Abstract：
:Improving spatial accessibility to hospitals is a major task for health care systems which can be facilitated using recent methodological improvements of spatial accessibility measures. We used the integrated floating catchment area (iFCA) method to analyze spatial accessibility of general inpatient care (internal medicine, surgery and neurology) on national level in Germany determining an accessibility index (AI) by integrating distances, hospital beds and morbidity data. The analysis of 358 million distances between hospitals and population locations revealed clusters of lower accessibility indices in areas in north east Germany. There was a correlation of urbanity and accessibility up to r = 0.31 (p < 0.001). Furthermore, 10% of the population lived in areas with significant clusters of low spatial accessibility for internal medicine and surgery (neurology: 20%). The analysis revealed the highest accessibility for heart failure (AI = 7.33) and the lowest accessibility for stroke (AI = 0.69). The method applied proofed to reveal important aspects of spatial accessibility i.e. geographic variations that need to be addressed. However, for the majority of the German population, accessibility of general inpatient care was either high or at least not significantly low, which suggests rather adequate allocation of hospital resources for most parts of Germany.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bauer J,Klingelhöfer D,Maier W,Schwettmann L,Groneberg DAdoi
10.1038/s41598-020-76212-0subject
Has Abstractpub_date
2020-11-05 00:00:00pages
19157issue
1issn
2045-2322pii
10.1038/s41598-020-76212-0journal_volume
10pub_type
杂志文章abstract：:Various folk remedies employ certain odorous compounds with analgesic effects. In fact, linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate pain responses via subcutaneous, intraperitoneal, intrathecal, and oral administration. However, the analgesic effects of odorous compounds med...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37129
更新日期：2016-11-15 00:00:00
abstract：:Hypothermic oxygenated machine perfusion (HOPE) was introduced in liver transplantation (LT) to mitigate ischemia-reperfusion injury. Available clinical data mainly concern LT with donors after circulatory-determined death, whereas data on brain-dead donors (DBD) are scarce. To assess the impact of end-ischemic HOPE i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45843-3
更新日期：2019-06-27 00:00:00
abstract：:During skin healing, periostin facilitates myofibroblast differentiation through a β1 integrin/FAK dependent mechanism and continued expression is associated with scarring. In contrast to skin, gingival tissue does not typically scar upon injury, but the role of periostin in gingival healing has never been investigate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35805-6
更新日期：2019-02-25 00:00:00
abstract：:Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects intrauterine inflammation, can trigger a fetal inflammatory response, and is closely associated with premature birth. In a cohort of 90 preterm infan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37932
更新日期：2016-12-01 00:00:00
abstract：:In this paper, we demonstrate a novel dual-pump approach to generate robust optical frequency comb with varying free spectral range (FSR) spacing in a CMOS-compatible high-Q micro-ring resonator (MRR). The frequency spacing of the comb can be tuned by an integer number FSR of the MRR freely in our dual-pump scheme. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28501
更新日期：2016-06-24 00:00:00
abstract：:At mid-ocean ridges volcanism generally decreases with spreading rate but surprisingly massive volcanic centres occur at the slowest spreading ridges. These volcanoes can host unexpectedly strong earthquakes and vigorous, explosive submarine eruptions. Our understanding of the geodynamic processes forming these volcan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42949
更新日期：2017-02-20 00:00:00
abstract：:To investigate the safety, cost-effectiveness, and clinical outcomes of simultaneous bilateral total knee arthroplasty (TKA) in hemophilic arthropathy (HA), the requirements for transfusions, complications, costs, hospital stays, Hospital for Special Surgery (HSS) knee scores, knee range of motion (ROM) and revision r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19852-7
更新日期：2018-01-25 00:00:00
abstract：:The placenta has emerged as an attractive source of mesenchymal stem cells (MSCs) because of the absence of ethical issues, non-invasive access, and abundant yield. However, inflammatory cell invasion into grafts negatively impacts the survival and efficacy of transplanted cells. Previous studies have shown that synth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22867-9
更新日期：2018-03-15 00:00:00
abstract：:Despite extensive research on various types of meditation, research on the neural correlates of religious chanting is in a nascent stage. Using multi-modal electrophysiological and neuroimaging methods, we illustrate that during religious chanting, the posterior cingulate cortex shows the largest decrease in eigenvect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40200-w
更新日期：2019-03-12 00:00:00
abstract：:Multidisciplinary applications of four-coordinate boron(III) complexes make them very attractive and challenging research field in chemistry, biology and material sciences. The dual role played by boron atom in stabilising the chelate ligand and enhancing the π-conjugation makes them very useful as luminescent materia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00236-2
更新日期：2017-03-21 00:00:00
abstract：:Vascular endothelial growth factor receptor 2 (VEGFR2) is a potential cell-type biomarker in clinical diagnoses. Besides, it's the target protein of many tyrosine kinase inhibitors and its expression significantly associates with clinical performance of these inhibitors. VEGFR2 detection provides an early warning for ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03982
更新日期：2014-02-05 00:00:00
abstract：:Cartilage engineering that combines competent seeding cells and a compatible scaffold is increasingly gaining popularity and is potentially useful for the treatment of various bone and cartilage diseases. Intensive efforts have been made by researchers to improve the viability and functionality of seeding cells of eng...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26617
更新日期：2016-05-25 00:00:00
