Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 biosynthesis by sonlicromanol's metabolite KH176m.

abstract：:Hedgehog (Hh) signaling plays a broad role in the development of many organs including bone and teeth. It is noted that sustained Hh activity in osteoblasts negatively regulates postnatal development in mice. However, it remains unknown whether Hh signaling contributes to cementum formation. In this study, to define t...

journal_title：Scientific reports

authors： Choi H,Liu Y,Yang L,Cho ES

更新日期：2020-04-29 00:00:00

abstract：:Although cisplatin plays a central role in cancer chemotherapy, the mechanisms of cell response to this drug have been unexplored. The present study demonstrates the relationships between the intracellular pH (pHi), cell bioenergetics and the response of cervical cancer to cisplatin. pHi was measured using genetically...

journal_title：Scientific reports

authors： Shirmanova MV,Druzhkova IN,Lukina MM,Dudenkova VV,Ignatova NI,Snopova LB,Shcheslavskiy VI,Belousov VV,Zagaynova EV

更新日期：2017-08-21 00:00:00

abstract：:Pseudoalteromonas haloplanktis TAC125 is among the most commonly studied bacteria adapted to cold environments. Aside from its ecological relevance, P. haloplanktis has a potential use for biotechnological applications. Due to its importance, we decided to take advantage of next generation sequencing (Illumina) and th...

journal_title：Scientific reports

authors： Qi W,Colarusso A,Olombrada M,Parrilli E,Patrignani A,Tutino ML,Toll-Riera M

更新日期：2019-11-11 00:00:00

abstract：:To assess the correlation between penile hypersensitivity and premature ejaculation (PE), a total of 420 consecutive subjects attending our andrologic clinic for suspected PE were enrolled. The entire cohort was asked to complete the self-report intravaginal ejaculation latency time (IELT) by stopwatch. According to t...

journal_title：Scientific reports

authors： Guo L,Liu Y,Wang X,Yuan M,Yu Y,Zhang X,Zhao S

更新日期：2017-09-05 00:00:00

abstract：:Adipose tissue inflammation is a central pathological element that regulates obesity-mediated insulin resistance and type II diabetes. Evidence demonstrates that extracellular signal-regulated kinase (ERK 1/2) activation (i.e. phosphorylation) links tumor necrosis factor α (TNFα) to pro-inflammatory gene expression in...

journal_title：Scientific reports

authors： Habibian JS,Jefic M,Bagchi RA,Lane RH,McKnight RA,McKinsey TA,Morrison RF,Ferguson BS

更新日期：2017-10-10 00:00:00

abstract：:We report the observation of a large linear magnetoresistance in the ohmic regime in commonplace commercial n-type silicon wafer with a P dopant density of (1.4±0.1) ×10(15) cm(-3), and report measurements of it in the temperature range 30-200 K. It arises from the deformation of current paths, which causes a part of ...

journal_title：Scientific reports

authors： Porter NA,Marrows CH

更新日期：2012-01-01 00:00:00

abstract：:Virus pseudotyping is a useful and safe technique for studying entry of emerging strains of influenza virus. However, few studies have compared different reassortant combinations in pseudoparticle systems, or compared entry kinetics of native viruses and their pseudotyped analogs. Here, vesicular stomatitis virus (VSV...

journal_title：Scientific reports

authors： Hsu HL,Millet JK,Costello DA,Whittaker GR,Daniel S

更新日期：2016-10-18 00:00:00

abstract：:For historic individuals, the outward appearance and other phenotypic characteristics remain often non-resolved. Unfortunately, images or detailed written sources are only scarcely available in many cases. Attempts to study historic individuals with genetic data so far focused on hypervariable regions of mitochondrial...

journal_title：Scientific reports

authors： Peltzer A,Mittnik A,Wang CC,Begg T,Posth C,Nieselt K,Krause J

更新日期：2018-02-01 00:00:00

abstract：:Infection diagnosis and antibiotic susceptibility testing (AST) are time-consuming and often laborious clinical practices. This paper presents a microwave-microfluidic biosensor for rapid, contactless and non-invasive device for testing the concentration and growth of Escherichia Coli (E. Coli) in medium solutions of ...

journal_title：Scientific reports

authors： Narang R,Mohammadi S,Ashani MM,Sadabadi H,Hejazi H,Zarifi MH,Sanati-Nezhad A

更新日期：2018-10-25 00:00:00

abstract：:Gene targeting in embryonic stem cells (ESCs) has become the principal technology for generating knockout models. Although numerous studies have predicted that the disruption of p53 leads to increased developmental anomalies and malignancies, most p53 knockout mice develop normally. Therefore, the role of p53 in anima...

