Abstract：
:We study the impact of light on the mammalian circadian system using the theory of phase response curves. Using a recently developed ansatz we derive a low-dimensional macroscopic model for the core circadian clock in mammals. Significantly, the variables and parameters in our model have physiological interpretations and may be compared with experimental results. We focus on the effect of four key factors which help shape the mammalian phase response to light: heterogeneity in the population of oscillators, the structure of the typical light phase response curve, the fraction of oscillators which receive direct light input and changes in the coupling strengths associated with seasonal day-lengths. We find these factors can explain several experimental results and provide insight into the processing of light information in the mammalian circadian system. In particular, we find that the sensitivity of the circadian system to light may be modulated by changes in the relative coupling forces between the light sensing and non-sensing populations. Finally, we show how seasonal day-length, after-effects to light entrainment and seasonal variations in light sensitivity in the mammalian circadian clock are interrelated.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hannay KM,Forger DB,Booth Vdoi
10.1038/s41598-020-74002-2subject
Has Abstractpub_date
2020-11-11 00:00:00pages
19506issue
1issn
2045-2322pii
10.1038/s41598-020-74002-2journal_volume
10pub_type
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