abstract：:Ga-68 Prostate-Specific Membrane Antigen PET/CT is a new tool for the assessment of prostate cancer. Standard imaging time is 60 minutes post injection of radiotracer. At 60 minutes, there is physiologic accumulation of radiotracer in the urinary bladder which may cause some lesions in its vicinity to be obscured. Our...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59296-6
更新日期：2020-02-17 00:00:00
abstract：:The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) in both DNA and RNA. AlkB homolog 3 (ALKBH3) was als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42271
更新日期：2017-02-13 00:00:00
abstract：:This study was aimed at elucidating the changes of mandible symmetry in a rabbit model with low estrogen levels induced by ovariectomy (OVX) combined with temporomandibular joint (TMJ) anterior disc displacement without reduction (ADDWoR). 32 growing rabbits were randomly allocated into 4 groups; OVX group, ADDWoR gro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34023-4
更新日期：2018-10-23 00:00:00
abstract：:A major challenge in current exome sequencing in autosomal recessive (AR) families is the lack of an effective method to prioritize single-nucleotide variants (SNVs). AR families are generally too small for linkage analysis, and length of homozygous regions is unreliable for identification of causative variants. Vario...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12028
更新日期：2015-07-06 00:00:00
abstract：:Evaluating and tuning the properties of two-dimensional (2D) materials is a major focus of advancing 2D science and technology. While many claim that the photonic properties of a 2D layer provide evidence that the material is "high quality", this may not be true for electronic performance. In this work, we deconvolute...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16970-6
更新日期：2017-12-05 00:00:00
abstract：:The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the core promoter of e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19495-8
更新日期：2018-01-22 00:00:00
abstract：:This work presents the measurement of the permittivities of water and methanol in the D-band. Water is a reference medium for dielectric measurement. The dielectric permittivity of water in the millimeter wave range is a fundamental parameter in many applications, and needs to be investigated systematically. The measu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55126-6
更新日期：2019-12-06 00:00:00
abstract：:Climate change-induced extinctions are estimated to eliminate one in six known species by the end of the century. One major factor that will contribute to these extinctions is extreme climatic events. Here, we show the ecological impacts of recent record warm air temperatures and simultaneous peak drought conditions i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60122-2
更新日期：2020-02-25 00:00:00
abstract：:We investigated if fermentation with probiotic cultures could improve the production of health-promoting biological compounds in Astragalus membranaceus. We tested the probiotics Enterococcus faecium, Lactobacillus plantarum and Enterococcus faecium + Lactobacillus plantarum and applied PacBio single molecule, real-ti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30288-x
更新日期：2018-08-08 00:00:00
abstract：:Defense mechanisms of plant genomes can epigenetically inactivate repetitive sequences and exogenous transgenes. Loss of mutant phenotypes in intronic T-DNA insertion lines by interaction with another T-DNA locus, termed T-DNA suppression, has been observed in Arabidopsis thaliana, although the molecular basis of esta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45166
更新日期：2017-03-24 00:00:00
abstract：:Several studies provide evidence of a link between vector-borne disease outbreaks and El Niño driven climate anomalies. Less investigated are the effects of the North Atlantic Oscillation (NAO). Here, we test its impact on outbreak occurrences of 13 infectious diseases over Europe during the last fifty years, controll...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01774
更新日期：2013-01-01 00:00:00
abstract：:External exposure to gamma-photon irradiation from soil contamination due to nuclear power plant (NPP) accidents has significant contribution to human radiation exposure in the proximity of the NPP. Detailed absorbed doses in human organs are rarely reported in the literature. We applied the Monte Carlo Neutron Partic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64812-9
更新日期：2020-05-13 00:00:00
abstract：:The quantification of hepatitis C virus (HCV) is essential for the management of chronic hepatitis C therapy. We have developed a fully automated microfluidic RT-qPCR system for rapid quantitative detection of HCV RNA in human EDTA-plasma and serum, and the performance of the method was assessed. The platform for the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64169-z
更新日期：2020-04-30 00:00:00
abstract：:Contest behaviour, and in particular the propensity to attack an unfamiliar conspecific, is influenced by an individual's aggressiveness, as well as by experience of winning and losing (so called 'winner-loser effects'). Individuals vary in aggressiveness and susceptibility to winner-loser effects but the relationship...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69664-x
更新日期：2020-08-07 00:00:00
abstract：:Rapid vertebrate diversity evaluation is invaluable for monitoring changing ecosystems worldwide. Wild blow flies naturally recover DNA and chemical signatures from animal carcasses and feces. We demonstrate the power of blow flies as biodiversity monitors through sampling of flies in three environments with varying h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46758-9
更新日期：2019-07-22 00:00:00
abstract：:Gold nanoparticle radiosensitization represents a novel technique in enhancement of ionising radiation dose and its effect on biological systems. Variation between theoretical predictions and experimental measurement is significant enough that the mechanism leading to an increase in cell killing and DNA damage is stil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19442
更新日期：2016-01-20 00:00:00
abstract：:Macroautophagy, the degradation of cytoplasmic content by lysosomal fusion, is an evolutionary conserved process promoting homeostasis and intracellular defence. Macroautophagy is initiated primarily by a complex containing ULK1 or ULK2 (two paralogs of the yeast Atg1 protein). To understand the differences between UL...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67780-2
更新日期：2020-07-02 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep45235. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46913
更新日期：2017-12-22 00:00:00
