Abstract：
:Osteoclasts are specialised bone resorbing cells that control both physiological and pathological bone turnover. Functional changes in the differentiation and activity of osteoclasts are accompanied by active metabolic reprogramming. However, the biological significance and the in vivo relevance of these events has remained unclear. Here we show that bone resorption of differentiated osteoclasts heavily relies on increased aerobic glycolysis and glycolysis-derived lactate production. While pharmacological inhibition of glycolysis did not affect osteoclast differentiation or viability, it efficiently blocked bone resorption in vitro and in vivo and consequently ameliorated ovariectomy-induced bone loss. Our experiments thus highlight the therapeutic potential of interfering with osteoclast-intrinsic metabolic pathways as possible strategy for the treatment of diseases characterized by accelerated bone loss.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Taubmann J,Krishnacoumar B,Böhm C,Faas M,Müller DIH,Adam S,Stoll C,Böttcher M,Mougiakakos D,Sonnewald U,Hofmann J,Schett G,Krönke G,Scholtysek Cdoi
10.1038/s41598-020-77892-4subject
Has Abstractpub_date
2020-12-03 00:00:00pages
21020issue
1issn
2045-2322pii
10.1038/s41598-020-77892-4journal_volume
10pub_type
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