journal_title：Scientific reports

authors： Kawamata M,Ochiya T

更新日期：2012-01-01 00:00:00

abstract：:M2BP (also called 90K) is an interferon-stimulated gene product that is upregulated in HIV-1 infection. A recent study revealed that M2BP reduces the infectivity of HIV-1 by inhibiting the processing of the viral envelope protein. Here we report that in addition to reducing viral infectivity, M2BP inhibits HIV-1 virio...

journal_title：Scientific reports

authors： Wang Q,Zhang X,Han Y,Wang X,Gao G

更新日期：2016-09-08 00:00:00

abstract：:Soft ferromagnetic Fe-based bulk metallic glass key-shaped specimens with a maximum and minimum width of 25.4 and 5 mm, respectively, were successfully produced using a high pressure die casting (HPDC) method, The influence of die material, alloy temperature and flow rate on the microstructure, thermal stability and s...

journal_title：Scientific reports

authors： Ramasamy P,Szabo A,Borzel S,Eckert J,Stoica M,Bárdos A

更新日期：2016-10-11 00:00:00

abstract：:Perhaps, oxidative stress progresses pupation in some Lepidopteran insects; however, the reasons for this remain obscure. In our previous study, we clarified Bombyx mori SOD1 (BmSOD1) and B. mori SOD2 (BmSOD2) proteins respond in common to ultraviolet irradiation (UV) oxidative stress and metamorphosis. This result st...

journal_title：Scientific reports

authors： Nojima Y,Bono H,Yokoyama T,Iwabuchi K,Sato R,Arai K,Tabunoki H

更新日期：2019-10-11 00:00:00

abstract：:Malaria is among the major threats to global health with the main burden of disease being in rural areas of developing countries where accurate diagnosis based on non-invasive samples is in high demand. We here present a novel molecular assay for detection of malaria parasites based on technology that may be adapted f...

journal_title：Scientific reports

authors： Hede MS,Fjelstrup S,Lötsch F,Zoleko RM,Klicpera A,Groger M,Mischlinger J,Endame L,Veletzky L,Neher R,Simonsen AKW,Petersen E,Mombo-Ngoma G,Stougaard M,Ho YP,Labouriau R,Ramharter M,Knudsen BR

更新日期：2018-03-07 00:00:00

abstract：:China has one of the highest rates of cesarean sections in the world. However, limited epidemiological studies have evaluated the risk factors for cesarean section among Chinese women. Thus, the aim of this cohort study was to investigate the associations between pre-pregnancy BMI, gestational weight gain (GWG) and th...

journal_title：Scientific reports

authors： Xiong C,Zhou A,Cao Z,Zhang Y,Qiu L,Yao C,Wang Y,Zhang B

更新日期：2016-11-22 00:00:00

abstract：:Studies reveal that there exists much interaction and communication between bacterial cells, with parts of these social behaviors depending on cell-cell contacts. The cell-cell contact has proved to be crucial for determining various biochemical processes. However, for cell culture with relatively low cell concentrati...

journal_title：Scientific reports

authors： Xin H,Zhang Y,Lei H,Li Y,Zhang H,Li B

更新日期：2013-01-01 00:00:00

abstract：:Cylindrical shell fused silica resonators coated with 8 axisymmetric Pb(Zr0.53Ti0.47)O3 (PZT) thin film electrodes (thickness ~2 μm) were reported. The resonators were firstly designed and fabricated, then annealed and processed by chemical etching to increase mechanical quality factor (Q factor) of resonators, which ...

journal_title：Scientific reports

authors： Luo Y,Qu T,Cui Y,Pan Y,Yu M,Luo H,Jia Y,Tan Z,Liu J,Zhang B

更新日期：2019-07-01 00:00:00

abstract：:Climate indices based on sea surface temperature (SST) can synthesize information related to physical processes that describe change and variability in continental precipitation from floods to droughts. The South Atlantic Subtropical Dipole index (SASD) is based on the distribution of SST in the South Atlantic and fit...

journal_title：Scientific reports

authors： Wainer I,Prado LF,Khodri M,Otto-Bliesner B

更新日期：2014-06-13 00:00:00

abstract：:Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the ...

journal_title：Scientific reports

authors： Shimada N,Inami S,Sato S,Kitamoto T,Sakai T

更新日期：2016-11-17 00:00:00

abstract：:Graphene grown by high temperature molecular beam epitaxy on hexagonal boron nitride (hBN) forms continuous domains with dimensions of order 20 μm, and exhibits moiré patterns with large periodicities, up to ~30 nm, indicating that the layers are highly strained. Topological defects in the moiré patterns are observed ...

journal_title：Scientific reports

authors： Summerfield A,Davies A,Cheng TS,Korolkov VV,Cho Y,Mellor CJ,Foxon CT,Khlobystov AN,Watanabe K,Taniguchi T,Eaves L,Novikov SV,Beton PH

