Metabolomic and transcriptomic analyses reveal the regulation of pigmentation in the purple variety of Dendrobium officinale.

abstract：:The number of magnetoelectric multiferroic materials reported to date is scarce, as magnetic structures that break inversion symmetry and induce an improper ferroelectric polarization typically arise through subtle competition between different magnetic interactions. The (NH4)2[FeCl5(H2O)] compound is a rare case wher...

journal_title：Scientific reports

authors： Alberto Rodríguez-Velamazán J,Fabelo Ó,Millán Á,Campo J,Johnson RD,Chapon L

更新日期：2015-09-29 00:00:00

abstract：:Central nervous system-specific proteins (CSPs), transported across the damaged blood-brain-barrier (BBB) to cerebrospinal fluid (CSF) and blood (serum), might be promising diagnostic, prognostic and predictive protein biomarkers of disease in individual multiple sclerosis (MS) patients because they are not expected t...

journal_title：Scientific reports

authors： Raphael I,Mahesula S,Purkar A,Black D,Catala A,Gelfond JA,Forsthuber TG,Haskins WE

更新日期：2014-09-03 00:00:00

abstract：:Fatty liver (FL) disease is the most common type of chronic liver disease. We hypothesized that liver's response to the process where large droplets of triglyceride fat accumulate in liver cells is reflected also in gene pathway expression in blood. Peripheral blood genome wide gene expression analysis and ultrasonic ...

journal_title：Scientific reports

authors： Taipale T,Seppälä I,Raitoharju E,Mononen N,Lyytikäinen LP,Illig T,Waldenberger M,Juonala M,Hutri-Kähönen N,Oksala N,Kähönen M,Raitakari O,Lehtimäki T

更新日期：2018-07-09 00:00:00

abstract：:We found that the coagulation and cytokine pathways were important mechanisms involve in the degeneration of intervertebral discs (IVD) using a microarray approach to analyze gene expression in different grades of specimens. Furthermore, using a cytokine/chemokine array, a significant increase in CXCL8 expression was ...

journal_title：Scientific reports

authors： Huang BR,Chen TS,Bau DT,Chuang IC,Tsai CF,Chang PC,Lu DY

更新日期：2017-08-17 00:00:00

abstract：:A key challenge of central nervous system tumor surgery is to discriminate between brain regions infiltrated by tumor cells and surrounding healthy tissue. Although monitoring of autofluorescence could potentially be an efficient way to provide reliable information for these regions, we found little information on thi...

journal_title：Scientific reports

authors： Poulon F,Mehidine H,Juchaux M,Varlet P,Devaux B,Pallud J,Abi Haidar D

更新日期：2017-10-25 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ashokkumar M,Sonawane A,Sperk M,Tripathy SP,Neogi U,Hanna LE

更新日期：2020-08-10 00:00:00

abstract：:Uropathogenic strains of Escherichia coli establish urinary tract infections by attaching to host epithelial cells using adhesive organelles called fimbriae. Fimbriae are helix-like structures with a remarkable adaptability, offering safeguarding for bacteria exposed to changing fluid forces in the urinary tract. We c...

journal_title：Scientific reports

authors： Mortezaei N,Singh B,Bullitt E,Uhlin BE,Andersson M

更新日期：2013-12-02 00:00:00

abstract：:Consistent cell preparation is a fundamental preliminary step for understanding complex cellular mechanisms in various cell-based research fields, including basic cell biology, cancer research, and tissue engineering. However, certain elusive factors, such as cellular de-differentiation and contamination with mycoplas...

journal_title：Scientific reports

authors： Osaki T,Kageyama T,Shimazu Y,Mysnikova D,Takahashi S,Takimoto S,Fukuda J

更新日期：2017-05-15 00:00:00

abstract：:Electrochemically generated bactericidal compounds have been shown to eradicate bacterial lawn biofilms through electroceutical treatment. However, the ultrastructure of biofilms exposed to these species has not been studied. Moreover, it is unknown if the efficacy of electroceutical treatment extends to antibiotic-re...

journal_title：Scientific reports

authors： Lochab V,Jones TH,Dusane DH,Peters CW,Stoodley P,Wozniak DJ,Subramaniam VV,Prakash S

更新日期：2020-06-18 00:00:00

abstract：:Recent studies showed that somatic cancer mutations target genes that are in specific signaling and cellular pathways. However, in each patient only a few of the pathway genes are mutated. Current approaches consider only existing pathways and ignore the topology of the pathways. For this reason, new efforts have been...

