,Ming Q,Gao Y,Ma R,Zhang X,Situ W,Wang X,Yao S,Huang B

更新日期：2016-11-14 00:00:00

abstract：:Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in sepsis due to infection with Gram-negative bacteria but not other microbes. Herein, we provided IκB kinase β (IKKβ) in innate immune process as a...

journal_title：Scientific reports

authors： Choi JH,Park SH,Jung JK,Cho WJ,Ahn B,Yun CY,Choi YP,Yeo JH,Lee H,Hong JT,Han SB,Kim Y

更新日期：2017-02-01 00:00:00

abstract：:For translocated animals, behavioral competence may be key to post-release survival. However, monitoring behavior is typically limited to tracking movements or inferring behavior at a gross scale via collar-mounted sensors. Animal-bourne acoustic monitoring may provide a unique opportunity to monitor behavior at a fin...

journal_title：Scientific reports

authors： Yan X,Zhang H,Li D,Wu D,Zhou S,Sun M,Hu H,Liu X,Mou S,He S,Owen MA,Huang Y

更新日期：2019-03-26 00:00:00

abstract：:This paper proposes a novel approach to sulfur removal by adding zinc during the digestion process. The effects of zinc dosage on the concentrations of different valence sulfur in sodium aluminate solution were investigated at length to find that high-valence sulfur (S2O32-, SO32-, SO42-) concentration in sodium alumi...

journal_title：Scientific reports

authors： Liu Z,Ma W,Yan H,Xie K,Li D,Zheng L,Li P

更新日期：2017-12-07 00:00:00

abstract：:Sorafenib is a RAF inhibitor approved for several cancers, including hepatocellular carcinoma (HCC). Inhibition of RAF kinases can induce a dose-dependent "paradoxical" upregulation of the downstream mitogen-activated protein kinase (MAPK) pathway in cancer cells. It is unknown whether "paradoxical" ERK activation occ...

journal_title：Scientific reports

authors： Chen Y,Liu YC,Sung YC,Ramjiawan RR,Lin TT,Chang CC,Jeng KS,Chang CF,Liu CH,Gao DY,Hsu FF,Duyverman AM,Kitahara S,Huang P,Dima S,Popescu I,Flaherty KT,Zhu AX,Bardeesy N,Jain RK,Benes CH,Duda DG

更新日期：2017-03-09 00:00:00

abstract：:Oxygen tolerance of selenium-containing [NiFeSe] hydrogenases (Hases) is attributable to the high reducing power of the selenocysteine residue, which sustains the bimetallic Ni-Fe catalytic center in the large subunit. Genes encoding [NiFeSe] Hases are inherited by few sulphate-reducing δ-proteobacteria globally distr...

journal_title：Scientific reports

authors： Tamura T,Tsunekawa N,Nemoto M,Inagaki K,Hirano T,Sato F

更新日期：2016-01-28 00:00:00

abstract：:The healthy adult heart primarily relies on fatty acid oxidation (FAO) for energy production but instantaneously adapts its substrate preference in response to physiological or pathological challenges. Accurate FAO measurements are crucial to investigate early metabolic (mal)adaptations. While measurements in intact c...

journal_title：Scientific reports

authors： Rech M,Luiken JJFP,Glatz JFC,van Bilsen M,Schroen B,Nabben M

更新日期：2018-01-24 00:00:00

abstract：:Acclimation and adaptation, which are key to species survival in a changing climate, can be observed in terms of membrane lipid composition. Remodelling membrane lipids, via homeoviscous adaptation (HVA), counteracts membrane dysfunction due to temperature in poikilotherms. In order to assess the potential for acclima...

journal_title：Scientific reports

authors： Muir AP,Nunes FL,Dubois SF,Pernet F

更新日期：2016-10-20 00:00:00

abstract：:In our previous study, a liver-targeting peptide CSP I-plus modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed and showed potent antiangiogenic capability and could specifically bind to human hepatocellular carcinoma cells to make a direct inhibition in vitro. In this study, the bi...

journal_title：Scientific reports

authors： Yan M,Dongmei B,Jingjing Z,Xiaobao J,Jie W,Yan W,Jiayong Z

更新日期：2017-10-26 00:00:00

abstract：:Rejuvenation is the configurational excitation of amorphous materials and is one of the more promising approaches for improving the deformability of amorphous metals that usually exhibit macroscopic brittle fracture modes. Here, we propose a method to control the level of rejuvenation through systematic thermal proces...

journal_title：Scientific reports

authors： Wakeda M,Saida J,Li J,Ogata S

更新日期：2015-05-26 00:00:00

abstract：:Advances in microfluidics technology has enabled many discoveries on microbial mechanisms and phenotypes owing to its exquisite controls over biological and chemical environments. However, emulating accurate ecologically relevant flow environments (e.g. microbes around a rising oil droplet) in microfluidics remains ch...