更新日期：2016-03-01 00:00:00

abstract：:Tuneable pressure effects associated with changing interlayer distances in two-dimensional graphene oxide (GO)/reduced GO (rGO) layers are demonstrated through monitoring the changes in the spin-crossover (SCO) temperature (T 1/2) of [Fe(Htrz)2(trz)](BF4) nanoparticles (NPs) incorporated in the interlayer spaces of th...

journal_title：Scientific reports

authors： Sekimoto Y,Ohtani R,Nakamura M,Koinuma M,Lindoy LF,Hayami S

更新日期：2017-09-22 00:00:00

abstract：:Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, usually via its interaction with small regulatory RNA. Besides these RNA-related functions, Hfq has also been described as one of the n...

journal_title：Scientific reports

authors： Malabirade A,Partouche D,El Hamoui O,Turbant F,Geinguenaud F,Recouvreux P,Bizien T,Busi F,Wien F,Arluison V

更新日期：2018-11-14 00:00:00

abstract：:The cardiac neural crest cells (cNCCs) and the second heart field (SHF) play key roles in development of the cardiac outflow tract (OFT) for establishment of completely separated pulmonary and systemic circulations in vertebrates. A neurovascular guiding factor, Semaphorin 3c (Sema3c), is required for the development ...

journal_title：Scientific reports

authors： Kodo K,Shibata S,Miyagawa-Tomita S,Ong SG,Takahashi H,Kume T,Okano H,Matsuoka R,Yamagishi H

更新日期：2017-07-28 00:00:00

abstract：:Soybean cyst nematode (SCN) Heterodera glycines is an obligate parasite that relies on the secretion of effector proteins to manipulate host cellular processes that favor the formation of a feeding site within host roots to ensure its survival. The sequence complexity and co-evolutionary forces acting upon these effec...

journal_title：Scientific reports

authors： Gardner M,Dhroso A,Johnson N,Davis EL,Baum TJ,Korkin D,Mitchum MG

更新日期：2018-02-06 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) are obligate symbionts, living in associations with the roots of most land plants. AMF produce wide networks of extraradical mycelium (ERM) of indeterminate length, spreading from host roots into the surrounding soil and establishing belowground interconnections among plants belongin...

journal_title：Scientific reports

authors： Pepe A,Giovannetti M,Sbrana C

更新日期：2018-07-06 00:00:00

abstract：:Tellurite (TeO32-) is a hazardous and toxic oxyanion for living organisms. However, several microorganisms can bioconvert TeO32- into the less toxic form of elemental tellurium (Te0). Here, Rhodococcus aetherivorans BCP1 resting (non-growing) cells showed the proficiency to produce tellurium-based nanoparticles (NPs) ...

journal_title：Scientific reports

authors： Presentato A,Piacenza E,Darbandi A,Anikovskiy M,Cappelletti M,Zannoni D,Turner RJ

更新日期：2018-03-02 00:00:00

abstract：:A common spinning toy, called "buzzer", consists of a perforated disk and flexible threads. Despite of its simple construction, a buzzer can effectively transfer translational motions into high-speed rotations. In the present work, we find that the disk can be spun by hand at an extremely high rotational speed, e.g., ...

journal_title：Scientific reports

authors： Zhao ZL,Zhou S,Xu S,Feng XQ,Xie YM

更新日期：2017-10-13 00:00:00

abstract：:Attosecond (asec) X-ray free-electron laser (XFEL) has attracted considerable interest over the past years. Nowadays typical XFEL application experiments demand 1010-1011 photons per pulse, which corresponds to a peak power of terawatts (TW) in case of asec hard X-ray pulse. To the realization of such TW asec-XFEL pul...

journal_title：Scientific reports

authors： Shim CH,Parc YW,Kim DE

更新日期：2020-01-28 00:00:00

abstract：:Cellular therapies for liver diseases and in vitro models for drug testing both require functional human hepatocytes (Hum-H), which have unfortunately been limited due to the paucity of donor liver tissues. Human pluripotent stem cells (hPSCs) represent a promising and potentially unlimited cell source to derive Hum-H...

journal_title：Scientific reports

authors： Song W,Lu YC,Frankel AS,An D,Schwartz RE,Ma M

更新日期：2015-11-23 00:00:00

abstract：:Porosity and permeability are the key factors in assessing the hydrocarbon productivity of unconventional (shale) reservoirs, which are complex in nature due to their heterogeneous mineralogy and poorly connected nano- and micro-pore systems. Experimental efforts to measure these petrophysical properties posse many li...

journal_title：Scientific reports

authors： Goral J,Panja P,Deo M,Andrew M,Linden S,Schwarz JO,Wiegmann A

更新日期：2020-01-08 00:00:00