journal_title：Scientific reports

authors： Ajwad R,Domaratzki M,Liu Q,Feizi N,Hu P

更新日期：2021-01-12 00:00:00

abstract：:To manage a stressful stimulus animals react both behaviorally and physiologically to restore the homeostasis. In stable horses, a stressful stimulus can be represented by social separation, riding discomfort or the presence of novel objects in their environment. Although Heart Rate Variability is a common indicator o...

journal_title：Scientific reports

authors： Scopa C,Palagi E,Sighieri C,Baragli P

更新日期：2018-11-30 00:00:00

abstract：:Multifunctional nanocarriers harbouring specific targeting moieties and with pH-responsive properties offer great potential for targeted cancer therapy. Several synthetic drug carriers have been studied extensively as drug delivery systems but not much information is available on the application of virus-like nanopart...

journal_title：Scientific reports

authors： Biabanikhankahdani R,Alitheen NBM,Ho KL,Tan WS

更新日期：2016-11-24 00:00:00

abstract：:The placenta has emerged as an attractive source of mesenchymal stem cells (MSCs) because of the absence of ethical issues, non-invasive access, and abundant yield. However, inflammatory cell invasion into grafts negatively impacts the survival and efficacy of transplanted cells. Previous studies have shown that synth...

journal_title：Scientific reports

authors： Tian KW,Zhang YY,Jiang H,Han S

更新日期：2018-03-15 00:00:00

abstract：:Congenital reproductive tract anomalies could impair fertility. Female and male reproductive tracts are developed from Müllerian ducts and Wolffian ducts, respectively, involving initiation, elongation and differentiation. Genetic basis solely for distal reproductive tract development is largely unknown. Lhfpl2 (lipom...

journal_title：Scientific reports

authors： Zhao F,Zhou J,Li R,Dudley EA,Ye X

更新日期：2016-03-11 00:00:00

abstract：:Nutrient inputs and ultraviolet radiation (UVR) are global factors affecting the structure and functioning of aquatic ecosystems, particularly clear-water ecosystems. We performed experiments in two model lakes highly exposed to UVR fluxes in order to test the effect that future increases in mineral nutrients transpor...

journal_title：Scientific reports

authors： Carrillo P,Medina-Sánchez JM,Villar-Argaiz M,Bullejos FJ,Durán C,Bastidas-Navarro M,Souza MS,Balseiro EG,Modenutti BE

更新日期：2017-07-24 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Shim CH,Parc YW,Kumar S,Ko IS,Kim DE

更新日期：2019-06-06 00:00:00

abstract：:To understand the role of commensal gut bacteria on the progression of cognitive decline in Alzheimer's disease via the microbiota-gut-brain axis, we isolated anti-inflammatory Bifidobacterium longum (NK46) from human gut microbiota, which potently inhibited gut microbiota endotoxin production and suppressed NF-κB act...

journal_title：Scientific reports

authors： Lee HJ,Lee KE,Kim JK,Kim DH

更新日期：2019-08-14 00:00:00

abstract：:In inflammatory bowel disease (IBD), compromised restitution of the epithelial barrier contributes to disease severity. Owing to the complexity in the pathogenesis of IBD, a variety of factors have been implicated in its progress. In this study, we report a functional interaction between macroautophagy and Corticotrop...

journal_title：Scientific reports

authors： Giannogonas P,Apostolou A,Manousopoulou A,Theocharis S,Macari SA,Psarras S,Garbis SD,Pothoulakis C,Karalis KP

更新日期：2016-03-18 00:00:00

abstract：:Fc domain fusion can improve the therapeutic effects of relatively small biological molecules such as peptides, cytokines, and antibody fragments. Fc fusion proteins can also be used to enhance the cytotoxic effects of small bispecific antibodies (bsAbs). However, fragmentation of Fc fusion proteins, which mainly occu...

journal_title：Scientific reports

authors： Suzuki S,Annaka H,Konno S,Kumagai I,Asano R

更新日期：2018-11-22 00:00:00

abstract：:A two-dimensional (2D) material placed on an atomically flat substrate can lead to the formation of surface nanobubbles trapping different types of substances. In this paper graphene nanobubbles of the radius of 7-34 nm with argon atoms inside are studied using molecular dynamics (MD). All modeled graphene nanobubbles...

journal_title：Scientific reports

authors： Iakovlev E,Zhilyaev P,Akhatov I

更新日期：2017-12-20 00:00:00

abstract：:Programmed cell death 1 (PD-1) monoclonal antibodies have been approved by regulatory agencies for the treatment of various types of cancer, and the mechanism involves the restoration of T cell functions. We report herein the X-ray crystal structure of a fully human monoclonal antibody mAb059c fragment antigen-binding...

