Abstract：
:Age-related accumulation of ploidy changes is associated with decreased expression of genes controlling chromosome segregation and cohesin functions. To determine the consequences of whole chromosome instability (W-CIN) we down-regulated the spindle assembly checkpoint component BUB1 and the mitotic cohesin SMC1A, and used four-color-interphase-FISH coupled with BrdU incorporation and analyses of senescence features to reveal the fate of W-CIN cells. We observed significant correlations between levels of not-diploid cells and senescence-associated features (SAFs). W-CIN induced DNA double strand breaks and elevated oxidative stress, but caused low apoptosis. SAFs of W-CIN cells were remarkably similar to those induced by replicative senescence but occurred in only 13 days versus 4 months. Cultures enriched with not-diploid cells acquired a senescence-associated secretory phenotype (SASP) characterized by IL1B, CXCL8, CCL2, TNF, CCL27 and other pro-inflammatory factors including a novel SASP component CLEC11A. These findings suggest that W-CIN triggers premature senescence, presumably to prevent the propagation of cells with an abnormal DNA content. Cells deviating from diploidy have the ability to communicate with their microenvironment by secretion of an array of signaling factors. Our results suggest that aneuploid cells that accumulate during aging in some mammalian tissues potentially contribute to age-related pathologies and inflammation through SASP secretion.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Andriani GA,Almeida VP,Faggioli F,Mauro M,Tsai WL,Santambrogio L,Maslov A,Gadina M,Campisi J,Vijg J,Montagna Cdoi
10.1038/srep35218subject
Has Abstractpub_date
2016-10-12 00:00:00pages
35218issn
2045-2322pii
srep35218journal_volume
6pub_type
杂志文章abstract：:A series of La1-xCexCoO3 perovskite nanoparticles with rhombohedral phases was synthesized via sol-gel chemical process. X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), Electron Diffraction Spectroscopy (EDS), Thermogravimetric Analysis (TGA), UV-Vis spectroscopy, Fourier Transform Infrared spectra (F...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71869-z
更新日期：2020-09-14 00:00:00
abstract：:This study aimed to define the width and length of the dental arch in 12-year-old Vietnamese children, and to elucidate differences between genders and among ethnic groups. A cross-sectional study was conducted in 4565 12 years-old children from the 4 major ethnic groups in Vietnam (Kinh, Muong, Thai, and Tay), with a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39710-4
更新日期：2019-02-28 00:00:00
abstract：:TRPV1 is a polymodal nociceptor for diverse physical and chemical stimuli that interact with different parts of the channel protein. Recent cryo-EM studies revealed detailed channel structures, opening the door for mapping structural elements mediating activation by each stimulus. Towards this goal, here we have combi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33827
更新日期：2016-09-26 00:00:00
abstract：:It is unknown whether YOD (young onset diabetes) and LOD (late onset diabetes) require similar insulin doses for intensive insulin therapy with a metformin add-on to achieve glycemic control. We analyzed data from our two previously performed randomized, controlled open-label trials. Patients were randomized to receiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16658-x
更新日期：2017-11-27 00:00:00
abstract：:The prion protein (PrPC), a mainly neuronal protein, is known to modulate glucose homeostasis in mouse models. We explored the underlying mechanism in mouse models and the human pancreatic β-cell line 1.1B4. We report expression of PrPC on mouse pancreatic β-cells, where it promoted uptake of iron through divalent-met...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24786-1
更新日期：2018-04-26 00:00:00
abstract：:Asymmetric transmission (AT) devices are fundamental elements for optical computing and information processing. We here propose an AT device consisting of a pair of coupled complementary subwavelength gratings. Different from previous works, asymmetric dielectric environment is employed for unidirectional excitation o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53586-4
更新日期：2019-11-19 00:00:00
abstract：:Human respiratory syncytial virus (RSV) A ON1 genotype, first detected in 2010 in Ontario, Canada, has been documented in 21 countries to date. This study investigated persistence and transmission dynamics of ON1 by grouping 406 randomly selected RSV-positive specimens submitted to Public Health Ontario from August 20...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14268
更新日期：2015-09-30 00:00:00
abstract：:Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neuro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32616-7
更新日期：2018-09-21 00:00:00
abstract：:During the last decades, atmospheric nitrogen loading in mountain ranges of the Northern Hemisphere has increased substantially, resulting in high nitrate concentrations in many lakes. Yet, how increased nitrogen has affected denitrification, a key process for nitrogen removal, is poorly understood. We measured actual...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59759-w
更新日期：2020-02-20 00:00:00
abstract：:Clobetasol propionate (CLO) is a potent glucocorticoid used to treat inflammation-based skin, scalp, and hair disorders. In such conditions, hair follicles (HF) are not only the target site but can also act as drug reservoirs when certain formulations are topically applied. Recently, we have demonstrated nanostructure...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56760-w
更新日期：2020-01-13 00:00:00
abstract：:During capillary transit, red blood cells (RBCs) must exchange large quantities of CO2 and O2 in typically less than one second, but the degree to which this is rate-limited by diffusion through cytoplasm is not known. Gas diffusivity is intuitively assumed to be fast and this would imply that the intracellular path-l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36018
更新日期：2016-10-25 00:00:00
abstract：:Ghrelin is the only orexigenic peptide currently known and a potent prokinetic by promoting gastric motility but novel insights suggest that its role extends beyond satiety regulation. Whereas ghrelin was shown to provide somatic and colonic antinociception, its impact on gastric sensitivity is unknown even though sto...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67053-y
更新日期：2020-06-19 00:00:00
abstract：:The development of selective visual attention is critical for effectively engaging with an ever-changing world. Its optimal deployment depends upon interactions between neural, motor, and sensory systems across multiple timescales and neurocognitive loci. Previous work illustrates the spatio-temporal dynamics of these...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73187-w