journal_title：Scientific reports

authors： White AR,Jalali M,Sheng J

更新日期：2019-09-24 00:00:00

abstract：:Exposure to affective stimuli could enhance perception and facilitate attention via increasing alertness, vigilance, and by decreasing attentional thresholds. However, evidence on the impact of affective sounds on perception and attention is scant. Here, a novel aspect of affective facilitation of attention is studied...

journal_title：Scientific reports

authors： Asutay E,Västfjäll D

更新日期：2017-09-04 00:00:00

abstract：:Supercapacitors with aqueous electrolytes and nanostructured composite electrodes are attractive because of their high charging-discharging speed, long cycle life, low environmental impact and wide commercial affordability. However, the energy capacity of aqueous supercapacitors is limited by the electrochemical windo...

journal_title：Scientific reports

authors： Dai Z,Peng C,Chae JH,Ng KC,Chen GZ

更新日期：2015-04-21 00:00:00

abstract：:Proper determination of agonist efficacy is essential in the assessment of agonist selectivity and signalling bias. Agonist efficacy is a relative term that is dependent on the system in which it is measured, especially being dependent on receptor expression level. The operational model (OM) of functional receptor ago...

journal_title：Scientific reports

authors： Jakubík J,Randáková A,Rudajev V,Zimčík P,El-Fakahany EE,Doležal V

更新日期：2019-03-15 00:00:00

abstract：:Multiplexed or simultaneous detection of multiple analytes is a valuable tool in many analytical applications. However, complications caused by the presence of interfering compounds in a sample form a major drawback in existing molecular sensor technologies, particularly in multi-analyte systems. Although separating a...

journal_title：Scientific reports

authors： Kasera S,Herrmann LO,del Barrio J,Baumberg JJ,Scherman OA

更新日期：2014-10-30 00:00:00

abstract：:Metabolic reprogramming is critical for T cell fate and polarization and is regulated by metabolic checkpoints, including Myc, HIF-1α, AMPK and mTORC1. Our objective was to determine the impact of mycophenolic acid (MPA) in comparison with rapamycin (Rapa), an inhibitor of mTORC1, on the metabolism of Jurkat T cells. ...

journal_title：Scientific reports

authors： Fernández-Ramos AA,Marchetti-Laurent C,Poindessous V,Antonio S,Petitgas C,Ceballos-Picot I,Laurent-Puig P,Bortoli S,Loriot MA,Pallet N

更新日期：2017-09-05 00:00:00

abstract：:Imaging the fields of magnetic materials provides crucial insight into the physical and chemical processes surrounding magnetism, and has been a key ingredient in the spectacular development of magnetic data storage. Existing approaches using the magneto-optic Kerr effect, x-ray and electron microscopy have limitation...

journal_title：Scientific reports

authors： Simpson DA,Tetienne JP,McCoey JM,Ganesan K,Hall LT,Petrou S,Scholten RE,Hollenberg LC

更新日期：2016-03-14 00:00:00

abstract：:The Monte Carlo (MC) method is widely used to solve various problems in radiotherapy. There has been an impetus to accelerate MC simulation on GPUs whereas thread divergence remains a major issue for MC codes based on acceptance-rejection sampling. Inverse transform sampling has the potential to eliminate thread diver...

journal_title：Scientific reports

authors： Liang Y,Muhammad W,Hart GR,Nartowt BJ,Chen ZJ,Yu JB,Roberts KB,Duncan JS,Deng J

更新日期：2020-06-17 00:00:00

abstract：:Alcoholic liver disease (ALD) causes significant morbidity and mortality, and pharmacological treatment options are limited. In this study, we evaluated the PCSK9 inhibitor alirocumab, a monoclonal antibody that robustly reduces low-density lipoprotein cholesterol (LDL-C), for the treatment of ALD using a rat model of...

journal_title：Scientific reports

authors： Lee JS,Mukhopadhyay P,Matyas C,Trojnar E,Paloczi J,Yang YR,Blank BA,Savage C,Sorokin AV,Mehta NN,Vendruscolo JCM,Koob GF,Vendruscolo LF,Pacher P,Lohoff FW

更新日期：2019-11-20 00:00:00

abstract：:Increased prostaglandin E2 (PGE2) levels were detected in mitochondrial disease patient cells harboring nuclear gene mutations in structural subunits of complex I, using a metabolomics screening approach. The increased levels of this principal inflammation mediator normalized following exposure of KH176m, an active re...

journal_title：Scientific reports

authors： Jiang X,Renkema H,Pennings B,Pecheritsyna S,Schoeman JC,Hankemeier T,Smeitink J,Beyrath J

更新日期：2021-01-13 00:00:00