journal_title：Scientific reports

authors： Liu J,Wang G,Liu L,Wu R,Wu Y,Fang C,Zhou X,Jiao J,Gu Y,Zhou H,Xie Z,Sun Z,Chen D,Dai K,Wang D,Tang W,Yang TTC

更新日期：2019-11-28 00:00:00

abstract：:Anoectochilus roxburghii and Anoectochilus formasanus are the major species of genus Anoectochilus used in traditional Chinese medicine for their abundant content of flavonoids and some other medicinal constituents. In recent years, their wild resources are gradually exhausted due to over-collection and ecological det...

journal_title：Scientific reports

authors： Yang L,Zhang JC,Qu JT,He G,Yu HQ,Li WC,Fu FL

更新日期：2019-12-27 00:00:00

abstract：:Accumulating evidence indicates the association between obesity and lung function. However, no previous study has examined whether obesity affects lung function in normal weight participants with high body fat. We hypothesized that subjects with normal weight obesity (NWO) were inversely associated with lung function ...

journal_title：Scientific reports

authors： Chen YY,Kao TW,Fang WH,Wang CC,Chang YW,Yang HF,Wu CJ,Sun YS,Chen WL

更新日期：2019-06-20 00:00:00

abstract：:That stalks reorient after flowering to face upwards is a common phenomenon in many flowering plants, indicating the potential importance of fruit orientation on seed dispersal. But this idea has not been subject to an empirical test. We examined this hypothesis by analysing the evolutionary correlation between fruit ...

journal_title：Scientific reports

authors： Niu Y,Zhou Z,Sha W,Sun H

更新日期：2016-02-02 00:00:00

abstract：:Ataxia-telangiectasia (AT) and related disorders feature cancer predisposition, neurodegeneration, and immunodeficiency resulting from failure to respond to DNA damage. Hypomorphic mutations in MRE11 cause an AT-like disorder (ATLD) with variable clinical presentation. We have sought to understand how diverse MRE11 mu...

journal_title：Scientific reports

authors： Hartlerode AJ,Regal JA,Ferguson DO

更新日期：2018-07-04 00:00:00

abstract：:A high throughput method for species identification and classification through chemometric processing of direct analysis in real time (DART) mass spectrometry-derived fingerprint signatures has been developed. The method entails introduction of samples to the open air space between the DART ion source and the mass spe...

journal_title：Scientific reports

authors： Musah RA,Espinoza EO,Cody RB,Lesiak AD,Christensen ED,Moore HE,Maleknia S,Drijfhout FP

更新日期：2015-07-09 00:00:00

abstract：:The temporal dynamics of brain activation during visual and auditory perception of congruent vs. incongruent musical video clips was investigated in 12 musicians from the Milan Conservatory of music and 12 controls. 368 videos of a clarinetist and a violinist playing the same score with their instruments were presente...

journal_title：Scientific reports

authors： Proverbio AM,Calbi M,Manfredi M,Zani A

更新日期：2014-07-29 00:00:00

abstract：:Phytoplasmas are transmitted by insect vectors in a persistent propagative manner; however, detailed movements and multiplication patterns of phytoplasmas within vectors remain elusive. In this study, spatiotemporal dynamics of onion yellows (OY) phytoplasma in its vector Macrosteles striifrons were investigated by im...

journal_title：Scientific reports

authors： Koinuma H,Maejima K,Tokuda R,Kitazawa Y,Nijo T,Wei W,Kumita K,Miyazaki A,Namba S,Yamaji Y

更新日期：2020-03-09 00:00:00

abstract：:Despite advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis. Recent studies have implicated cancer stem cells within glioblastoma (glioma stem cells, GSCs) as mediators of therapeutic resistance and tumor progression. In this study, we investigated the role of the transforming growth...

journal_title：Scientific reports

authors： Sachdeva R,Wu M,Johnson K,Kim H,Celebre A,Shahzad U,Graham MS,Kessler JA,Chuang JH,Karamchandani J,Bredel M,Verhaak R,Das S

更新日期：2019-10-10 00:00:00

abstract：:Tandem solar cells are suited for space applications due to their high performance, but also have to be designed in such a way to minimize influence of degradation by the high energy particle flux in space. The analysis of the subcell performance is crucial to understand the device physics and achieve optimized design...

journal_title：Scientific reports

authors： Tex DM,Nakamura T,Imaizumi M,Ohshima T,Kanemitsu Y

更新日期：2017-05-16 00:00:00