更新日期：2020-10-14 00:00:00
abstract：:Current control of insect pests relies on chemical insecticides, however, insecticide resistance development by pests is a growing concern in pest management. The main mechanisms for insecticide resistance typically involve elevated activity of detoxifying enzymes and xenobiotic transporters that break-down and excret...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01961-4
更新日期：2017-05-11 00:00:00
abstract：:We demonstrate fluorescent Fe embedded magnetic nanodiamonds by ion implantation and two-step annealing. The diamond characteristics with a highly ordered core and a graphite surface layer are maintained after the implantation process. After the two-step annealing process, a bright red fluorescence associated with nit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37820-z
更新日期：2019-02-04 00:00:00
abstract：:Tumor growth and metastasis are responsible for most cancer patients' deaths. Here, we report that eupolyphaga sinensis walker has an essential role in resisting hepatocellular carcinoma growth and metastasis. Compared with proliferation, colony formation, transwell assay and transplantable tumor in nude mouse in vitr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05518
更新日期：2014-07-01 00:00:00
abstract：:Activation of cell cycle regulated transcription during the G1-to-S transition initiates S phase entry and cell cycle commitment. The molecular mechanisms involving G1/S transcriptional regulation are well established and have been shown to be evolutionary conserved from yeast to humans. Previous work has suggested th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47170-z
更新日期：2019-07-23 00:00:00
abstract：:We developed a virus-like particle (VLP)-based therapeutic vaccine against angiotensin II receptor type 1, ATR-AP205-001, which could significantly reduce the blood pressure and protect target organs of hypertensive animals. In this study, we focused on the immunological effect and safety of the VLP-based vaccine. By ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12996-y
更新日期：2017-10-03 00:00:00
abstract：:The clinical and mycobacterial features of tuberculous meningitis (TBM) cases in China are not well described; especially in western provinces with poor tuberculosis control. We prospectively enrolled patients in whom TBM was considered in Shaanxi Province, northwestern China, over a 2-year period (September 2010 to D...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25251
更新日期：2016-05-04 00:00:00
abstract：:Cell surface expression of alpha-enolase, a glycolytic enzyme displaying moonlighting activities, has been shown to contribute to the motility and invasiveness of cancer cells through the protein non-enzymatic function of binding plasminogen and enhancing plasmin formation. Although a few recent records indicate the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04185-8
更新日期：2017-06-19 00:00:00
abstract：:Increased evidence suggests that dysregulation of cholesterol metabolism may be a key event contributing to progression of multiple sclerosis (MS). Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the mRNA and protein expression of key molecules involved in the maint...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02638-8
更新日期：2017-06-02 00:00:00
abstract：:We have identified a gene (PpSAP1) of Prunus persica coding for a stress-associated protein (SAP) containing Zn-finger domains A20 and AN1. SAPs have been described as regulators of the abiotic stress response in plant species, emerging as potential candidates for improvement of stress tolerance in plants. PpSAP1 was ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00471-7
更新日期：2017-03-23 00:00:00
abstract：:Biological hydrogen production is based on activity of specific enzymes called hydrogenases. Hydrogenases are oxygen sensitive metalloenzymes containing Ni and/or Fe atoms at the active site, catalyzing reversible reduction of protons. Generally, [Fe-Fe] hydrogenases prefer proton reduction to molecular hydrogen, a po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36034
更新日期：2016-10-27 00:00:00
abstract：:The comet assay is an electrophoretic technique used to assess DNA damage, as a marker of genotoxicity and oxidative stress, in tissues and biological samples including peripheral blood mononuclear cells (PBMCs) and whole blood (WB). Although numerous studies are performed on stored samples, the impact of cryopreserva...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79670-8
更新日期：2021-01-11 00:00:00
abstract：:Delivery and expression of recombinant genes, a key methodology for many applications in biological research, remains a challenge especially for mature neurons. Here, we report easy, highly efficient and well tolerated transduction of adult peripheral and central neuronal populations of diverse species in culture usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38928
更新日期：2016-12-13 00:00:00
abstract：:Osteoclasts are specialised bone resorbing cells that control both physiological and pathological bone turnover. Functional changes in the differentiation and activity of osteoclasts are accompanied by active metabolic reprogramming. However, the biological significance and the in vivo relevance of these events has re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77892-4
更新日期：2020-12-03 00:00:00
abstract：:One-year time series of current velocities and hydrographic parameters based on four deep moorings deployed east of the Luzon Strait are employed to study the deep current at the western boundary (DCWB) of the northern Philippine Basin. While the mean current is relatively weak, the DCWB is highly variable on an intra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32541-9
更新日期：2018-09-25 00:00:00
abstract：:Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in hea...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-40343-w
更新日期：2019-03-06 00:00:00
abstract：:Improving spatial accessibility to hospitals is a major task for health care systems which can be facilitated using recent methodological improvements of spatial accessibility measures. We used the integrated floating catchment area (iFCA) method to analyze spatial accessibility of general inpatient care (internal med...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76212-0
更新日期：2020-11-05 00:00:00
abstract：:Balance disorders have been poorly investigated and somewhat neglected in people infected with the human immunodeficiency virus, especially in children, whose have intrinsic and extrinsic risk factors that may compromise the balance. To evaluate the foot plantar pressures and the balance in children with acquired immu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41028-0
更新日期：2019-03-13 00:00:00
